Gene: CXCL16

58191
CXCLG16|SR-PSOX|SRPSOX
C-X-C motif chemokine ligand 16
protein-coding
17p13.2
Ensembl:ENSG00000161921 MIM:605398 Vega:OTTHUMG00000090761 UniprotKB:Q9H2A7
NC_000017.11
PubMed
0   ANCO-SNPs
ND
9   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.889e-1 (AD)  7.081e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TGFB10.912
SPI10.904
CMTM70.895
PTPN60.893
TNFRSF1B0.89
GPSM30.886
RIN30.886
ARHGAP300.883
LYN0.882
SASH30.881

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KCNB2-0.533
MARCH4-0.524
SLC7A4-0.516
CALHM1-0.51
ABCC12-0.509
NEUROD6-0.492
TMEM179-0.49
BCL11A-0.489
PPEF1-0.489
HAS1-0.485

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4778983-(4-(4-((1-(2-chlorophenyl)ethoxy)carbonyl amino)-3-methyl-5-isoxazolyl) benzylsulfanyl) propanoic acid3-(4-(4-((1-(2-chlorophenyl)ethoxy)carbonyl amino)-3-methyl-5-isoxazolyl) benzylsulfanyl) propanoic acid inhibits the reaction [lysophosphatidic acid results in increased expression of CXCL16 protein]25822713
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of CXCL16 mRNA"25380136
D000171AcroleinAcrolein results in decreased expression of CXCL16 mRNA18515264
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in increased expression of CXCL16 mRNA"22863853
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of CXCL16 mRNA24449571
D001151ArsenicArsenic affects the expression of CXCL16 protein24675094
C006632arsenic trioxidearsenic trioxide results in increased expression of CXCL16 mRNA25258189
C547126AZM551248AZM551248 results in increased expression of CXCL16 mRNA22323515
D001554BenzeneBenzene affects the expression of CXCL16 mRNA17119257
D001554BenzeneBenzene results in increased expression of CXCL16 mRNA15929907|1916216
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of CXCL16 mRNA26377693
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CXCL16 mRNA18164116
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CXCL16 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CXCL16 mRNA22228805|2373587
D001622BetaineBetaine results in decreased expression of CXCL16 mRNA26391144
C006780bisphenol Abisphenol A affects the expression of CXCL16 mRNA25181051
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of CXCL16 mRNA17484886
D002635Chenodeoxycholic AcidChenodeoxycholic Acid results in increased expression of CXCL16 mRNA21224055
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CXCL16 mRNA20938992
D003035CobaltTNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CXCL16 mRNA]23503329
D003035Cobalt[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CXCL16 mRNA23503329
D003436Croton OilCroton Oil results in increased expression of CXCL16 mRNA19647056
D003471CuprizoneCuprizone results in increased expression of CXCL16 mRNA26577399|2752363
D016572CyclosporineCyclosporine results in increased expression of CXCL16 mRNA20106945
D003907DexamethasoneTNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CXCL16 mRNA]23503329
D003907Dexamethasone[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CXCL16 mRNA23503329
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of CXCL16 mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of CXCL16 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with TNF protein] results in increased expression of CXCL16 mRNA23103562
D004041Dietary FatsDietary Fats results in increased expression of CXCL16 mRNA22609946
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CXCL16 mRNA18164116
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of CXCL16 mRNA25380136
D005485FlutamideFlutamide results in decreased expression of CXCL16 mRNA24793618
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CXCL16 mRNA20938992
C039281furanfuran results in increased expression of CXCL16 mRNA26194646|2738771
D017313FenretinideFenretinide results in increased expression of CXCL16 mRNA28973697
D0150561-Methyl-3-isobutylxanthineTNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CXCL16 mRNA]23503329
D0150561-Methyl-3-isobutylxanthine[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CXCL16 mRNA23503329
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with Monocrotaline] results in increased expression of CXCL16 protein21279329
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of CXCL16 mRNA26582142
D008070Lipopolysaccharides[Monocrotaline co-treated with Lipopolysaccharides] results in decreased expression of CXCL16 protein21327618
C032881lysophosphatidic acid3-(4-(4-((1-(2-chlorophenyl)ethoxy)carbonyl amino)-3-methyl-5-isoxazolyl) benzylsulfanyl) propanoic acid inhibits the reaction [lysophosphatidic acid results in increased expression of CXCL16 protein]25822713
C032881lysophosphatidic acidlysophosphatidic acid results in increased expression of CXCL16 protein25822713
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of CXCL16 mRNA21641980
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] affects the expression of CXCL16 mRNA26378955
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CXCL16 mRNA20938992
D016686Monocrotaline[Lipopolysaccharides co-treated with Monocrotaline] results in increased expression of CXCL16 protein21279329
D016686Monocrotaline[Monocrotaline co-treated with Lipopolysaccharides] results in decreased expression of CXCL16 protein21327618
D009151Mustard GasMustard Gas results in increased expression of CXCL16 mRNA25102026
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CXCL16 mRNA"25554681
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of CXCL16 mRNA25380136
D009532NickelNickel results in increased expression of CXCL16 mRNA25583101
D009532NickelTNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CXCL16 mRNA]23503329
D009532Nickel[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CXCL16 mRNA23503329
C022838nickel chloridenickel chloride results in increased expression of CXCL16 mRNA26044615
C029938nickel sulfatenickel sulfate results in increased expression of CXCL16 mRNA22714537
