Gene: PTPRB

5787
HPTP-BETA|HPTPB|PTPB|R-PTP-BETA|VEPTP
protein tyrosine phosphatase, receptor type B
protein-coding
12q15
Ensembl:ENSG00000127329 MIM:176882 Vega:OTTHUMG00000169499 UniprotKB:P23467
NG_029940.2
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.632e-2 (AD)  7.713e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2465810chr12:70621500 (GRCh38.p7)A>Gnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ABCB10.888
ABCG20.85
CYYR10.848
COBLL10.842
A2M0.839
CLEC14A0.831
PAQR50.831
GATA20.824
FGD50.824
SHE0.822

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ASPDH-0.39
FAM43B-0.369
C1orf53-0.353
MESP1-0.338
ZNF771-0.333
CLDND2-0.311
TMEM121-0.31
CHST8-0.308
C17orf50-0.303
HAGHL-0.303

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB06989{4-[2-BENZYL-3-METHOXY-2-(METHOXYCARBONYL)-3-OXOPROPYL]PHENYL}SULFAMIC ACIDSmall MoleculeExperimentalTarget
DB07068(4-{4-[(TERT-BUTOXYCARBONYL)AMINO]-2,2-BIS(ETHOXYCARBONYL)BUTYL}PHENYL)SULFAMIC ACIDSmall MoleculeExperimentalTarget
DB07127{4-[2,2-BIS(5-METHYL-1,2,4-OXADIAZOL-3-YL)-3-PHENYLPROPYL]PHENYL}SULFAMIC ACIDSmall MoleculeExperimentalTarget
DB08678(4-ETHYLPHENYL)SULFAMIC ACIDSmall MoleculeExperimentalTarget
ID Drug Name Action PubMed
C0326681-nitropyrene1-nitropyrene results in increased expression of PTPRB mRNA19041380
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of PTPRB mRNA19933214
C4059432-(oxalylamino)benzoic acid2-(oxalylamino)benzoic acid analog results in decreased activity of PTPRB protein10744717
C4059432-(oxalylamino)benzoic acid2-(oxalylamino)benzoic acid results in decreased activity of PTPRB protein10744717
C496492abrineabrine results in decreased expression of PTPRB mRNA22595364
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of PTPRB gene27153756
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of PTPRB mRNA24449571
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of PTPRB mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of PTPRB mRNA27858113
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in decreased expression of PTPRB mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased methylation of PTPRB promoter28329817
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of PTPRB mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PTPRB mRNA21569818
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PTPRB mRNA22228805
D002509CephaloridineCephaloridine results in decreased expression of PTPRB mRNA18500788
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of PTPRB mRNA27858113
D002994ClofibrateClofibrate results in decreased expression of PTPRB mRNA17585979
D003042CocaineCocaine results in decreased expression of PTPRB mRNA18000554
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of PTPRB mRNA20971185
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of PTPRB mRNA27392435
D002945CisplatinCisplatin results in increased expression of PTPRB mRNA27392435
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of PTPRB mRNA26924002
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of PTPRB mRNA27614199
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of PTPRB mRNA20227414
C020326ferric nitrilotriacetateferric nitrilotriacetate results in decreased expression of PTPRB mRNA10854235
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of PTPRB mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of PTPRB mRNA24796395|2675264
C045463leflunomideleflunomide results in increased expression of PTPRB mRNA28988120
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of PTPRB mRNA26011545
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of PTPRB mRNA"20188158
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of PTPRB mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of PTPRB mRNA"25554681
C051752nefazodonenefazodone results in decreased expression of PTPRB mRNA24136188
D009532NickelNickel results in decreased expression of PTPRB mRNA25583101
C022838nickel chloridenickel chloride results in increased expression of PTPRB mRNA17312168|2145529
C029938nickel sulfatenickel sulfate results in decreased expression of PTPRB mRNA22714537
C012655nimesulidenimesulide results in decreased expression of PTPRB mRNA24136188
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of PTPRB mRNA20971185
D010100OxygenOxygen deficiency results in increased expression of PTPRB mRNA24236059|2651600
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of PTPRB mRNA27614199
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in decreased expression of PTPRB mRNA]19482888
D010634PhenobarbitalPhenobarbital results in decreased expression of PTPRB mRNA19482888|2309116
D015474IsotretinoinIsotretinoin results in increased expression of PTPRB mRNA20436886
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of PTPRB mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in decreased expression of PTPRB mRNA23221170
C009277sodium arsenatesodium arsenate results in decreased expression of PTPRB mRNA21795629
C009277sodium arsenatesodium arsenate results in increased expression of PTPRB mRNA21795629
C017947sodium arsenitesodium arsenite results in decreased expression of PTPRB mRNA22714537
D053260SootSoot affects the expression of PTPRB mRNA26551751
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PTPRB mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PTPRB mRNA19465110|1993321
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PTPRB mRNA22298810
C009495titanium dioxidetitanium dioxide results in decreased expression of PTPRB mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of PTPRB mRNA28065790
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of PTPRB mRNA18087596
D014212TretinoinTretinoin results in increased expression of PTPRB mRNA23724009
C011559tributyltintributyltin results in decreased expression of PTPRB mRNA27614199
C012589trichostatin Atrichostatin A results in increased expression of PTPRB mRNA24935251
C057693troglitazonetroglitazone results in decreased expression of PTPRB mRNA28973697
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of PTPRB gene25560391
C029297vinylidene chloridevinylidene chloride results in decreased expression of PTPRB mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005001transmembrane receptor protein tyrosine phosphatase activity-TAS2170109  
GO:0005515protein binding-IPI12840032  12907755  16101282  19167335  19451274  
GO ID GO Term Qualifier Evidence PubMed
GO:0001525angiogenesis-IEA-  
GO:0006470protein dephosphorylation-TAS2170109  
GO:0006796phosphate-containing compound metabolic process-TAS2170109  
GO:0016311dephosphorylation-IDA19116766  19136612  
GO:0035335peptidyl-tyrosine dephosphorylation-IEA-  
GO:0043312neutrophil degranulation-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-TAS2170109  
GO:0035579specific granule membrane-TAS-  
GO:0043235receptor complex-IDA23382219  
GO:0070821tertiary granule membrane-TAS-  
KEGG ID KEGG Term
hsa04520Adherens junction
Reactome ID Reactome Term Evidence
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-6798695Neutrophil degranulationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
18361428Association of PTPRB gene polymorphism with drug addiction. (2008 Oct 5)Ishiguro HAm J Med Genet B Neuropsychiatr Genet