Gene info: ID 57835

Gene: SLC4A5

GENE ID: 57835

Synonyms: NBC4|NBCe2

Description: solute carrier family 4 member 5

Gene type: protein-coding

Location: 2p13.1

dbXrefs: Ensembl:ENSG00000188687 MIM:606757 Vega:OTTHUMG00000090263 UniprotKB:Q9BY07

RefSeq: NG_032663.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 3.381e-2 (AD) 8.756e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
GANC	0.765
DNHD1	0.743
KIAA0355	0.721
UVSSA	0.719
BTAF1	0.716
CECR2	0.709
TMTC2	0.705
SHROOM4	0.705
ELF2	0.704
BRWD3	0.701

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ADRA2C	-0.376
SLC29A4	-0.322
NANOS3	-0.322
ARSF	-0.316
PLA2G5	-0.303
PRTN3	-0.299
HES5	-0.294
MUC12	-0.283
OR4F16	-0.277
ASPDH	-0.274

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB01390	Sodium bicarbonate	Small Molecule	144-55-8	Approved	Transporter

ID	Drug Name	Action	PubMed
C029790	2,2',3',4,4',5-hexachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of SLC4A5 mRNA"	25510870
C081766	2,4,4'-trichlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of SLC4A5 mRNA"	25510870
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of SLC4A5 mRNA"	25510870
C009828	2,4,5,2',5'-pentachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of SLC4A5 mRNA"	25510870
C009407	2,5,2',5'-tetrachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of SLC4A5 mRNA"	25510870
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of SLC4A5 gene	27153756
D001151	Arsenic	Arsenic affects the methylation of SLC4A5 gene	25304211
D001152	Arsenicals	Arsenicals results in increased expression of SLC4A5 mRNA	28625800
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of SLC4A5 mRNA	27195522
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SLC4A5 mRNA"	20382639
C006780	bisphenol A	bisphenol A results in decreased expression of SLC4A5 mRNA	25181051
C074702	chromium hexavalent ion	chromium hexavalent ion affects the expression of SLC4A5 mRNA	28472532
D003010	Clorgyline	Clorgyline results in increased expression of SLC4A5 mRNA	19691856
D019833	Genistein	Genistein results in decreased methylation of SLC4A5 gene	28505145
C492448	ICG 001	ICG 001 results in increased expression of SLC4A5 mRNA	26191083
C008261	lead acetate	lead acetate affects the expression of SLC4A5 mRNA	21864555
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of SLC4A5 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of SLC4A5 mRNA"	25554681
C572573	N-nitroso-tris-chloroethylurea	[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of SLC4A5 mRNA	27935865
C410127	PCB 180	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of SLC4A5 mRNA"	25510870
C060836	pioglitazone	[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of SLC4A5 mRNA	27935865
C005556	propionaldehyde	propionaldehyde results in increased expression of SLC4A5 mRNA	26079696
D053260	Soot	Soot results in decreased expression of SLC4A5 mRNA	26551751

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005452	inorganic anion exchanger activity	-	IEA	-
GO:0008509	anion transmembrane transporter activity	-	IBA	21873635
GO:0008510	sodium:bicarbonate symporter activity	-	IBA	21873635
GO:0008510	sodium:bicarbonate symporter activity	-	NAS	10978526
GO:0008510	sodium:bicarbonate symporter activity	-	TAS	-
GO:0015301	anion:anion antiporter activity	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0002064	epithelial cell development	-	IEA	-
GO:0003014	renal system process	-	IBA	21873635
GO:0003073	regulation of systemic arterial blood pressure	-	IEA	-
GO:0006814	sodium ion transport	-	IEA	-
GO:0010468	regulation of gene expression	-	IEA	-
GO:0015698	inorganic anion transport	-	IEA	-
GO:0015701	bicarbonate transport	-	IBA	21873635
GO:0015701	bicarbonate transport	-	NAS	10978526
GO:0015701	bicarbonate transport	-	TAS	-
GO:0033326	cerebrospinal fluid secretion	-	IEA	-
GO:0048311	mitochondrion distribution	-	IEA	-
GO:0051453	regulation of intracellular pH	-	IBA	21873635
GO:0060041	retina development in camera-type eye	-	IEA	-
GO:0098656	anion transmembrane transport	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005886	plasma membrane	-	TAS	-
GO:0005887	integral component of plasma membrane	-	IBA	21873635
GO:0016021	integral component of membrane	-	NAS	10978526
GO:0016324	apical plasma membrane	-	IEA	-

KEGG ID	KEGG Term
hsa04976	Bile secretion

Reactome ID	Reactome Term	Evidence
R-HSA-382551	Transport of small molecules	TAS
R-HSA-425381	Bicarbonate transporters	TAS
R-HSA-425393	Transport of inorganic cations/anions and amino acids/oligopeptides	TAS
R-HSA-425407	SLC-mediated transmembrane transport	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
29069027	The combined effects of genetic risk and perceived discrimination on blood pressure among African Americans in the Jackson Heart Study. (2017 Oct)	Taylor JY	Medicine (Baltimore)