Gene: MYL7

58498
MYL2A|MYLC2A
myosin light chain 7
protein-coding
7p13
Ensembl:ENSG00000106631 MIM:613993 Vega:OTTHUMG00000023125 UniprotKB:Q01449
NC_000007.14
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.158e-1 (AD)  7.819e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs882020chr7:44139144 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MYH60.768
MYL40.741
BMP100.707
SBK20.583
SPANXN20.582
ITLN10.518
NPPA0.513
F2RL30.503
ACCSL0.503
DEFA10.493

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
BOLA2-0.255
SLCO4C1-0.214
PPP1R1C-0.214
PLS1-0.208
TRIQK-0.203
CCDC158-0.199
MTX3-0.198
APOOL-0.196
RGS7BP-0.195
OR52N5-0.195

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in increased expression of MYL7 mRNA"19162173
C0333101,8-dinitropyrene"1,8-dinitropyrene results in decreased expression of MYL7 mRNA"28186253
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of MYL7 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of MYL7 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of MYL7 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of MYL7 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of MYL7 mRNA"25510870
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of MYL7 mRNA16788091
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MYL7 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MYL7 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of MYL7 mRNA17562736
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in decreased expression of MYL7 mRNA26377693
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in decreased expression of MYL7 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to MYL7 promoter]19654925
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MYL7 mRNA22228805
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of MYL7 mRNA25566086
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydeMYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of MYL7 mRNA]25566086
C006780bisphenol Abisphenol A results in decreased expression of MYL7 mRNA26322593
C006780bisphenol Abisphenol A results in increased expression of MYL7 mRNA26063408
C006780bisphenol Abisphenol A results in decreased expression of MYL7 mRNA25181051
C018475butyraldehydebutyraldehyde results in increased expression of MYL7 mRNA26079696
D002220CarbamazepineCarbamazepine affects the expression of MYL7 mRNA25979313
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of MYL7 mRNA28472532
D003300Copper[Copper co-treated with Dietary Sucrose] results in increased expression of MYL7 mRNA26033743
D003300CopperCopper deficiency results in increased expression of MYL7 mRNA26033743
D003561CytarabineCytarabine results in decreased expression of MYL7 mRNA21198554
C014347decitabinedecitabine results in increased expression of MYL7 mRNA18989703
D016264Dextran SulfateDextran Sulfate results in increased expression of MYL7 mRNA23894361
D019422Dietary Sucrose[Copper co-treated with Dietary Sucrose] results in increased expression of MYL7 mRNA26033743
D019422Dietary SucroseDietary Sucrose results in increased expression of MYL7 mRNA26033743
D002117CalcitriolCalcitriol results in increased expression of MYL7 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of MYL7 mRNA21592394
D004317DoxorubicinDoxorubicin affects the expression of MYL7 protein29385562
D004317DoxorubicinDMD protein affects the reaction [Doxorubicin results in increased expression of MYL7 mRNA]17888722
D004317DoxorubicinDoxorubicin results in increased expression of MYL7 mRNA17888722
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of MYL7 protein20227414
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of MYL7 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of MYL7 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MYL7 mRNA17942748
C069837fullerene C60fullerene C60 results in decreased expression of MYL7 mRNA19167457
C041508indeno(1,2,3-cd)pyrene"indeno(1,2,3-cd)pyrene results in decreased expression of MYL7 mRNA"26377693
D015122MercaptopurineMercaptopurine results in increased expression of MYL7 mRNA23358152
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of MYL7 mRNA23179753
C070571ML 7ML 7 inhibits the reaction [Phenylephrine results in increased phosphorylation of MYL7 protein]15621049
C070571ML 7ML 7 results in decreased phosphorylation of MYL7 protein15621049
D037742Nanotubes, Carbon"Nanotubes, Carbon analog affects the expression of MYL7 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of MYL7 mRNA"25554681
D010126OzoneOzone results in decreased expression of MYL7 mRNA12763052
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of MYL7 mRNA"25510870
D010656PhenylephrineML 7 inhibits the reaction [Phenylephrine results in increased phosphorylation of MYL7 protein]15621049
D010656PhenylephrinePhenylephrine results in increased phosphorylation of MYL7 protein15621049
D010656Phenylephrinewortmannin inhibits the reaction [Phenylephrine results in increased phosphorylation of MYL7 protein]15621049
D010656PhenylephrineY 27632 inhibits the reaction [Phenylephrine results in increased phosphorylation of MYL7 protein]15621049
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MYL7 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of MYL7 mRNA26272509
C089730rosiglitazonerosiglitazone results in increased expression of MYL7 mRNA21172411
D017632Asbestos, Serpentine"Asbestos, Serpentine results in decreased expression of MYL7 mRNA"21514415
D017632Asbestos, Serpentine"SPP1 gene mutant form inhibits the reaction [Asbestos, Serpentine results in decreased expression of MYL7 mRNA]"21514415
D053260SootSoot results in decreased expression of MYL7 mRNA26551751
D013629TamoxifenTamoxifen affects the expression of MYL7 mRNA17555576
D013629TamoxifenTamoxifen results in increased expression of MYL7 mRNA25123088
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of MYL7 mRNA21592394
D013739TestosteroneTestosterone results in increased expression of MYL7 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MYL7 mRNA26377647
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MYL7 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to MYL7 promoter]19654925
D013792ThalidomideThalidomide results in decreased expression of MYL7 mRNA26217789
C009495titanium dioxidetitanium dioxide results in decreased expression of MYL7 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of MYL7 mRNA20133372
C012589trichostatin Atrichostatin A results in decreased expression of MYL7 mRNA15901671
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of MYL7 mRNA"26743178
D014635Valproic AcidValproic Acid results in decreased expression of MYL7 mRNA15901671
D014635Valproic AcidValproic Acid affects the expression of MYL7 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of MYL7 mRNA29154799
C025643vinclozolinvinclozolin affects the expression of MYL7 mRNA19015723
C009687wortmanninwortmannin inhibits the reaction [Phenylephrine results in increased phosphorylation of MYL7 protein]15621049
C009687wortmanninwortmannin results in decreased phosphorylation of MYL7 protein15621049
C108830Y 27632Y 27632 inhibits the reaction [Phenylephrine results in increased phosphorylation of MYL7 protein]15621049
C108830Y 27632Y 27632 results in decreased phosphorylation of MYL7 protein15621049

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005509calcium ion binding-IEA-  
GO:0005515protein binding-IPI25416956  
GO ID GO Term Qualifier Evidence PubMed
GO:0006936muscle contraction-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
GO:0016459myosin complex-NAS1429676  
GO:0031672A band-IDA15621049  
GO:0043197dendritic spine-IEA-  
KEGG ID KEGG Term
hsa04510Focal adhesion
hsa04530Tight junction
hsa04670Leukocyte transendothelial migration
hsa04810Regulation of actin cytoskeleton
Reactome ID Reactome Term Evidence
R-HSA-397014Muscle contractionTAS
R-HSA-445355Smooth Muscle ContractionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal