Gene info: ID 57817

Gene: HAMP

GENE ID: 57817

Synonyms: HEPC|HFE2B|LEAP1|PLTR

Description: hepcidin antimicrobial peptide

Gene type: protein-coding

Location: 19q13.12

dbXrefs: Ensembl:ENSG00000105697 MIM:606464 Vega:OTTHUMG00000183295 UniprotKB:P81172

RefSeq: NG_011563.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND|AD

# Publications: 2

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 2.683e-1 (AD) 3.399e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
CD300A	0.882
ABI3	0.879
SLC2A5	0.879
HCK	0.876
FPR1	0.871
CD14	0.868
FCGR1A	0.865
FCGR3A	0.864
FCGR2A	0.861
TLR2	0.861

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
KCNIP3	-0.438
ST6GAL2	-0.435
HES5	-0.425
NEUROD6	-0.413
CPLX3	-0.41
WNT7A	-0.409
EDN3	-0.407
ATP2C2	-0.402
ARSF	-0.375
ANKRD55	-0.371

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C013759	10-(alpha-diethylaminopropionyl)phenothiazine	10-(alpha-diethylaminopropionyl)phenothiazine results in decreased expression of HAMP mRNA	25633564
C025205	1,10-phenanthroline	"1,10-phenanthroline results in decreased expression of HAMP mRNA"	25633564
C026486	1,2,5,6-dibenzanthracene	"1,2,5,6-dibenzanthracene results in increased expression of HAMP mRNA"	16269432
C068543	1,2-diethyl-3-hydroxypyridin-4-one	"1,2-diethyl-3-hydroxypyridin-4-one results in decreased expression of HAMP mRNA"	21558026
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of HAMP mRNA"	27413110
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of HAMP mRNA"	25614096
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of HAMP mRNA"	23146750
C014211	2,3,7,8-tetrachlorodibenzofuran	"2,3,7,8-tetrachlorodibenzofuran results in decreased expression of HAMP mRNA"	28213091
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"2,4,5,2',4',5'-hexachlorobiphenyl results in decreased expression of HAMP mRNA"	25686467
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of HAMP mRNA"	21346803
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of HAMP mRNA"	25686467
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of HAMP mRNA"	25686467
C023035	3,4,5,3',4'-pentachlorobiphenyl	"HAMP protein results in decreased susceptibility to 3,4,5,3',4'-pentachlorobiphenyl"	25686467
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [BMP6 protein results in increased expression of HAMP mRNA]"	25633564
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [BMP6 protein results in increased secretion of HAMP protein modified form]"	25633564
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [IL6 protein results in increased expression of HAMP mRNA]"	25633564
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine results in decreased expression of HAMP mRNA"	25633564
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine results in decreased secretion of HAMP protein modified form"	25633564
C052410	9-chloro-2-(2-furyl)-(1,2,4)triazolo(1,5-c)quinazolin-5-imine	"9-chloro-2-(2-furyl)-(1,2,4)triazolo(1,5-c)quinazolin-5-imine inhibits the reaction [BMP6 protein results in increased expression of HAMP mRNA]"	25633564
C052410	9-chloro-2-(2-furyl)-(1,2,4)triazolo(1,5-c)quinazolin-5-imine	"9-chloro-2-(2-furyl)-(1,2,4)triazolo(1,5-c)quinazolin-5-imine inhibits the reaction [BMP6 protein results in increased secretion of HAMP protein modified form]"	25633564
C052410	9-chloro-2-(2-furyl)-(1,2,4)triazolo(1,5-c)quinazolin-5-imine	"9-chloro-2-(2-furyl)-(1,2,4)triazolo(1,5-c)quinazolin-5-imine results in decreased expression of HAMP mRNA"	25633564
C052410	9-chloro-2-(2-furyl)-(1,2,4)triazolo(1,5-c)quinazolin-5-imine	"9-chloro-2-(2-furyl)-(1,2,4)triazolo(1,5-c)quinazolin-5-imine results in decreased secretion of HAMP protein modified form"	25633564
D000079	Acetaldehyde	Acetaldehyde inhibits the reaction [Ethanol results in decreased expression of HAMP mRNA]	16737972
D000079	Acetaldehyde	Acetaldehyde results in decreased expression of HAMP mRNA	16737972
D000082	Acetaminophen	Acetaminophen results in decreased expression of HAMP mRNA	29067470
D000082	Acetaminophen	Acetaminophen results in increased expression of HAMP mRNA	22230336
D000082	Acetaminophen	Acetaminophen results in decreased expression of HAMP mRNA	22610607
D000082	Acetaminophen	[Acetaminophen results in decreased expression of HAMP mRNA] which results in increased abundance of Iron	22610607
D020106	Acrylamide	Acrylamide results in decreased expression of HAMP mRNA	28959563
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of HAMP mRNA	21632981\|2164198
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of HAMP mRNA	19770486
D016604	Aflatoxin B1	[sulforafan co-treated with Aflatoxin B1] affects the expression of HAMP mRNA	25450479
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of HAMP mRNA	16483693
D001058	Apomorphine	Apomorphine inhibits the reaction [BMP6 protein results in increased expression of HAMP mRNA]	25633564
D001058	Apomorphine	Apomorphine inhibits the reaction [BMP6 protein results in increased secretion of HAMP protein modified form]	25633564
D001058	Apomorphine	Apomorphine inhibits the reaction [IL6 protein results in increased expression of HAMP mRNA]	25633564
D001058	Apomorphine	Apomorphine results in decreased expression of HAMP mRNA	25633564
D001058	Apomorphine	Apomorphine results in decreased secretion of HAMP protein modified form	25633564
C013407	benzamil	benzamil inhibits the reaction [BMP6 protein results in increased expression of HAMP mRNA]	25633564
C013407	benzamil	benzamil results in decreased expression of HAMP mRNA	25633564
C006703	benzo(b)fluoranthene	benzo(b)fluoranthene results in increased expression of HAMP mRNA	16269432
C006703	benzo(b)fluoranthene	benzo(b)fluoranthene results in decreased expression of HAMP mRNA	26377693
C041512	benzo(b)fluorene	[Benzophenanthridines analog co-treated with benzo(b)fluorene co-treated with retene] results in increased expression of HAMP mRNA	22120849
D019324	beta-Naphthoflavone	[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of HAMP mRNA	18164116
D053119	Benzophenanthridines	[Benzophenanthridines analog co-treated with benzo(b)fluorene co-treated with retene] results in increased expression of HAMP mRNA	22120849
D053119	Benzophenanthridines	Benzophenanthridines analog results in increased expression of HAMP mRNA	22120849
D001564	Benzo(a)pyrene	"[Benzo(a)pyrene co-treated with dibenzo(a,l)pyrene] results in increased expression of HAMP mRNA"	17690111
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of HAMP mRNA	20106945
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of HAMP mRNA	16269432
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of HAMP mRNA	22228805
D001564	Benzo(a)pyrene	Benzo(a)pyrene affects the expression of HAMP mRNA	22610821
D001564	Benzo(a)pyrene	Benzo(a)pyrene affects the reaction [Lipopolysaccharides results in increased expression of HAMP mRNA]	22610821
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of HAMP mRNA"	26238291
D004958	Estradiol	Estradiol results in decreased expression of HAMP mRNA	20106945\|2568646
D004958	Estradiol	Tamoxifen inhibits the reaction [Estradiol results in decreased expression of HAMP mRNA]	25686467
D015082	2,2'-Dipyridyl	"2,2'-Dipyridyl results in decreased expression of HAMP mRNA"	19924283
C074212	bis(maltolato)oxovanadium(IV)	bis(maltolato)oxovanadium(IV) results in increased expression of HAMP mRNA	25168077
C006780	bisphenol A	bisphenol A results in increased expression of HAMP mRNA	25565130
C006780	bisphenol A	bisphenol A results in increased expression of HAMP mRNA	27104808
C006780	bisphenol A	bisphenol A results in increased expression of HAMP mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased methylation of HAMP gene	28505145
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide affects the expression of HAMP mRNA	23410634
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide affects the expression of HAMP mRNA	18804290
D002104	Cadmium	Cadmium results in decreased expression of HAMP mRNA	23358151
D002104	Cadmium	Cadmium results in decreased expression of HAMP mRNA	24084258
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of HAMP mRNA	27671773
D019256	Cadmium Chloride	Cadmium Chloride affects the expression of HAMP mRNA	18804290
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of HAMP mRNA	21540277
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of HAMP mRNA	25993096
D019256	Cadmium Chloride	[Cadmium Chloride results in increased expression of IL6 mRNA] which results in increased expression of HAMP mRNA	21540277
C055494	caffeic acid phenethyl ester	[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in increased expression of HAMP mRNA	20360939
D002166	Camptothecin	Camptothecin results in decreased expression of HAMP mRNA	25633564
D002193	Cantharidin	Cantharidin analog results in decreased expression of HAMP mRNA	25633564
D002193	Cantharidin	Cantharidin results in decreased expression of HAMP mRNA	25633564
D002235	Carbofuran	Carbofuran results in increased expression of HAMP mRNA	20211217
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the expression of HAMP mRNA	17484886
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of HAMP mRNA	16239168
D002734	Chlorophyll	"[Chlorophyll co-treated with dibenzo(a,l)pyrene] results in increased expression of HAMP mRNA"	22079312
D004390	Chlorpyrifos	Chlorpyrifos results in decreased expression of HAMP mRNA	25176568
C039671	ciglitazone	[ciglitazone binds to PPARG protein alternative form] which results in increased expression of HAMP mRNA	16197558
D002922	Ciguatoxins	Ciguatoxins affects the expression of HAMP mRNA	18353800
C018021	cobaltous chloride	cobaltous chloride inhibits the reaction [BMP6 protein results in increased expression of HAMP mRNA]	25633564
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of HAMP mRNA	25633564
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of HAMP mRNA	21558026
D005576	Colforsin	Colforsin affects the expression of HAMP mRNA	25633564
D005576	Colforsin	Colforsin inhibits the reaction [IL6 protein results in increased expression of HAMP mRNA]	25633564
D003300	Copper	Copper affects the expression of HAMP mRNA	16614410
D003300	Copper	Copper deficiency results in decreased expression of HAMP mRNA	23555700
D003300	Copper	Copper deficiency results in decreased expression of HAMP mRNA	20164366\|2245724
D003300	Copper	[Fructose co-treated with Copper deficiency] results in decreased expression of HAMP protein	25813056
D019327	Copper Sulfate	Copper Sulfate affects the expression of HAMP mRNA	19549813
D003314	Corn Oil	Corn Oil affects the expression of HAMP mRNA	16360708
C029892	cupric chloride	cupric chloride results in increased expression of HAMP mRNA	17211630
D003474	Curcumin	Curcumin results in decreased expression of HAMP mRNA	24634837
D016572	Cyclosporine	Cyclosporine results in decreased expression of HAMP mRNA	27989131
D016572	Cyclosporine	Cyclosporine results in increased expression of HAMP mRNA	25562108
D016572	Cyclosporine	Cyclosporine results in increased expression of HAMP mRNA	19770486
C035996	deacylketoconazole	deacylketoconazole results in decreased expression of HAMP mRNA	17966066
C526360	dechlorane plus	dechlorane plus results in decreased expression of HAMP mRNA	22913625
D003676	Deferoxamine	Deferoxamine affects the expression of HAMP mRNA	25633564
D003676	Deferoxamine	Deferoxamine inhibits the reaction [BMP6 protein results in increased expression of HAMP mRNA]	25633564
D003676	Deferoxamine	Deferoxamine promotes the reaction [ferric ammonium citrate results in decreased expression of HAMP mRNA]	25633564
D003676	Deferoxamine	ferric ammonium citrate affects the reaction [Deferoxamine inhibits the reaction [BMP6 protein results in increased expression of HAMP mRNA]]	25633564
D003676	Deferoxamine	Deferoxamine results in decreased expression of HAMP protein	21558026
C041517	dibenzo(a,l)pyrene	"[Benzo(a)pyrene co-treated with dibenzo(a,l)pyrene] results in increased expression of HAMP mRNA"	17690111
C041517	dibenzo(a,l)pyrene	"[Chlorophyll co-treated with dibenzo(a,l)pyrene] results in increased expression of HAMP mRNA"	22079312
D002945	Cisplatin	Cisplatin results in decreased expression of HAMP mRNA	25270620
D002945	Cisplatin	Cisplatin results in decreased expression of HAMP mRNA	22023808
D004008	Diclofenac	Diclofenac affects the expression of HAMP mRNA	26934552
C000944	dicrotophos	dicrotophos results in increased expression of HAMP mRNA	28302478
D004052	Diethylnitrosamine	Diethylnitrosamine results in decreased expression of HAMP mRNA	19061943
D004052	Diethylnitrosamine	Iron inhibits the reaction [Diethylnitrosamine results in decreased expression of HAMP mRNA]	19061943
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of HAMP mRNA	18164116
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in increased expression of HAMP mRNA	20360939
D004110	Diltiazem	Diltiazem promotes the reaction [Iron-Dextran Complex results in increased expression of HAMP mRNA]	27095094
C015835	dimethyl-4-toluidine	dimethyl-4-toluidine results in decreased expression of HAMP mRNA	27638505
D004178	Diquat	Diquat results in increased expression of HAMP mRNA	21698372
D004317	Doxorubicin	Doxorubicin results in increased expression of HAMP mRNA	20211217
D004785	Environmental Pollutants	Environmental Pollutants results in increased expression of HAMP mRNA	24534155
D000431	Ethanol	Acetaldehyde inhibits the reaction [Ethanol results in decreased expression of HAMP mRNA]	16737972
D000431	Ethanol	BMP6 protein inhibits the reaction [Ethanol results in decreased expression of HAMP mRNA]	24746831
D000431	Ethanol	Ethanol results in decreased expression of HAMP mRNA	16737972
D000431	Ethanol	Ethanol results in decreased expression of HAMP protein	16737972
D000431	Ethanol	fomepizole inhibits the reaction [Ethanol results in decreased expression of HAMP mRNA]	16737972
D000431	Ethanol	BMP6 protein affects the reaction [Ethanol inhibits the reaction [SMAD4 protein binds to HAMP promoter]]	24746831
D000431	Ethanol	Ethanol inhibits the reaction [Iron Carbonyl Compounds results in increased expression of HAMP mRNA]	24746831
D000431	Ethanol	Ethanol inhibits the reaction [Iron Carbonyl Compounds results in increased expression of HAMP protein]	24746831
D000431	Ethanol	Ethanol inhibits the reaction [SMAD4 protein binds to HAMP promoter]	24746831
D000431	Ethanol	Ethanol results in decreased expression of HAMP mRNA	16737972\|1720711
D000431	Ethanol	Ethanol results in decreased expression of HAMP protein	24746831
D000431	Ethanol	HAMP protein inhibits the reaction [Ethanol results in increased expression of SLC11A2 protein]	16737972
D000431	Ethanol	HAMP protein inhibits the reaction [Ethanol results in increased expression of SLC40A1 protein]	16737972
D000431	Ethanol	Quercetin inhibits the reaction [Ethanol inhibits the reaction [SMAD4 protein binds to HAMP promoter]]	24746831
D000431	Ethanol	Quercetin inhibits the reaction [Ethanol results in decreased expression of HAMP mRNA]	24746831
D000431	Ethanol	Quercetin inhibits the reaction [Ethanol results in decreased expression of HAMP protein]	24746831
D000431	Ethanol	Vitamin E inhibits the reaction [Ethanol results in decreased expression of HAMP mRNA]	16737972
D005047	Etoposide	Etoposide inhibits the reaction [BMP6 protein results in increased expression of HAMP mRNA]	25633564
D005047	Etoposide	Etoposide results in decreased expression of HAMP mRNA	25633564
D005047	Etoposide	Etoposide results in decreased expression of HAMP mRNA	25270620
C013531	ferric ammonium citrate	Deferoxamine promotes the reaction [ferric ammonium citrate results in decreased expression of HAMP mRNA]	25633564
C013531	ferric ammonium citrate	ferric ammonium citrate affects the reaction [Deferoxamine inhibits the reaction [BMP6 protein results in increased expression of HAMP mRNA]]	25633564
C013531	ferric ammonium citrate	ferric ammonium citrate inhibits the reaction [BMP6 protein results in increased expression of HAMP mRNA]	25633564
C013531	ferric ammonium citrate	ferric ammonium citrate results in decreased expression of HAMP mRNA	25633564
D015073	2-Acetylaminofluorene	2-Acetylaminofluorene inhibits the reaction [CEBPB protein binds to HAMP promoter]	21785164
D015073	2-Acetylaminofluorene	2-Acetylaminofluorene results in decreased expression of HAMP mRNA	21785164
D005485	Flutamide	Flutamide results in increased expression of HAMP mRNA	24793618
C010238	fomepizole	fomepizole inhibits the reaction [Ethanol results in decreased expression of HAMP mRNA]	16737972
D005632	Fructose	[Fructose co-treated with Copper deficiency] results in decreased expression of HAMP protein	25813056
C069837	fullerene C60	fullerene C60 results in increased expression of HAMP mRNA	19167457
C039281	furan	furan results in decreased expression of HAMP mRNA	25539665\|2619464
C038958	gadolinium chloride	gadolinium chloride results in increased expression of HAMP	19721414
C546771	gardiquimod	gardiquimod results in increased expression of HAMP mRNA	28003376
C546771	gardiquimod	Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of HAMP mRNA]	28003376
D019833	Genistein	Genistein affects the expression of HAMP mRNA	24967385
D006493	Heparin	Heparin inhibits the reaction [BMP6 protein results in increased expression of HAMP mRNA]	25633564
D006493	Heparin	Heparin inhibits the reaction [BMP6 protein results in increased secretion of HAMP protein modified form]	25633564
D006493	Heparin	Heparin inhibits the reaction [IL6 protein results in increased expression of HAMP mRNA]	25633564
D006493	Heparin	Heparin results in decreased expression of HAMP mRNA	25633564\|2568646
D006493	Heparin	Heparin results in decreased secretion of HAMP protein modified form	25633564
D006493	Heparin	Heparin results in decreased expression of HAMP mRNA	25686467
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of HAMP mRNA	23410634
C016517	indole-3-carbinol	indole-3-carbinol affects the expression of HAMP mRNA	21396975
D007501	Iron	HAMP protein results in decreased secretion of Iron	16460831
D007501	Iron	[IL6 protein results in increased expression of HAMP protein] which results in decreased secretion of Iron	16460831
D007501	Iron	Iron affects the reaction [HAMP protein results in increased uptake of SLC40A1 protein]	20655381
D007501	Iron	[Acetaminophen results in decreased expression of HAMP mRNA] which results in increased abundance of Iron	22610607
D007501	Iron	HAMP protein affects the metabolism of Iron	16574947\|1719459
D007501	Iron	HAMP protein results in decreased secretion of Iron	16648237
D007501	Iron	Iron inhibits the reaction [Diethylnitrosamine results in decreased expression of HAMP mRNA]	19061943
D007501	Iron	Iron results in increased expression of HAMP mRNA	11113132\|1725531
D007501	Iron	Iron affects the expression of HAMP mRNA	17116712
D007501	Iron	Iron deficiency results in decreased expression of HAMP mRNA	21540277\|2245724
D007501	Iron	Iron results in increased expression of HAMP protein	22659129
D054354	Iron Carbonyl Compounds	Ethanol inhibits the reaction [Iron Carbonyl Compounds results in increased expression of HAMP mRNA]	24746831
D054354	Iron Carbonyl Compounds	Ethanol inhibits the reaction [Iron Carbonyl Compounds results in increased expression of HAMP protein]	24746831
D054354	Iron Carbonyl Compounds	Iron Carbonyl Compounds results in increased expression of HAMP mRNA	24746831
D054354	Iron Carbonyl Compounds	Iron Carbonyl Compounds results in increased expression of HAMP protein	24746831
D054354	Iron Carbonyl Compounds	Quercetin inhibits the reaction [Iron Carbonyl Compounds results in increased expression of HAMP mRNA]	24746831
D054354	Iron Carbonyl Compounds	Quercetin inhibits the reaction [Iron Carbonyl Compounds results in increased expression of HAMP protein]	24746831
D007505	Iron-Dextran Complex	Diltiazem promotes the reaction [Iron-Dextran Complex results in increased expression of HAMP mRNA]	27095094
D007505	Iron-Dextran Complex	Iron-Dextran Complex results in increased expression of HAMP mRNA	27095094
D007505	Iron-Dextran Complex	Nimodipine promotes the reaction [Iron-Dextran Complex results in increased expression of HAMP mRNA]	27095094
D007505	Iron-Dextran Complex	Verapamil promotes the reaction [Iron-Dextran Complex results in increased expression of HAMP mRNA]	27095094
D019266	Iron, Dietary	"Iron, Dietary promotes the reaction [[HAMP protein binds to and results in increased degradation of SLC40A1 protein] which results in decreased uptake of Iron, Dietary]"	20105537
D019266	Iron, Dietary	"Iron, Dietary results in increased expression of HAMP mRNA"	20105537
C515100	iron pentacarbonyl	[Streptozocin co-treated with iron pentacarbonyl] results in increased expression of HAMP mRNA	22170771
D007545	Isoproterenol	Isoproterenol results in increased expression of HAMP mRNA	21335049
D007545	Isoproterenol	Isoproterenol results in increased expression of HAMP mRNA	20211217
C410337	K 7174	K 7174 results in decreased expression of HAMP mRNA	24086573
C410337	K 7174	K 7174 results in decreased expression of HAMP mRNA	24086573
C119620	kenpaullone	kenpaullone inhibits the reaction [BMP6 protein results in increased secretion of HAMP protein modified form]	25633564
C119620	kenpaullone	kenpaullone inhibits the reaction [IL6 protein results in increased expression of HAMP mRNA]	25633564
C119620	kenpaullone	kenpaullone results in decreased expression of HAMP mRNA	25633564
C119620	kenpaullone	kenpaullone results in decreased secretion of HAMP protein modified form	25633564
D007654	Ketoconazole	Ketoconazole inhibits the reaction [IL6 protein results in increased expression of HAMP mRNA]	17966066
D007654	Ketoconazole	Ketoconazole results in decreased expression of HAMP protein	17966066
D007654	Ketoconazole	Ketoconazole inhibits the reaction [CEBPA protein results in increased expression of HAMP mRNA]	17966066
D007654	Ketoconazole	Ketoconazole inhibits the reaction [CEBPB protein results in increased expression of HAMP mRNA]	17966066
D007657	Ketone Bodies	Ketone Bodies results in decreased expression of HAMP mRNA	16807920
C017461	lead nitrate	[lead nitrate co-treated with EIF2AK1 gene mutant form] results in increased expression of HAMP mRNA	25411909
C045463	leflunomide	leflunomide results in increased expression of HAMP mRNA	28988120
D001556	Lindane	Lindane results in decreased expression of HAMP mRNA	18804290
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in increased expression of HAMP mRNA"	21926164
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in increased expression of HAMP mRNA"	21664976
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in increased expression of HAMP mRNA"	22610821
C442865	lipopolysaccharide, Helicobacter pylori	"lipopolysaccharide, Helicobacter pylori results in increased expression of HAMP mRNA"	21220698
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of HAMP mRNA	21685415
D008070	Lipopolysaccharides	TNF protein affects the reaction [Lipopolysaccharides results in increased expression of HAMP mRNA]	21685415
D008070	Lipopolysaccharides	BMP6 gene mutant form inhibits the reaction [Lipopolysaccharides results in increased expression of HAMP mRNA]	19252488
D008070	Lipopolysaccharides	IL6 protein affects the reaction [Lipopolysaccharides results in increased expression of HAMP mRNA]	17255318
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of HAMP mRNA	11113132\|1656541
D008070	Lipopolysaccharides	sulforafan inhibits the reaction [Lipopolysaccharides results in increased expression of HAMP mRNA]	21303654
D008070	Lipopolysaccharides	TLR4 protein affects the reaction [Lipopolysaccharides results in increased expression of HAMP mRNA]	17255318
D008070	Lipopolysaccharides	Benzo(a)pyrene affects the reaction [Lipopolysaccharides results in increased expression of HAMP mRNA]	22610821
C025340	manganese chloride	manganese chloride results in decreased expression of HAMP mRNA	20635692
D015122	Mercaptopurine	Mercaptopurine results in increased expression of HAMP mRNA	23358152
D008628	Mercury	[HAMP protein results in decreased expression of SLC11A2 mRNA] which results in decreased uptake of Mercury	25772431
D008701	Methapyrilene	Methapyrilene results in increased expression of HAMP mRNA	28935588
D008713	Methimazole	Methimazole results in decreased expression of HAMP mRNA	20144635
D008713	Methimazole	Methimazole results in increased expression of HAMP mRNA	20144635
D008748	Methylcholanthrene	Methylcholanthrene affects the expression of HAMP mRNA	18804290
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of HAMP mRNA	23458150
D016685	Mitomycin	Mitomycin results in decreased expression of HAMP mRNA	25270620
C500085	muraglitazar	muraglitazar results in decreased expression of HAMP mRNA	21515302
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog affects the expression of HAMP mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of HAMP mRNA"	25554681
C051752	nefazodone	nefazodone results in decreased expression of HAMP mRNA	24136188
D009532	Nickel	Nickel results in decreased expression of HAMP mRNA	24084258
D009534	Niclosamide	Niclosamide results in decreased expression of HAMP mRNA	25633564
D009553	Nimodipine	Nimodipine promotes the reaction [Iron-Dextran Complex results in increased expression of HAMP mRNA]	27095094
D015739	Nocodazole	Nocodazole results in decreased expression of HAMP mRNA	25633564
D010100	Oxygen	Oxygen deficiency affects the expression of HAMP mRNA	19924283
D019308	Palmitic Acid	Palmitic Acid results in increased expression of HAMP mRNA	17658692
D010208	Papaverine	Papaverine results in decreased expression of HAMP mRNA	25633564
D010269	Paraquat	Paraquat results in increased expression of HAMP mRNA	17275934
D052638	Particulate Matter	Particulate Matter affects the expression of HAMP mRNA	25858758
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether results in decreased expression of HAMP mRNA	23948077
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of HAMP mRNA	18804290
D010656	Phenylephrine	Phenylephrine results in decreased expression of HAMP mRNA	18158353
C006253	pirinixic acid	pirinixic acid results in decreased expression of HAMP mRNA	20813756\|2381119
D028321	Plant Preparations	Plant Preparations results in increased expression of HAMP mRNA	26945725
D017035	Pravastatin	Pravastatin results in increased expression of HAMP mRNA	27225895
D017035	Pravastatin	Pravastatin results in increased expression of HAMP mRNA	27225895
D047428	Protein Kinase Inhibitors	Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of HAMP mRNA]	28003376
D011794	Quercetin	Quercetin results in decreased expression of HAMP mRNA	21632981
D011794	Quercetin	Quercetin inhibits the reaction [Ethanol inhibits the reaction [SMAD4 protein binds to HAMP promoter]]	24746831
D011794	Quercetin	Quercetin inhibits the reaction [Ethanol results in decreased expression of HAMP mRNA]	24746831
D011794	Quercetin	Quercetin inhibits the reaction [Ethanol results in decreased expression of HAMP protein]	24746831
D011794	Quercetin	Quercetin inhibits the reaction [Iron Carbonyl Compounds results in increased expression of HAMP mRNA]	24746831
D011794	Quercetin	Quercetin inhibits the reaction [Iron Carbonyl Compounds results in increased expression of HAMP protein]	24746831
D015125	Oxyquinoline	Oxyquinoline results in decreased expression of HAMP mRNA	21632981
C059514	resveratrol	resveratrol results in decreased expression of HAMP mRNA	23419489
C447880	retene	[Benzophenanthridines analog co-treated with benzo(b)fluorene co-treated with retene] results in increased expression of HAMP mRNA	22120849
C085746	rottlerin	rottlerin results in decreased expression of HAMP mRNA	25633564
C028632	rutecarpine	rutecarpine inhibits the reaction [IL6 protein results in increased expression of HAMP mRNA]	25633564
C028632	rutecarpine	rutecarpine results in decreased expression of HAMP mRNA	25633564
C541923	sandostatinLAR	sandostatinLAR results in increased expression of HAMP mRNA	17210224
D017632	Asbestos, Serpentine	"Asbestos, Serpentine results in decreased expression of HAMP mRNA"	21514415
D017632	Asbestos, Serpentine	"SPP1 gene mutant form inhibits the reaction [Asbestos, Serpentine results in decreased expression of HAMP mRNA]"	21514415
D012834	Silver	Silver results in increased expression of HAMP mRNA	26014281
C016104	sodium bichromate	sodium bichromate results in increased expression of HAMP mRNA	24612858
C075117	squalestatin 1	squalestatin 1 affects the expression of HAMP mRNA	27225895
C075117	squalestatin 1	squalestatin 1 results in decreased expression of HAMP mRNA	27225895
D013311	Streptozocin	[Streptozocin co-treated with iron pentacarbonyl] results in increased expression of HAMP mRNA	22170771
C433985	SU 9516	SU 9516 affects the expression of HAMP mRNA	25633564
C433985	SU 9516	SU 9516 inhibits the reaction [IL6 protein results in increased expression of HAMP mRNA]	25633564
C433985	SU 9516	SU 9516 results in decreased secretion of HAMP protein modified form	25633564
C016766	sulforafan	sulforafan inhibits the reaction [Lipopolysaccharides results in increased expression of HAMP mRNA]	21303654
