Gene: DNASE2B

58511
DLAD
deoxyribonuclease 2 beta
protein-coding
1p31.1-p22.3
Ensembl:ENSG00000137976 MIM:608057 Vega:OTTHUMG00000009860 UniprotKB:Q8WZ79
NC_000001.11
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.198e-1 (AD)  9.143e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OTOF0.646
ANKRD34B0.619
DRD20.592
SLC35D30.586
FAM169B0.582
B3GALT50.581
ZMYND100.58
ATG9B0.57
COCH0.562
GREB1L0.561

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TULP1-0.311
KLRB1-0.286
ALDH1A1-0.273
SIX1-0.271
P2RY14-0.27
MTRNR2L6-0.262
C2orf83-0.26
FOXL1-0.253
CXCR1-0.252
KCNJ15-0.249

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of DNASE2B mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of DNASE2B mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of DNASE2B mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of DNASE2B mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of DNASE2B mRNA"25510870
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of DNASE2B mRNA"18648102
D000082AcetaminophenAcetaminophen affects the expression of DNASE2B mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of DNASE2B gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of DNASE2B mRNA16483693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of DNASE2B mRNA20064835|2180250
C006780bisphenol Abisphenol A results in increased methylation of DNASE2B promoter27312807
C006780bisphenol Abisphenol A affects the methylation of DNASE2B promoter27415467
C006780bisphenol Abisphenol A results in decreased expression of DNASE2B mRNA25181051
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of DNASE2B mRNA27339419
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of DNASE2B protein12629582
C018021cobaltous chloridecobaltous chloride results in decreased expression of DNASE2B mRNA24386269
D004041Dietary FatsDietary Fats results in decreased expression of DNASE2B mRNA25016146
C074283estradiol 3-benzoateestradiol 3-benzoate results in increased methylation of DNASE2B promoter27415467
C024565ethylene dichlorideethylene dichloride results in decreased expression of DNASE2B mRNA28189721
C069837fullerene C60fullerene C60 results in decreased expression of DNASE2B mRNA19167457
C039281furanfuran results in increased methylation of DNASE2B gene22079235
C098607JP8 aviation fuelJP8 aviation fuel results in increased expression of DNASE2B protein17337753
D008727MethotrexateMethotrexate affects the expression of DNASE2B mRNA18502557
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of DNASE2B mRNA"25620056
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of DNASE2B mRNA"25510870
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of DNASE2B mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of DNASE2B mRNA20813756
C006253pirinixic acidpirinixic acid results in increased expression of DNASE2B mRNA18301758
D017035PravastatinPravastatin results in decreased expression of DNASE2B mRNA27225895
D017035PravastatinPravastatin results in increased expression of DNASE2B mRNA27225895
D011441PropylthiouracilPropylthiouracil results in decreased expression of DNASE2B mRNA24780913
C009250sevofluranesevoflurane affects the expression of DNASE2B mRNA15967596
C075117squalestatin 1squalestatin 1 affects the expression of DNASE2B mRNA27225895
C075117squalestatin 1squalestatin 1 results in increased expression of DNASE2B mRNA27225895
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of DNASE2B mRNA21802500
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of DNASE2B mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of DNASE2B mRNA21215274
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid results in decreased expression of DNASE2B mRNA15885361
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of DNASE2B gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004531deoxyribonuclease II activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006309apoptotic DNA fragmentation-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IEA-  
GO:0005764lysosome-IEA-  
KEGG ID KEGG Term
hsa04142Lysosome
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11. (2010 May)Edenberg HJAlcohol Clin Exp Res