Gene: PTPRS

5802
PTPSIGMA|R-PTP-S|R-PTP-sigma
protein tyrosine phosphatase, receptor type S
protein-coding
19p13.3
Ensembl:ENSG00000105426 MIM:601576 Vega:OTTHUMG00000180325 UniprotKB:Q13332
NG_033964.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.493e-1 (AD)  1.629e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs4807016chr19:5258479 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg23239817chr19:5334979PTPRSPromoter3.889e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CELSR20.954
MEGF80.948
ABCA30.946
MAPT0.945
CLSTN10.943
RUSC20.942
CLCN60.939
ATP6V0A10.937
PGBD50.935
WNK20.934

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.582
OR4F29-0.525
TFPI2-0.513
IL18RAP-0.484
CLEC2B-0.48
CST7-0.479
WWTR1-0.461
BCL2A1-0.458
CXCR2-0.457
FCGR3B-0.456

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00630Alendronic acidSmall Molecule66376-36-1ApprovedTarget
DB01077Etidronic acidSmall Molecule2809-21-4ApprovedTarget
ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PTPRS mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PTPRS mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PTPRS mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PTPRS mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PTPRS mRNA"25510870
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PTPRS mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PTPRS mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PTPRS mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PTPRS mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PTPRS mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PTPRS mRNA"27188386
D020106AcrylamideAcrylamide results in decreased expression of PTPRS mRNA28959563
D001151ArsenicArsenic affects the methylation of PTPRS gene25304211
D001280AtrazineAtrazine results in decreased expression of PTPRS mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to PTPRS promoter]19654925
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PTPRS mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PTPRS mRNA22228805
D004958EstradiolEstradiol affects the expression of PTPRS mRNA22574217
D004958EstradiolEstradiol results in increased expression of PTPRS mRNA19484750
C006780bisphenol Abisphenol A affects the expression of PTPRS mRNA25181051
C006780bisphenol A[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of PTPRS promoter23359474
D002737ChloropreneChloroprene results in increased expression of PTPRS mRNA23125180
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of PTPRS20938992
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PTPRS mRNA20938992
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of PTPRS gene20938992
D013759DronabinolDronabinol results in decreased expression of PTPRS mRNA12237329
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of PTPRS mRNA17361019
D003993Dibutyl Phthalate[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of PTPRS promoter23359474
C000944dicrotophosdicrotophos results in increased expression of PTPRS mRNA28302478
D004051Diethylhexyl Phthalate[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of PTPRS promoter23359474
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of PTPRS mRNA19041683
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in increased expression of PTPRS mRNA27638505
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of PTPRS mRNA17555576
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of PTPRS20938992
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PTPRS mRNA20938992
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of PTPRS gene20938992
D005978GlutathioneGlutathione deficiency results in decreased expression of PTPRS mRNA20621112
C010974glyphosateglyphosate results in increased expression of PTPRS mRNA28711546
C016517indole-3-carbinolindole-3-carbinol affects the expression of PTPRS mRNA21396975
D008694MethamphetamineMethamphetamine results in increased expression of PTPRS mRNA26307267
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of PTPRS20938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PTPRS mRNA20938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of PTPRS gene20938992
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of PTPRS mRNA"26251327
D008769MethylnitronitrosoguanidineMethylnitronitrosoguanidine results in decreased expression of PTPRS mRNA12634122
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of PTPRS mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of PTPRS mRNA"25554681|2562005
C017096n-butoxyethanoln-butoxyethanol results in decreased expression of PTPRS mRNA19812364
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PTPRS mRNA"25510870
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PTPRS mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of PTPRS mRNA26272509
D010882Piperonyl ButoxidePiperonyl Butoxide results in decreased expression of PTPRS mRNA22484513
C006253pirinixic acidpirinixic acid results in increased expression of PTPRS mRNA18301758|2381119
D011192Potassium DichromatePotassium Dichromate results in increased expression of PTPRS protein23718831
C005556propionaldehydepropionaldehyde results in decreased expression of PTPRS mRNA26079696
D011441PropylthiouracilPropylthiouracil results in increased expression of PTPRS mRNA24780913
C016104sodium bichromatesodium bichromate affects the expression of PTPRS mRNA22110744
C016104sodium bichromatesodium bichromate results in decreased expression of PTPRS mRNA25993096
D012969Sodium FluorideSodium Fluoride results in increased expression of PTPRS mRNA21340527
D013629TamoxifenTamoxifen affects the expression of PTPRS mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PTPRS mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PTPRS mRNA19465110
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PTPRS mRNA22298810
D013853ThioacetamideThioacetamide results in decreased expression of PTPRS mRNA23411599
C009495titanium dioxidetitanium dioxide results in decreased expression of PTPRS mRNA27760801
D014212TretinoinTretinoin results in decreased expression of PTPRS mRNA21934132
D014241TrichloroethyleneTrichloroethylene results in decreased expression of PTPRS mRNA15363585
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PTPRS mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of PTPRS mRNA26272509
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PTPRS mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of PTPRS mRNA23179753|2627250
D014635Valproic AcidValproic Acid results in increased expression of PTPRS mRNA23179753
D014635Valproic AcidValproic Acid results in increased methylation of PTPRS gene29154799
D014638VanadatesVanadates results in increased expression of PTPRS mRNA22714537
C025643vinclozolinvinclozolin results in increased expression of PTPRS mRNA23034163
C111237vorinostatvorinostat results in decreased expression of PTPRS mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004721phosphoprotein phosphatase activity-IDA8524829  
GO:0004725protein tyrosine phosphatase activity-ISS-  
GO:0005515protein binding-IPI16273344  
GO:0008201heparin binding-ISS-  
GO:0035374chondroitin sulfate binding-ISS-  
GO:0043395heparan sulfate proteoglycan binding-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006470protein dephosphorylation-IDA8524829  
GO:0007155cell adhesion-IEA-  
GO:0010977negative regulation of neuron projection development-ISS-  
GO:0021510spinal cord development-IEA-  
GO:0021549cerebellum development-IEA-  
GO:0021766hippocampus development-IEA-  
GO:0021987cerebral cortex development-IEA-  
GO:0022038corpus callosum development-IEA-  
GO:0030517negative regulation of axon extension-ISS-  
GO:0032687negative regulation of interferon-alpha production-IMP26231120  
GO:0032688negative regulation of interferon-beta production-IMP26231120  
GO:0034164negative regulation of toll-like receptor 9 signaling pathway-IMP26231120  
GO:0035335peptidyl-tyrosine dephosphorylation-ISS-  
GO:0048671negative regulation of collateral sprouting-ISS-  
GO:0048681negative regulation of axon regeneration-ISS-  
GO:0061000negative regulation of dendritic spine development-ISS-  
GO:0090557establishment of endothelial intestinal barrier-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IDA26231120  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-TAS8524829  
GO:0030054cell junction-IEA-  
GO:0030285integral component of synaptic vesicle membrane-ISS-  
GO:0030424axon-ISS-  
GO:0043204perikaryon-IEA-  
GO:0070062extracellular exosome-HDA23533145  
GO:0099061integral component of postsynaptic density membrane-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-112316Neuronal SystemTAS
R-HSA-1474244Extracellular matrix organizationIEA
R-HSA-3000178ECM proteoglycansIEA
R-HSA-388844Receptor-type tyrosine-protein phosphatasesTAS
R-HSA-6794362Protein-protein interactions at synapsesTAS
R-HSA-8849932Synaptic adhesion-like moleculesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal