Gene: CCNB1IP1

57820
C14orf18|HEI10
cyclin B1 interacting protein 1
protein-coding
14q11.2
Ensembl:ENSG00000100814 MIM:608249 Vega:OTTHUMG00000029509 UniprotKB:Q9NPC3
NC_000014.9
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.885e-1 (AD)  8.698e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs10498267chr14:20334156 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CSTF30.869
POLR1D0.868
N4BP2L10.856
SS18L20.854
THYN10.85
TIMM90.847
PSMG20.845
INTS100.842
BID0.841
MNAT10.841

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.681
OR4F29-0.643
KLRB1-0.22
C8orf74-0.207
HMHB1-0.203
IGF2-0.197
LCK-0.196
IL2RB-0.187
CETP-0.185
TDGF1-0.183

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C49562614-deoxy-11,12-didehydroandrographolide"14-deoxy-11,12-didehydroandrographolide results in increased expression of CCNB1IP1 mRNA"22101062
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether analog results in increased expression of CCNB1IP1 mRNA"19095052
C517041(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in increased expression of CCNB1IP1 mRNA"19561079
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CCNB1IP1 mRNA20106945|2163298
C053541bicalutamidebicalutamide results in increased expression of CCNB1IP1 mRNA15638997
C006780bisphenol Abisphenol A results in decreased expression of CCNB1IP1 mRNA20678512
C006780bisphenol Abisphenol A affects the expression of CCNB1IP1 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in increased expression of CCNB1IP1 mRNA21457566
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of CCNB1IP1 mRNA28472532
C018021cobaltous chloridecobaltous chloride results in increased expression of CCNB1IP1 mRNA19376846
D016572CyclosporineCyclosporine results in increased expression of CCNB1IP1 mRNA25562108
C014347decitabinedecitabine affects the expression of CCNB1IP1 mRNA23300844
D002945CisplatinCisplatin affects the expression of CCNB1IP1 mRNA23300844
C000944dicrotophosdicrotophos results in decreased expression of CCNB1IP1 mRNA28302478
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of CCNB1IP1 mRNA22079256
D000431EthanolEthanol results in decreased expression of CCNB1IP1 mRNA28069986
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of CCNB1IP1 mRNA23649840
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CCNB1IP1 mRNA25613284
C051890irinotecanCCNB1IP1 protein results in increased susceptibility to irinotecan16734730
C045463leflunomideleflunomide results in increased expression of CCNB1IP1 mRNA28988120
C004925methylmercuric chloridemethylmercuric chloride affects the expression of CCNB1IP1 mRNA21613230
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of CCNB1IP1 mRNA23649840
C086401pentabromodiphenyl etherpentabromodiphenyl ether analog results in increased expression of CCNB1IP1 mRNA19095052
D010634PhenobarbitalPhenobarbital affects the expression of CCNB1IP1 mRNA19159669
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of CCNB1IP1 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of CCNB1IP1 mRNA22079256
D011794QuercetinQuercetin results in increased expression of CCNB1IP1 mRNA21632981
D013605T-2 ToxinT-2 Toxin results in increased expression of CCNB1IP1 mRNA26141394
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CCNB1IP1 mRNA25613284
D019284ThapsigarginThapsigargin results in increased expression of CCNB1IP1 mRNA22378314
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of CCNB1IP1 mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of CCNB1IP1 mRNA"26179874
D014415TunicamycinTunicamycin results in increased expression of CCNB1IP1 mRNA22378314
D014635Valproic AcidValproic Acid affects the expression of CCNB1IP1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of CCNB1IP1 mRNA23179753|2519280
D014635Valproic AcidValproic Acid results in decreased methylation of CCNB1IP1 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of CCNB1IP1 mRNA29154799
D015032ZincZinc deficiency results in decreased expression of CCNB1IP1 mRNA22171008

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI12612082  25416956  27107014  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001825blastocyst formation-IEA-  
GO:0007131reciprocal meiotic recombination-IBA21873635  
GO:0007131reciprocal meiotic recombination-ISS-  
GO:0007286spermatid development-IEA-  
GO:0016567protein ubiquitination-IEA-  
GO:0051026chiasma assembly-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000795synaptonemal complexcolocalizes_withISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal