Gene: PTPRF

5792
BNAH2|LAR
protein tyrosine phosphatase, receptor type F
protein-coding
1p34.2
Ensembl:ENSG00000142949 MIM:179590 Vega:OTTHUMG00000007501 UniprotKB:P10586
NG_047072.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.439e-1 (AD)  8.823e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs11582876chr1:43597156 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg26064481chr1:44000558PTPRFPromoter2.832e-4Alcohol use disorders26763658
cg02283735chr1:44011587PTPRF1.580e-8Maternal smoking in pregnancy27040690
cg02283735chr1:44011587PTPRF6.210e-9Maternal smoking in pregnancy27040690

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PDK20.922
MEGF80.911
ASTN10.91
ABR0.91
ABCA30.903
CHST10.899
STIM10.898
ATG9A0.898
RPTOR0.898
GRAMD40.897

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.592
OR4F29-0.525
TFPI2-0.49
SIX1-0.468
CD48-0.468
KCNJ15-0.46
SLAMF6-0.456
CD2-0.453
GZMK-0.451
CST7-0.446

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4059432-(oxalylamino)benzoic acid2-(oxalylamino)benzoic acid analog results in decreased activity of PTPRF protein10744717
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of PTPRF mRNA"20959002
C0179063-dinitrobenzene3-dinitrobenzene results in increased expression of PTPRF mRNA21983209
D000082AcetaminophenAcetaminophen results in decreased expression of PTPRF mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of PTPRF mRNA17562736
D020106AcrylamideAcrylamide results in decreased expression of PTPRF mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of PTPRF gene27153756
D000452AldrinAldrin results in increased expression of PTPRF mRNA18579281
D000638AmiodaroneAmiodarone results in increased expression of PTPRF mRNA19774075
D000638AmiodaroneAmiodarone affects the expression of PTPRF mRNA19483382
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PTPRF mRNA16483693
C015001arsenitearsenite results in increased expression of PTPRF mRNA18191166
D001553BenzbromaroneBenzbromarone affects the expression of PTPRF mRNA19483382
D001554Benzene[Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in decreased expression of PTPRF mRNA17905399
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PTPRF mRNA22228805
C006780bisphenol Abisphenol A affects the expression of PTPRF mRNA21786754
C006780bisphenol Abisphenol A results in decreased methylation of PTPRF promoter27312807
C006780bisphenol Abisphenol A affects the expression of PTPRF mRNA21786754
C006780bisphenol Abisphenol A affects the expression of PTPRF mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of PTPRF gene28505145
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of PTPRF mRNA28628672
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of PTPRF mRNA22079614
D002065BuspironeBuspirone results in decreased expression of PTPRF mRNA24136188
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of PTPRF mRNA19010381
D002220CarbamazepineCarbamazepine affects the expression of PTPRF mRNA25979313
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of PTPRF mRNA17484886
C054133casticincasticin results in decreased expression of PTPRF mRNA28444820
C100187chloropicrinchloropicrin results in decreased expression of PTPRF mRNA26352163|2847649
D004390ChlorpyrifosChlorpyrifos results in decreased expression of PTPRF mRNA18668222
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of PTPRF mRNA20938992
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PTPRF gene20938992
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of PTPRF mRNA28472532
D002994ClofibrateClofibrate results in decreased expression of PTPRF mRNA23811191
D002994ClofibrateClofibrate affects the expression of PTPRF mRNA19483382
D002995Clofibric AcidClofibric Acid affects the expression of PTPRF mRNA17602206
D002995Clofibric Acid[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of PTPRF mRNA17602206
C018021cobaltous chloridecobaltous chloride results in decreased expression of PTPRF mRNA19320972|1937684
D003314Corn OilCorn Oil affects the expression of PTPRF mRNA16360708
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in decreased expression of PTPRF mRNA19167446
D003375CoumestrolCoumestrol results in decreased expression of PTPRF mRNA19167446
D016572CyclosporineCyclosporine results in decreased expression of PTPRF mRNA20106945|2798913
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of PTPRF mRNA28628672
D002945Cisplatin[Cisplatin co-treated with panobinostat] affects the expression of PTPRF mRNA21791302
D002945CisplatinCisplatin results in decreased expression of PTPRF mRNA27392435|2759478
C000944dicrotophosdicrotophos results in increased expression of PTPRF mRNA28302478
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of PTPRF mRNA17602206
D002117CalcitriolCalcitriol results in increased expression of PTPRF mRNA26485663
D004147DioxinsDioxins affects the expression of PTPRF mRNA20463971
D004317DoxorubicinDoxorubicin results in increased expression of PTPRF mRNA25896364
D004785Environmental PollutantsEnvironmental Pollutants results in decreased expression of PTPRF mRNA12655031
D004785Environmental PollutantsEnvironmental Pollutants results in increased expression of PTPRF mRNA12655031
D005001EthionineEthionine affects the expression of PTPRF mRNA19483382
D011345FenofibrateFenofibrate affects the expression of PTPRF mRNA20801182
D005419FlavonoidsFlavonoids results in decreased expression of PTPRF mRNA18035473
D005485FlutamideFlutamide results in decreased expression of PTPRF mRNA24136188|2479361
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of PTPRF mRNA20938992
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PTPRF gene20938992
D004397FonofosFonofos results in increased methylation of PTPRF promoter22847954
D005557FormaldehydeFormaldehyde results in decreased expression of PTPRF mRNA20655997
D005978GlutathioneGlutathione deficiency results in decreased expression of PTPRF mRNA20621112
D017313FenretinideFenretinide results in increased expression of PTPRF mRNA28973697
C492448ICG 001ICG 001 results in increased expression of PTPRF mRNA26191083
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of PTPRF mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of PTPRF mRNA28628672
D007545IsoproterenolIsoproterenol results in increased expression of PTPRF mRNA20003209
D007854LeadLead affects the expression of PTPRF mRNA28903495
D007854LeadLead affects the splicing of PTPRF mRNA28903495
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of PTPRF mRNA20938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PTPRF gene20938992
C030957methylmercury II[Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in decreased expression of PTPRF mRNA17905399
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of PTPRF mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of PTPRF mRNA"25620056
C051752nefazodonenefazodone results in decreased expression of PTPRF mRNA24136188
C012655nimesulidenimesulide results in decreased expression of PTPRF mRNA24136188
C558013NSC 689534NSC 689534 results in increased expression of PTPRF mRNA20971185
D009853OmeprazoleOmeprazole affects the expression of PTPRF mRNA19483382
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in decreased expression of PTPRF mRNA"21673326
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of PTPRF mRNA25729387
C496932panobinostat[Cisplatin co-treated with panobinostat] affects the expression of PTPRF mRNA21791302
C016030pantogabpantogab results in decreased expression of PTPRF mRNA17379144
D010278ParathionParathion results in increased methylation of PTPRF promoter22847954
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid affects the expression of PTPRF mRNA19429403
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of PTPRF mRNA19162173
C023036perfluorooctanoic acidperfluorooctanoic acid affects the expression of PTPRF mRNA19429403
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of PTPRF mRNA19162173
D010634PhenobarbitalPhenobarbital affects the expression of PTPRF mRNA23091169
D010656PhenylephrinePhenylephrine results in decreased expression of PTPRF mRNA18158353
C006253pirinixic acidpirinixic acid results in decreased expression of PTPRF mRNA17426115|1844570
C006253pirinixic acidpirinixic acid affects the expression of PTPRF mRNA19483382
C006253pirinixic acidpirinixic acid results in decreased expression of PTPRF mRNA19162173|2248451
D011192Potassium DichromatePotassium Dichromate results in increased expression of PTPRF protein23718831
C045950propiconazolepropiconazole results in decreased expression of PTPRF mRNA21278054
D011441PropylthiouracilPropylthiouracil affects the expression of PTPRF mRNA19483382
C059514resveratrol[Coumestrol co-treated with resveratrol] results in decreased expression of PTPRF mRNA19167446
C017947sodium arsenitesodium arsenite results in decreased expression of PTPRF mRNA12377979
C016104sodium bichromatesodium bichromate results in decreased expression of PTPRF mRNA22155349
D012969Sodium FluorideSodium Fluoride results in increased expression of PTPRF protein28918527
D012999SomanSoman results in increased expression of PTPRF mRNA19281266
C025462sulindac sulfidesulindac sulfide results in decreased expression of PTPRF mRNA16184548
C061133tamibarotenetamibarotene results in decreased expression of PTPRF mRNA15498508
C012568terbufosterbufos results in increased methylation of PTPRF promoter22847954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PTPRF mRNA24680724
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PTPRF mRNA26290441
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PTPRF mRNA20959002
D013853ThioacetamideThioacetamide affects the expression of PTPRF mRNA19483382
C009495titanium dioxidetitanium dioxide results in increased expression of PTPRF mRNA27760801
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of PTPRF mRNA25729387
D019772TopotecanTopotecan results in increased expression of PTPRF mRNA25729387
D014212TretinoinTretinoin results in decreased expression of PTPRF mRNA15498508|2372400
D014241Trichloroethylene[Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in decreased expression of PTPRF mRNA17905399
C012589trichostatin Atrichostatin A results in increased expression of PTPRF mRNA26705709
C001899triptolidetriptolide results in decreased expression of PTPRF mRNA23639586
C057693troglitazonetroglitazone results in decreased expression of PTPRF mRNA28973697
D014415TunicamycinTunicamycin results in decreased expression of PTPRF mRNA17127020
D014635Valproic AcidValproic Acid affects the expression of PTPRF mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of PTPRF mRNA19101580|2317975
C025643vinclozolinvinclozolin affects the expression of PTPRF mRNA19015723
C025643vinclozolinvinclozolin results in decreased expression of PTPRF mRNA23034163
D014873Water PollutantsWater Pollutants results in decreased expression of PTPRF mRNA23591932

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004725protein tyrosine phosphatase activity-IDA10338209  
GO:0004725protein tyrosine phosphatase activity-IMP23358419  
GO:0005001transmembrane receptor protein tyrosine phosphatase activity-TAS8995282  
GO:0008201heparin binding-IEA-  
GO:0035373chondroitin sulfate proteoglycan binding-IEA-  
GO:0044877protein-containing complex binding-IEA-  
GO:0050839cell adhesion molecule binding-IPI23986473  
GO ID GO Term Qualifier Evidence PubMed
GO:0007155cell adhesion-IEA-  
GO:0007185transmembrane receptor protein tyrosine phosphatase signaling pathway-TAS8995282  
GO:0016477cell migration-IMP23358419  
GO:0031102neuron projection regeneration-IEA-  
GO:0035335peptidyl-tyrosine dephosphorylation-IMP23358419  
GO:0048679regulation of axon regeneration-IEA-  
GO:1900121negative regulation of receptor binding-IMP23358419  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-TAS2972792  
GO:0043005neuron projection-IEA-  
GO:0043025neuronal cell body-IEA-  
GO:0070062extracellular exosome-HDA19199708  
KEGG ID KEGG Term
hsa04514Cell adhesion molecules (CAMs)
hsa04520Adherens junction
hsa04910Insulin signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-112316Neuronal SystemTAS
R-HSA-388844Receptor-type tyrosine-protein phosphatasesTAS
R-HSA-6794362Protein-protein interactions at synapsesTAS
R-HSA-8849932Synaptic adhesion-like moleculesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal