Gene: PLEKHB1

58473
KPL1|PHR1|PHRET1
pleckstrin homology domain containing B1
protein-coding
11q13.4
Ensembl:ENSG00000021300 MIM:607651 Vega:OTTHUMG00000168030 UniprotKB:Q9UF11
NC_000011.10
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.883e-1 (AD)  7.935e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs642490chr11:73654570 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PAQR60.913
S100B0.91
LHPP0.903
CENPB0.9
MARCKSL10.891
ZCCHC240.884
TSC22D40.876
SEPT40.862
OLIG10.859
MID1IP10.858

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.628
OR4F5-0.566
HRH2-0.476
KCNH5-0.469
KCNH1-0.447
HS6ST3-0.438
MTUS2-0.437
HTR3B-0.432
SCN8A-0.43
PRSS12-0.429

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0326681-nitropyrene1-nitropyrene results in decreased expression of PLEKHB1 mRNA19041380
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PLEKHB1 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PLEKHB1 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PLEKHB1 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PLEKHB1 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PLEKHB1 mRNA"25510870
C0303702-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in decreased expression of PLEKHB1 mRNA"20206263
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of PLEKHB1 mRNA"25380136
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PLEKHB1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PLEKHB1 mRNA"27188386
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PLEKHB1 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of PLEKHB1 mRNA24449571
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PLEKHB1 mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PLEKHB1 mRNA22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PLEKHB1 mRNA19770486
C006780bisphenol Abisphenol A results in decreased methylation of PLEKHB1 promoter27312807
C006780bisphenol Abisphenol A results in increased methylation of PLEKHB1 promoter27312807
D002995Clofibric AcidClofibric Acid affects the expression of PLEKHB1 mRNA17602206
D019327Copper SulfateCopper Sulfate results in decreased expression of PLEKHB1 mRNA19549813
D003471CuprizoneCuprizone results in decreased expression of PLEKHB1 mRNA26577399|2752363
C009160cyclonitecyclonite results in decreased expression of PLEKHB1 mRNA25559034
D016572CyclosporineCyclosporine results in decreased expression of PLEKHB1 mRNA25562108
C014347decitabinedecitabine affects the expression of PLEKHB1 mRNA23300844
D013759DronabinolDronabinol results in decreased expression of PLEKHB1 mRNA12237329
D002945CisplatinCisplatin affects the expression of PLEKHB1 mRNA23300844
D004041Dietary FatsDietary Fats results in decreased expression of PLEKHB1 mRNA22609946
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of PLEKHB1 mRNA19850644
D004051Diethylhexyl PhthalatePPARA protein promotes the reaction [Diethylhexyl Phthalate results in increased expression of PLEKHB1 mRNA]19850644
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of PLEKHB1 mRNA24535843
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of PLEKHB1 mRNA28943392
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of PLEKHB1 mRNA19638242
D004237DiuronDiuron results in decreased expression of PLEKHB1 mRNA21551480
C118739entinostatentinostat results in increased expression of PLEKHB1 mRNA27188386
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of PLEKHB1 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PLEKHB1 mRNA17942748
D005472FluorouracilFluorouracil results in increased expression of PLEKHB1 mRNA16510598
D005485FlutamideFlutamide results in decreased expression of PLEKHB1 mRNA24136188
C039281furanfuran results in decreased expression of PLEKHB1 mRNA25539665|2619464
D017313FenretinideFenretinide results in increased expression of PLEKHB1 mRNA28973697
C492448ICG 001ICG 001 results in decreased expression of PLEKHB1 mRNA26191083
D007649KetamineKetamine results in increased expression of PLEKHB1 mRNA20080153
D007854LeadLead affects the expression of PLEKHB1 mRNA28903495
D007854LeadLead results in decreased expression of PLEKHB1 mRNA19921347
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of PLEKHB1 mRNA28001369
C030589methylmercury cysteinemethylmercury cysteine results in decreased expression of PLEKHB1 mRNA19465457
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of PLEKHB1 mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of PLEKHB1 mRNA"25554681|2562005
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in decreased expression of PLEKHB1 mRNA25380136
C051752nefazodonenefazodone results in decreased expression of PLEKHB1 mRNA24136188
D009532NickelNickel results in decreased expression of PLEKHB1 mRNA25583101
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PLEKHB1 mRNA"25510870
C046012pentanalpentanal results in increased expression of PLEKHB1 mRNA26079696
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in decreased expression of PLEKHB1 mRNA]19482888
D010634PhenobarbitalPhenobarbital affects the expression of PLEKHB1 mRNA23091169
D010634PhenobarbitalPhenobarbital results in decreased expression of PLEKHB1 mRNA19482888
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PLEKHB1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of PLEKHB1 mRNA26272509
C006253pirinixic acidpirinixic acid results in increased expression of PLEKHB1 mRNA17426115|1830175
D010936Plant ExtractsPlant Extracts results in decreased expression of PLEKHB1 mRNA23557933
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls affects the expression of PLEKHB1 mRNA21334430
C005556propionaldehydepropionaldehyde results in increased expression of PLEKHB1 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in decreased expression of PLEKHB1 mRNA24780913
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of PLEKHB1 mRNA25172293
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PLEKHB1 mRNA21632981
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PLEKHB1 mRNA26377647
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PLEKHB1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PLEKHB1 mRNA21215274
D013849ThimerosalThimerosal results in decreased expression of PLEKHB1 mRNA27188386
D013853Thioacetamide[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of PLEKHB1 mRNA28943392
D013853ThioacetamideThioacetamide results in decreased expression of PLEKHB1 mRNA23411599
D014212TretinoinTretinoin results in increased expression of PLEKHB1 mRNA16505366
D014212TretinoinTretinoin results in increased expression of PLEKHB1 mRNA20488242
D014635Valproic AcidValproic Acid affects the expression of PLEKHB1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of PLEKHB1 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased methylation of PLEKHB1 gene29154799
C034028vanadyl sulfatevanadyl sulfate results in increased expression of PLEKHB1 mRNA16330358
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of PLEKHB1 gene25560391
C029297vinylidene chloridevinylidene chloride results in decreased expression of PLEKHB1 mRNA26682919
C111237vorinostatvorinostat results in increased expression of PLEKHB1 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI25416956  
GO ID GO Term Qualifier Evidence PubMed
GO:0007275multicellular organism development-IEA-  
GO:0007602phototransduction-NAS10585447  
GO:0045595regulation of cell differentiation-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IEA-  
GO:0016021integral component of membrane-IBA21873635  
GO:0016021integral component of membrane-IDA10585447  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal