Gene: CYP4F11

57834
CYPIVF11
cytochrome P450 family 4 subfamily F member 11
protein-coding
19p13.12
Ensembl:ENSG00000171903 MIM:611517 Vega:OTTHUMG00000182294 UniprotKB:Q9HBI6
NG_008335.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.331e-1 (AD)  7.653e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RFX40.884
LRIG10.878
BMPR1B0.876
ALDH1L10.864
SLC2A100.86
PLCD10.859
TGFB20.848
PHKG10.848
NPAS30.847
TP53BP20.844

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
VIT-0.482
SAMD5-0.481
GALNT14-0.477
MCHR1-0.47
AGMAT-0.469
CACNA1F-0.466
GABRG3-0.465
DUSP27-0.464
KCNK2-0.463
ZNF860-0.459

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0388644-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid"4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in decreased expression of CYP4F11 mRNA"19812349
C0388644-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid"4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in decreased expression of CYP4F11 protein"19812349
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of CYP4F11 mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of CYP4F11 mRNA21641981
D000393Air PollutantsAir Pollutants analog results in decreased expression of CYP4F11 mRNA21757418
C103303alitretinoinalitretinoin inhibits the reaction [TNF protein results in increased expression of CYP4F11 mRNA]19812349
C103303alitretinoinalitretinoin results in decreased expression of CYP4F11 mRNA19812349
C103303alitretinoinalitretinoin results in decreased expression of CYP4F11 protein19812349
C006632arsenic trioxidearsenic trioxide results in decreased expression of CYP4F11 mRNA20458559
D001379AzathioprineAzathioprine results in increased expression of CYP4F11 mRNA22623647
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CYP4F11 mRNA20106945|2163298
D004958Estradiol[Estradiol binds to ESR2 protein] which results in increased expression of CYP4F11 mRNA20404318
C006780bisphenol Abisphenol A results in decreased expression of CYP4F11 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of CYP4F11 mRNA26079696
D002104CadmiumCadmium results in increased expression of CYP4F11 mRNA21120746
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of CYP4F11 mRNA20971185
D016572CyclosporineCyclosporine results in increased expression of CYP4F11 mRNA20106945|2163298
D003976DiazinonDiazinon results in increased methylation of CYP4F11 gene22964155
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of CYP4F11 mRNA27392435
D002945CisplatinCisplatin results in increased expression of CYP4F11 mRNA27392435
D002117CalcitriolCalcitriol results in increased expression of CYP4F11 mRNA26485663
D000431EthanolEthanol results in increased expression of CYP4F11 mRNA28062356
C071834glycidamideglycidamide results in increased expression of CYP4F11 mRNA17822822
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of CYP4F11 mRNA27392435
C544151jinfukangjinfukang results in increased expression of CYP4F11 mRNA27392435
C423914LG 268LG 268 results in increased expression of CYP4F11 mRNA19812349
C423914LG 268LG 268 results in increased expression of CYP4F11 protein19812349
C406082monomethylarsonous acidmonomethylarsonous acid results in increased expression of CYP4F11 mRNA22108045|2387685
C570897NSC668394NSC668394 results in increased expression of CYP4F11 mRNA27137931
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of CYP4F11 mRNA20971185
C464660obeticholic acidobeticholic acid results in decreased expression of CYP4F11 mRNA27939613
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of CYP4F11 mRNA18467677
C023036perfluorooctanoic acidPPARA protein promotes the reaction [perfluorooctanoic acid results in decreased expression of CYP4F11 mRNA]18467677
C027579periodate-oxidized adenosineperiodate-oxidized adenosine affects the expression of CYP4F11 mRNA17097637
C005556propionaldehydepropionaldehyde results in decreased expression of CYP4F11 mRNA26079696
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [IL1B protein results in increased expression of CYP4F11 mRNA]19812349
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [TNF protein results in increased expression of CYP4F11 mRNA]19812349
C432165pyrazolanthronepyrazolanthrone results in decreased expression of CYP4F11 mRNA19812349
D011794QuercetinQuercetin results in increased expression of CYP4F11 mRNA21632981
C009237senecioninesenecionine results in increased expression of CYP4F11 mRNA26100227
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of CYP4F11 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in increased expression of CYP4F11 mRNA25351596
C017947sodium arsenitesodium arsenite affects the expression of CYP4F11 mRNA29319823
C017947sodium arsenitesodium arsenite results in increased expression of CYP4F11 mRNA23876855
D014212TretinoinTretinoin inhibits the reaction [TNF protein results in increased expression of CYP4F11 mRNA]19812349
D014212TretinoinTretinoin results in decreased expression of CYP4F11 mRNA19812349
D014212TretinoinTretinoin results in decreased expression of CYP4F11 protein19812349
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of CYP4F11 mRNA"26179874
D014635Valproic AcidValproic Acid results in increased expression of CYP4F11 mRNA29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004497monooxygenase activity-TAS-  
GO:0005504fatty acid binding-IDA18065749  
GO:0005506iron ion binding-IEA-  
GO:0016709oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen-IDA18065749  24138531  
GO:0020037heme binding-TAS10964514  
GO ID GO Term Qualifier Evidence PubMed
GO:0006631fatty acid metabolic process-IDA18065749  
GO:0006954inflammatory response-TAS10964514  
GO:0007596blood coagulation-TAS24138531  
GO:0042361menaquinone catabolic process-IDA24138531  
GO:0042376phylloquinone catabolic process-IDA24138531  
GO:0042376phylloquinone catabolic process-IEA-  
GO:0042377vitamin K catabolic process-IDA24138531  
GO:0055114oxidation-reduction process-TAS10964514  
GO ID GO Term Qualifier Evidence PubMed
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0016021integral component of membrane-IEA-  
GO:0031090organelle membrane-IEA-  
KEGG ID KEGG Term
hsa00590Arachidonic acid metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-211859Biological oxidationsTAS
R-HSA-211897Cytochrome P450 - arranged by substrate typeTAS
R-HSA-211935Fatty acidsTAS
R-HSA-211945Phase I - Functionalization of compoundsTAS
R-HSA-211958Miscellaneous substratesTAS
R-HSA-211979EicosanoidsTAS
R-HSA-2142691Synthesis of Leukotrienes (LT) and Eoxins (EX)TAS
R-HSA-2142753Arachidonic acid metabolismTAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-8978868Fatty acid metabolismTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22631658CYP2W1, CYP4F11 and CYP8A1 polymorphisms and interaction of CYP2W1 genotypes with risk factors in Mexican women with breast cancer. (2012)Cardenas-Rodriguez NAsian Pac J Cancer Prev