Gene: RHOU

58480
ARHU|CDC42L1|G28K|WRCH1|hG28K
ras homolog family member U
protein-coding
1q42.13
Ensembl:ENSG00000116574 MIM:606366 Vega:OTTHUMG00000037919 UniprotKB:Q7L0Q8
NC_000001.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.646e-1 (AD)  3.143e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TSPAN150.884
FAM107B0.877
TMEM1440.875
HSPA20.868
CLDND10.867
CNP0.866
MAL0.862
SLAIN10.861
PRR180.86
COL4A50.857

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CHRNA2-0.463
BEAN1-0.461
FBLN7-0.459
HCN4-0.454
ASB2-0.452
KCNG1-0.452
CUX2-0.451
SSTR4-0.444
PRTN3-0.441
CDH22-0.439

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in decreased expression of RHOU mRNA"26377693
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RHOU mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RHOU mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RHOU mRNA"27188386
C0126064-vinyl-1-cyclohexene dioxide4-vinyl-1-cyclohexene dioxide affects the expression of RHOU mRNA20829426
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RHOU mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RHOU mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RHOU mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of RHOU mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of RHOU mRNA17562736
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of RHOU mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of RHOU mRNA]17585979
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of RHOU mRNA28522335
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in increased expression of RHOU mRNA"22863853
D001280AtrazineAtrazine results in decreased expression of RHOU mRNA22378314
C030935benz(a)anthracenebenz(a)anthracene results in decreased expression of RHOU mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of RHOU mRNA22610609
D004958EstradiolEstradiol results in increased expression of RHOU mRNA23019147
D004958EstradiolEstradiol affects the expression of RHOU mRNA15598610
D004958EstradiolEstradiol results in increased expression of RHOU mRNA19484750
C006780bisphenol Abisphenol A results in decreased expression of RHOU mRNA22576693
C006780bisphenol Abisphenol A results in increased expression of RHOU mRNA27685785
C006780bisphenol Abisphenol A results in increased methylation of RHOU gene22576693
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of RHOU mRNA22079614
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of RHOU mRNA18974090
D019256Cadmium ChlorideCadmium Chloride affects the expression of RHOU mRNA18804290
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of RHOU mRNA17484886
D002737ChloropreneChloroprene results in increased expression of RHOU mRNA23125180
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of RHOU mRNA17585979
D002994ClofibrateClofibrate results in increased expression of RHOU mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of RHOU mRNA]17585979
D003471CuprizoneCuprizone results in decreased expression of RHOU mRNA27523638
D016572CyclosporineCyclosporine results in increased expression of RHOU mRNA25562108
C014347decitabinedecitabine affects the expression of RHOU mRNA23300844
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of RHOU mRNA21266533
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of RHOU mRNA28962523
D002945CisplatinCisplatin affects the expression of RHOU mRNA23300844
D004041Dietary FatsDietary Fats results in decreased expression of RHOU mRNA18042831
D004041Dietary FatsDietary Fats results in increased expression of RHOU mRNA15238619
D004041Dietary Fats[Dietary Fats co-treated with resveratrol] results in increased expression of RHOU mRNA21852083
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of RHOU mRNA21527772
D004178DiquatDiquat affects the expression of RHOU mRNA22814884
D005480FlurbiprofenFlurbiprofen results in increased expression of RHOU mRNA16949054
C056933fumonisin B1fumonisin B1 results in increased expression of RHOU mRNA16221962
D019833GenisteinGenistein results in increased expression of RHOU mRNA23019147
D005947Glucose[INS protein co-treated with Glucose] results in decreased expression of RHOU mRNA22634610
D006046Gold[Gold co-treated with Polyethylene Glycols] results in decreased expression of RHOU mRNA19695318
D017313FenretinideFenretinide results in decreased expression of RHOU mRNA28973697
D017313FenretinideFenretinide results in increased expression of RHOU mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of RHOU mRNA20044591
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of RHOU mRNA25613284
C051890irinotecanirinotecan analog results in increased expression of RHOU mRNA18927307
D007545IsoproterenolIsoproterenol results in increased expression of RHOU mRNA20003209
D048628KetolidesKetolides analog results in increased expression of RHOU mRNA24967691
D008727MethotrexateMethotrexate results in increased expression of RHOU mRNA21678067
D008727MethotrexateMethotrexate affects the expression of RHOU mRNA18502557
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of RHOU mRNA23103053
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of RHOU mRNA"26251327
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of RHOU mRNA22776087
D015741MetriboloneMetribolone results in increased expression of RHOU mRNA16751804
C517284monomethyl phthalatemonomethyl phthalate affects the expression of RHOU mRNA26924002
D009151Mustard GasMustard Gas affects the expression of RHOU mRNA15651846
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of RHOU mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of RHOU mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of RHOU mRNA"25554681
C012655nimesulidenimesulide results in decreased expression of RHOU mRNA24136188
D000073878Palm OilPalm Oil results in decreased expression of RHOU mRNA18042831
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of RHOU mRNA18593933
D010634PhenobarbitalPhenobarbital affects the expression of RHOU mRNA23091169
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RHOU mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of RHOU mRNA26272509
C006253pirinixic acidpirinixic acid results in increased expression of RHOU mRNA16221962|1742611
C006253pirinixic acidPPARA protein affects the reaction [pirinixic acid results in increased expression of RHOU mRNA]16221962
D011092Polyethylene Glycols[Gold co-treated with Polyethylene Glycols] results in decreased expression of RHOU mRNA19695318
D011374ProgesteroneProgesterone results in increased expression of RHOU mRNA18037150|2086464
D011794QuercetinQuercetin results in decreased expression of RHOU mRNA21632981
C059514resveratrol[Dietary Fats co-treated with resveratrol] results in increased expression of RHOU mRNA21852083
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of RHOU mRNA25895662
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of RHOU mRNA23806026
D012834SilverSilver results in increased expression of RHOU mRNA28959546
D012834SilverSilver results in decreased expression of RHOU mRNA27131904
C017947sodium arsenitesodium arsenite affects the expression of RHOU mRNA29319823
C017947sodium arsenitesodium arsenite affects the expression of RHOU mRNA16507464
D053260SootSoot results in increased expression of RHOU mRNA26551751
C061133tamibarotenetamibarotene results in decreased expression of RHOU mRNA17229644
D013629TamoxifenTamoxifen results in increased expression of RHOU mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of RHOU mRNA21570461
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of RHOU mRNA25613284
D013849ThimerosalThimerosal results in decreased expression of RHOU mRNA27188386
C009495titanium dioxidetitanium dioxide results in increased expression of RHOU mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of RHOU mRNA20133372
D014212TretinoinTretinoin results in increased expression of RHOU mRNA23724009|2383079
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RHOU mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of RHOU mRNA24935251|2627250
C012589trichostatin Atrichostatin A results in increased expression of RHOU mRNA24935251
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RHOU mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of RHOU mRNA25979313|2607246
D014635Valproic AcidValproic Acid results in decreased expression of RHOU mRNA23179753|2493525
D014635Valproic AcidValproic Acid results in increased expression of RHOU mRNA24935251|2800136
D014635Valproic AcidValproic Acid affects the expression of RHOU mRNA17292431|2607246
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of RHOU gene25560391
C029297vinylidene chloridevinylidene chloride results in increased expression of RHOU mRNA26682919
C111237vorinostatvorinostat results in decreased expression of RHOU mRNA27188386
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of RHOU mRNA18593933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003924GTPase activity-IBA21873635  
GO:0003924GTPase activity-IEA-  
GO:0005515protein binding-IPI14521508  15350535  15556869  16752908  18086875  
GO:0005525GTP binding-IBA21873635  
GO:0005525GTP binding-IEA-  
GO:0019901protein kinase binding-IBA21873635  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000082G1/S transition of mitotic cell cycle-IEA-  
GO:0006897endocytosis-IBA21873635  
GO:0007010cytoskeleton organization-IMP21834987  
GO:0007015actin filament organization-IBA21873635  
GO:0007163establishment or maintenance of cell polarity-IBA21873635  
GO:0007266Rho protein signal transduction-IBA21873635  
GO:0008360regulation of cell shape-IBA21873635  
GO:0008360regulation of cell shape-IMP21834987  
GO:0016477cell migration-IBA21873635  
GO:0016601Rac protein signal transduction-IEA-  
GO:0019221cytokine-mediated signaling pathway-TAS-  
GO:0030031cell projection assembly-IBA21873635  
GO:0030036actin cytoskeleton organization-IBA21873635  
GO:0030036actin cytoskeleton organization-IEA-  
GO:0030865cortical cytoskeleton organization-IBA21873635  
GO:0032488Cdc42 protein signal transduction-IBA21873635  
GO:0032956regulation of actin cytoskeleton organization-IBA21873635  
GO:0051056regulation of small GTPase mediated signal transduction-TAS-  
GO:1903955positive regulation of protein targeting to mitochondrion-HMP24270810  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-IEA-  
GO:0002102podosome-IEA-  
GO:0005737cytoplasm-IBA21873635  
GO:0005829cytosol-TAS-  
GO:0005856cytoskeleton-IBA21873635  
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-TAS-  
GO:0005925focal adhesion-IEA-  
GO:0005938cell cortex-IBA21873635  
GO:0031410cytoplasmic vesicle-IBA21873635  
GO:0031982vesicle-IBA21873635  
GO:0042995cell projection-IBA21873635  
GO:0042995cell projection-IEA-  
GO:0043231intracellular membrane-bounded organelle-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-162582Signal TransductionTAS
R-HSA-168256Immune SystemTAS
R-HSA-194315Signaling by Rho GTPasesTAS
R-HSA-194840Rho GTPase cycleTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-6785807Interleukin-4 and 13 signalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
11787557Evaluation of denture stomatitis in Croatian adult population. (2001 Jun)Celic RColl Antropol