Gene: PTPRJ

5795
CD148|DEP1|HPTPeta|R-PTP-ETA|SCC1
protein tyrosine phosphatase, receptor type J
protein-coding
11p11.2
Ensembl:ENSG00000149177 MIM:600925 Vega:OTTHUMG00000166573 UniprotKB:Q12913
NG_012209.1
SNP Mapped
2   ANCO-SNPs
ND|AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.586e-2 (AD)  2.314e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs17198978chr11:48150813 (GRCh38.p7)C>Tnicotine dependenceSNV(Single Nucleotide Variation)
rs6485806chr11:48081254 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg26468891chr11:48077221PTPRJ1.100e-8Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DDX60.911
UBE4A0.909
SLC12A60.901
SMCR80.899
TSTD20.892
SPIRE10.879
NFAT50.875
FTO0.871
MTPN0.868
PLEKHM30.866

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
S100A1-0.395
APOA1-0.338
RBP1-0.334
C19orf18-0.327
APOM-0.315
OR4F5-0.315
RARRES2-0.313
TMEM253-0.312
EIF4EBP3-0.301
BCL7C-0.298

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PTPRJ mRNA"25510870
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of PTPRJ mRNA"23829299
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PTPRJ mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PTPRJ mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PTPRJ mRNA"25510870
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of PTPRJ mRNA"21346803
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PTPRJ mRNA"25510870
C5830744,4'-hexafluorisopropylidene diphenol"4,4'-hexafluorisopropylidene diphenol results in increased expression of PTPRJ mRNA"27567155
C5830744,4'-hexafluorisopropylidene diphenol"4,4'-hexafluorisopropylidene diphenol results in increased expression of PTPRJ protein"27567155
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PTPRJ mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PTPRJ mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of PTPRJ mRNA21420995
D000082AcetaminophenAcetaminophen results in increased expression of PTPRJ mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of PTPRJ mRNA17562736
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of PTPRJ mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of PTPRJ mRNA]17585979
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of PTPRJ mRNA22100608
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PTPRJ mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of PTPRJ mRNA24449571
C526219apple polyphenol extractapple polyphenol extract results in increased expression of PTPRJ mRNA18351577
D001151ArsenicArsenic affects the methylation of PTPRJ gene25304211
C015001arsenitearsenite results in increased methylation of PTPRJ promoter23974009
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PTPRJ mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PTPRJ mRNA20106945
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PTPRJ mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PTPRJ mRNA27195522
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PTPRJ mRNA"19150397
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of PTPRJ mRNA20660070
C006780bisphenol Abisphenol A affects the expression of PTPRJ mRNA25181051
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of PTPRJ mRNA17484886
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of PTPRJ mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of PTPRJ mRNA]17585979
D002995Clofibric Acid[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of PTPRJ mRNA17602206
C018021cobaltous chloridecobaltous chloride results in decreased expression of PTPRJ mRNA24386269
D003471CuprizoneCuprizone results in decreased expression of PTPRJ mRNA26577399
D016572CyclosporineCyclosporine results in increased expression of PTPRJ mRNA20106945
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of PTPRJ mRNA23914054
C007262deoxynivalenoldeoxynivalenol results in increased expression of PTPRJ mRNA15371230
D004008DiclofenacDiclofenac results in increased expression of PTPRJ mRNA26934552
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of PTPRJ mRNA17602206
D004237DiuronDiuron results in decreased expression of PTPRJ mRNA25152437
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of PTPRJ mRNA22079256
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PTPRJ mRNA17942748
D005485FlutamideFlutamide results in decreased expression of PTPRJ mRNA24136188
C004312glycidolglycidol results in increased expression of PTPRJ mRNA24915197
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of PTPRJ mRNA17183730
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of PTPRJ mRNA25613284
D048628KetolidesKetolides analog results in decreased expression of PTPRJ mRNA24967691
C045463leflunomideleflunomide results in increased expression of PTPRJ mRNA28988120
D008727MethotrexateMethotrexate results in increased expression of PTPRJ mRNA24449571
D008727MethotrexateMethotrexate affects the expression of PTPRJ mRNA18502557
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of PTPRJ mRNA"26251327
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased methylation of PTPRJ promoter"26251327
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PTPRJ mRNA"25510870
D010936Plant ExtractsPlant Extracts results in increased expression of PTPRJ mRNA18351577
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of PTPRJ mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of PTPRJ mRNA22079256
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of PTPRJ mRNA19162173
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of PTPRJ mRNA20660070
C045950propiconazolepropiconazole results in decreased expression of PTPRJ mRNA21278054
D011441PropylthiouracilPropylthiouracil results in decreased expression of PTPRJ mRNA24780913
D012969Sodium FluorideSodium Fluoride results in increased expression of PTPRJ mRNA27862939
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PTPRJ mRNA21632981
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PTPRJ mRNA17942748
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in decreased expression of PTPRJ mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PTPRJ mRNA19933214
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PTPRJ mRNA22298810
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of PTPRJ mRNA25613284
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of PTPRJ mRNA"26179874
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of PTPRJ mRNA17183730
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PTPRJ mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of PTPRJ mRNA26272509
D014635Valproic AcidValproic Acid results in decreased methylation of PTPRJ gene29154799
D014635Valproic AcidValproic Acid affects the expression of PTPRJ mRNA17292431
C025643vinclozolinvinclozolin affects the expression of PTPRJ mRNA19015723

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004725protein tyrosine phosphatase activity-IDA9531590  10821867  12913111  16778204  18348712  18936167  
19332538  
GO:0004725protein tyrosine phosphatase activity-IMP9780142  12475979  
GO:0004725protein tyrosine phosphatase activity-TAS-  
GO:0005161platelet-derived growth factor receptor binding-IPI10821867  
GO:0005515protein binding-IPI10821867  12370829  12475979  12771128  16893970  18936167  
19167335  19494114  23650535  
GO:0008013beta-catenin binding-IPI12370829  
GO:0016791phosphatase activity-IDA12062403  12370829  19494114  
GO:0016791phosphatase activity-IMP11259588  19836242  
GO:0019901protein kinase binding-IPI19332538  
GO:0042802identical protein binding-IPI11526512  15978577  
GO:0045295gamma-catenin binding-IPI12370829  
GO:0051019mitogen-activated protein kinase binding-IPI19494114  
GO:0070097delta-catenin binding-IPI12370829  19332538  
GO ID GO Term Qualifier Evidence PubMed
GO:0008285negative regulation of cell proliferation-IDA14709717  16682945  16778204  
GO:0010642negative regulation of platelet-derived growth factor receptor signaling pathway-IDA14709717  
GO:0030155regulation of cell adhesion-IMP12370829  
GO:0030308negative regulation of cell growth-IDA14709717  
GO:0030336negative regulation of cell migration-IDA16682945  
GO:0035335peptidyl-tyrosine dephosphorylation-IDA9531590  10821867  12913111  16778204  18348712  18936167  19332538  
GO:0035335peptidyl-tyrosine dephosphorylation-IMP9780142  12475979  
GO:0042059negative regulation of epidermal growth factor receptor signaling pathway-IMP19836242  
GO:0043116negative regulation of vascular permeability-IDA19332538  
GO:0043312neutrophil degranulation-TAS-  
GO:0043407negative regulation of MAP kinase activity-IDA19494114  
GO:0045785positive regulation of cell adhesion-IMP21091576  
GO:0048008platelet-derived growth factor receptor signaling pathway-IMP21091576  
GO:0050852T cell receptor signaling pathway-TAS-  
GO:0050860negative regulation of T cell receptor signaling pathway-IDA12913111  
GO:0050860negative regulation of T cell receptor signaling pathway-IMP9780142  11259588  
GO:0050918positive chemotaxis-IDA14709717  
GO:0051894positive regulation of focal adhesion assembly-IMP21091576  
GO:0051897positive regulation of protein kinase B signaling-IMP18936167  
GO:0051898negative regulation of protein kinase B signaling-IMP19922411  
GO:0060242contact inhibition-NAS7937872  
GO ID GO Term Qualifier Evidence PubMed
GO:0001772immunological synapse-IDA12913111  
GO:0005886plasma membrane-IDA9531590  18348712  19836242  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-TAS7937872  
GO:0005911cell-cell junction-IDA12370829  19332538  
GO:0009986cell surface-IDA12913111  
GO:0032587ruffle membrane-IEA-  
GO:0035579specific granule membrane-TAS-  
GO:0070062extracellular exosome-HDA19056867  23533145  
KEGG ID KEGG Term
hsa04520Adherens junction
Reactome ID Reactome Term Evidence
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-162582Signal TransductionTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-202403TCR signalingTAS
R-HSA-202427Phosphorylation of CD3 and TCR zeta chainsTAS
R-HSA-6798695Neutrophil degranulationTAS
R-HSA-6806834Signaling by METTAS
R-HSA-6807004Negative regulation of MET activityTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal