Gene: PXN

5829
-
paxillin
protein-coding
12q24.23
Ensembl:ENSG00000089159 MIM:602505 Vega:OTTHUMG00000169169 UniprotKB:P49023
NG_029820.1
PubMed
0   ANCO-SNPs
ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.604e-1 (AD)  2.238e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg15893360chr12:120700361PXN1.660e-8Maternal smoking in pregnancy27040690

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TNFRSF10B0.885
DOCK60.884
IL4R0.881
ACSL50.878
SBNO20.874
RBMS20.87
TEP10.868
CHSY10.864
IL6R0.864
CDH50.863

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CRH-0.474
SMIM18-0.452
PPEF1-0.444
ABCC12-0.432
NEUROD6-0.422
MARCH4-0.42
VWC2-0.413
ADRA1D-0.413
HAPLN1-0.412
AARD-0.41

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5179431-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone"1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone results in increased phosphorylation of PXN protein"27026707
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of PXN mRNA"19114083
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of PXN mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of PXN mRNA"21346803
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of PXN mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PXN mRNA"27188386
C0688054-hydroxycoumarin4-hydroxycoumarin affects the localization of PXN protein18492274
C0688054-hydroxycoumarin4-hydroxycoumarin results in decreased expression of PXN mRNA alternative form18492274
C0688054-hydroxycoumarin4-hydroxycoumarin results in decreased expression of PXN protein alternative form18492274
C0688054-hydroxycoumarin4-hydroxycoumarin results in decreased phosphorylation of PXN protein18492274
C0126064-vinyl-1-cyclohexene dioxide4-vinyl-1-cyclohexene dioxide affects the expression of PXN mRNA20829426
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PXN mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of PXN mRNA22230336|2669055
D000082AcetaminophenAcetaminophen affects the expression of PXN mRNA17562736
C412373AG 1879AG 1879 results in decreased phosphorylation of PXN protein17186241
D000781Anethole TrithioneAnethole Trithione inhibits the reaction [Reactive Oxygen Species results in increased phosphorylation of PXN protein]11213483
D000968Antimycin AAntimycin A results in decreased expression of PXN protein12490576
D000968Antimycin APD 150606 inhibits the reaction [Antimycin A results in decreased expression of PXN protein]12490576
D001241AspirinAspirin results in decreased expression of PXN mRNA15928584
D001280AtrazineAtrazine results in increased expression of PXN mRNA25929836
D001285AtropineAtropine inhibits the reaction [[oxotremorine M co-treated with wortmannin] inhibits the reaction [oxophenylarsine results in increased phosphorylation of PXN protein]]10537051
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PXN mRNA26001963
D004958EstradiolEGF protein inhibits the reaction [Estradiol results in decreased expression of PXN mRNA]24758408
D004958EstradiolEstradiol affects the expression of PXN mRNA22574217
D004958EstradiolEstradiol results in decreased expression of PXN mRNA24758408
D004958EstradiolEstradiol results in increased phosphorylation of PXN protein27026707
C006780bisphenol Abisphenol A affects the expression of PXN mRNA21786754
C006780bisphenol Abisphenol A affects the expression of PXN mRNA25181051
C086539BQ 788[BQ 788 co-treated with cyclo(Trp-Asp-Pro-Val-Leu)] inhibits the reaction [EDN1 protein results in increased phosphorylation of PXN protein]12875994
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of PXN mRNA18804290
C584509C646 compoundC646 compound results in decreased expression of PXN mRNA26191083
D002104CadmiumCadmium results in increased expression of PXN mRNA22562489
D019256Cadmium ChlorideCadmium Chloride results in increased expression of PXN protein28527916
D019256Cadmium ChlorideCadmium Chloride results in increased expression of PXN mRNA23741332
D002220CarbamazepineCarbamazepine affects the expression of PXN mRNA25979313
D004390ChlorpyrifosChlorpyrifos results in increased expression of PXN mRNA20691718
C018021cobaltous chloridecobaltous chloride results in decreased expression of PXN mRNA19320972
D016572CyclosporineCyclosporine results in increased expression of PXN mRNA25562108
C072247cyclo(Trp-Asp-Pro-Val-Leu)[BQ 788 co-treated with cyclo(Trp-Asp-Pro-Val-Leu)] inhibits the reaction [EDN1 protein results in increased phosphorylation of PXN protein]12875994
D000069439DasatinibDasatinib results in decreased phosphorylation of PXN protein20682659
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of PXN mRNA21266533
D002945CisplatinCisplatin results in increased expression of PXN mRNA21151649
C000944dicrotophosdicrotophos results in increased expression of PXN mRNA28302478
C058064dinitrophenyl-human serum albumin conjugatedinitrophenyl-human serum albumin conjugate results in increased phosphorylation of PXN protein26621445
C058064dinitrophenyl-human serum albumin conjugateresveratrol inhibits the reaction [dinitrophenyl-human serum albumin conjugate results in increased phosphorylation of PXN protein]26621445
C058064dinitrophenyl-human serum albumin conjugatedinitrophenyl-human serum albumin conjugate results in increased phosphorylation of PXN protein26621445
C058064dinitrophenyl-human serum albumin conjugateresveratrol inhibits the reaction [dinitrophenyl-human serum albumin conjugate results in increased phosphorylation of PXN protein]26621445
D004726EndosulfanEndosulfan results in decreased expression of PXN mRNA28108160
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of PXN protein23301498
D005466FluorocarbonsFluorocarbons analog results in increased phosphorylation of PXN protein27572461
D005557FormaldehydeFormaldehyde results in increased phosphorylation of and results in increased activity of PXN protein16352387
D019833GenisteinGenistein results in decreased expression of PXN mRNA22228119
D006493HeparinHeparin results in decreased phosphorylation of PXN protein18674534
D017313FenretinideFenretinide results in increased expression of PXN mRNA28973697
D007052IbuprofenIbuprofen results in decreased expression of PXN mRNA16463375
D007052IbuprofenIbuprofen results in decreased expression of PXN protein16463375
C492448ICG 001ICG 001 results in decreased expression of PXN mRNA26191083
D007529IsoflavonesIsoflavones affects the expression of PXN mRNA16365062
D048628KetolidesKetolides analog results in decreased expression of PXN mRNA24967691
D018021Lithium ChlorideLithium Chloride results in increased expression of PXN mRNA23527032
D008095Lithocholic AcidLithocholic Acid results in decreased phosphorylation of and results in decreased activity of PXN protein21224350
D008274MagnesiumMagnesium inhibits the reaction [Ofloxacin inhibits the reaction [ITGB1 protein binds to PXN protein]]23274517
D008694MethamphetamineMethamphetamine results in increased expression of PXN mRNA26307267
D008727MethotrexateMethotrexate results in increased expression of PXN mRNA17400583|2167806
D008731MethoxychlorMethoxychlor affects the expression of PXN mRNA20829426
C587228methyl 3-hydroxyimino-11-oxoolean-12-en-28-oatemethyl 3-hydroxyimino-11-oxoolean-12-en-28-oate affects the expression of and results in decreased phosphorylation of PXN protein28322779
C587228methyl 3-hydroxyimino-11-oxoolean-12-en-28-oatemethyl 3-hydroxyimino-11-oxoolean-12-en-28-oate results in decreased expression of PXN mRNA28322779
D008798Mevalonic AcidMevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [AGT protein results in increased phosphorylation of PXN protein]]22306966
D009543NifedipineNifedipine inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of PXN protein]19556728
C512715NSC-87877NSC-87877 results in increased phosphorylation of PXN protein27572461
D015242OfloxacinMagnesium inhibits the reaction [Ofloxacin inhibits the reaction [ITGB1 protein binds to PXN protein]]23274517
D015242OfloxacinOfloxacin inhibits the reaction [ITGB1 protein binds to PXN protein]23274517
C029341oxophenylarsineAtropine inhibits the reaction [[oxotremorine M co-treated with wortmannin] inhibits the reaction [oxophenylarsine results in increased phosphorylation of PXN protein]]10537051
C029341oxophenylarsineoxophenylarsine affects the localization of PXN protein9546377
C029341oxophenylarsineoxophenylarsine results in increased phosphorylation of PXN protein10537051
C029341oxophenylarsine[oxotremorine M co-treated with wortmannin] inhibits the reaction [oxophenylarsine results in increased phosphorylation of PXN protein]10537051
C042743oxotremorine MAtropine inhibits the reaction [[oxotremorine M co-treated with wortmannin] inhibits the reaction [oxophenylarsine results in increased phosphorylation of PXN protein]]10537051
C042743oxotremorine M[oxotremorine M co-treated with wortmannin] inhibits the reaction [oxophenylarsine results in increased phosphorylation of PXN protein]10537051
C042743oxotremorine Moxotremorine M results in increased phosphorylation of PXN protein10537051
C042743oxotremorine Mwortmannin inhibits the reaction [oxotremorine M results in increased phosphorylation of PXN protein]10537051
C100442PD 150606PD 150606 inhibits the reaction [Antimycin A results in decreased expression of PXN protein]12490576
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of PXN mRNA23948077
C046012pentanalpentanal results in increased expression of PXN mRNA26079696
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased phosphorylation of PXN protein27572461
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased phosphorylation of PXN protein27572461
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of PXN mRNA19162173
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PXN mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of PXN mRNA26272509
D017382Reactive Oxygen SpeciesAnethole Trithione inhibits the reaction [Reactive Oxygen Species results in increased phosphorylation of PXN protein]11213483
D017382Reactive Oxygen SpeciesReactive Oxygen Species results in increased phosphorylation of PXN protein11213483
C059514resveratrolresveratrol inhibits the reaction [dinitrophenyl-human serum albumin conjugate results in increased phosphorylation of PXN protein]26621445
C059514resveratrolresveratrol inhibits the reaction [dinitrophenyl-human serum albumin conjugate results in increased phosphorylation of PXN protein]26621445
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of PXN mRNA23806026
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of PXN mRNA25895662
D019821SimvastatinMevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [AGT protein results in increased phosphorylation of PXN protein]]22306966
D019821SimvastatinSimvastatin affects the localization of PXN protein22306966
D019821SimvastatinSimvastatin inhibits the reaction [AGT protein results in increased phosphorylation of and affects the localization of PXN protein]22306966
D019821SimvastatinSimvastatin results in decreased phosphorylation of PXN protein22306966
C017947sodium arsenitesodium arsenite results in decreased expression of PXN protein19072884
C017947sodium arsenitesodium arsenite results in decreased phosphorylation of PXN protein15537746
D018038Sodium SeleniteSodium Selenite results in decreased expression of PXN mRNA18175754
D012999SomanSoman results in increased expression of PXN mRNA19281266
D013229Stearic AcidsStearic Acids analog results in increased phosphorylation of PXN protein27572461
C041359terbinafineterbinafine results in decreased phosphorylation of PXN protein17172416
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PXN mRNA21570461
D014112ToxapheneCAT protein inhibits the reaction [Toxaphene results in increased degradation of PXN protein]12139946
D014112ToxapheneToxaphene results in increased degradation of PXN protein12139946
D014212Tretinoin[LCP2 protein co-treated with CSF1R protein] promotes the reaction [Tretinoin results in increased expression of PXN protein]16439309
D014212TretinoinSUMO1 mutant form inhibits the reaction [Tretinoin results in increased expression of PXN mRNA]24819975
D014212TretinoinTretinoin results in increased expression of PXN9081214
D014212TretinoinTretinoin results in increased expression of PXN mRNA24819975
C057693troglitazonetroglitazone results in decreased expression of PXN mRNA28973697
