Gene info: ID 5781

Gene: PTPN11

GENE ID: 5781

Description: protein tyrosine phosphatase, non-receptor type 11

Gene type: protein-coding

Location: 12q24.13

dbXrefs: Ensembl:ENSG00000179295 MIM:176876 Vega:OTTHUMG00000134334 UniprotKB:Q06124

RefSeq: NG_007459.1

Retrived from: PubMed|SNP Mapped

SNPs: 1 ANCO-SNPs

Phenotype: ND|AD

# Publications: 3

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 4.455e-2 (AD) 3.185e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs143894582	chr12:112469070-112469078 (GRCh38.p7)	dupA	alcohol dependence	Indel(Insertion and Deletion)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ZFP91	0.944
SEPT7	0.922
ZNF664	0.907
ZMYND11	0.905
HINT3	0.904
C4orf3	0.903
PLA2G12A	0.901
NUCKS1	0.9
DYNC1LI2	0.896
SECISBP2L	0.894

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F29	-0.732
OR4F5	-0.665
EPPIN	-0.184
CELSR1	-0.178
ESPN	-0.17
MMP23B	-0.161
PPEF2	-0.159
S100A7	-0.158
OR2T35	-0.147
NPC1L1	-0.137

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB02779	Dodecane-Trimethylamine	Small Molecule		Experimental	Target

ID	Drug Name	Action	PubMed
C097240	15-deoxy-delta(12,14)-prostaglandin J2	"15-deoxy-delta(12,14)-prostaglandin J2 results in increased phosphorylation of PTPN11 protein"	12584205
C532162	2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine	"PTPN11 protein mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"	22315502
C532162	2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine	"tipifarnib promotes the reaction [PTPN11 protein mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine]"	22315502
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of PTPN11 mRNA"	21346803
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [PTPN11 protein mutant form results in increased susceptibility to CSF2 protein]	22315502
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of PTPN11 mRNA"	21346803
C030370	2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone	"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in decreased expression of PTPN11 mRNA"	20206263
C572491	3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol	3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol results in increased expression of PTPN11 protein	26194647
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PTPN11 mRNA"	27188386
C018511	4-dichlorobenzene	4-dichlorobenzene results in increased expression of PTPN11 mRNA	26975756
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PTPN11 mRNA"	27188386
D000082	Acetaminophen	Acetaminophen results in decreased expression of PTPN11 mRNA	21420995
D000082	Acetaminophen	Acetaminophen results in increased expression of PTPN11 mRNA	22230336
D000082	Acetaminophen	Acetaminophen affects the expression of PTPN11 mRNA	17562736
C016601	afimoxifene	afimoxifene results in decreased activity of PTPN11 protein	17272397
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of PTPN11 mRNA	19770486
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of PTPN11 mRNA	16483693
C031385	anthranilic acid	[oxovanadium IV binds to anthranilic acid analog] which results in decreased activity of PTPN11 protein	22864521
D018501	Antirheumatic Agents	Antirheumatic Agents results in increased expression of PTPN11 mRNA	24449571
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of PTPN11 mRNA	19763917
D001280	Atrazine	Atrazine results in decreased expression of PTPN11 mRNA	22378314
D001564	Benzo(a)pyrene	Benzo(a)pyrene metabolite results in increased expression of PTPN11 mRNA	26314263
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of PTPN11 mRNA	22228805
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PTPN11 mRNA"	19150397
C005961	bis(tri-n-butyltin)oxide	bis(tri-n-butyltin)oxide results in increased expression of PTPN11 mRNA	26314263
D000069286	Bortezomib	Bortezomib results in decreased expression of PTPN11 mRNA	20977926
C013418	bromfenacoum	bromfenacoum results in increased expression of PTPN11 protein	28903499
C071482	calpeptin	calpeptin results in decreased phosphorylation of PTPN11 protein	25277379
C071482	calpeptin	LM11A-31 inhibits the reaction [calpeptin results in decreased phosphorylation of PTPN11 protein]	25277379
D002509	Cephaloridine	Cephaloridine results in decreased expression of PTPN11 mRNA	18500788
D002713	Chlorine	[Ozone co-treated with Chlorine] results in decreased expression of PTPN11 mRNA	18636392
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of PTPN11 mRNA	19376846
C018021	cobaltous chloride	cobaltous chloride results in increased expression of PTPN11 mRNA	26314263
D019327	Copper Sulfate	Copper Sulfate results in increased expression of PTPN11 mRNA	19549813
D003471	Cuprizone	Cuprizone results in decreased expression of PTPN11 mRNA	27523638
D003474	Curcumin	Curcumin results in decreased expression of PTPN11	18462866
D016572	Cyclosporine	Cyclosporine results in decreased expression of PTPN11 mRNA	20106945
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of PTPN11 mRNA	21266533
D002945	Cisplatin	Cisplatin results in decreased phosphorylation of PTPN11 protein	25277379
D002945	Cisplatin	LM11A-31 inhibits the reaction [Cisplatin results in decreased phosphorylation of PTPN11 protein]	25277379
D004041	Dietary Fats	Dietary Fats results in increased expression of PTPN11 mRNA	19030233
C007517	diphenyleneiodonium	diphenyleneiodonium inhibits the reaction [EDN1 protein results in increased oxidation of PTPN11 protein]	16391241
D004221	Disulfiram	Disulfiram results in decreased expression of PTPN11 mRNA	20530235
D004237	Diuron	Diuron results in decreased expression of PTPN11 mRNA	21551480
D017292	Doxazosin	[Doxazosin results in increased phosphorylation of and results in increased activity of EPHA2 protein] which results in increased phosphorylation of and results in increased activity of PTPN11 protein	22845314
