Gene: NGB

58157
-
neuroglobin
protein-coding
14q24.3
Ensembl:ENSG00000165553 MIM:605304 Vega:OTTHUMG00000171558 UniprotKB:Q9NPG2
NC_000014.9
PubMed
0   ANCO-SNPs
CD|ND
6   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.332e-1 (AD)  3.442e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NR2F10.791
NLRP10.778
VSTM2L0.775
SNCG0.768
ABHD80.765
HS6ST10.763
HPCAL10.763
CYGB0.759
C2CD4C0.759
IGLON50.758

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.525
TRPV5-0.502
VRK2-0.494
OR4F29-0.468
ZFP57-0.467
CTNNA3-0.466
RAI14-0.464
SGMS2-0.461
DTHD1-0.446
PRR5L-0.444

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of NGB mRNA"19114083
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of NGB mRNA"18648102
D000643Ammonium ChlorideAmmonium Chloride affects the expression of NGB mRNA16483693
C030419andrographolide[andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of NGB mRNA19737545
D001280AtrazineAtrazine results in increased expression of NGB mRNA25929836
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of NGB mRNA26377693
D019324beta-Naphthoflavone[andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of NGB mRNA19737545
C006780bisphenol Abisphenol A affects the expression of NGB mRNA28721559
C006780bisphenol Abisphenol A results in decreased expression of NGB mRNA25181051
D002118CalciumNGB protein affects the transport of Calcium19154338
D002245Carbon DioxideCarbon Dioxide binds to [Heme binds to NGB protein]16684569
D002713ChlorineNGB protein affects the abundance of Chlorine19154338
D003300CopperNGB protein results in decreased uptake of Copper19154338
D003471CuprizoneCuprizone results in decreased expression of NGB mRNA27523638
C017160cypermethrincypermethrin results in increased expression of NGB mRNA21142847
D004041Dietary FatsDietary Fats results in increased expression of NGB mRNA25016146
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate inhibits the reaction [SP3 protein binds to NGB promoter]25068794
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of NGB mRNA25068794
D004051Diethylhexyl PhthalateMC1568 inhibits the reaction [Diethylhexyl Phthalate inhibits the reaction [SP3 protein binds to NGB promoter]]25068794
D004051Diethylhexyl PhthalateMC1568 inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of NGB mRNA]25068794
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of NGB protein28934723
D004237DiuronDiuron results in increased expression of NGB mRNA21551480
D006418HemeCarbon Dioxide binds to [Heme binds to NGB protein]16684569
D006418HemeHeme binds to NGB protein16684569
D007501IronNGB protein results in decreased uptake of Iron19154338
D007854LeadLead affects the expression of NGB mRNA28903495
D014975LuteinLutein results in increased expression of NGB mRNA24865317
C577554MC1568MC1568 inhibits the reaction [Diethylhexyl Phthalate inhibits the reaction [SP3 protein binds to NGB promoter]]25068794
C577554MC1568MC1568 inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of NGB mRNA]25068794
C577554MC1568MC1568 results in increased expression of NGB mRNA25068794
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of NGB mRNA"20188158
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of NGB mRNA24810058
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of NGB mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of NGB mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of NGB mRNA]"20230807
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of NGB mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of NGB mRNA"25554681
D009538Nicotine"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of NGB mRNA"20230807
D009538Nicotine"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of NGB mRNA]"20230807
D010269ParaquatNGB protein inhibits the reaction [GLB-13 gene mutant form results in increased susceptibility to Paraquat]23508993
D010269ParaquatNGB protein inhibits the reaction [[GLB-13 gene mutant form results in increased susceptibility to Paraquat] which results in increased abundance of Reactive Oxygen Species]23508993
D010269ParaquatNGB protein inhibits the reaction [Paraquat results in increased abundance of Reactive Oxygen Species]23508993
C006253pirinixic acidpirinixic acid results in decreased expression of NGB mRNA23811191
D011188PotassiumNGB protein affects the abundance of Potassium19154338
D011441PropylthiouracilPropylthiouracil results in decreased expression of NGB mRNA24780913
D017382Reactive Oxygen SpeciesNGB protein inhibits the reaction [[GLB-13 gene mutant form results in increased susceptibility to Paraquat] which results in increased abundance of Reactive Oxygen Species]23508993
D017382Reactive Oxygen SpeciesNGB protein inhibits the reaction [Paraquat results in increased abundance of Reactive Oxygen Species]23508993
D017382Reactive Oxygen SpeciesReactive Oxygen Species results in increased expression of NGB mRNA16524376
D012834SilverSilver results in increased expression of NGB mRNA19429238
C017947sodium arsenitesodium arsenite results in increased expression of NGB mRNA21117137
D053260SootSoot results in increased expression of NGB mRNA21914721
D013455SulfurNGB protein affects the abundance of Sulfur19154338
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NGB mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of NGB mRNA28213091
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of NGB mRNA27441981
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of NGB protein27441981
D014635Valproic AcidValproic Acid results in increased methylation of NGB gene29154799
D015032ZincNGB protein results in decreased uptake of Zinc19154338

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005344oxygen carrier activity-TAS11029004  
GO:0005515protein binding-IPI25416956  
GO:0019825oxygen binding-IEA-  
GO:0020037heme binding-IEA-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006915apoptotic process-IEA-  
GO:0015671oxygen transport-NAS11029004  
GO:0015671oxygen transport-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-IEA-  
GO:0005829cytosol-TAS-  
GO:0043204perikaryon-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-382551Transport of small moleculesTAS
R-HSA-8981607Intracellular oxygen transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
17627675Pharmacological actions of NGB 2904, a selective dopamine D3 receptor antagonist, in animal models of drug addiction. (2007 Summer)Xi ZXCNS Drug Rev
21289600Influence of cocaine history on the behavioral effects of Dopamine D(3) receptor-selective compounds in monkeys. (2011 Apr)Blaylock BLNeuropsychopharmacology
16205781The novel dopamine D3 receptor antagonist NGB 2904 inhibits cocaine's rewarding effects and cocaine-induced reinstatement of drug-seeking behavior in rats. (2006 Jul)Xi ZXNeuropsychopharmacology
15689168Novel heterocyclic trans olefin analogues of N-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl}arylcarboxamides as selective probes with high affinity for the dopamine D3 receptor. (2005 Feb 10)Grundt PJ Med Chem
27441981Evaluation of globins expression in brain, heart, and lung in rats exposed to side stream cigarette smoke. (2017 Apr)Tae BEnviron Toxicol
17272677Effects of two novel D3-selective compounds, NGB 2904 [N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)-9H-fluorene-2-carboxamide] and CJB 090 [N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)-4-(pyridin-2-yl)benzamide], on the reinforcing and discriminative stimulus effects of cocaine in rhesus monkeys. (2007 May)Martelle JLJ Pharmacol Exp Ther