D014635Valproic AcidValproic Acid affects the expression of PXN mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of PXN mRNA23527032
D014635Valproic AcidValproic Acid results in increased expression of PXN mRNA23179753
C025643vinclozolinvinclozolin affects the expression of PXN mRNA23034163
D002762CholecalciferolCholecalciferol results in increased expression of PXN9081214
C111237vorinostatvorinostat results in increased expression of PXN mRNA19911379
C111237vorinostatvorinostat results in increased expression of PXN protein19911379
C009687wortmanninAtropine inhibits the reaction [[oxotremorine M co-treated with wortmannin] inhibits the reaction [oxophenylarsine results in increased phosphorylation of PXN protein]]10537051
C009687wortmannin[oxotremorine M co-treated with wortmannin] inhibits the reaction [oxophenylarsine results in increased phosphorylation of PXN protein]10537051
C009687wortmanninwortmannin inhibits the reaction [oxotremorine M results in increased phosphorylation of PXN protein]10537051
C104536xanthohumolxanthohumol results in decreased expression of PXN protein23503627

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005178integrin binding-IEA-  
GO:0005515protein binding-IPI7561682  9114003  9756887  10604475  10814581  11035932  
12861019  14665621  14688263  15572663  16478788  16628223  
17082770  20489202  21034468  21173240  21741599  22270917  
22728435  23393263  23397142  24863063  25241761  
GO:0008013beta-catenin binding-IPI17513457  
GO:0017166vinculin binding-IPI9054445  
GO:0019901protein kinase binding-IEA-  
GO:0031625ubiquitin protein ligase binding-IEA-  
GO:0038191neuropilin binding-IPI24863063  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006936muscle contraction-TAS-  
GO:0007155cell adhesion-NAS10840040  
GO:0007160cell-matrix adhesion-IEA-  
GO:0007165signal transduction-TAS7534286  
GO:0007172signal complex assembly-TAS9054445  
GO:0007179transforming growth factor beta receptor signaling pathway-IDA24036928  
GO:0034614cellular response to reactive oxygen species-IEP12686598  
GO:0043542endothelial cell migration-IMP24863063  
GO:0048010vascular endothelial growth factor receptor signaling pathway-TAS-  
GO:0051496positive regulation of stress fiber assembly-IMP24863063  
GO:0060396growth hormone receptor signaling pathway-IDA10925297  
GO ID GO Term Qualifier Evidence PubMed
GO:0001725stress fiber-IDA24036928  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0005875microtubule associated complex-TAS10840040  
GO:0005886plasma membrane-IDA17449030  
GO:0005886plasma membrane-TAS-  
GO:0005925focal adhesion-HDA21423176  
GO:0005925focal adhesion-IDA12686598  20086044  24863063  
GO:0005938cell cortex-IEA-  
GO:0030027lamellipodium-IDA12686598  
KEGG ID KEGG Term
hsa04062Chemokine signaling pathway
hsa04370VEGF signaling pathway
hsa04510Focal adhesion
hsa04670Leukocyte transendothelial migration
hsa04810Regulation of actin cytoskeleton
hsa05100Bacterial invasion of epithelial cells
Reactome ID Reactome Term Evidence
R-HSA-1500931Cell-Cell communicationTAS
R-HSA-162582Signal TransductionTAS
R-HSA-177929Signaling by EGFRTAS
R-HSA-180292GAB1 signalosomeTAS
R-HSA-194138Signaling by VEGFTAS
R-HSA-397014Muscle contractionTAS
R-HSA-4420097VEGFA-VEGFR2 PathwayTAS
R-HSA-445355Smooth Muscle ContractionTAS
R-HSA-446343Localization of the PINCH-ILK-PARVIN complex to focal adhesionsTAS
R-HSA-446353Cell-extracellular matrix interactionsTAS
R-HSA-446388Regulation of cytoskeletal remodeling and cell spreading by IPP complex componentsTAS
R-HSA-446728Cell junction organizationTAS
R-HSA-8848021Signaling by PTK6TAS
R-HSA-8849471PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinasesTAS
R-HSA-9006927Signaling by Non-Receptor Tyrosine KinasesTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26120261Gene-based and pathway-based genome-wide association study of alcohol dependence. (2015 Apr 25)Zuo LShanghai Arch Psychiatry
27143927Integrin and gene network analysis reveals that ITGA5 and ITGB1 are prognostic in non-small-cell lung cancer. (2016)Zheng WOnco Targets Ther