Gene: PTX3

5806
TNFAIP5|TSG-14
pentraxin 3
protein-coding
3q25.32
Ensembl:ENSG00000163661 MIM:602492 Vega:OTTHUMG00000158750 UniprotKB:P26022
NG_051000.1
PubMed
0   ANCO-SNPs
ND
10   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.703e-2 (AD)  9.693e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CLCF10.71
CHRNB40.687
MMP100.682
LRRC150.67
C2CD4A0.667
CALCA0.662
ADAM120.661
SOD20.659
NKX3-10.654
BIRC30.651

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OMG-0.224
LY6D-0.214
LRRC38-0.212
GPR17-0.21
SYT15-0.209
C2orf27A-0.209
IGLON5-0.207
CHRM1-0.206
LHX6-0.202
SCRT1-0.199

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of PTX3 mRNA"26377693
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in increased expression of PTX3 mRNA28329830
C0512461-methylanthraceneSB 203580 inhibits the reaction [[1-methylanthracene co-treated with fluoranthene] results in increased expression of PTX3 mRNA]28329830
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of PTX3 mRNA19933214
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of PTX3 mRNA"23146750
C0109142,4-diaminotoluene"2,4-diaminotoluene results in decreased expression of PTX3 mRNA"20713471
C0127962-butenal2-butenal results in decreased expression of PTX3 mRNA20471460
C0127962-butenal2-butenal results in increased expression of PTX3 mRNA20471460
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[[4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased activity of [SMAD2 protein co-treated with SMAD3 protein]] which co-treated with FSHB protein] results in increased expression of PTX3 mRNA"21520325
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PTX3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PTX3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PTX3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PTX3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PTX3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PTX3 mRNA"27188386
C0821644-methoxycinnamate methyl ester4-methoxycinnamate methyl ester promotes the reaction [Thapsigargin results in decreased expression of PTX3 mRNA]19442820
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PTX3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PTX3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PTX3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PTX3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PTX3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PTX3 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of PTX3 mRNA29067470
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Zearalenone results in decreased expression of PTX3 mRNA]26386189
D020106AcrylamideAcrylamide results in decreased expression of PTX3 mRNA28959563
D020106AcrylamideAcrylamide results in increased expression of PTX3 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 affects the expression of PTX3 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of PTX3 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of PTX3 mRNA22100608
D000447AldehydesAldehydes results in increased expression of PTX3 mRNA25014914
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of PTX3 mRNA21298039
D0150812-Naphthylamine2-Naphthylamine results in decreased expression of PTX3 mRNA18247414
D001151ArsenicArsenic affects the expression of PTX3 mRNA18414638
D001151ArsenicArsenic affects the expression of PTX3 protein24675094
D001151ArsenicArsenic results in decreased expression of PTX3 mRNA16835338
C006632arsenic trioxidearsenic trioxide results in increased expression of PTX3 mRNA27750169
C006632arsenic trioxidearsenic trioxide results in increased expression of PTX3 protein27750169
C015001arsenitearsenite results in decreased expression of PTX3 mRNA18929588
C015001arseniteTRP53 protein affects the reaction [arsenite results in decreased expression of PTX3 mRNA]18929588
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of PTX3 mRNA"25757056
D001280AtrazineAtrazine results in decreased expression of PTX3 mRNA27614199
C487081belinostatbelinostat results in decreased expression of PTX3 mRNA26272509
D001554BenzeneBenzene affects the expression of PTX3 mRNA21147609
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PTX3 mRNA18247414|2006483
D004958EstradiolESR1 protein promotes the reaction [Estradiol results in decreased expression of PTX3 mRNA]25210133
D004958EstradiolEstradiol results in decreased expression of PTX3 mRNA25210133
D004958EstradiolEstradiol results in increased expression of PTX3 mRNA19484750
C483161beta-hydroxy simvastatin acidbeta-hydroxy simvastatin acid results in increased expression of PTX3 mRNA18192240
D001622BetaineBetaine inhibits the reaction [Copper deficiency affects the expression of PTX3 protein]25150618
C006780bisphenol Abisphenol A affects the expression of PTX3 mRNA25181051
D000069286BortezomibBortezomib results in decreased expression of PTX3 mRNA20471514
C018475butyraldehydebutyraldehyde results in increased expression of PTX3 mRNA26079696
C040048caffeic acidcaffeic acid promotes the reaction [Thapsigargin results in decreased expression of PTX3 mRNA]19442820
C459604candoxincandoxin results in increased expression of PTX3 mRNA16309724
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PTX3 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in decreased expression of PTX3 mRNA26272509
C018021cobaltous chloridecobaltous chloride results in decreased expression of PTX3 mRNA19320972
C018021cobaltous chloridecobaltous chloride results in increased expression of PTX3 mRNA23052192
D003300CopperBetaine inhibits the reaction [Copper deficiency affects the expression of PTX3 protein]25150618
D003300CopperCopper deficiency affects the expression of PTX3 protein25150618
D003300Copper[Disulfiram binds to Copper] which results in increased expression of PTX3 mRNA24690739
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of PTX3 mRNA20971185
D003471CuprizoneCuprizone results in decreased expression of PTX3 mRNA26577399
D003471CuprizoneCuprizone results in increased expression of PTX3 mRNA27523638
D003474CurcuminCurcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PTX3 mRNA]18200517
D016572CyclosporineCyclosporine results in increased expression of PTX3 mRNA20106945
D000069439DasatinibDasatinib results in decreased expression of PTX3 mRNA20579391
D003703DemecolcineDemecolcine results in increased expression of PTX3 mRNA23649840
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of PTX3 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of PTX3 mRNA27392435
D002945CisplatinCisplatin results in increased expression of PTX3 mRNA27594783
D002945Cisplatin[Piroxicam co-treated with Cisplatin] results in decreased expression of PTX3 mRNA21858171
D004041Dietary FatsDietary Fats results in decreased expression of PTX3 mRNA18042831
D004139DinitrofluorobenzeneDinitrofluorobenzene results in increased expression of PTX3 mRNA23999411
D004221Disulfiram[Disulfiram binds to Copper] which results in increased expression of PTX3 mRNA24690739
D004317DoxorubicinPTX3 protein affects the susceptibility to Doxorubicin16217747
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal promotes the reaction [Thapsigargin results in decreased expression of PTX3 mRNA]"19442820
C118739entinostatentinostat results in decreased expression of PTX3 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PTX3 mRNA"27188386
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of PTX3 mRNA22079256
C074283estradiol 3-benzoateestradiol 3-benzoate results in decreased methylation of PTX3 promoter27415467
D015025ZearalenoneAcetylcysteine inhibits the reaction [Zearalenone results in decreased expression of PTX3 mRNA]26386189
D015025ZearalenoneZearalenone results in decreased expression of PTX3 mRNA26386189
C540355fenamidonefenamidone results in increased expression of PTX3 mRNA27029645
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in increased expression of PTX3 mRNA28329830
C007738fluoranthenefluoranthene results in increased expression of PTX3 mRNA28329830
C007738fluorantheneSB 203580 inhibits the reaction [[1-methylanthracene co-treated with fluoranthene] results in increased expression of PTX3 mRNA]28329830
D004397FonofosFonofos results in increased methylation of PTX3 promoter22847954
C039281furanfuran results in increased expression of PTX3 mRNA27387713
C546771gardiquimodgardiquimod results in increased expression of PTX3 mRNA28003376
C546771gardiquimodProtein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of PTX3 mRNA]28003376
D017313FenretinideFenretinide results in increased expression of PTX3 mRNA28973697
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of PTX3 mRNA25613284
D007501IronIron deficiency results in increased expression of PTX3 mRNA20368581
D007529IsoflavonesIsoflavones affects the expression of PTX3 mRNA16365062
D007545IsoproterenolIsoproterenol results in increased expression of PTX3 mRNA20003209|2182321
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of PTX3 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of PTX3 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of PTX3 mRNA24796395
C561695(+)-JQ1 compound[PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of PTX3 mRNA25119042
C442865lipopolysaccharide, Helicobacter pylori"lipopolysaccharide, Helicobacter pylori results in increased expression of PTX3 mRNA"21220698
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of PTX3 mRNA22235868
D018021Lithium ChlorideLithium Chloride results in decreased expression of PTX3 mRNA23527032
D008345ManganeseManganese results in increased expression of PTX3 mRNA17175027
C025340manganese chloridemanganese chloride results in increased expression of PTX3 mRNA17175027
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PTX3 mRNA"27188386
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of PTX3 mRNA28001369
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of PTX3 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of PTX3 mRNA"25554681
C031721naphthalenenaphthalene results in increased expression of PTX3 mRNA18978301
D009532NickelNickel results in increased expression of PTX3 mRNA24768652|2558310
