Gene: NLRC4

58484
AIFEC|CARD12|CLAN|CLAN1|CLANA|CLANB|CLANC|CLAND|CLR2.1|FCAS4|IPAF
NLR family CARD domain containing 4
protein-coding
2p22.3
Ensembl:ENSG00000091106 MIM:606831 Vega:OTTHUMG00000152107 UniprotKB:Q9NPP4
NG_041780.1
PubMed
0   ANCO-SNPs
CD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.282e-1 (AD)  4.376e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DOK30.771
PTPN20.758
COLGALT10.755
ARHGAP90.75
RNF1490.743
JAK30.738
SLC25A190.727
ST140.714
SLAMF80.708
FKBP150.706

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HES5-0.409
HPDL-0.404
FGFBP3-0.346
ALDH1L1-AS2-0.34
ENDOU-0.339
ENHO-0.337
SOX3-0.331
DIO2-0.326
MMD2-0.322
ZNF98-0.317

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in increased expression of NLRC4 mRNA19191707
D020106AcrylamideAcrylamide results in decreased expression of NLRC4 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of NLRC4 gene27153756
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of NLRC4 mRNA"23195993
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of NLRC4 mRNA24449571
D001151ArsenicArsenic affects the methylation of NLRC4 gene25304211
C058667cadmium selenide[cadmium selenide co-treated with zinc sulfide] results in increased expression of NLRC4 mRNA22342292
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of NLRC4 mRNA20971185
D003471CuprizoneCuprizone results in increased expression of NLRC4 mRNA27523638
D016572CyclosporineCyclosporine results in increased expression of NLRC4 mRNA25562108
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of NLRC4 mRNA27392435
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of NLRC4 mRNA26924002
D037741FullerenesFullerenes analog affects the expression of NLRC4 mRNA22342292
C016517indole-3-carbinolindole-3-carbinol affects the expression of NLRC4 mRNA21396975
D007501IronIron deficiency results in increased expression of NLRC4 mRNA20368581
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of NLRC4 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of NLRC4 mRNA27392435
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of NLRC4 mRNA22147977
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of NLRC4 mRNA26378955
C517284monomethyl phthalatemonomethyl phthalate affects the expression of NLRC4 mRNA26924002
D009532NickelNickel results in decreased expression of NLRC4 mRNA23195993
D009532NickelNickel results in increased expression of NLRC4 mRNA25583101
C022838nickel chloridenickel chloride affects the expression of NLRC4 mRNA22546817
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of NLRC4 mRNA20971185
D009966OrphenadrineOrphenadrine affects the expression of NLRC4 mRNA23665939
D012834SilverSilver affects the expression of NLRC4 mRNA22342292
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of NLRC4 mRNA26378955
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NLRC4 mRNA22298810
C009495titanium dioxidetitanium dioxide results in decreased expression of NLRC4 mRNA22342292
C031238zinc sulfide[cadmium selenide co-treated with zinc sulfide] results in increased expression of NLRC4 mRNA22342292

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000287magnesium ion binding-TAS15882992  
GO:0005515protein binding-IPI11374873  11390368  11472070  15107016  17418785  22801494  
GO:0005524ATP binding-IDA15882992  
GO:0042802identical protein binding-IPI11374873  11390368  
GO:0042803protein homodimerization activity-IDA15107016  
GO ID GO Term Qualifier Evidence PubMed
GO:0002218activation of innate immune response-ISS-  
GO:0006915apoptotic process-IEA-  
GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process-IDA15030775  
GO:0006954inflammatory response-ISS-  
GO:0016045detection of bacterium-IDA15107016  
GO:0016567protein ubiquitination-IEA-  
GO:0042742defense response to bacterium-IDA15107016  
GO:0042981regulation of apoptotic process-TAS-  
GO:0043065positive regulation of apoptotic process-IDA12646168  
GO:0050702interleukin-1 beta secretion-IDA15882992  
GO:0051092positive regulation of NF-kappaB transcription factor activity-IDA12646168  
GO:0051260protein homooligomerization-ISS-  
GO:0070269pyroptosis-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005622intracellular-NAS15107016  
GO:0005829cytosol-ISS-  
GO:0005829cytosol-TAS-  
GO:0072557IPAF inflammasome complex-IBA21873635  
GO:0072557IPAF inflammasome complex-ISS-  
KEGG ID KEGG Term
hsa04621NOD-like receptor signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-168249Innate Immune SystemTAS
R-HSA-168249Innate Immune SystemIEA
R-HSA-168256Immune SystemTAS
R-HSA-168256Immune SystemIEA
R-HSA-168643Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathwaysTAS
R-HSA-168643Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathwaysIEA
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-3700989Transcriptional Regulation by TP53TAS
R-HSA-5633008TP53 Regulates Transcription of Cell Death GenesTAS
R-HSA-622312InflammasomesTAS
R-HSA-622312InflammasomesIEA
R-HSA-6803207TP53 Regulates Transcription of Caspase Activators and CaspasesTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-844623The IPAF inflammasomeTAS
R-HSA-844623The IPAF inflammasomeIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25531528Flagellin as carrier and adjuvant in cocaine vaccine development. (2015 Feb 2)Lockner JWMol Pharm