Gene info: ID 5817

Gene: PVR

GENE ID: 5817

Description: poliovirus receptor

Gene type: protein-coding

Location: 19q13.31

dbXrefs: Ensembl:ENSG00000073008 MIM:173850 Vega:OTTHUMG00000151527 UniprotKB:P15151

RefSeq: NG_008781.2

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 8

Sherlock p-value : 6.885e-1 (AD) 3.161e-1 (ND) (Frontal_Cortex)

Pascal p-value : 8.623e-1 (AD) 3.219e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
B4GALT5	0.914
CHPF2	0.903
POM121C	0.897
RAB35	0.895
SLC25A25	0.893
IARS	0.892
HYOU1	0.887
ALAS1	0.886
SLC25A44	0.885
ZDHHC5	0.885

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.505
OR4F29	-0.464
STON2	-0.373
CTNNA3	-0.368
ASB4	-0.361
AKR1C3	-0.36
MYOM1	-0.349
COPZ2	-0.348
BBOX1	-0.341
PON3	-0.335

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB03203	Sphingosine	Small Molecule	123-78-4	Experimental	Target
DB08231	Myristic acid	Small Molecule	544-63-8	Experimental	Target

ID	Drug Name	Action	PubMed
C051246	1-methylanthracene	[1-methylanthracene co-treated with fluoranthene] results in increased expression of PVR mRNA	28329830
C029790	2,2',3',4,4',5-hexachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PVR mRNA"	25510870
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of PVR mRNA"	19114083
C081766	2,4,4'-trichlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PVR mRNA"	25510870
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PVR mRNA"	25510870
C009828	2,4,5,2',5'-pentachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PVR mRNA"	25510870
C010914	2,4-diaminotoluene	"2,4-diaminotoluene results in increased expression of PVR mRNA"	20713471
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of PVR mRNA"	21346803
C009407	2,5,2',5'-tetrachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PVR mRNA"	25510870
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of PVR mRNA"	21346803
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of PVR mRNA"	23196670
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in increased expression of PVR mRNA"	18648102
C035207	4-amino-2,6-dinitrotoluene	"4-amino-2,6-dinitrotoluene affects the expression of PVR mRNA"	21346803
D000082	Acetaminophen	Acetaminophen results in decreased expression of PVR mRNA	26690555
D000082	Acetaminophen	MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of PVR mRNA]	18700144
D020106	Acrylamide	Acrylamide results in decreased expression of PVR mRNA	28959563
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of PVR mRNA	16483693
C059765	amphotericin B, deoxycholate drug combination	"amphotericin B, deoxycholate drug combination results in increased expression of PVR mRNA"	22863853
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of PVR mRNA	24449571
D001151	Arsenic	Arsenic results in decreased expression of PVR mRNA	19654921
D001280	Atrazine	Atrazine results in decreased expression of PVR mRNA	22378314
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of PVR mRNA	19770486
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of PVR mRNA	21569818
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PVR mRNA"	19150397
D004958	Estradiol	Estradiol affects the expression of PVR mRNA	22574217
D004958	Estradiol	Estradiol results in increased expression of PVR mRNA	23019147
C006780	bisphenol A	bisphenol A affects the expression of PVR mRNA	20170705
C006780	bisphenol A	bisphenol A results in increased expression of PVR mRNA	25181051
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased expression of PVR mRNA	15336504
D002104	Cadmium	Cadmium results in increased expression of PVR mRNA	25543212
D019256	Cadmium Chloride	Cadmium Chloride affects the expression of PVR mRNA	22110744
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of PVR mRNA	19010381
D002235	Carbofuran	Carbofuran results in increased expression of PVR mRNA	20211217
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of PVR mRNA	27339419
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of PVR mRNA	16440345\|1752207
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of PVR protein	12629582
D002509	Cephaloridine	Cephaloridine results in increased expression of PVR mRNA	18500788
D002725	Chloroform	Chloroform results in increased expression of PVR mRNA	17522070
C418118	CI 1044	CI 1044 results in increased expression of PVR mRNA	17569694
D003471	Cuprizone	Cuprizone results in increased expression of PVR mRNA	26577399
D016572	Cyclosporine	Cyclosporine results in increased expression of PVR mRNA	25562108
D016572	Cyclosporine	Cyclosporine results in increased expression of PVR mRNA	19770486
C093628	cyproconazole	cyproconazole results in increased expression of PVR mRNA	29038839
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of PVR mRNA	21266533
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in decreased expression of PVR mRNA	27392435
D002945	Cisplatin	Cisplatin results in increased expression of PVR mRNA	27594783
C000944	dicrotophos	dicrotophos results in increased expression of PVR mRNA	28302478
D004041	Dietary Fats	Dietary Fats affects the expression of PVR mRNA	19680557
D004317	Doxorubicin	Doxorubicin results in increased expression of PVR mRNA	20211217
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of PVR mRNA	20170705
C007738	fluoranthene	[1-methylanthracene co-treated with fluoranthene] results in increased expression of PVR mRNA	28329830
D005557	Formaldehyde	Formaldehyde results in increased expression of PVR mRNA	18499655
C039281	furan	furan results in increased expression of PVR mRNA	27387713
D005839	Gentamicins	Gentamicins results in increased expression of PVR mRNA	22061828
D005947	Glucose	Glucose results in increased expression of PVR mRNA	17178593
D005947	Glucose	[INS protein co-treated with Glucose] results in increased expression of PVR mRNA	22634610
D006046	Gold	[Polyethyleneimine binds to Gold] which results in decreased expression of PVR mRNA	28433809
C492448	ICG 001	ICG 001 results in increased expression of PVR mRNA	26191083
C016517	indole-3-carbinol	indole-3-carbinol affects the expression of PVR mRNA	21396975
D007545	Isoproterenol	Isoproterenol results in increased expression of PVR mRNA	20211217
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in decreased expression of PVR mRNA	27392435
C098607	JP8 aviation fuel	JP8 aviation fuel affects the expression of PVR mRNA	17085751
D007854	Lead	Lead affects the expression of PVR mRNA	28903495
C045463	leflunomide	leflunomide results in increased expression of PVR mRNA	28988120
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of PVR mRNA	16415329
D008070	Lipopolysaccharides	Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of PVR mRNA]	16415329
D008345	Manganese	Manganese results in decreased expression of PVR mRNA	17175027
C025340	manganese chloride	manganese chloride results in decreased expression of PVR mRNA	17175027
D008627	Mercuric Chloride	Mercuric Chloride results in increased expression of PVR mRNA	16507785
D008694	Methamphetamine	Methamphetamine results in increased expression of PVR mRNA	19564919
D008701	Methapyrilene	Methapyrilene results in increased expression of PVR mRNA	16393664
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of PVR mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of PVR mRNA"	25554681
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in increased expression of PVR mRNA	17522070
D009532	Nickel	Nickel results in increased expression of PVR mRNA	24768652\|2558310
C022838	nickel chloride	nickel chloride affects the expression of PVR mRNA	22110744
C014707	nitrosobenzylmethylamine	nitrosobenzylmethylamine results in increased expression of PVR mRNA	17616710
D009966	Orphenadrine	Orphenadrine affects the expression of PVR mRNA	23665939
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in increased expression of PVR mRNA	25729387
D010126	Ozone	Ozone results in increased expression of PVR mRNA	27206323
C016030	pantogab	pantogab results in increased expression of PVR mRNA	17379144
C410127	PCB 180	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PVR mRNA"	25510870
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of PVR protein	26879310
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of PVR mRNA	19162173
D010634	Phenobarbital	Phenobarbital results in increased expression of PVR mRNA	19162173
D010656	Phenylephrine	Phenylephrine results in increased expression of PVR mRNA	18158353
C006253	pirinixic acid	pirinixic acid results in increased expression of PVR mRNA	17426115
C006253	pirinixic acid	pirinixic acid results in increased expression of PVR mRNA	12832660\|1916217
D011094	Polyethyleneimine	[Polyethyleneimine binds to Gold] which results in decreased expression of PVR mRNA	28433809
C045950	propiconazole	propiconazole results in increased expression of PVR mRNA	21278054
D011899	Ranitidine	Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of PVR mRNA]	16415329
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of PVR mRNA	19073995\|2322117
D012999	Soman	Soman results in increased expression of PVR mRNA	19281266
C013698	tallow	tallow affects the expression of PVR mRNA	19680557
C020806	tetrabromobisphenol A	tetrabromobisphenol A results in increased expression of PVR mRNA	25172293
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of PVR mRNA	21570461
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of PVR mRNA	21215274
D013752	Tetracycline	Tetracycline results in increased expression of PVR mRNA	17522070
D013853	Thioacetamide	Thioacetamide results in increased expression of PVR mRNA	23411599
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of PVR	23757602
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in increased expression of PVR mRNA	25729387
D019772	Topotecan	Topotecan results in increased expression of PVR mRNA	25729387
C483909	torcetrapib	torcetrapib results in increased expression of PVR mRNA	23228038
D014241	Trichloroethylene	Trichloroethylene results in increased methylation of PVR gene	27618143
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of PVR mRNA"	26179874
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of PVR mRNA"	26179874
D014635	Valproic Acid	Valproic Acid results in increased expression of PVR mRNA	23179753
D014635	Valproic Acid	Valproic Acid results in increased methylation of PVR gene	29154799
D014640	Vancomycin	Vancomycin results in decreased expression of PVR mRNA	18930951
D001335	Vehicle Emissions	Vehicle Emissions results in increased expression of PVR mRNA	19465080

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001618	virus receptor activity	-	IEA	-
GO:0005102	signaling receptor binding	-	IBA	21873635
GO:0005515	protein binding	-	IPI	19011627 21982860 25416956 28515320
GO:0038023	signaling receptor activity	-	TAS	2538245
GO:0042803	protein homodimerization activity	-	IBA	21873635
GO:0050839	cell adhesion molecule binding	-	IBA	21873635
GO:0050839	cell adhesion molecule binding	-	IPI	12913096

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0002860	positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	-	IBA	21873635
GO:0002860	positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	-	IMP	12913096
GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	-	IBA	21873635
GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	-	IBA	21873635
GO:0007165	signal transduction	-	IEA	-
GO:0008037	cell recognition	-	IBA	21873635
GO:0034332	adherens junction organization	-	TAS	-
GO:0042271	susceptibility to natural killer cell mediated cytotoxicity	-	IBA	21873635
GO:0042271	susceptibility to natural killer cell mediated cytotoxicity	-	IMP	12913096
GO:0045954	positive regulation of natural killer cell mediated cytotoxicity	-	IMP	16304049
GO:0046718	viral entry into host cell	-	IEA	-
GO:0050776	regulation of immune response	-	TAS	-
GO:0060370	susceptibility to T cell mediated cytotoxicity	-	IBA	21873635
GO:0060370	susceptibility to T cell mediated cytotoxicity	-	IDA	15039383

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005615	extracellular space	-	TAS	2170108
GO:0005737	cytoplasm	-	TAS	2170108
GO:0005886	plasma membrane	-	TAS	-
GO:0005913	cell-cell adherens junction	-	IBA	21873635
GO:0005925	focal adhesion	-	HDA	21423176
GO:0009986	cell surface	-	IDA	16831868
GO:0016021	integral component of membrane	-	IDA	12913096

KEGG ID	KEGG Term
hsa04514	Cell adhesion molecules (CAMs)

Reactome ID	Reactome Term	Evidence
R-HSA-1280218	Adaptive Immune System	TAS
R-HSA-1500931	Cell-Cell communication	TAS
R-HSA-168256	Immune System	TAS
R-HSA-198933	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	TAS
R-HSA-418990	Adherens junctions interactions	TAS
R-HSA-420597	Nectin/Necl trans heterodimerization	TAS
R-HSA-421270	Cell-cell junction organization	TAS
R-HSA-446728	Cell junction organization	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
28012803	Airway and Pulmonary beta2-Adrenergic Vasodilatory Function in Current Smokers and Never Smokers. (2017 Mar)	Hurwitz BE	Chest
28204989	Assessment of noninvasive predictors of bladder detrusor underactivity in BPH/LUTs patients. (2017 May)	Luo F	Int Urol Nephrol
18698542	Remote second-hand tobacco exposure in flight attendants is associated with systemic but not pulmonary hypertension. (2008)	Ren X	Cardiol J
7474617	[A study of middle-high aged impotent patients]. (1995 Aug)	Oka Y	Nihon Hinyokika Gakkai Zasshi
23512652	Insulin's microvascular vasodilatory effects are inversely related to peripheral vascular resistance in overweight, but insulin-sensitive subjects. (2013 Dec)	Hornstra JM	Obesity (Silver Spring)
1619697	[Influence of cigarette smoking on the hypoxic pulmonary vasoconstriction in isolated rat lungs--the role of prostaglandins and leukotrienes]. (1992)	Yang GT	J Tongji Med Univ
28215234	Moderate-to-severe obstructive sleep apnea is associated with subclinical myocardial injury and impaired hemodynamics in pulmonary hypertension patients. (2017 Feb)	Kohno T	Sleep Med
26663649	Men with Hypertension are More Likely to Have Severe Lower Urinary Tract Symptoms and Large Prostate Volume. (2015 Jan)	Hwang EC	Low Urin Tract Symptoms