D009532NickelNickel results in increased expression of PTX3 mRNA12540486
D009538NicotineNicotine results in decreased expression of PTX3 mRNA18247414
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of PTX3 mRNA20971185
C558013NSC 689534NSC 689534 results in increased expression of PTX3 mRNA20971185
C510784ormosil[ormosil binds to Polyethylene Glycols] which results in increased expression of PTX3 mRNA24888373
D010100OxygenOxygen deficiency results in decreased expression of PTX3 mRNA26516004
D010100OxygenOxygen deficiency results in increased expression of PTX3 mRNA17175027
D010126OzoneOzone results in increased expression of PTX3 mRNA17460151
D000073878Palm OilPalm Oil results in decreased expression of PTX3 mRNA18042831
D010278ParathionParathion results in increased methylation of PTX3 promoter22847954
D052638Particulate MatterParticulate Matter results in increased expression of PTX3 protein27295300
C506614PD 0325901[PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of PTX3 mRNA25119042
C506614PD 0325901PD 0325901 results in decreased expression of PTX3 mRNA25119042
C046012pentanalpentanal results in increased expression of PTX3 mRNA26079696
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of PTX3 mRNA27614199
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PTX3 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of PTX3 mRNA26272509
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of PTX3 mRNA19710929
D010894Piroxicam[Piroxicam co-treated with Cisplatin] results in decreased expression of PTX3 mRNA21858171
D010938Plant OilsPlant Oils results in increased expression of PTX3 mRNA23370395
D011092Polyethylene Glycols[ormosil binds to Polyethylene Glycols] which results in increased expression of PTX3 mRNA24888373
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of PTX3 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of PTX3 mRNA22079256|2271453
D011374ProgesteroneProgesterone affects the expression of PTX3 mRNA23034158
D011374ProgesteroneProgesterone results in increased expression of PTX3 mRNA21795739
C005556propionaldehydepropionaldehyde results in increased expression of PTX3 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in increased expression of PTX3 mRNA24780913
D047428Protein Kinase InhibitorsProtein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of PTX3 mRNA]28003376
C513428pyrachlostrobinpyrachlostrobin results in increased expression of PTX3 mRNA27029645
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [IL1A protein results in increased expression of PTX3 mRNA]12832416
D020849Raloxifene Hydrochloride[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of PTX3 mRNA19059307
C059514resveratrolresveratrol results in increased expression of PTX3 mRNA24314921|2586637
D012402RotenoneRotenone results in increased expression of PTX3 mRNA27900601
C093642SB 203580SB 203580 inhibits the reaction [[1-methylanthracene co-treated with fluoranthene] results in increased expression of PTX3 mRNA]28329830
D012643SeleniumSelenium results in increased expression of PTX3 mRNA17293063
D017632Asbestos, Serpentine"Asbestos, Serpentine results in increased expression of PTX3 mRNA"21148743
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of PTX3 mRNA23806026
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of PTX3 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in increased expression of PTX3 mRNA25351596
D012969Sodium FluorideSodium Fluoride results in increased expression of PTX3 mRNA27750169
D012969Sodium FluorideSodium Fluoride results in increased expression of PTX3 protein27750169
D053260SootSoot results in increased expression of PTX3 mRNA26551751
C016766sulforafansulforafan results in increased expression of PTX3 mRNA26833863
D013629Tamoxifen[Tamoxifen co-treated with ESR2 protein] results in increased expression of PTX3 mRNA19059307
C012568terbufosterbufos results in increased methylation of PTX3 promoter22847954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PTX3 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PTX3 mRNA18691609|1993321
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PTX3 mRNA11752688
D013755Tetradecanoylphorbol Acetate[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of PTX3 mRNA16979875
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of PTX3 mRNA25613284
D019284Thapsigargin4-methoxycinnamate methyl ester promotes the reaction [Thapsigargin results in decreased expression of PTX3 mRNA]19442820
D019284Thapsigargincaffeic acid promotes the reaction [Thapsigargin results in decreased expression of PTX3 mRNA]19442820
D019284Thapsigargin"Drugs, Chinese Herbal promotes the reaction [Thapsigargin results in decreased expression of PTX3 mRNA]"19442820
D013853ThioacetamideThioacetamide results in decreased expression of PTX3 mRNA23411599
C009495titanium dioxidetitanium dioxide results in increased expression of PTX3 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of PTX3 mRNA28111298
D019772TopotecanPTX3 protein affects the susceptibility to Topotecan16217747
D014212TretinoinTretinoin results in decreased expression of PTX3 mRNA23724009
D014212TretinoinTretinoin results in increased expression of PTX3 mRNA21934132
C011559tributyltintributyltin results in decreased expression of PTX3 mRNA27614199
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PTX3 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of PTX3 mRNA24935251|2627250
C012589trichostatin Atrichostatin A results in increased expression of PTX3 mRNA24935251
D014302Trinitrobenzenesulfonic AcidCurcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PTX3 mRNA]18200517
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of PTX3 mRNA18200517
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PTX3 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of PTX3 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of PTX3 mRNA23179753|2352703
D014635Valproic AcidValproic Acid results in increased expression of PTX3 mRNA24935251
D014635Valproic AcidValproic Acid affects the expression of PTX3 mRNA17292431
D001335Vehicle EmissionsVehicle Emissions results in increased expression of PTX3 protein27295300
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of PTX3 gene25560391
D014747VinblastinePTX3 protein affects the susceptibility to Vinblastine16217747
D014800VitalliumVitallium analog results in decreased expression of PTX3 mRNA23825117
D015032Zinc[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of PTX3 mRNA16979875
D015054ZymosanPTX3 protein binds to Zymosan14726497
D015054ZymosanPTX3 protein promotes the reaction [Zymosan results in increased expression of CLEC7A mRNA]14726497
D015054ZymosanPTX3 protein promotes the reaction [Zymosan results in increased expression of TLR6 mRNA]14726497
D015054ZymosanPTX3 protein results in increased uptake of Zymosan14726497
D015054ZymosanZymosan results in increased expression of PTX3 mRNA14726497

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001849complement component C1q binding-IBA21873635  
GO:0001849complement component C1q binding-IDA23544079  
GO:0001872(1->3)-beta-D-glucan binding-IEA-  
GO:0005515protein binding-IPI19050261  19632990  20363749  21490156  22267482  
GO:0042802identical protein binding-IPI20363749  
GO:0046790virion binding-IDA23544079  
GO ID GO Term Qualifier Evidence PubMed
GO:0001878response to yeast-IEA-  
GO:0006954inflammatory response-TAS1429570  
GO:0008228opsonization-IEA-  
GO:0043312neutrophil degranulation-TAS-  
GO:0044793negative regulation by host of viral process-IBA21873635  
GO:0044869negative regulation by host of viral exo-alpha-sialidase activity-IDA23544079  
GO:0044871negative regulation by host of viral glycoprotein metabolic process-IDA23544079  
GO:0045087innate immune response-IBA21873635  
GO:0045087innate immune response-IDA23544079  
GO:0045429positive regulation of nitric oxide biosynthetic process-IEA-  
GO:0046597negative regulation of viral entry into host cell-IDA23544079  
GO:0050766positive regulation of phagocytosis-IEA-  
GO:1903016negative regulation of exo-alpha-sialidase activity-IDA23544079  
GO:1903019negative regulation of glycoprotein metabolic process-IDA23544079  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IBA21873635  
GO:0005615extracellular space-IDA23544079  
GO:0035580specific granule lumen-TAS-  
GO:1904724tertiary granule lumen-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-6798695Neutrophil degranulationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25303877Pentraxin 3 as a novel biomarker of inflammation in chronic obstructive pulmonary disease. (2015 Feb)Kurt OKInflammation
21079193Racial differences in the association of pentraxin-3 with kidney dysfunction: the Multi-Ethnic Study of Atherosclerosis. (2011 Jun)Dubin RNephrol Dial Transplant
28733767Relationship between plasma pentraxin 3 level and risk of chronic kidney disease in the Korean elderly: the Dong-gu study. (2017 Nov)Lee RInt Urol Nephrol
21616640Pentraxin 3 as a biomarker for acute coronary syndrome: comparison with biomarkers for cardiac damage. (2011 Jul)Kume NJ Cardiol
25496999Genes expressed in coronary thrombi are associated with ischemic time in patients with acute myocardial infarction. (2015 Feb)Helseth RThromb Res
28238190Effects of 6 months of resveratrol versus placebo on pentraxin 3 in patients with type 2 diabetes mellitus: a double-blind randomized controlled trial. (2017 May)Bo SActa Diabetol
25006444Pentraxin-3 and the right ventricle: the Multi-Ethnic Study of Atherosclerosis-Right Ventricle Study. (2014 Jun)Leary PJPulm Circ
22305847Associations of pentraxin-3 with cardiovascular events, incident heart failure, and mortality among persons with coronary heart disease: data from the Heart and Soul Study. (2012 Feb)Dubin RAm Heart J
24244639Echocardiography, spirometry, and systemic acute-phase inflammatory proteins in smokers with COPD or CHF: an observational study. (2013)Beghe BPLoS One
29616311Serum levels of Pentraxin 3 differ significantly at the time of blastocyst transfer depending on implantation success: a pilot study. (2018 Jun)Freis AArch Gynecol Obstet