Gene: PTBP2

58155
PTBLP|brPTB|nPTB
polypyrimidine tract binding protein 2
protein-coding
1p21.3
Ensembl:ENSG00000117569 MIM:608449 Vega:OTTHUMG00000010685 UniprotKB:Q9UKA9
NC_000001.11
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.138e-1 (AD)  5.061e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FBXO30.904
VPS37A0.904
PIGK0.903
ATE10.901
CDK170.898
EXOC10.897
ZDHHC170.896
CASD10.896
SLC35A50.896
IMPAD10.894

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.578
OR4F29-0.537
MTRNR2L9-0.401
MTRNR2L8-0.386
MTRNR2L6-0.381
MTRNR2L10-0.379
CSAG1-0.375
MTRNR2L2-0.361
TTLL10-0.353
MTRNR2L3-0.316

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PTBP2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PTBP2 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of PTBP2 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of PTBP2 mRNA19770486
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of PTBP2 mRNA24449571
D001280AtrazineAtrazine results in increased expression of PTBP2 mRNA22378314
C006780bisphenol Abisphenol A affects the expression of PTBP2 mRNA21786754
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of PTBP2 mRNA28628672
C006780bisphenol Abisphenol A affects the expression of PTBP2 mRNA21786754
C006780bisphenol Abisphenol A results in increased methylation of PTBP2 gene28505145
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of PTBP2 mRNA15336504
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of PTBP2 mRNA17484886
D016572CyclosporineCyclosporine results in decreased expression of PTBP2 mRNA27989131
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of PTBP2 mRNA28628672
D003907DexamethasoneDexamethasone inhibits the reaction [Lipopolysaccharides results in decreased expression of PTBP2 mRNA]22185406
D003907DexamethasoneDexamethasone results in decreased expression of PTBP2 mRNA22185406
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of PTBP2 mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of PTBP2 mRNA24893172
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of PTBP2 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of PTBP2 mRNA27392435
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of PTBP2 mRNA26924002
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of PTBP2 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of PTBP2 mRNA17557909
C039281furanfuran results in increased expression of PTBP2 mRNA27387713
D005947Glucose[INS protein co-treated with Glucose] results in decreased expression of PTBP2 mRNA22634610
D006046GoldGold results in decreased expression of PTBP2 mRNA25523186
D017313FenretinideFenretinide results in increased expression of PTBP2 mRNA28973697
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of PTBP2 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of PTBP2 mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of PTBP2 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of PTBP2 mRNA27392435
D008070LipopolysaccharidesDexamethasone inhibits the reaction [Lipopolysaccharides results in decreased expression of PTBP2 mRNA]22185406
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of PTBP2 mRNA22185406
D008070LipopolysaccharidesQuercetin inhibits the reaction [Lipopolysaccharides results in decreased expression of PTBP2 mRNA]22185406
D008070Lipopolysaccharides"tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in decreased expression of PTBP2 mRNA]"22185406
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of PTBP2 mRNA28001369
D008767Methylmercury Compounds[Methylmercury Compounds co-treated with Polychlorinated Biphenyls] results in increased expression of PTBP2 mRNA20020106
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of PTBP2 protein26558463
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of PTBP2 mRNA23649840
D015735MifepristoneMifepristone results in increased expression of PTBP2 mRNA17584828
D009538NicotineNicotine results in increased expression of PTBP2 mRNA16949557
D016912Levonorgestrel[testosterone undecanoate co-treated with Levonorgestrel] results in decreased expression of PTBP2 mRNA19074003
C464660obeticholic acidobeticholic acid results in decreased expression of PTBP2 mRNA27939613
D010100OxygenOxygen deficiency results in increased expression of PTBP2 mRNA24205000
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of PTBP2 mRNA26794494
D010634PhenobarbitalPhenobarbital affects the expression of PTBP2 mRNA23091169
D010634PhenobarbitalPhenobarbital results in increased expression of PTBP2 mRNA19270015
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PTBP2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of PTBP2 mRNA26272509
D010672PhenytoinPhenytoin results in increased expression of PTBP2 mRNA20345932
C006253pirinixic acidpirinixic acid results in increased expression of PTBP2 mRNA18301758|1844570
D011078Polychlorinated Biphenyls[Methylmercury Compounds co-treated with Polychlorinated Biphenyls] results in increased expression of PTBP2 mRNA20020106
D011192Potassium DichromatePotassium Dichromate results in decreased expression of PTBP2 mRNA23608068
D011374ProgesteroneProgesterone affects the expression of PTBP2 mRNA17251523
D011794QuercetinQuercetin results in increased expression of PTBP2 mRNA21632981
D011794QuercetinQuercetin inhibits the reaction [Lipopolysaccharides results in decreased expression of PTBP2 mRNA]22185406
D011794QuercetinQuercetin results in decreased expression of PTBP2 mRNA22185406
D012834SilverSilver results in decreased expression of PTBP2 mRNA27131904
C009277sodium arsenatesodium arsenate results in increased expression of PTBP2 mRNA21795629|2775181
D013629TamoxifenTamoxifen affects the expression of PTBP2 mRNA17555576
C010792testosterone undecanoate[testosterone undecanoate co-treated with Levonorgestrel] results in decreased expression of PTBP2 mRNA19074003
D013849ThimerosalThimerosal results in increased expression of PTBP2 mRNA27188386
D013853ThioacetamideThioacetamide results in increased expression of PTBP2 mRNA23411599
C082097tocotrienol, delta"tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in decreased expression of PTBP2 mRNA]"22185406
C082097tocotrienol, delta"tocotrienol, delta results in increased expression of PTBP2 mRNA"22185406
D014241TrichloroethyleneTrichloroethylene results in increased methylation of PTBP2 gene27618143
C012589trichostatin Atrichostatin A results in decreased expression of PTBP2 mRNA15901671
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of PTBP2 mRNA29024780
D014635Valproic AcidValproic Acid results in decreased expression of PTBP2 mRNA15901671
D014635Valproic AcidValproic Acid affects the expression of PTBP2 mRNA24849673|2597931
D014635Valproic AcidValproic Acid results in decreased expression of PTBP2 mRNA23179753|2493525
D014635Valproic AcidValproic Acid results in decreased methylation of PTBP2 gene29154799
D014635Valproic AcidValproic Acid affects the expression of PTBP2 mRNA17963808
C025643vinclozolinvinclozolin results in decreased expression of PTBP2 mRNA23869203

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-HDA22658674  22681889  
GO:0003729mRNA binding-IEA-  
GO:0036002pre-mRNA binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006376mRNA splice site selection-IEA-  
GO:0021510spinal cord development-IEA-  
GO:0021549cerebellum development-IEA-  
GO:0033119negative regulation of RNA splicing-IDA18335065  
GO:2000177regulation of neural precursor cell proliferation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005681spliceosomal complex-IEA-  
GO:0030426growth cone-IEA-  
GO:0043025neuronal cell body-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26162562Polymorphisms in alternative splicing associated genes are associated with lung cancer risk in a Chinese population. (2015 Sep)Shen WLung Cancer
26683835Physical activity, smoking, and genetic predisposition to obesity in people from Pakistan: the PROMIS study. (2015 Dec 18)Ahmad SBMC Med Genet