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of CXCL16 mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of CXCL16 mRNA25729387
D052638Particulate MatterParticulate Matter results in decreased expression of CXCL16 mRNA24769257
C006253pirinixic acidpirinixic acid results in decreased expression of CXCL16 mRNA17426115
C060540polyhexamethyleneguanidinepolyhexamethyleneguanidine results in increased expression of CXCL16 protein29175452
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of CXCL16 mRNA22714537
D011374ProgesteroneProgesterone results in decreased expression of CXCL16 mRNA20631399
D011374ProgesteroneProgesterone results in increased expression of CXCL16 mRNA23018184
C513428pyrachlostrobinpyrachlostrobin results in increased expression of CXCL16 mRNA27029645
D011794QuercetinQuercetin results in increased expression of CXCL16 mRNA21632981
D019821SimvastatinSimvastatin results in decreased expression of CXCL16 mRNA25055962
D012906SmokeSmoke results in decreased expression of CXCL16 mRNA21095227
D012999SomanSoman results in increased expression of CXCL16 mRNA19281266
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of CXCL16 mRNA21641980
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] affects the expression of CXCL16 mRNA26378955
D013656Taurocholic AcidTaurocholic Acid results in increased expression of CXCL16 mRNA21224055
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CXCL16 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CXCL16 mRNA27562557
D013755Tetradecanoylphorbol AcetateIL17RA gene mutant form inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of CXCL16 mRNA]22359662
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in decreased expression of CXCL16 mRNA22359662
C009495titanium dioxidetitanium dioxide results in increased expression of CXCL16 mRNA23557971|2776080
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of CXCL16 mRNA20133372
D014051Toluene 2,4-Diisocyanate"Toluene 2,4-Diisocyanate results in increased expression of CXCL16 mRNA"19647056
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of CXCL16 mRNA25729387
D019772TopotecanTopotecan results in increased expression of CXCL16 mRNA25729387
D014212TretinoinTretinoin results in increased expression of CXCL16 mRNA16142401
D014212TretinoinTretinoin results in increased secretion of CXCL16 protein16142401
D014635Valproic AcidValproic Acid results in increased expression of CXCL16 mRNA23179753|2915479
D014640VancomycinVancomycin results in decreased expression of CXCL16 mRNA18930951
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of CXCL16 gene25560391
C025643vinclozolinvinclozolin affects the expression of CXCL16 mRNA19015723
C029297vinylidene chloridevinylidene chloride results in increased expression of CXCL16 mRNA26682919
D015032ZincTNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CXCL16 mRNA]23503329
D015032Zinc[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CXCL16 mRNA23503329
C088658zoledronic acidzoledronic acid results in increased expression of CXCL16 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005041low-density lipoprotein particle receptor activity-IBA21873635  
GO:0005041low-density lipoprotein particle receptor activity-ISS-  
GO:0005044scavenger receptor activity-IBA21873635  
GO:0005044scavenger receptor activity-TAS11060282  
GO:0008009chemokine activity-IBA21873635  
GO:0008009chemokine activity-IDA18373975  
GO:0008009chemokine activity-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006898receptor-mediated endocytosis-NAS11060282  
GO:0006935chemotaxis-NAS11290797  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0010818T cell chemotaxis-IBA21873635  
GO:0030307positive regulation of cell growth-IMP18373975  
GO:0030335positive regulation of cell migration-IBA21873635  
GO:0030335positive regulation of cell migration-IMP18373975  
GO:0034097response to cytokine-IDA18373975  
GO:0034341response to interferon-gamma-IDA18373975  
GO:0034612response to tumor necrosis factor-IDA18373975  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IBA21873635  
GO:0005615extracellular space-IDA18373975  
GO:0005886plasma membrane-IEA-  
GO:0016020membrane-TAS11060282  
GO:0016021integral component of membrane-NAS11290797  
KEGG ID KEGG Term
hsa04060Cytokine-cytokine receptor interaction
hsa04062Chemokine signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-375276Peptide ligand-binding receptorsTAS
R-HSA-380108Chemokine receptors bind chemokinesTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26649903Soluble CXCL16 and risk of myocardial infarction: The HUNT study in Norway. (2016 Jan)Laugsand LEAtherosclerosis
21467783CXC chemokine ligand 16 as a prognostic marker in patients with intermediate coronary artery lesions: a 2-year follow-up study. (2011 Apr)Tan KTohoku J Exp Med
28975971The relationship between serum CXCL16 level and carotid vulnerable plaque in patients with ischemic stroke. (2017 Oct)Jin GEur Rev Med Pharmacol Sci
29285224Soluble chemokine (C-X-C motif) ligand 16 (CXCL16) in urine as a novel biomarker candidate to identify high grade and muscle invasive urothelial carcinomas. (2017 Dec 1)Lang KOncotarget
25720858An acute bout of exercise modulate the inflammatory response in peripheral blood mononuclear cells in healthy young men. (2015 May)Ulven SMArch Physiol Biochem
19643942Systemic inflammatory markers in COPD: results from the Bergen COPD Cohort Study. (2010 Mar)Eagan TMEur Respir J
29326688Cigarette Smoke Increases Endothelial CXCL16-Leukocyte CXCR6 Adhesion In Vitro and In Vivo. Potential Consequences in Chronic Obstructive Pulmonary Disease. (2017)Marques PFront Immunol
28599467Association between CXCL16/CXCR6 expression and the clinicopathological features of patients with non-small cell lung cancer. (2017 Jun)Ke COncol Lett
19729872Circulating soluble SR-PSOX/CXCL16 as a biomarker for acute coronary syndrome -comparison with high-sensitivity C-reactive protein. (2009 Oct)Mitsuoka HJ Atheroscler Thromb