Gene: PURA

5813
MRD31|PUR-ALPHA|PUR1|PURALPHA
purine rich element binding protein A
protein-coding
5q31.3
Ensembl:ENSG00000185129 MIM:600473 Vega:OTTHUMG00000129242 UniprotKB:Q00577
NG_041813.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.681e-1 (AD)  8.946e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SDE20.736
SPPL2A0.733
TXNRD10.732
ZNF8000.721
RBM120.718
SCAF110.718
ARF60.716
LYSMD30.713
BMP2K0.707
CDKN2AIP0.706

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.528
OR4F29-0.505
FAM186A-0.18
OR4F16-0.172
OR7A17-0.164
OR6C74-0.163
AKR1B15-0.154
SSX2B-0.151
OR7C1-0.148
COL20A1-0.142

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of PURA mRNA"19162173
C5724913-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol results in decreased expression of PURA protein26194647
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of PURA mRNA"18648102
D000082AcetaminophenAcetaminophen results in decreased expression of PURA mRNA18246545
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of PURA gene27153756
D013196DihydrotestosteroneDihydrotestosterone results in increased expression of PURA mRNA17023530
D001241AspirinAspirin results in increased expression of PURA mRNA12800193
D004958EstradiolEstradiol affects the expression of PURA mRNA23557687
C006780bisphenol Abisphenol A affects the expression of PURA mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of PURA mRNA22576693
C006780bisphenol Abisphenol A results in increased methylation of PURA gene22576693
C006780bisphenol Abisphenol A affects the methylation of PURA promoter27334623
C006780bisphenol Abisphenol A results in increased expression of PURA mRNA25181051
C006780bisphenol A[Fructose co-treated with bisphenol A] results in increased expression of PURA protein26930160
C013418bromfenacoumbromfenacoum results in increased expression of PURA protein28903499
C018475butyraldehydebutyraldehyde results in decreased expression of PURA mRNA26079696
D020148Butyric AcidButyric Acid results in increased expression of PURA mRNA12800193
D002220CarbamazepineCarbamazepine affects the expression of PURA mRNA25979313
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of PURA mRNA23650126
D002858Chromium AlloysChromium Alloys results in decreased expression of PURA mRNA17376492
D002994ClofibrateClofibrate affects the expression of PURA mRNA16081524
D003520CyclophosphamideCyclophosphamide results in increased expression of PURA mRNA11599041
D016572CyclosporineCyclosporine results in decreased expression of PURA mRNA25562108
D002945CisplatinCisplatin results in decreased expression of PURA mRNA27392435
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of PURA mRNA26924002
D004041Dietary FatsDietary Fats results in decreased expression of PURA mRNA25016146
C024629dimethyl phthalatedimethyl phthalate affects the expression of PURA mRNA26924002
D004221DisulfiramDisulfiram results in decreased expression of PURA mRNA20530235
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of PURA protein23301498
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of PURA mRNA17942748
D005472FluorouracilFluorouracil affects the expression of PURA mRNA16584549
D005632Fructose[Fructose co-treated with bisphenol A] results in increased expression of PURA protein26930160
C106014geduningedunin results in decreased expression of PURA mRNA17010675
D005839GentamicinsGentamicins results in increased expression of PURA mRNA22061828
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of PURA mRNA25613284
C544151jinfukangjinfukang results in decreased expression of PURA mRNA27392435
C410337K 7174K 7174 results in increased expression of PURA mRNA24086573
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of PURA mRNA"15329391
C517284monomethyl phthalatemonomethyl phthalate affects the expression of PURA mRNA26924002
C031721naphthalenenaphthalene metabolite binds to PURA protein15892573
C022838nickel chloridenickel chloride results in decreased expression of PURA mRNA17312168
D010634PhenobarbitalPhenobarbital affects the expression of PURA mRNA23091169
C006253pirinixic acidpirinixic acid results in decreased expression of PURA mRNA18445702
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of PURA mRNA19162173
C045950propiconazolepropiconazole results in decreased expression of PURA mRNA21278054
C015586propiverinepropiverine binds to PURA protein29273565
D011441PropylthiouracilPropylthiouracil results in decreased expression of PURA mRNA24780913
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of PURA mRNA21427059
D012524SarinSarin affects the expression of PURA protein28973502
D012822Silicon DioxideSilicon Dioxide results in decreased expression of PURA mRNA19073995
C080703SK&F 83959SK&F 83959 results in increased expression of PURA protein25852303
D012969Sodium FluorideSodium Fluoride results in decreased expression of PURA protein28918527
D012999SomanSoman results in decreased expression of PURA mRNA19281266
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PURA mRNA24058054
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PURA mRNA21215274
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of PURA mRNA25613284
D0156472,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine"2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine affects the expression of PURA protein"25852303
D013893ThiramThiram results in decreased expression of PURA mRNA20530235
C009495titanium dioxidetitanium dioxide affects the expression of PURA mRNA17656681
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of PURA mRNA28065790
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of PURA protein24486158
D014241TrichloroethyleneTrichloroethylene results in increased expression of PURA mRNA19448997|2897337
C050414tripterinetripterine results in decreased expression of PURA mRNA17010675
C057693troglitazonetroglitazone results in decreased expression of PURA mRNA28973697
D014635Valproic AcidValproic Acid affects the expression of PURA mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of PURA mRNA23179753|2627250
D014635Valproic AcidValproic Acid results in increased expression of PURA mRNA21427059
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of PURA gene25560391
D024483Vitamin K 3Vitamin K 3 results in decreased expression of PURA mRNA25270620
D015032ZincZinc deficiency results in decreased expression of PURA mRNA12888634

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000900translation repressor activity, mRNA regulatory element binding-IEA-  
GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding-IBA21873635  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0001227transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding-IBA21873635  
GO:0003690double-stranded DNA binding-IBA21873635  
GO:0003691double-stranded telomeric DNA binding-IDA15777841  
GO:0003697single-stranded DNA binding-ISS-  
GO:0003705transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding-TAS9334258  
GO:0003723RNA binding-HDA22658674  22681889  
GO:0005515protein binding-IPI7592647  9830007  
GO:0008134transcription factor binding-ISS-  
GO:0032422purine-rich negative regulatory element binding-IBA21873635  
GO:0032422purine-rich negative regulatory element binding-IEA-  
GO:0043565sequence-specific DNA binding-IBA21873635  
GO:0046332SMAD binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006268DNA unwinding involved in DNA replication-IDA15777841  
GO:0006270DNA replication initiation-TAS1545807  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-IEA-  
GO:0007399nervous system development-IEA-  
GO:0008284positive regulation of cell proliferation-IEA-  
GO:0017148negative regulation of translation-IEA-  
GO:0030154cell differentiation-IEA-  
GO:0045892negative regulation of transcription, DNA-templated-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000784nuclear chromosome, telomeric region-IC15777841  
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA9716182  
GO:0005662DNA replication factor A complex-ISS-  
GO:0005737cytoplasm-IEA-  
GO:0030425dendrite-IEA-  
GO:0043025neuronal cell body-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26203295Altered placental DNA methylation patterns associated with maternal smoking: current perspectives. (2015 May 7)Maccani JZAdv Genomics Genet