C016766	sulforafan	[sulforafan co-treated with Aflatoxin B1] affects the expression of HAMP mRNA	25450479
D013629	Tamoxifen	Tamoxifen inhibits the reaction [Estradiol results in decreased expression of HAMP mRNA]	25686467
C501413	tesaglitazar	tesaglitazar results in decreased expression of HAMP mRNA	21515302
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of HAMP mRNA	20106945\|2163298
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of HAMP mRNA	26377647
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to HAMP promoter]	19654925
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of HAMP mRNA	28213091
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of HAMP mRNA	15703262
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of HAMP mRNA	15703262\|1626733
C009495	titanium dioxide	titanium dioxide results in decreased expression of HAMP mRNA	23557971
C009495	titanium dioxide	titanium dioxide results in increased expression of HAMP mRNA	27760801
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of HAMP mRNA	20133372
D014112	Toxaphene	Toxaphene results in increased expression of HAMP mRNA	21220043
C013320	tris(2-butoxyethyl) phosphate	tris(2-butoxyethyl) phosphate affects the expression of HAMP mRNA	29024780
D014520	Urethane	Urethane results in decreased expression of HAMP mRNA	28818685
D014635	Valproic Acid	Valproic Acid results in decreased expression of HAMP mRNA	29154799
D014700	Verapamil	Verapamil promotes the reaction [Iron-Dextran Complex results in increased expression of HAMP mRNA]	27095094
D014750	Vincristine	Vincristine results in decreased expression of HAMP mRNA	25633564
D014810	Vitamin E	Vitamin E inhibits the reaction [Ethanol results in decreased expression of HAMP mRNA]	16737972
D024483	Vitamin K 3	Vitamin K 3 affects the expression of HAMP mRNA	23410634
D015054	Zymosan	EPO protein inhibits the reaction [Zymosan results in increased expression of HAMP mRNA]	18664788
D015054	Zymosan	Zymosan results in increased expression of HAMP mRNA	18664788
D015054	Zymosan	Zymosan results in increased expression of HAMP	19721414

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005179	hormone activity	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000122	negative regulation of transcription by RNA polymerase II	-	ISS	-
GO:0006879	cellular iron ion homeostasis	-	IBA	21873635
GO:0006879	cellular iron ion homeostasis	-	IDA	15514116
GO:0006953	acute-phase response	-	IEA	-
GO:0006955	immune response	-	TAS	11113131
GO:0007568	aging	-	IEA	-
GO:0010039	response to iron ion	-	IMP	12469120
GO:0010043	response to zinc ion	-	IEA	-
GO:0010469	regulation of signaling receptor activity	-	IEA	-
GO:0031640	killing of cells of other organism	-	IEA	-
GO:0033189	response to vitamin A	-	IEA	-
GO:0034760	negative regulation of iron ion transmembrane transport	-	IBA	21873635
GO:0036017	response to erythropoietin	-	IEA	-
GO:0042742	defense response to bacterium	-	IBA	21873635
GO:0045471	response to ethanol	-	IEA	-
GO:0050832	defense response to fungus	-	IEA	-
GO:0060586	multicellular organismal iron ion homeostasis	-	IMP	12469120
GO:0061051	positive regulation of cell growth involved in cardiac muscle cell development	-	IEA	-
GO:0071222	cellular response to lipopolysaccharide	-	IEA	-
GO:0071354	cellular response to interleukin-6	-	IEA	-
GO:0071356	cellular response to tumor necrosis factor	-	IEA	-
GO:0071481	cellular response to X-ray	-	IEA	-
GO:0097421	liver regeneration	-	IEA	-
GO:1903413	cellular response to bile acid	-	IEA	-
GO:1904479	negative regulation of intestinal absorption	-	IMP	12469120
GO:1990641	response to iron ion starvation	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	NAS	11034317
GO:0005615	extracellular space	-	IBA	21873635
GO:0014704	intercalated disc	-	IEA	-
GO:0045179	apical cortex	-	IEA	-

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
26474245	The role of genetic factors in patients with hepatocellular carcinoma and iron overload - a prospective series of 234 patients. (2016 May)	Funakoshi N	Liver Int
27170390	Pathogenesis, Diagnosis and Treatment of Hemochromatosis. (2016)	Zoller H	Dig Dis