Gene: PTPRH

5794
R-PTP-H|SAP1
protein tyrosine phosphatase, receptor type H
protein-coding
19q13.42
Ensembl:ENSG00000080031 MIM:602510 Vega:OTTHUMG00000180701 UniprotKB:Q9HD43
NC_000019.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.072e-1 (AD)  1.338e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GALNT60.846
DNAH170.841
NIPAL40.838
BTBD160.827
TP53TG50.826
ZNF5360.816
DMRT20.813
LIPE0.812
LGR50.812
SMIM50.811

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SPRY1-0.397
WTIP-0.377
FZD1-0.359
RERG-0.359
NEUROD1-0.355
RNF43-0.342
FGD6-0.34
CCDC85C-0.338
NHS-0.336
CHRDL1-0.336

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of PTPRH mRNA"23829299
C0142112,3,7,8-tetrachlorodibenzofuran"2,3,7,8-tetrachlorodibenzofuran results in decreased expression of PTPRH mRNA"25768209
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of PTPRH mRNA"21346803
D020106AcrylamideAcrylamide affects the expression of PTPRH mRNA28959563
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of PTPRH mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PTPRH mRNA16483693
D004958EstradiolEstradiol results in increased expression of PTPRH mRNA20106945
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in decreased expression of PTPRH mRNA27685785
C006780bisphenol Abisphenol A results in increased expression of PTPRH mRNA25181051
C018475butyraldehydebutyraldehyde results in increased expression of PTPRH mRNA26079696
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of PTPRH mRNA20971185
D019327Copper SulfateCopper Sulfate results in increased expression of PTPRH mRNA19549813
D003471CuprizoneCuprizone results in increased expression of PTPRH mRNA27523638
D016572CyclosporineCyclosporine results in increased expression of PTPRH mRNA20106945|2556210
D004317DoxorubicinPTPRH mRNA affects the susceptibility to Doxorubicin16044152
C410337K 7174K 7174 results in increased expression of PTPRH mRNA24086573
D007649KetamineKetamine results in decreased expression of PTPRH mRNA20080153
C045463leflunomideleflunomide results in increased expression of PTPRH mRNA28988120
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of PTPRH mRNA24810058
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in increased expression of PTPRH mRNA22401849
C028007nickel monoxidenickel monoxide results in decreased expression of PTPRH mRNA19167457
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of PTPRH mRNA20971185
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of PTPRH mRNA18593933
D010634PhenobarbitalPhenobarbital affects the expression of PTPRH mRNA19159669
D011441PropylthiouracilPropylthiouracil results in increased expression of PTPRH mRNA24780913
D011794QuercetinQuercetin results in increased expression of PTPRH mRNA21632981
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride affects the expression of PTPRH mRNA14699072
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of PTPRH mRNA25895662
C017947sodium arsenitesodium arsenite results in decreased expression of PTPRH mRNA28595984
D013629TamoxifenESR2 protein affects the reaction [Tamoxifen results in decreased expression of PTPRH mRNA]14699072
D013629TamoxifenTamoxifen affects the expression of PTPRH mRNA14699072
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PTPRH mRNA21632981
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PTPRH mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PTPRH mRNA22298810
D019284ThapsigarginThapsigargin results in increased expression of PTPRH mRNA22378314
D014212TretinoinTretinoin results in increased expression of PTPRH mRNA23724009|2383079
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of PTPRH mRNA"26179874
D014415TunicamycinTunicamycin results in increased expression of PTPRH mRNA22378314
D014520UrethaneUrethane results in increased expression of PTPRH mRNA28818685
D014635Valproic AcidValproic Acid results in increased methylation of PTPRH gene29154799
D014800VitalliumVitallium analog results in increased expression of PTPRH mRNA23825117
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of PTPRH mRNA18593933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005001transmembrane receptor protein tyrosine phosphatase activity-IEA-  
GO:0005515protein binding-IPI12907755  25416956  
GO ID GO Term Qualifier Evidence PubMed
GO:0006470protein dephosphorylation-TAS8294459  
GO:0006915apoptotic process-IEA-  
GO:0035335peptidyl-tyrosine dephosphorylation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IEA-  
GO:0005887integral component of plasma membrane-TAS8294459  
GO:0016324apical plasma membrane-IEA-  
GO:0031528microvillus membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21203850Copy number variations of chromosome 17p13.1 might be linked to high risk of lung cancer in heavy smokers. (2011 Nov)Lee MMol Biol Rep