Gene: PEX2

5828
PAF1|PBD5A|PBD5B|PMP3|PMP35|PXMP3|RNF72|ZWS3
peroxisomal biogenesis factor 2
protein-coding
8q21.13
Ensembl:ENSG00000164751 MIM:170993 Vega:OTTHUMG00000164530 UniprotKB:P28328
NG_008371.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.379e-2 (AD)  2.116e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FBXO80.881
ASF1A0.875
SNX50.872
AK30.871
DARS0.87
PPP2R5A0.869
TMCO10.865
CGRRF10.857
HIBADH0.852
RAB9A0.852

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.607
OR4F29-0.571
OPRD1-0.34
FAM160A1-0.312
THEM5-0.29
NPBWR2-0.29
RHO-0.289
PNPLA5-0.285
NKD2-0.285
CALHM1-0.279

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of PEX2 mRNA"19162173
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of PEX2 mRNA19933214
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of PEX2 mRNA"21394737
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of PEX2 mRNA"19114083
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl affects the expression of PEX2 mRNA"24680724
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of PEX2 mRNA"21346803
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PEX2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PEX2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PEX2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PEX2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PEX2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PEX2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PEX2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PEX2 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of PEX2 mRNA26690555
D000082AcetaminophenAcetaminophen affects the expression of PEX2 mRNA17562736
D006710HomocysteineHomocysteine results in decreased expression of PEX2 mRNA17326132
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PEX2 mRNA16483693
D004958EstradiolEstradiol results in decreased expression of PEX2 mRNA23019147
C006780bisphenol Abisphenol A results in increased expression of PEX2 mRNA17706920
C006780bisphenol ALHB protein affects the reaction [bisphenol A results in increased expression of PEX2 mRNA]17706920
C006780bisphenol Abisphenol A affects the expression of PEX2 mRNA25181051
D002994ClofibrateClofibrate results in decreased expression of PEX2 mRNA17585979
D003042CocaineCocaine affects the expression of PEX2 mRNA20187946
C014347decitabinedecitabine results in decreased methylation of PEX2 gene27923600
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of PEX2 mRNA21266533
C000944dicrotophosdicrotophos results in decreased expression of PEX2 mRNA28302478
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of PEX2 mRNA22079256
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of PEX2 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PEX2 mRNA17942748
D018120FinasterideFinasteride results in increased expression of PEX2 mRNA24136188
D005419FlavonoidsFlavonoids results in increased expression of PEX2 mRNA18035473
D005485FlutamideFlutamide results in increased expression of PEX2 mRNA24136188
D005557FormaldehydeFormaldehyde results in decreased expression of PEX2 mRNA23649840
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of PEX2 mRNA25613284
D007545IsoproterenolIsoproterenol results in increased expression of PEX2 mRNA21335049
D007854LeadLead results in increased expression of PEX2 mRNA19921347
C008261lead acetatelead acetate results in decreased expression of PEX2 mRNA21829687
C482199lipopolysaccharide, E coli O55-B5"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of PEX2 mRNA"18930950
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PEX2 mRNA"27188386
D008767Methylmercury CompoundsMethylmercury Compounds results in decreased expression of PEX2 mRNA22129749
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of PEX2 mRNA26011545
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of PEX2 mRNA"20188158
C051752nefazodonenefazodone results in increased expression of PEX2 mRNA24136188
D010126OzoneOzone results in decreased expression of PEX2 mRNA16183385
C046012pentanalpentanal results in decreased expression of PEX2 mRNA26079696
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PEX2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of PEX2 mRNA26272509
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of PEX2 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of PEX2 mRNA22079256|2271453
D011794QuercetinQuercetin results in decreased expression of PEX2 mRNA21632981
C017947sodium arsenitesodium arsenite results in increased expression of PEX2 mRNA12679051
D013467SulindacSulindac results in increased expression of PEX2 mRNA24136188
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PEX2 mRNA21570461|2468072
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PEX2 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PEX2 mRNA28213091
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PEX2 mRNA19933214
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PEX2 mRNA11752688
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of PEX2 mRNA25613284
D019284ThapsigarginThapsigargin results in decreased expression of PEX2 protein24648495
D014212TretinoinTretinoin results in increased expression of PEX2 mRNA16604517
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PEX2 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of PEX2 mRNA26272509
C080163trovafloxacin"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of PEX2 mRNA"18930950
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PEX2 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of PEX2 mRNA23179753|2627250
D014635Valproic AcidValproic Acid results in decreased methylation of PEX2 gene29154799
D001335Vehicle EmissionsVehicle Emissions affects the methylation of PEX2 gene25560391
D000069470Venlafaxine HydrochlorideVenlafaxine Hydrochloride affects the expression of PEX2 mRNA25423262
C111237vorinostatvorinostat results in increased expression of PEX2 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI10837480  11590176  20531392  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000038very long-chain fatty acid metabolic process-IMP9765053  
GO:0000122negative regulation of transcription by RNA polymerase II-IMP18987311  
GO:0006625protein targeting to peroxisome-TAS-  
GO:0006635fatty acid beta-oxidation-IMP9765053  10528859  
GO:0007031peroxisome organization-IMP1546315  9765053  
GO:0016558protein import into peroxisome matrix-IMP10528859  
GO:0016567protein ubiquitination-TAS-  
GO:0031648protein destabilization-IMP18987311  
GO:0048147negative regulation of fibroblast proliferation-IMP18987311  
GO:0050680negative regulation of epithelial cell proliferation-IMP18987311  
GO ID GO Term Qualifier Evidence PubMed
GO:0005778peroxisomal membrane-HDA21525035  
GO:0005778peroxisomal membrane-TAS-  
GO:0005779integral component of peroxisomal membrane-IMP12751901  
GO:0016020membrane-HDA19946888  
GO:0016593Cdc73/Paf1 complex-IDA18987311  
KEGG ID KEGG Term
hsa04146Peroxisome
Reactome ID Reactome Term Evidence
R-HSA-392499Metabolism of proteinsTAS
R-HSA-392499Metabolism of proteinsIEA
R-HSA-597592Post-translational protein modificationTAS
R-HSA-8852135Protein ubiquitinationTAS
R-HSA-8866654E3 ubiquitin ligases ubiquitinate target proteinsTAS
R-HSA-9033241Peroxisomal protein importTAS
R-HSA-9033241Peroxisomal protein importIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28440896Genome-wide meta-analysis identifies a novel susceptibility signal at CACNA2D3 for nicotine dependence. (2017 Apr 25)Yin XAm J Med Genet B Neuropsychiatr Genet