Gene: PTS

5805
PTPS
6-pyruvoyltetrahydropterin synthase
protein-coding
11q23.1
Ensembl:ENSG00000150787 MIM:612719 Vega:OTTHUMG00000167167 UniprotKB:Q03393
NG_008743.1
PubMed
0   ANCO-SNPs
ND|AD
25   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.571e-1 (AD)  6.136e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
POLR2K0.934
PFDN40.927
THOC70.924
NDUFB60.916
ANAPC130.913
SUMO10.91
CISD20.902
NDUFV20.901
MPC20.901
BCAS20.901

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.681
OR4F29-0.647
MAGEA12-0.277
GLI2-0.269
EVC2-0.265
KCNK5-0.262
P2RY14-0.259
CXCR2-0.253
ZBTB20-0.25
TBX15-0.249

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB03886BiopterinSmall MoleculeExperimentalTarget
ID Drug Name Action PubMed
C5756314-(4-(2,4-dioxothiazolidin-5-ylidenemethyl)-2-methoxyphenoxy)-3-trifluoromethylbenzonitrile"4-(4-(2,4-dioxothiazolidin-5-ylidenemethyl)-2-methoxyphenoxy)-3-trifluoromethylbenzonitrile affects the expression of PTS mRNA"21218783
D000082AcetaminophenAcetaminophen affects the expression of PTS mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of PTS gene27153756
D013196DihydrotestosteroneDihydrotestosterone results in increased expression of PTS mRNA16631469
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PTS mRNA16483693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PTS mRNA21632981|2623829
C006780bisphenol Abisphenol A results in increased expression of PTS mRNA26364221
C006780bisphenol Abisphenol A results in decreased expression of PTS mRNA29275510
C006780bisphenol Abisphenol A results in decreased expression of PTS mRNA25181051
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of PTS mRNA22079614
D019256Cadmium ChlorideCadmium Chloride affects the expression of PTS mRNA18804290
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of PTS mRNA27339419
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of PTS mRNA23650126
D002994ClofibrateClofibrate results in increased expression of PTS mRNA22300585
C018021cobaltous chloridecobaltous chloride results in decreased expression of PTS mRNA24386269
D019327Copper SulfateCopper Sulfate results in increased expression of PTS mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of PTS mRNA25562108
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of PTS mRNA21266533
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of PTS mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of PTS mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PTS mRNA17942748
D005839GentamicinsGentamicins results in increased expression of PTS mRNA22061828
D006046GoldGold results in decreased expression of PTS mRNA25523186
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of PTS mRNA20044591
C492448ICG 001ICG 001 results in increased expression of PTS mRNA26191083
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of PTS mRNA25613284
D007854LeadLead affects the splicing of PTS mRNA28903495
D008748MethylcholanthreneMethylcholanthrene results in decreased expression of PTS mRNA18804290
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of PTS mRNA23649840
C568376MT19c compoundMT19c compound results in increased expression of PTS mRNA21781307
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of PTS mRNA"25620056
C031721naphthalenenaphthalene results in decreased expression of PTS protein19438287
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of PTS mRNA18804290
C006253pirinixic acidpirinixic acid results in increased expression of PTS mRNA19162173
D012110ReserpineReserpine results in increased expression of PTS mRNA7545485
D015474IsotretinoinIsotretinoin results in decreased expression of PTS mRNA20436886
D012524SarinSarin results in decreased expression of PTS mRNA19522546
C017947sodium arsenitesodium arsenite affects the methylation of PTS gene28589171
D013629TamoxifenTamoxifen affects the expression of PTS mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PTS mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PTS mRNA17942748
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of PTS mRNA25613284
D014635Valproic AcidValproic Acid affects the expression of PTS mRNA17292431
D001335Vehicle EmissionsVehicle Emissions affects the methylation of PTS gene25560391
C025643vinclozolinvinclozolin results in increased expression of PTS mRNA23034163
D015032ZincZinc results in decreased expression of PTS mRNA15226459
D019287Zinc SulfateZinc Sulfate results in decreased expression of PTS mRNA15226459

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:00038746-pyruvoyltetrahydropterin synthase activity-IBA21873635  
GO:00038746-pyruvoyltetrahydropterin synthase activity-TAS-  
GO:0005515protein binding-IPI25416956  27107014  
GO:0042802identical protein binding-IPI16169070  16189514  21516116  25416956  25910212  
GO:0042803protein homodimerization activity-IEA-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006520cellular amino acid metabolic process-TAS3308682  
GO:0006729tetrahydrobiopterin biosynthetic process-IBA21873635  
GO:0006729tetrahydrobiopterin biosynthetic process-IEA-  
GO:0007417central nervous system development-TAS3308682  
GO:0051186cofactor metabolic process-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IDA-  
GO:0005739mitochondrion-IBA21873635  
GO:0005739mitochondrion-IDA-  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa00790Folate biosynthesis
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1474151Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulationTAS
R-HSA-196854Metabolism of vitamins and cofactorsTAS
R-HSA-8978934Metabolism of cofactorsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
18379354Plasma DNA, microsatellite alterations, and p53 tumor mutations are associated with disease-free survival in radically resected non-small cell lung cancer patients: a study of the perugia multidisciplinary team for thoracic oncology. (2008 Apr)Ludovini VJ Thorac Oncol
11757211[Subjective quality of life in patients with coronary artery disease after percutaneous coronary angioplasty in elderly patients after 65 years of age]. (2001 Aug)Ochala APol Merkur Lekarski
27603946[Subgroup Analysis of the Non-interventional REASON Study: PFS and OS According to Age, Smoking History, Gender, and Histology in NSCLC Patients Treated with Gefitinib or Chemotherapy]. (2016 Sep)Schuette WPneumologie
11795863Helicobacter pylori (H. pylori) infection in coronary artery disease: influence of H. pylori eradication on coronary artery lumen after percutaneous transluminal coronary angioplasty. The detection of H. pylori specific DNA in human coronary atherosclerotic plaque. (2001 Aug)Kowalski MJ Physiol Pharmacol
24099733Prognostic factors in a multicentre study of 247 atypical pulmonary carcinoids. (2014 Apr)Daddi NEur J Cardiothorac Surg
17727241Hemorheological aspects in the microvasculature of several pathologies. (2007)Cicco GAdv Exp Med Biol
23879483Prognostic impact of serum CYFRA 21-1 in patients with advanced lung adenocarcinoma: a retrospective study. (2013 Jul 23)Ono ABMC Cancer
9426834Enkephalin, PPE mRNA, and PTS-1 in alcohol withdrawal seizure-prone and -resistant mice. (1998 Jan)Plotkin SRAlcohol
21994404Prenatal smoke exposure and genomic DNA methylation in a multiethnic birth cohort. (2011 Dec)Flom JDCancer Epidemiol Biomarkers Prev
11325389Withdrawal from alcohol in withdrawal seizure-prone and -resistant mice: evidence for enkephalin resistance. (2001 Mar)Plotkin SRPharmacol Biochem Behav
2241595[Single nocturnal dose of ranitidine in the treatment of duodenal ulcer: results of an open multicenter, comparative trial]. (1990 Jan-Mar)Castro Lde PArq Gastroenterol
19649630Amongst eligible patients, age and comorbidity do not predict for dose-limiting toxicity from phase I chemotherapy. (2010 Mar)LoConte NKCancer Chemother Pharmacol
17436151CD14 gene polymorphism 159C/T in a group of patients with coronary artery disease from a population with high morbidity of cardiovascular diseases. (2007 Mar)Rechcinski TKardiol Pol
10816064Current smokers develop more posterior myocardial infarctions probably due to increased tendency to thrombosis. (2000)Landmark KScand Cardiovasc J
15202298[Multivascular atherosclerosis, the Sarajevo Vascular Study]. (2004)Dilic MMed Arh
25642748Differential effects of anxiety sensitivity components in the relation between emotional non-acceptance and post-traumatic stress symptoms among trauma-exposed treatment-seeking smokers. (2015)Bakhshaie JCogn Behav Ther
21548412Risk factors for cerebrovascular events: end-diastolic flow velocity. (2007)Dilic MMed Arh
19856871[Prevalence and difficulties in chronic obstructive pulmonary disease diagnosis in patients suffering from severe peripheral arterial disease]. (2009 Aug)Sleszycka JPol Merkur Lekarski
17053757Usefulness of D-Dimers and fibrinogen plasma determination in patients with polyvascular disease. (2006)Bosevski MAngiol Sosud Khir
26826503The role of inflammation in post-thrombotic syndrome after pregnancy-related deep vein thrombosis: A population-based, cross-sectional study. (2016 Feb)Wik HSThromb Res
15355818[The relationship between serum C-reactive protein levels and coronary artery disease in patients with stable angina pectoris and positive exercise stress test]. (2004 Sep)Turkoglu EIAnadolu Kardiyol Derg
18724969COPD as a systemic disease: impact on physical functional limitations. (2008 Sep)Eisner MDAm J Med
28077977Two Subsets of Large Vessel Vasculitis Characterized by the Absence or Presence of Spondyloarthritis or its Associated Diseases. (2016)Ernst DOpen Rheumatol J
23886169Relationship between epidermal growth factor receptor gene mutations and clinicopathological features in patients with non-small cell lung cancer in western Turkey. (2013)Unal OUAsian Pac J Cancer Prev
15939586Aromatase and comparative response to its inhibitors in two types of endometrial cancer. (2005 May)Berstein LJ Steroid Biochem Mol Biol