Gene: SLC4A5

57835
NBC4|NBCe2
solute carrier family 4 member 5
protein-coding
2p13.1
Ensembl:ENSG00000188687 MIM:606757 Vega:OTTHUMG00000090263 UniprotKB:Q9BY07
NG_032663.1
PubMed
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.381e-2 (AD)  8.756e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GANC0.765
DNHD10.743
KIAA03550.721
UVSSA0.719
BTAF10.716
CECR20.709
TMTC20.705
SHROOM40.705
ELF20.704
BRWD30.701

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ADRA2C-0.376
SLC29A4-0.322
NANOS3-0.322
ARSF-0.316
PLA2G5-0.303
PRTN3-0.299
HES5-0.294
MUC12-0.283
OR4F16-0.277
ASPDH-0.274

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01390Sodium bicarbonateSmall Molecule144-55-8ApprovedTransporter
ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of SLC4A5 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of SLC4A5 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of SLC4A5 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of SLC4A5 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of SLC4A5 mRNA"25510870
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of SLC4A5 gene27153756
D001151ArsenicArsenic affects the methylation of SLC4A5 gene25304211
D001152ArsenicalsArsenicals results in increased expression of SLC4A5 mRNA28625800
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SLC4A5 mRNA27195522
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SLC4A5 mRNA"20382639
C006780bisphenol Abisphenol A results in decreased expression of SLC4A5 mRNA25181051
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of SLC4A5 mRNA28472532
D003010ClorgylineClorgyline results in increased expression of SLC4A5 mRNA19691856
D019833GenisteinGenistein results in decreased methylation of SLC4A5 gene28505145
C492448ICG 001ICG 001 results in increased expression of SLC4A5 mRNA26191083
C008261lead acetatelead acetate affects the expression of SLC4A5 mRNA21864555
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of SLC4A5 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of SLC4A5 mRNA"25554681
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of SLC4A5 mRNA27935865
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of SLC4A5 mRNA"25510870
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of SLC4A5 mRNA27935865
C005556propionaldehydepropionaldehyde results in increased expression of SLC4A5 mRNA26079696
D053260SootSoot results in decreased expression of SLC4A5 mRNA26551751

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005452inorganic anion exchanger activity-IEA-  
GO:0008509anion transmembrane transporter activity-IBA21873635  
GO:0008510sodium:bicarbonate symporter activity-IBA21873635  
GO:0008510sodium:bicarbonate symporter activity-NAS10978526  
GO:0008510sodium:bicarbonate symporter activity-TAS-  
GO:0015301anion:anion antiporter activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0002064epithelial cell development-IEA-  
GO:0003014renal system process-IBA21873635  
GO:0003073regulation of systemic arterial blood pressure-IEA-  
GO:0006814sodium ion transport-IEA-  
GO:0010468regulation of gene expression-IEA-  
GO:0015698inorganic anion transport-IEA-  
GO:0015701bicarbonate transport-IBA21873635  
GO:0015701bicarbonate transport-NAS10978526  
GO:0015701bicarbonate transport-TAS-  
GO:0033326cerebrospinal fluid secretion-IEA-  
GO:0048311mitochondrion distribution-IEA-  
GO:0051453regulation of intracellular pH-IBA21873635  
GO:0060041retina development in camera-type eye-IEA-  
GO:0098656anion transmembrane transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0016021integral component of membrane-NAS10978526  
GO:0016324apical plasma membrane-IEA-  
KEGG ID KEGG Term
hsa04976Bile secretion
Reactome ID Reactome Term Evidence
R-HSA-382551Transport of small moleculesTAS
R-HSA-425381Bicarbonate transportersTAS
R-HSA-425393Transport of inorganic cations/anions and amino acids/oligopeptidesTAS
R-HSA-425407SLC-mediated transmembrane transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29069027The combined effects of genetic risk and perceived discrimination on blood pressure among African Americans in the Jackson Heart Study. (2017 Oct)Taylor JYMedicine (Baltimore)