Gene: PTPRR

5801
EC-PTP|PCPTP1|PTP-SL|PTPBR7|PTPRQ
protein tyrosine phosphatase, receptor type R
protein-coding
12q15
Ensembl:ENSG00000153233 MIM:602853 Vega:OTTHUMG00000169502 UniprotKB:Q15256
NC_000012.12
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.852e-1 (AD)  6.980e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs12229663chr12:70856216 (GRCh38.p7)A>G / A>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PGM2L10.952
GDA0.949
PAK30.942
FAXC0.941
ROBO20.94
TENM30.939
EPHA50.939
KRT2220.937
FRMPD40.936
SVOP0.936

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CSAG1-0.636
RNF135-0.635
RAB13-0.612
CHST14-0.606
SYDE1-0.604
REST-0.596
YES1-0.593
INHBB-0.591
TEAD3-0.591
WWTR1-0.59

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of PTPRR mRNA"26377693
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of PTPRR mRNA"19114083
C0065512-amino-2-methyl-1-propanol2-amino-2-methyl-1-propanol results in decreased expression of PTPRR mRNA25088246
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of PTPRR mRNA"18648102
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of PTPRR gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PTPRR mRNA16483693
D001280AtrazineAtrazine results in decreased expression of PTPRR mRNA22378314
C547126AZM551248AZM551248 results in decreased expression of PTPRR mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PTPRR mRNA22316170
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PTPRR mRNA21569818
D004958Estradiol[Progesterone co-treated with Estradiol] results in increased expression of PTPRR mRNA17404688
C006780bisphenol Abisphenol A results in decreased expression of PTPRR mRNA24586524
C006780bisphenol Abisphenol A results in decreased methylation of PTPRR promoter27312807
C006780bisphenol Abisphenol A results in decreased expression of PTPRR mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of PTPRR gene28505145
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of PTPRR mRNA15336504
C018475butyraldehydebutyraldehyde results in increased expression of PTPRR mRNA26079696
D002713ChlorineChlorine results in decreased expression of PTPRR mRNA18636392
D002713Chlorine[Ozone co-treated with Chlorine] affects the expression of PTPRR mRNA18636392
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of PTPRR mRNA28472532
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of PTPRR mRNA20971185
D003471CuprizoneCuprizone results in decreased expression of PTPRR mRNA26577399
D003474CurcuminCurcumin results in decreased expression of PTPRR mRNA21594647
D003703DemecolcineDemecolcine results in increased expression of PTPRR mRNA23649840
D003907DexamethasoneDexamethasone results in increased expression of PTPRR mRNA20032058
D003907DexamethasoneTestosterone inhibits the reaction [Dexamethasone results in increased expression of PTPRR mRNA]20032058
D004041Dietary FatsDietary Fats results in increased expression of PTPRR mRNA18042831
D004041Dietary FatsDietary Fats results in increased expression of PTPRR mRNA21852083
D004041Dietary Fatsresveratrol inhibits the reaction [Dietary Fats results in increased expression of PTPRR mRNA]21852083
D004237DiuronDiuron results in increased expression of PTPRR mRNA21551480
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of PTPRR mRNA17351261|1755790
D005557FormaldehydeFormaldehyde results in decreased expression of PTPRR mRNA28937961
D005557FormaldehydeFormaldehyde results in increased expression of PTPRR mRNA27664576
C412815GW 4064GW 4064 results in increased expression of PTPRR mRNA26655953
D007854LeadLead affects the expression of PTPRR mRNA28903495
D008727MethotrexateMethotrexate affects the expression of PTPRR mRNA18502557
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of PTPRR mRNA"25554681
D005996NitroglycerinNitroglycerin results in increased expression of PTPRR mRNA12102619
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of PTPRR mRNA20971185
C558013NSC 689534NSC 689534 results in increased expression of PTPRR mRNA20971185
C484027oligofectamineoligofectamine results in increased expression of PTPRR mRNA14668052
C510784ormosil[ormosil binds to Polyethylene Glycols] which results in increased expression of PTPRR mRNA24888373
D010100OxygenOxygen deficiency results in increased expression of PTPRR mRNA26516004
D010126Ozone[Ozone co-treated with Chlorine] affects the expression of PTPRR mRNA18636392
D000073878Palm OilPalm Oil results in increased expression of PTPRR mRNA18042831
C046012pentanalpentanal results in increased expression of PTPRR mRNA26079696
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of PTPRR mRNA19162173
D011092Polyethylene Glycols[ormosil binds to Polyethylene Glycols] which results in increased expression of PTPRR mRNA24888373
D011374Progesterone[Progesterone co-treated with Estradiol] results in increased expression of PTPRR mRNA17404688
D011374ProgesteroneProgesterone results in increased expression of PTPRR mRNA21540246
D011374ProgesteroneProgesterone results in increased expression of PTPRR mRNA20726854
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride affects the expression of PTPRR mRNA14699072
C059514resveratrolresveratrol results in increased expression of PTPRR mRNA19228061
C059514resveratrolresveratrol inhibits the reaction [Dietary Fats results in increased expression of PTPRR mRNA]21852083
D012524SarinSarin results in decreased expression of PTPRR mRNA19522546
C009250sevofluranesevoflurane affects the expression of PTPRR mRNA15967596
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of PTPRR mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in increased expression of PTPRR mRNA25351596
D012834SilverSilver results in decreased expression of PTPRR mRNA27131904
C017947sodium arsenitesodium arsenite affects the methylation of PTPRR gene28589171
C016104sodium bichromatesodium bichromate results in decreased expression of PTPRR mRNA22155349
D012999SomanSoman results in decreased expression of PTPRR mRNA19281266
D013739TestosteroneTestosterone inhibits the reaction [Dexamethasone results in increased expression of PTPRR mRNA]20032058
D013749TetrachlorodibenzodioxinAHR protein alternative form affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of PTPRR mRNA]21215274
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PTPRR mRNA21215274
D014212TretinoinTretinoin results in increased expression of PTPRR mRNA23724009
D014241TrichloroethyleneTrichloroethylene results in decreased expression of PTPRR mRNA26745549
D001335Vehicle EmissionsVehicle Emissions affects the methylation of PTPRR gene25560391
D014750VincristineVincristine results in increased expression of PTPRR mRNA23649840

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004725protein tyrosine phosphatase activity-TAS7836467  
GO:0005001transmembrane receptor protein tyrosine phosphatase activity-TAS7836467  
GO:0005515protein binding-IPI10601328  25241761  
GO:0019901protein kinase binding-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001701in utero embryonic development-IEP10601328  
GO:0006470protein dephosphorylation-TAS7836467  
GO:0010633negative regulation of epithelial cell migration-IMP21724833  
GO:0035335peptidyl-tyrosine dephosphorylation-IEA-  
GO:0038128ERBB2 signaling pathway-IMP21724833  
GO:0070373negative regulation of ERK1 and ERK2 cascade-IMP21724833  
GO:1903385regulation of homophilic cell adhesionNOTIMP21724833  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-HDA22664934  
GO:0005829cytosol-IDA-  
GO:0005886plasma membrane-IDA-  
GO:0016021integral component of membrane-IEA-  
GO:0030054cell junction-IDA-  
GO:0048471perinuclear region of cytoplasm-IEA-  
KEGG ID KEGG Term
hsa04010MAPK signaling pathway
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27865370Hypermethylated ZNF582 and PAX1 are effective biomarkers for detection of oral dysplasia and oral cancer. (2016 Nov)Cheng SJOral Oncol