D004791	Enzyme Inhibitors	[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of PTPN11 protein	23301498
D005466	Fluorocarbons	Fluorocarbons analog binds to and results in decreased activity of PTPN11 protein	27572461
D005466	Fluorocarbons	Fluorocarbons analog results in increased expression of PTPN11 mRNA	27572461
D005485	Flutamide	Flutamide results in increased expression of PTPN11 mRNA	24136188
D005557	Formaldehyde	Formaldehyde results in decreased expression of PTPN11 mRNA	23649840
C001277	geldanamycin	geldanamycin results in increased expression of PTPN11 mRNA	26705709
C056507	gemcitabine	gemcitabine affects the expression of PTPN11 mRNA	17039268
D019833	Genistein	[Genistein co-treated with Methoxychlor] results in increased expression of PTPN11 mRNA	21782745
D005839	Gentamicins	Gentamicins results in increased expression of PTPN11 mRNA	22061828
D005947	Glucose	[INS protein co-treated with Glucose] results in increased expression of PTPN11 mRNA	22634610
C477872	IC 87114	IC 87114 inhibits the reaction [PTPN11 protein mutant form results in increased susceptibility to CSF2 protein]	22315502
C477872	IC 87114	PTPN11 protein mutant form results in increased susceptibility to IC 87114	22315502
C492448	ICG 001	ICG 001 results in increased expression of PTPN11 mRNA	26191083
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of PTPN11 mRNA	25613284
D007545	Isoproterenol	Isoproterenol results in increased expression of PTPN11 mRNA	20003209
D008070	Lipopolysaccharides	Lipopolysaccharides results in decreased expression of PTPN11 mRNA	12057914
C575077	LM11A-31	LM11A-31 inhibits the reaction [calpeptin results in decreased phosphorylation of PTPN11 protein]	25277379
C575077	LM11A-31	LM11A-31 inhibits the reaction [Cisplatin results in decreased phosphorylation of PTPN11 protein]	25277379
D058185	Magnetite Nanoparticles	[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of PTPN11 mRNA	26378955
D008731	Methoxychlor	[Genistein co-treated with Methoxychlor] results in increased expression of PTPN11 mRNA	21782745
D008731	Methoxychlor	Methoxychlor results in increased expression of PTPN11 mRNA	21782745
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of PTPN11 mRNA	26272509\|2800136
C004925	methylmercuric chloride	"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PTPN11 mRNA"	27188386
C030957	methylmercury II	methylmercury II results in increased expression of PTPN11 mRNA	26314263
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of PTPN11 mRNA	23649840
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of PTPN11 mRNA"	26251327
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium affects the expression of PTPN11 mRNA	12710931
C583365	N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide	"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of PTPN11 mRNA"	29244179
C078131	N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide	N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide affects the reaction [PTPN11 protein affects the reaction [EDN1 protein results in increased phosphorylation of and results in increased activity of EGFR protein]]	16261333
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of PTPN11 mRNA"	25554681
C051752	nefazodone	nefazodone results in increased expression of PTPN11 mRNA	24136188
C512715	NSC-87877	NSC-87877 inhibits the reaction [[HLA-G protein results in increased phosphorylation of and results in increased activity of PTPN11 protein] which results in decreased phosphorylation of and results in decreased activity of MTOR protein]	21887223
C512715	NSC-87877	NSC-87877 inhibits the reaction [PTPN11 protein results in increased activity of HLA-G protein]	21887223
C512715	NSC-87877	NSC-87877 results in decreased activity of PTPN11 protein	21887223\|2903152
C025589	ochratoxin A	ochratoxin A metabolite results in increased expression of PTPN11 mRNA	26314263
C025589	ochratoxin A	ochratoxin A results in increased expression of PTPN11 mRNA	26314263
C075743	oxovanadium IV	[oxovanadium IV binds to anthranilic acid analog] which results in decreased activity of PTPN11 protein	22864521
C075743	oxovanadium IV	[oxovanadium IV binds to salicylideneaniline analog] which results in decreased activity of PTPN11 protein	22864521
C075743	oxovanadium IV	[oxovanadium IV binds to Schiff Bases] which results in decreased activity of PTPN11 protein	22864521
D010126	Ozone	[Ozone co-treated with Chlorine] results in decreased expression of PTPN11 mRNA	18636392
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether results in increased expression of PTPN11 protein	19954255
C539348	perfluorobutanesulfonic acid	perfluorobutanesulfonic acid binds to and results in decreased activity of PTPN11 protein	27572461
C033094	perfluorobutyric acid	perfluorobutyric acid binds to and results in decreased activity of PTPN11 protein	27572461
C036567	perfluorodecanoic acid	perfluorodecanoic acid binds to and results in decreased activity of PTPN11 protein	27572461
C522391	perfluorododecanoic acid	perfluorododecanoic acid binds to and results in decreased activity of PTPN11 protein	27572461
C000610525	perfluoroheptanoic acid	perfluoroheptanoic acid binds to and results in decreased activity of PTPN11 protein	27572461
C471071	perfluorohexanesulfonic acid	perfluorohexanesulfonic acid binds to and results in decreased activity of PTPN11 protein	27572461
C479228	perfluorohexanoic acid	perfluorohexanoic acid binds to and results in decreased activity of PTPN11 protein	27572461
C584865	perfluorononanoic acid	perfluorononanoic acid binds to and results in decreased activity of PTPN11 protein	27572461
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid binds to and results in decreased activity of and results in increased expression of PTPN11 protein	27572461
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in increased expression of PTPN11 mRNA	27572461
C023036	perfluorooctanoic acid	perfluorooctanoic acid binds to and results in decreased activity of and results in increased expression of PTPN11 protein	27572461
C586085	perfluoroundecanoic acid	perfluoroundecanoic acid binds to and results in decreased activity of PTPN11 protein	27572461
D010634	Phenobarbital	Phenobarbital affects the expression of PTPN11 mRNA	23091169
C006253	pirinixic acid	pirinixic acid results in increased expression of PTPN11 mRNA	12832660
D010936	Plant Extracts	Plant Extracts results in increased expression of PTPN11 mRNA	23557933
D011078	Polychlorinated Biphenyls	Polychlorinated Biphenyls affects the expression of PTPN11 mRNA	21334430
C059514	resveratrol	resveratrol inhibits the reaction [COL1A1 protein promotes the reaction [PTPN11 protein binds to BTK protein]]	26482867
C059514	resveratrol	resveratrol inhibits the reaction [COL1A1 protein promotes the reaction [PTPN11 protein binds to SYK protein]]	26482867
C059514	resveratrol	resveratrol inhibits the reaction [COL1A1 protein promotes the reaction [PTPN11 protein binds to VAV1 protein]]	26482867
C059514	resveratrol	resveratrol inhibits the reaction [COL1A1 protein results in increased oxidation of and results in decreased activity of PTPN11 protein]	26482867
C059514	resveratrol	resveratrol results in increased expression of PTPN11 mRNA	26911335
C059514	resveratrol	resveratrol results in increased expression of PTPN11 protein	26911335
C059514	resveratrol	PTPN11 protein affects the reaction [resveratrol inhibits the reaction [EGF protein results in increased phosphorylation of and results in increased activity of AKT1 protein]]	15849355
C059514	resveratrol	resveratrol results in increased activity of PTPN11 protein	15849355
C510217	salicylideneaniline	[oxovanadium IV binds to salicylideneaniline analog] which results in decreased activity of PTPN11 protein	22864521
D012545	Schiff Bases	[oxovanadium IV binds to Schiff Bases] which results in decreased activity of PTPN11 protein	22864521
D012822	Silicon Dioxide	Silicon Dioxide results in decreased expression of PTPN11 mRNA	25351596
C017947	sodium arsenite	sodium arsenite results in decreased expression of PTPN11 mRNA	12679051
D012969	Sodium Fluoride	Sodium Fluoride results in increased expression of PTPN11 mRNA	27862939
D013229	Stearic Acids	Stearic Acids analog binds to and results in decreased activity of PTPN11 protein	27572461
D013229	Stearic Acids	Stearic Acids analog results in increased expression of PTPN11 mRNA	27572461
D004113	Succimer	[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of PTPN11 mRNA	26378955
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of PTPN11 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of PTPN11 mRNA	19770486
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of PTPN11 mRNA	25613284
D013893	Thiram	Thiram results in decreased expression of PTPN11 mRNA	20530235
C402769	tipifarnib	"tipifarnib promotes the reaction [PTPN11 protein mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine]"	22315502
C011559	tributyltin	tributyltin results in increased expression of PTPN11 mRNA	26314263
C046488	trimethyltin	trimethyltin results in increased expression of PTPN11 mRNA	21435392
D014635	Valproic Acid	Valproic Acid results in increased expression of PTPN11 mRNA	23527032
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of PTPN11 gene	25560391
C025643	vinclozolin	vinclozolin affects the expression of PTPN11 mRNA	19015723
D014750	Vincristine	Vincristine results in decreased expression of PTPN11 mRNA	23649840
D024483	Vitamin K 3	Vitamin K 3 affects the expression of PTPN11 mRNA	20044591

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001784	phosphotyrosine residue binding	-	IMP	12051764
GO:0001784	phosphotyrosine residue binding	-	IPI	11986327 12051764
GO:0004721	phosphoprotein phosphatase activity	-	IDA	15133037
GO:0004725	protein tyrosine phosphatase activity	-	EXP	22759635
GO:0004725	protein tyrosine phosphatase activity	-	IDA	15133037 23029125 26742426 28074573
GO:0004725	protein tyrosine phosphatase activity	-	IMP	17562706
GO:0004725	protein tyrosine phosphatase activity	-	TAS	-
GO:0004726	non-membrane spanning protein tyrosine phosphatase activity	-	IMP	10655584
GO:0004726	non-membrane spanning protein tyrosine phosphatase activity	-	TAS	-
GO:0005070	SH3/SH2 adaptor activity	-	IPI	7493946
GO:0005158	insulin receptor binding	-	IPI	7493946
GO:0005515	protein binding	-	IPI	7493946 7504175 7513703 7523381 7530043 7642582 7688466 8119896 8183548 8538796 8648092 8810330 8895367 9312087 9535915 9593725 9658397 9774457 9792637 10206955 10540326 10660596 10681522 10704309 11323411 11453982 11743164 12391297 12577067 12614164 12855672 14665621 14701753 14963045 15133037 15170389 15240681 15556604 15574420 16253990 16254138 16273093 16337946 16339535 16729043 16963136 17562706 17936057 17947393 18579758 18604210 19172738 19380743 19509291 19843936 20308328 20933011 21516116 21706016 23112346 23397142 24642916 24728074 25416956 26742426 26755705 28046066
GO:0016303	1-phosphatidylinositol-3-kinase activity	-	TAS	-
GO:0019904	protein domain specific binding	-	IEA	-
GO:0030971	receptor tyrosine kinase binding	-	IEA	-
GO:0031748	D1 dopamine receptor binding	-	IEA	-
GO:0043274	phospholipase binding	-	IEA	-
GO:0043560	insulin receptor substrate binding	-	IEA	-
GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity	-	TAS	-
GO:0050839	cell adhesion molecule binding	-	IEA	-
GO:0051428	peptide hormone receptor binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000077	DNA damage checkpoint	-	IEA	-
GO:0000187	activation of MAPK activity	-	IEA	-
GO:0006641	triglyceride metabolic process	-	IEA	-
GO:0007173	epidermal growth factor receptor signaling pathway	-	TAS	-
GO:0007229	integrin-mediated signaling pathway	-	IEA	-
GO:0007411	axon guidance	-	TAS	-
GO:0007420	brain development	-	IMP	11704759
GO:0007507	heart development	-	IMP	12058348
GO:0008543	fibroblast growth factor receptor signaling pathway	-	TAS	-
GO:0009755	hormone-mediated signaling pathway	-	IEA	-
GO:0019221	cytokine-mediated signaling pathway	-	TAS	-
GO:0021697	cerebellar cortex formation	-	IEA	-
GO:0030168	platelet activation	-	TAS	-
GO:0030220	platelet formation	-	IEA	-
GO:0031295	T cell costimulation	-	TAS	-
GO:0032528	microvillus organization	-	IEA	-
GO:0033277	abortive mitotic cell cycle	-	IEA	-
GO:0033628	regulation of cell adhesion mediated by integrin	-	IMP	10655584
GO:0033629	negative regulation of cell adhesion mediated by integrin	-	IEA	-
GO:0035264	multicellular organism growth	-	IEA	-
GO:0035265	organ growth	-	IEA	-
GO:0035335	peptidyl-tyrosine dephosphorylation	-	IDA	15133037
GO:0035335	peptidyl-tyrosine dephosphorylation	-	IMP	10655584 17562706
GO:0035855	megakaryocyte development	-	IEA	-
GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process	-	IEA	-
GO:0036302	atrioventricular canal development	-	IMP	12058348
GO:0038127	ERBB signaling pathway	-	IDA	15133037
GO:0040014	regulation of multicellular organism growth	-	IEA	-
GO:0042445	hormone metabolic process	-	IEA	-
GO:0042593	glucose homeostasis	-	IEA	-
GO:0043254	regulation of protein complex assembly	-	IDA	7493946
GO:0045931	positive regulation of mitotic cell cycle	-	IEA	-
GO:0046676	negative regulation of insulin secretion	-	IEA	-
GO:0046825	regulation of protein export from nucleus	-	IEA	-
GO:0046854	phosphatidylinositol phosphorylation	-	IEA	-
GO:0046887	positive regulation of hormone secretion	-	IEA	-
GO:0048008	platelet-derived growth factor receptor signaling pathway	-	IEA	-
GO:0048011	neurotrophin TRK receptor signaling pathway	-	IEA	-
GO:0048013	ephrin receptor signaling pathway	-	IDA	10655584
GO:0048609	multicellular organismal reproductive process	-	IEA	-
GO:0048806	genitalia development	-	IMP	12058348
GO:0048839	inner ear development	-	IMP	12058348
GO:0048873	homeostasis of number of cells within a tissue	-	IEA	-
GO:0050900	leukocyte migration	-	TAS	-
GO:0051463	negative regulation of cortisol secretion	-	IEA	-
GO:0051897	positive regulation of protein kinase B signaling	-	TAS	-
GO:0060020	Bergmann glial cell differentiation	-	IEA	-
GO:0060125	negative regulation of growth hormone secretion	-	IEA	-
GO:0060325	face morphogenesis	-	IMP	11704759
GO:0060338	regulation of type I interferon-mediated signaling pathway	-	TAS	-
GO:0061582	intestinal epithelial cell migration	-	IEA	-
GO:0070102	interleukin-6-mediated signaling pathway	-	TAS	-
GO:0070374	positive regulation of ERK1 and ERK2 cascade	-	IMP	28074573
GO:0071260	cellular response to mechanical stimulus	-	IEA	-
GO:0071345	cellular response to cytokine stimulus	-	TAS	-
GO:0071364	cellular response to epidermal growth factor stimulus	-	IMP	28074573
GO:2001275	positive regulation of glucose import in response to insulin stimulus	-	IDA	7493946

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IDA	15133037 26742426
GO:0005654	nucleoplasm	-	TAS	-
GO:0005737	cytoplasm	-	IDA	10940933 15133037 26742426
GO:0005739	mitochondrion	-	IEA	-
GO:0005829	cytosol	-	TAS	-
GO:0032991	protein-containing complex	-	IMP	17562706

KEGG ID	KEGG Term
hsa04630	Jak-STAT signaling pathway
hsa04650	Natural killer cell mediated cytotoxicity
hsa04670	Leukocyte transendothelial migration
hsa04722	Neurotrophin signaling pathway
hsa04920	Adipocytokine signaling pathway
hsa05120	Epithelial cell signaling in Helicobacter pylori infection
hsa05211	Renal cell carcinoma
hsa05220	Chronic myeloid leukemia

Reactome ID	Reactome Term	Evidence
R-HSA-1059683	Interleukin-6 signaling	TAS
R-HSA-109582	Hemostasis	TAS
R-HSA-109704	PI3K Cascade	TAS
R-HSA-110056	MAPK3 (ERK1) activation	TAS
R-HSA-112399	IRS-mediated signalling	TAS
R-HSA-112409	RAF-independent MAPK1/3 activation	TAS
R-HSA-112411	MAPK1 (ERK2) activation	TAS
R-HSA-114604	GPVI-mediated activation cascade	TAS
R-HSA-1170546	Prolactin receptor signaling	IEA
R-HSA-1257604	PIP3 activates AKT signaling	TAS
R-HSA-1266738	Developmental Biology	TAS
R-HSA-1266738	Developmental Biology	IEA
R-HSA-1280215	Cytokine Signaling in Immune system	TAS
R-HSA-1280215	Cytokine Signaling in Immune system	IEA
R-HSA-1280218	Adaptive Immune System	TAS
R-HSA-1295596	Spry regulation of FGF signaling	TAS
R-HSA-1433557	Signaling by SCF-KIT	TAS
R-HSA-1500931	Cell-Cell communication	IEA
R-HSA-162582	Signal Transduction	TAS
R-HSA-162582	Signal Transduction	IEA
R-HSA-1643685	Disease	TAS
R-HSA-166016	Toll Like Receptor 4 (TLR4) Cascade	TAS
R-HSA-166166	MyD88-independent TLR4 cascade	TAS
R-HSA-166520	Signaling by NTRKs	IEA
R-HSA-168249	Innate Immune System	TAS
R-HSA-168256	Immune System	TAS
R-HSA-168256	Immune System	IEA
R-HSA-168898	Toll-Like Receptors Cascades	TAS
R-HSA-177929	Signaling by EGFR	TAS
R-HSA-180292	GAB1 signalosome	TAS
R-HSA-186763	Downstream signal transduction	TAS
R-HSA-186797	Signaling by PDGF	TAS
R-HSA-190236	Signaling by FGFR	TAS
R-HSA-199418	Negative regulation of the PI3K/AKT network	TAS
R-HSA-202733	Cell surface interactions at the vascular wall	TAS
R-HSA-210990	PECAM1 interactions	TAS
R-HSA-210993	Tie2 Signaling	TAS
R-HSA-212436	Generic Transcription Pathway	TAS
R-HSA-2219528	PI3K/AKT Signaling in Cancer	TAS
R-HSA-2219530	Constitutive Signaling by Aberrant PI3K in Cancer	TAS
R-HSA-2404192	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	TAS
R-HSA-2428924	IGF1R signaling cascade	TAS
R-HSA-2428928	IRS-related events triggered by IGF1R	TAS
R-HSA-2586552	Signaling by Leptin	IEA
R-HSA-373752	Netrin-1 signaling	IEA
R-HSA-388841	Costimulation by the CD28 family	TAS
R-HSA-389513	CTLA4 inhibitory signaling	TAS
R-HSA-389948	PD-1 signaling	TAS
R-HSA-391160	Signal regulatory protein family interactions	IEA
R-HSA-418346	Platelet homeostasis	TAS
R-HSA-418886	Netrin mediated repulsion signals	IEA
R-HSA-422475	Axon guidance	TAS
R-HSA-422475	Axon guidance	IEA
R-HSA-432142	Platelet sensitization by LDL	TAS
R-HSA-446652	Interleukin-1 family signaling	TAS
R-HSA-449147	Signaling by Interleukins	TAS
R-HSA-449147	Signaling by Interleukins	IEA
R-HSA-512988	Interleukin-3, 5 and GM-CSF signaling	IEA
R-HSA-512988	Interleukin-3, 5 and GM-CSF signaling	TAS
R-HSA-5654687	Downstream signaling of activated FGFR1	TAS
R-HSA-5654689	PI-3K cascade:FGFR1	TAS
R-HSA-5654693	FRS-mediated FGFR1 signaling	TAS
R-HSA-5654695	PI-3K cascade:FGFR2	TAS
R-HSA-5654696	Downstream signaling of activated FGFR2	TAS
R-HSA-5654700	FRS-mediated FGFR2 signaling	TAS
R-HSA-5654706	FRS-mediated FGFR3 signaling	TAS
R-HSA-5654708	Downstream signaling of activated FGFR3	TAS
R-HSA-5654710	PI-3K cascade:FGFR3	TAS
R-HSA-5654712	FRS-mediated FGFR4 signaling	TAS
R-HSA-5654716	Downstream signaling of activated FGFR4	TAS
R-HSA-5654720	PI-3K cascade:FGFR4	TAS
R-HSA-5654726	Negative regulation of FGFR1 signaling	TAS
R-HSA-5654727	Negative regulation of FGFR2 signaling	TAS
R-HSA-5654732	Negative regulation of FGFR3 signaling	TAS
R-HSA-5654733	Negative regulation of FGFR4 signaling	TAS
R-HSA-5654736	Signaling by FGFR1	TAS
R-HSA-5654738	Signaling by FGFR2	TAS
R-HSA-5654741	Signaling by FGFR3	TAS
R-HSA-5654743	Signaling by FGFR4	TAS
R-HSA-5663202	Diseases of signal transduction	TAS
R-HSA-5683057	MAPK family signaling cascades	TAS
R-HSA-5684996	MAPK1/MAPK3 signaling	TAS
R-HSA-6783589	Interleukin-6 family signaling	TAS
R-HSA-6806834	Signaling by MET	TAS
R-HSA-6811558	PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	TAS
R-HSA-73857	RNA Polymerase II Transcription	TAS
R-HSA-74160	Gene expression (Transcription)	TAS
R-HSA-74751	Insulin receptor signalling cascade	TAS
R-HSA-74752	Signaling by Insulin receptor	TAS
R-HSA-76002	Platelet activation, signaling and aggregation	TAS
R-HSA-877300	Interferon gamma signaling	IEA
R-HSA-877312	Regulation of IFNG signaling	IEA
R-HSA-8853659	RET signaling	TAS
R-HSA-8854691	Interleukin-20 family signaling	TAS
R-HSA-8865999	MET activates PTPN11	TAS
R-HSA-8878171	Transcriptional regulation by RUNX1	TAS
R-HSA-8934593	Regulation of RUNX1 Expression and Activity	TAS
R-HSA-9006115	Signaling by NTRK2 (TRKB)	IEA
R-HSA-9006925	Intracellular signaling by second messengers	TAS
R-HSA-9006934	Signaling by Receptor Tyrosine Kinases	TAS
R-HSA-9006934	Signaling by Receptor Tyrosine Kinases	IEA
R-HSA-9008059	Interleukin-37 signaling	TAS
R-HSA-9028731	Activated NTRK2 signals through FRS2 and FRS3	IEA
R-HSA-909733	Interferon alpha/beta signaling	TAS
R-HSA-912694	Regulation of IFNA signaling	TAS
R-HSA-913531	Interferon Signaling	TAS
R-HSA-913531	Interferon Signaling	IEA
R-HSA-936964	Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon	TAS
R-HSA-937061	TRIF(TICAM1)-mediated TLR4 signaling	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
29460428	Genomewide Association Study of Alcohol Dependence and Related Traits in a Thai Population. (2018 May)	Gelernter J	Alcohol Clin Exp Res
27614952	Chemotherapy Effectiveness and Prognosis of Gastric Cancer Influenced by PTPN11 Polymorphisms. (2016)	Zhuo C	Cell Physiol Biochem
21479456	Modification of the effect of smoking on cholesterol in Japanese carriers of a PTPN11 polymorphism. (2008 Jul-Aug)	Okada R	Mol Med Rep