Gene: PXMP2

5827
PMP22
peroxisomal membrane protein 2
protein-coding
12q24.33
Ensembl:ENSG00000176894 MIM:617399 Vega:OTTHUMG00000168019 UniprotKB:Q9NR77
NC_000012.12
PubMed
0   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.701e-3 (AD)  6.154e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DCXR0.849
MT30.844
RAMP10.842
PHPT10.832
PRADC10.831
PMVK0.82
AK10.818
SMIM200.818
VEGFB0.811
CST30.807

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.653
OR4F29-0.609
PZP-0.346
SULT1E1-0.324
KRT73-0.322
ZC3H11B-0.321
GADL1-0.32
DPPA4-0.316
MROH5-0.309
FER1L6-0.309

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of PXMP2 mRNA"19114083
C0293704-toluidine4-toluidine results in decreased expression of PXMP2 mRNA27638505
D000082AcetaminophenAcetaminophen results in decreased expression of PXMP2 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of PXMP2 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 affects the expression of PXMP2 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of PXMP2 mRNA22100608|2715375
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of PXMP2 mRNA19770486
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PXMP2 mRNA16483693
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in decreased expression of PXMP2 mRNA"22863853
C006632arsenic trioxidearsenic trioxide results in increased expression of PXMP2 mRNA20458559
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PXMP2 mRNA26238291
C006780bisphenol Abisphenol A affects the expression of PXMP2 mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of PXMP2 mRNA15336504
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of PXMP2 mRNA27339419
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PXMP2 gene20938992
D002994ClofibrateClofibrate results in decreased expression of PXMP2 mRNA17585979
C018021cobaltous chloridecobaltous chloride results in decreased expression of PXMP2 mRNA19320972
D019327Copper SulfateCopper Sulfate results in decreased expression of PXMP2 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of PXMP2 mRNA20106945|2383089
D016572CyclosporineCyclosporine results in decreased expression of PXMP2 mRNA23830897
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of PXMP2 mRNA21266533
D002945CisplatinCisplatin results in increased expression of PXMP2 mRNA27594783
D004041Dietary FatsDietary Fats results in increased expression of PXMP2 mRNA18042831
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of PXMP2 mRNA19850644
D004051Diethylhexyl PhthalatePPARA protein promotes the reaction [Diethylhexyl Phthalate results in decreased expression of PXMP2 mRNA]19850644
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of PXMP2 mRNA19638242
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in decreased expression of PXMP2 mRNA27638505
D000431EthanolEthanol results in decreased expression of PXMP2 mRNA17920746
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PXMP2 mRNA17942748
D005419FlavonoidsFlavonoids results in increased expression of PXMP2 mRNA18035473
D005472FluorouracilFluorouracil affects the expression of PXMP2 mRNA20421339
D005485FlutamideFlutamide results in decreased expression of PXMP2 mRNA24136188
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PXMP2 gene20938992
C056933fumonisin B1fumonisin B1 results in decreased expression of PXMP2 mRNA16221962
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of PXMP2 mRNA20044591
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of PXMP2 mRNA24796395
C410337K 7174K 7174 results in decreased expression of PXMP2 mRNA24086573
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PXMP2 gene20938992
C013598methoxyacetic acidmethoxyacetic acid affects the expression of PXMP2 mRNA20421339
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of PXMP2 mRNA28001369
C028577monobutyl phthalatemonobutyl phthalate affects the expression of PXMP2 mRNA20421339
C568376MT19c compoundMT19c compound results in decreased expression of PXMP2 mRNA21781307
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of PXMP2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of PXMP2 mRNA"25554681
D009532NickelNickel results in decreased expression of PXMP2 mRNA24768652|2558310
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of PXMP2 mRNA27935865
D000073878Palm OilPalm Oil results in increased expression of PXMP2 mRNA18042831
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of PXMP2 mRNA20936131
C027579periodate-oxidized adenosineperiodate-oxidized adenosine affects the expression of PXMP2 mRNA17097637
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of PXMP2 mRNA27935865
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of PXMP2 mRNA19710929
D015474IsotretinoinIsotretinoin results in decreased expression of PXMP2 mRNA20436886
D018038Sodium SeleniteSodium Selenite results in increased expression of PXMP2 mRNA18175754
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PXMP2 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PXMP2 mRNA15328365
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PXMP2 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PXMP2 mRNA21215274
D013853ThioacetamideThioacetamide results in decreased expression of PXMP2 mRNA23411599
D014212TretinoinTretinoin affects the expression of PXMP2 mRNA20421339
D014241TrichloroethyleneTrichloroethylene results in increased methylation of PXMP2 gene27618143
C012589trichostatin Atrichostatin A results in increased expression of PXMP2 mRNA15901671
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of PXMP2 mRNA"26179874
C057693troglitazone[troglitazone co-treated with TNF protein] results in decreased expression of PXMP2 mRNA12732648
D014520UrethaneUrethane results in decreased expression of PXMP2 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of PXMP2 mRNA20421339
D014635Valproic AcidValproic Acid results in increased expression of PXMP2 mRNA15901671
D014640VancomycinVancomycin results in increased expression of PXMP2 mRNA18930951
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of PXMP2 gene25560391
C029297vinylidene chloridevinylidene chloride results in decreased expression of PXMP2 mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI11590176  14709540  16683188  21102411  
GO ID GO Term Qualifier Evidence PubMed
GO:0008150biological_process-ND-  
GO:0034614cellular response to reactive oxygen species-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IDA8624723  
GO:0005739mitochondrion-IBA21873635  
GO:0005778peroxisomal membrane-IDA11590176  
GO:0016020membrane-HDA19946888  
GO:0032991protein-containing complex-IDA18174172  
KEGG ID KEGG Term
hsa04146Peroxisome
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismIEA
R-HSA-389661Glyoxylate metabolism and glycine degradationIEA
R-HSA-71291Metabolism of amino acids and derivativesIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal