Gene: PTPRK

5796
R-PTP-kappa
protein tyrosine phosphatase, receptor type K
protein-coding
6q22.33
Ensembl:ENSG00000152894 MIM:602545 Vega:OTTHUMG00000015536 UniprotKB:Q15262
NC_000006.12
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.762e-1 (AD)  3.672e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs6923822chr6:128518325 (GRCh38.p7)G>A / G>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg24389102chr6:128759061PTPRKGene body6.656e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TTBK20.942
RAB3GAP10.936
BCAP290.929
PRUNE20.929
RASA10.929
ALS20.929
ADAM220.928
EIF4G30.928
NLK0.927
PLEKHA10.927

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.497
OR4F29-0.472
LRAT-0.445
AQP5-0.405
MDFI-0.394
HEY2-0.377
MTRNR2L10-0.376
RAB13-0.375
EVA1A-0.37
CSAG1-0.37

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of PTPRK mRNA"22698814
C49562614-deoxy-11,12-didehydroandrographolide"14-deoxy-11,12-didehydroandrographolide results in increased expression of PTPRK mRNA"22101062
C0293704-toluidine4-toluidine results in decreased expression of PTPRK mRNA27638505
D000082AcetaminophenAcetaminophen results in decreased expression of PTPRK mRNA22230336
D000082AcetaminophenAcetaminophen results in increased expression of PTPRK mRNA21420995
D000082AcetaminophenPTPRK gene polymorphism affects the susceptibility to Acetaminophen26104854
D016604Aflatoxin B1Aflatoxin B1 affects the expression of PTPRK protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of PTPRK mRNA21641981|2210060
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of PTPRK gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of PTPRK mRNA19770486
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PTPRK mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of PTPRK mRNA24449571
C547126AZM551248AZM551248 results in decreased expression of PTPRK mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of PTPRK mRNA21714911
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PTPRK mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PTPRK mRNA19770486|2171566
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PTPRK mRNA21839799
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PTPRK mRNA"19150397
D004958EstradiolEstradiol affects the expression of PTPRK mRNA22574217
C006780bisphenol Abisphenol A results in increased expression of PTPRK mRNA25047013
C006780bisphenol Abisphenol A results in increased expression of PTPRK mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of PTPRK gene28505145
C018475butyraldehydebutyraldehyde results in decreased expression of PTPRK mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in increased expression of PTPRK mRNA26472689
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of PTPRK mRNA17484886
D002737ChloropreneChloroprene results in decreased expression of PTPRK mRNA23125180
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of PTPRK mRNA20938992
D002994ClofibrateClofibrate affects the expression of PTPRK mRNA16081524
D002994ClofibrateClofibrate results in decreased expression of PTPRK mRNA23811191
D019327Copper SulfateCopper Sulfate results in decreased expression of PTPRK mRNA19549813
D003375CoumestrolCoumestrol results in decreased expression of PTPRK mRNA19167446
D016572CyclosporineCyclosporine results in decreased expression of PTPRK mRNA25562108
D016572CyclosporineCyclosporine results in decreased expression of PTPRK mRNA19770486
C014347decitabinedecitabine affects the methylation of PTPRK gene17630775
D002945CisplatinCisplatin promotes the reaction [jinfukang results in decreased expression of PTPRK mRNA]27392435
D002945CisplatinCisplatin results in decreased expression of PTPRK mRNA19561079|2428008
D002945Cisplatinjinfukang promotes the reaction [Cisplatin results in decreased expression of PTPRK mRNA]27392435
D002945CisplatinCisplatin results in decreased expression of PTPRK mRNA24280081
D005419FlavonoidsFlavonoids results in increased expression of PTPRK mRNA18035473
D005472FluorouracilPTPRK protein affects the susceptibility to Fluorouracil16217747
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of PTPRK mRNA20938992
D004397FonofosFonofos results in increased methylation of PTPRK promoter22847954
D005557FormaldehydeFormaldehyde results in decreased expression of PTPRK mRNA20655997
D017313FenretinideFenretinide results in increased expression of PTPRK mRNA28973697
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of PTPRK mRNA25613284
C544151jinfukangCisplatin promotes the reaction [jinfukang results in decreased expression of PTPRK mRNA]27392435
C544151jinfukangjinfukang promotes the reaction [Cisplatin results in decreased expression of PTPRK mRNA]27392435
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of PTPRK mRNA20938992
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of PTPRK mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of PTPRK mRNA26011545
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of PTPRK mRNA"26251327
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased methylation of PTPRK promoter"26251327
D015735MifepristoneMifepristone results in increased expression of PTPRK mRNA17584828
D009151Mustard GasMustard Gas results in increased expression of PTPRK mRNA15674844
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of PTPRK mRNA"25620056
C022838nickel chloridenickel chloride results in increased expression of PTPRK mRNA17312168
C025589ochratoxin Aochratoxin A results in increased expression of PTPRK mRNA18417182
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of PTPRK mRNA25729387
D010278ParathionParathion results in increased methylation of PTPRK promoter22847954
C046012pentanalpentanal results in decreased expression of PTPRK mRNA26079696
D010634PhenobarbitalPhenobarbital affects the expression of PTPRK mRNA23091169
D010656PhenylephrinePhenylephrine results in decreased expression of PTPRK mRNA18158353
C006253pirinixic acidpirinixic acid results in decreased expression of PTPRK mRNA20813756|2381119
D011192Potassium DichromatePotassium Dichromate results in increased expression of PTPRK mRNA23608068
D011374ProgesteroneProgesterone affects the expression of PTPRK mRNA17251523
D011441PropylthiouracilPropylthiouracil results in increased expression of PTPRK mRNA24780913
D011794QuercetinQuercetin results in decreased expression of PTPRK mRNA21632981
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of PTPRK mRNA25895662
C017947sodium arsenitesodium arsenite results in increased expression of PTPRK protein21925251
C016104sodium bichromatesodium bichromate affects the expression of PTPRK mRNA22110744
D012999SomanSoman results in decreased expression of PTPRK mRNA19281266
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in increased expression of PTPRK mRNA"26680231
C021751tanshinonetanshinone results in decreased expression of PTPRK mRNA15849732
D013654TaurineTaurine results in decreased expression of PTPRK mRNA16579726
C012568terbufosterbufos results in increased methylation of PTPRK promoter22847954
D013739TestosteroneTestosterone results in decreased expression of PTPRK mRNA21669218
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PTPRK mRNA21570461
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of PTPRK mRNA25613284
D019284ThapsigarginThapsigargin results in decreased expression of PTPRK protein24648495
D013849ThimerosalThimerosal results in increased expression of PTPRK mRNA27188386
D019772TopotecanPTPRK protein affects the susceptibility to Topotecan16217747
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of PTPRK mRNA25729387
D014212TretinoinTretinoin results in decreased expression of PTPRK mRNA17045167
D014241TrichloroethyleneTrichloroethylene results in increased methylation of PTPRK gene27618143
C012589trichostatin Atrichostatin A results in increased expression of PTPRK mRNA24935251
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of PTPRK mRNA19042947
C057693troglitazonetroglitazone results in decreased expression of PTPRK mRNA28973697
D017974Uranium CompoundsUranium Compounds results in decreased expression of PTPRK mRNA19654044
D014635Valproic AcidValproic Acid affects the expression of PTPRK mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of PTPRK mRNA23179753|2718838
D001335Vehicle EmissionsVehicle Emissions affects the methylation of PTPRK gene25560391
C025643vinclozolinvinclozolin results in decreased expression of PTPRK mRNA23034163
D014750VincristineVincristine results in increased expression of PTPRK mRNA23649840

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004725protein tyrosine phosphatase activity-IDA8663237  16263724  16849327  
GO:0005001transmembrane receptor protein tyrosine phosphatase activity-NAS9047348  
GO:0005515protein binding-IPI15899872  19167335  21690299  
GO:0008013beta-catenin binding-IPI8663237  
GO:0019901protein kinase binding-IPI15899872  
GO:0045295gamma-catenin binding-IPI8663237  
GO ID GO Term Qualifier Evidence PubMed
GO:0006470protein dephosphorylation-IDA16263724  
GO:0007155cell adhesion-IMP15899872  
GO:0007165signal transduction-IDA16849327  
GO:0007179transforming growth factor beta receptor signaling pathway-IDA15899872  
GO:0008285negative regulation of cell proliferation-IDA15899872  18276111  
GO:0010839negative regulation of keratinocyte proliferation-IDA16263724  
GO:0016477cell migration-IMP15899872  
GO:0030336negative regulation of cell migration-IDA18276111  
GO:0031175neuron projection development-IEA-  
GO:0034394protein localization to cell surface-IDA18276111  
GO:0034614cellular response to reactive oxygen species-IDA16849327  
GO:0034644cellular response to UV-IDA16849327  
GO:0035335peptidyl-tyrosine dephosphorylation-IEA-  
GO:0045786negative regulation of cell cycle-IDA15899872  
GO:0045892negative regulation of transcription, DNA-templated-IDA18276111  
GO:0048041focal adhesion assembly-IMP15899872  
GO ID GO Term Qualifier Evidence PubMed
GO:0001750photoreceptor outer segment-IEA-  
GO:0005886plasma membrane-IDA-  
GO:0005887integral component of plasma membrane-NAS9047348  
GO:0005911cell-cell junction-IDA8663237  
GO:0005912adherens junction-IEA-  
GO:0009986cell surface-IDA18276111  
GO:0016021integral component of membrane-NAS9047348  
GO:0030054cell junction-IDA-  
GO:0030424axon-IEA-  
GO:0030425dendrite-IEA-  
GO:0031256leading edge membrane-IDA15899872  
GO:0043025neuronal cell body-IEA-  
GO:0043231intracellular membrane-bounded organelle-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-177929Signaling by EGFRTAS
R-HSA-182971EGFR downregulationTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal