Gene: PTPRO

5800
GLEPP1|NPHS6|PTP-OC|PTP-U2|PTPROT|PTPU2|R-PTP-O
protein tyrosine phosphatase, receptor type O
protein-coding
12p12.3|12p13-p12
Ensembl:ENSG00000151490 MIM:600579 Vega:OTTHUMG00000168786 UniprotKB:Q16827
NG_031857.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.793e-1 (AD)  5.500e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DGKB0.955
LNX10.939
ELMOD10.937
RGS60.93
STYK10.929
TMEM178B0.929
MYCBP20.928
NBEA0.926
AKAP50.925
BTBD100.924

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HEY2-0.595
COPZ2-0.557
MYL3-0.554
CSAG1-0.55
YES1-0.539
ROM1-0.533
RAI14-0.513
RAB13-0.511
REST-0.507
RNF135-0.504

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of PTPRO mRNA"18648102
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of PTPRO mRNA"25380136
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PTPRO mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PTPRO mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PTPRO mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PTPRO mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PTPRO mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PTPRO mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of PTPRO mRNA17562736
D020106AcrylamideAcrylamide results in decreased expression of PTPRO mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of PTPRO gene27153756
D000537Aluminum OxideAluminum Oxide results in decreased activity of PTPRO protein20163174
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PTPRO mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of PTPRO mRNA24449571
C006632arsenic trioxidearsenic trioxide results in decreased expression of PTPRO mRNA26705709
D001374AzacitidineAzacitidine results in increased expression of PTPRO mRNA14508512
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of PTPRO mRNA]22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PTPRO mRNA21569818|2222880
D004958EstradiolESR1 protein affects the reaction [Estradiol results in decreased expression of PTPRO mRNA]15223131
D004958EstradiolESR2 protein affects the reaction [Estradiol results in decreased expression of PTPRO mRNA]19095770
D004958EstradiolEstradiol results in decreased expression of PTPRO mRNA15223131|1909577
D004958EstradiolEstradiol results in increased expression of PTPRO mRNA19484750
C006780bisphenol Abisphenol A results in decreased expression of PTPRO mRNA15223131
C006780bisphenol AESR1 protein affects the reaction [bisphenol A results in decreased expression of PTPRO mRNA]15223131
C006780bisphenol Abisphenol A results in decreased expression of PTPRO mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of PTPRO gene28505145
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of PTPRO mRNA24982889
D002166CamptothecinPTPRO mRNA results in decreased susceptibility to Camptothecin25269479
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of PTPRO protein12629582
D002737ChloropreneChloroprene results in decreased expression of PTPRO mRNA23125180
D002737ChloropreneChloroprene results in decreased expression of PTPRO mRNA23125180
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PTPRO mRNA20938992
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of PTPRO mRNA28472532
C480342clothianidinclothianidin results in decreased expression of PTPRO mRNA29044138
C018021cobaltous chloridecobaltous chloride results in decreased expression of PTPRO mRNA19376846
C029892cupric chloridecupric chloride results in decreased expression of PTPRO mRNA17211630
D003471CuprizoneCuprizone results in increased expression of PTPRO mRNA26577399
D003474CurcuminCurcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PTPRO mRNA]18200517
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of PTPRO mRNA]27941970
D004026DieldrinDieldrin affects the expression of PTPRO mRNA23041725
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of PTPRO mRNA25380136
D004237DiuronDiuron results in decreased expression of PTPRO mRNA25152437
C118739entinostatentinostat results in decreased expression of PTPRO mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PTPRO mRNA"27188386
D000431EthanolEthanol results in decreased expression of PTPRO mRNA15353170
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of PTPRO mRNA17351261
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of PTPRO mRNA12655037
D005419FlavonoidsFlavonoids results in increased expression of PTPRO mRNA18035473
C061365flusilazoleflusilazole results in decreased expression of PTPRO mRNA22382673
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PTPRO mRNA20938992
D004397FonofosFonofos results in increased methylation of PTPRO promoter22847954
D005557FormaldehydeFormaldehyde results in increased expression of PTPRO mRNA23649840
C039281furanfuran results in increased expression of PTPRO mRNA27387713
C039281furanfuran results in increased methylation of PTPRO gene22079235
D017313FenretinideFenretinide results in decreased expression of PTPRO mRNA28973697
D007213IndomethacinIndomethacin results in increased expression of PTPRO mRNA28201806
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of PTPRO mRNA26752646
C008261lead acetate[lead acetate co-treated with zinc protoporphyrin] results in increased expression of PTPRO mRNA22839698
C008261lead acetatelead acetate results in decreased expression of PTPRO mRNA21829687
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PTPRO mRNA20938992
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of PTPRO mRNA23103053
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of PTPRO mRNA28001369
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of PTPRO mRNA23179753|2800136
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of PTPRO mRNA23649840
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of PTPRO mRNA24810058
D008777MethyltestosteroneMethyltestosterone results in decreased expression of PTPRO mRNA29191790
D037742Nanotubes, Carbon"Nanotubes, Carbon analog affects the expression of PTPRO mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of PTPRO mRNA"25554681
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of PTPRO mRNA25380136
D009532NickelNickel results in increased expression of PTPRO mRNA25583101
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PTPRO mRNA"27188386
C496932panobinostatpanobinostat results in decreased expression of PTPRO mRNA26272509
D010278ParathionParathion results in increased methylation of PTPRO promoter22847954
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of PTPRO mRNA26705709
D010634PhenobarbitalPhenobarbital affects the methylation of PTPRO gene19233941
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PTPRO mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of PTPRO mRNA26272509
D011374ProgesteroneProgesterone results in increased expression of PTPRO mRNA22238285
D011374ProgesteroneProgesterone results in increased expression of PTPRO mRNA19690047
D011441PropylthiouracilPropylthiouracil results in increased expression of PTPRO mRNA24780913
D011692Puromycin AminonucleosidePuromycin Aminonucleoside affects the expression of PTPRO mRNA11961407
D011692Puromycin AminonucleosidePuromycin Aminonucleoside affects the expression of PTPRO protein11961407
D012643SeleniumSelenium results in decreased expression of PTPRO mRNA19244175
D012822Silicon DioxideSilicon Dioxide results in decreased activity of PTPRO protein20163174
D012822Silicon DioxideSilicon Dioxide results in decreased expression of PTPRO mRNA19073995
D013629TamoxifenESR2 protein affects the reaction [Tamoxifen results in increased expression of PTPRO mRNA]19095770
D013629TamoxifenPTPRO protein results in increased susceptibility to Tamoxifen19095770
D013629TamoxifenTamoxifen promotes the reaction [ESR2 protein binds to [[FOS protein binds to JUN protein] which binds to PTPRO promoter]]19095770
D013629TamoxifenTamoxifen results in increased expression of PTPRO mRNA19095770
C012568terbufosterbufos results in increased methylation of PTPRO promoter22847954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PTPRO mRNA15652763
C009495titanium dioxidetitanium dioxide results in decreased expression of PTPRO mRNA27760801
C009495titanium dioxidetitanium dioxide results in increased expression of PTPRO mRNA23557971
D024505TocopherolsTocopherols results in increased expression of PTPRO mRNA17056531
D014212TretinoinTretinoin results in decreased expression of PTPRO mRNA20488242
C012589trichostatin Atrichostatin A results in increased expression of PTPRO mRNA15901671
D014302Trinitrobenzenesulfonic AcidCurcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PTPRO mRNA]18200517
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of PTPRO mRNA18200517
D014635Valproic AcidValproic Acid results in increased expression of PTPRO mRNA15901671
D014635Valproic AcidValproic Acid results in decreased expression of PTPRO mRNA28001369
D014635Valproic AcidValproic Acid results in increased expression of PTPRO mRNA23179753|2718838
D001335Vehicle EmissionsVehicle Emissions affects the methylation of PTPRO gene25560391
C025643vinclozolinvinclozolin results in increased expression of PTPRO mRNA23034163
D014750VincristineVincristine results in increased expression of PTPRO mRNA23649840
C029297vinylidene chloridevinylidene chloride results in decreased expression of PTPRO mRNA26682919
D014810Vitamin EVitamin E results in decreased expression of PTPRO mRNA19244175
C017803zinc protoporphyrin[lead acetate co-treated with zinc protoporphyrin] results in increased expression of PTPRO mRNA22839698

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004725protein tyrosine phosphatase activity-IDA19167335  
GO:0004725protein tyrosine phosphatase activity-IMP19233845  
GO:0004725protein tyrosine phosphatase activity-TAS10498613  
GO:0005001transmembrane receptor protein tyrosine phosphatase activity-NAS7665166  
GO:0005515protein binding-IPI19167335  28330616  
GO:0016791phosphatase activity-ISS-  
GO:0017147Wnt-protein binding-ISS-  
GO:0042802identical protein binding-IPI15978577  
GO:0042803protein homodimerization activity-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000902cell morphogenesis-ISS-  
GO:0002548monocyte chemotaxis-IMP19233845  
GO:0003093regulation of glomerular filtration-ISS-  
GO:0003105negative regulation of glomerular filtration-ISS-  
GO:0006470protein dephosphorylation-ISS-  
GO:0006470protein dephosphorylation-TAS10498613  
GO:0007411axon guidance-ISS-  
GO:0010812negative regulation of cell-substrate adhesion-ISS-  
GO:0010977negative regulation of neuron projection development-ISS-  
GO:0030032lamellipodium assembly-ISS-  
GO:0032835glomerulus development-IMP21722858  
GO:0035335peptidyl-tyrosine dephosphorylation-IMP19233845  
GO:0036060slit diaphragm assembly-ISS-  
GO:0036060slit diaphragm assembly-NAS20633639  
GO:0072112glomerular visceral epithelial cell differentiation-ISS-  
GO:0090090negative regulation of canonical Wnt signaling pathway-ISS-  
GO:0090260negative regulation of retinal ganglion cell axon guidance-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-ISS-  
GO:0005887integral component of plasma membrane-NAS7665166  
GO:0016021integral component of membrane-TAS10498613  
GO:0016324apical plasma membrane-ISS-  
GO:0016328lateral plasma membrane-ISS-  
GO:0030027lamellipodium-ISS-  
GO:0030424axon-ISS-  
GO:0030426growth cone-ISS-  
GO:0043005neuron projection-ISS-  
GO:0043197dendritic spine-ISS-  
GO:0070062extracellular exosome-HDA19056867  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25480659DNA methylation alterations in response to prenatal exposure of maternal cigarette smoking: A persistent epigenetic impact on health from maternal lifestyle? (2016 Feb)Nielsen CHArch Toxicol
19498054Prenatal tobacco smoke exposure affects global and gene-specific DNA methylation. (2009 Sep 1)Breton CVAm J Respir Crit Care Med