Gene: PTPN14

5784
CATLPH|PEZ|PTP36
protein tyrosine phosphatase, non-receptor type 14
protein-coding
1q32.3-q41
Ensembl:ENSG00000152104 MIM:603155 Vega:OTTHUMG00000037039 UniprotKB:Q15678
NG_028036.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.024e-1 (AD)  7.197e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg07031542chr1:214567074PTPN14Gene body3.968e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MAST40.834
NFAT50.827
PIAS10.797
CDK120.797
HIVEP10.796
ARHGEF120.793
ANKRD170.792
TRAK10.792
COG50.792
HELZ0.79

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.426
OR4F29-0.393
KLRC3-0.384
TNFRSF13B-0.366
SH2D1A-0.362
CTNNA3-0.353
FXYD4-0.349
C11orf88-0.343
GNG8-0.337
APOA1-0.336

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of PTPN14 mRNA"19114083
D000082AcetaminophenAcetaminophen results in increased expression of PTPN14 mRNA29067470
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of PTPN14 gene27153756
C547126AZM551248AZM551248 results in decreased expression of PTPN14 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PTPN14 mRNA19770486|2156981
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of PTPN14 mRNA28628672
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of PTPN14 mRNA28628672
C006780bisphenol A[bisphenol A co-treated with Genistein] results in increased methylation of PTPN14 gene28505145
C006780bisphenol Abisphenol A results in decreased expression of PTPN14 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of PTPN14 mRNA28628672
C059041calyculin Acalyculin A results in increased expression of PTPN14 mRNA25270620
D002185CannabidiolCannabidiol results in increased expression of PTPN14 mRNA21542829
D002220CarbamazepineCarbamazepine affects the expression of PTPN14 mRNA25979313
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of PTPN14 mRNA17484886
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of PTPN14 mRNA25270620
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of PTPN1420938992
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PTPN14 gene20938992
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PTPN14 mRNA20938992
C018021cobaltous chloridecobaltous chloride results in decreased expression of PTPN14 mRNA19320972
D019327Copper SulfateCopper Sulfate results in increased expression of PTPN14 mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of PTPN14 mRNA25562108
D016572CyclosporineCyclosporine results in increased expression of PTPN14 mRNA19770486
C089595cylindrospermopsincylindrospermopsin results in increased expression of PTPN14 mRNA24921660
D013759DronabinolDronabinol results in increased expression of PTPN14 mRNA21542829
C007262deoxynivalenoldeoxynivalenol results in increased phosphorylation of PTPN14 protein23811945
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of PTPN14 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of PTPN14 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of PTPN14 mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of PTPN14 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of PTPN14 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of PTPN14 mRNA21603599|2739243
C014476diethyl maleatediethyl maleate results in increased expression of PTPN14 mRNA25270620
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of PTPN14 mRNA24535843
D004237DiuronDiuron results in decreased expression of PTPN14 mRNA25152437
C540355fenamidonefenamidone results in increased expression of PTPN14 mRNA27029645
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of PTPN1420938992
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PTPN14 gene20938992
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PTPN14 mRNA20938992
D019833Genistein[bisphenol A co-treated with Genistein] results in increased methylation of PTPN14 gene28505145
D006997Hypochlorous AcidHypochlorous Acid results in increased expression of PTPN14 mRNA19376150
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of PTPN14 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of PTPN14 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of PTPN14 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of PTPN14 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of PTPN14 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of PTPN14 mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of PTPN14 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of PTPN14 mRNA27392435
C008261lead acetatelead acetate results in increased expression of PTPN14 mRNA25270620
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in increased expression of PTPN14 mRNA21641980
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of PTPN1420938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PTPN14 gene20938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PTPN14 mRNA20938992
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of PTPN14 mRNA28001369
D008770MethylnitrosoureaMethylnitrosourea results in increased expression of PTPN14 mRNA25270620
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of PTPN14 mRNA"25554681
D010126OzoneOzone results in increased expression of PTPN14 mRNA17095637
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of PTPN14 mRNA24535843
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of PTPN14 mRNA19710929
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of PTPN14 mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of PTPN14 mRNA20813756
C513428pyrachlostrobinpyrachlostrobin results in increased expression of PTPN14 mRNA27029645
C078903seocalcitolseocalcitol results in increased expression of PTPN14 mRNA12040012
D012822Silicon DioxideSilicon Dioxide results in decreased expression of PTPN14 mRNA25351596
D012834SilverSilver results in increased expression of PTPN14 mRNA27131904
C017947sodium arsenitesodium arsenite results in increased expression of PTPN14 mRNA25270620
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in increased expression of PTPN14 mRNA21641980
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PTPN14 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PTPN14 mRNA22298810
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of PTPN14 mRNA20133372
C483909torcetrapibtorcetrapib results in increased expression of PTPN14 mRNA23228038
D014635Valproic AcidValproic Acid affects the expression of PTPN14 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of PTPN14 mRNA27188386
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of PTPN14 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003712transcription coregulator activity-IMP22525271  
GO:0004725protein tyrosine phosphatase activity-IMP22525271  
GO:0005515protein binding-IPI22525271  22948661  24255178  24366813  25283809  25751139  
GO:0030971receptor tyrosine kinase binding-IPI20826270  
GO ID GO Term Qualifier Evidence PubMed
GO:0001946lymphangiogenesis-IMP20826270  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006355regulation of transcription, DNA-templated-IEA-  
GO:0006470protein dephosphorylation-TAS7733990  
GO:0008285negative regulation of cell proliferation-IMP22948661  
GO:0035335peptidyl-tyrosine dephosphorylation-IEA-  
GO:0046825regulation of protein export from nucleus-IDA22948661  
GO:0071345cellular response to cytokine stimulus-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA10934049  22525271  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IDA10934049  22525271  
GO:0005856cytoskeleton-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-168256Immune SystemTAS
R-HSA-446652Interleukin-1 family signalingTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-9008059Interleukin-37 signalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28816646Chronic Cigarette Smoke Mediated Global Changes in Lung Mucoepidermoid Cells: A Phosphoproteomic Analysis. (2017 Aug)Solanki HSOMICS