Gene: BCAT1

586
BCATC|BCT1|ECA39|MECA39|PNAS121|PP18
branched chain amino acid transaminase 1
protein-coding
12p12.1
Ensembl:ENSG00000060982 MIM:113520 Vega:OTTHUMG00000169053 UniprotKB:P54687
NG_008170.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.649e-1 (AD)  8.943e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EHBP10.859
LGALSL0.849
SLC36A40.847
FAR20.847
DYNLT30.843
CAMK2D0.842
RFK0.838
SLC25A320.837
TBC1D90.836
SLC25A460.836

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EYA2-0.518
ACOX2-0.484
PLIN4-0.481
RFX2-0.48
SMO-0.449
STON2-0.445
GPR143-0.44
NWD1-0.436
FAM151A-0.436
NHSL1-0.435

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00161L-ValineSmall Molecule72-18-4Approved|NutraceuticalEnzyme
DB00996GabapentinSmall Molecule60142-96-3Approved|InvestigationalEnzyme
DB00432TrifluridineSmall Molecule70-00-8Approved|InvestigationalEnzyme
DB00495ZidovudineSmall Molecule30516-87-1ApprovedEnzyme
ID Drug Name Action PubMed
C0630022,3-dimethoxy-1,4-naphthoquinone"2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of BCAT1 mRNA"17547211
C0131862,3-pentanedione"2,3-pentanedione results in increased expression of BCAT1 mRNA"25710175
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of BCAT1 mRNA"23196670
C0261373-hydroxyacetanilide3-hydroxyacetanilide results in decreased expression of BCAT1 mRNA18544908
D000082AcetaminophenAcetaminophen results in decreased expression of BCAT1 mRNA21420995
D000082AcetaminophenAcetaminophen results in decreased expression of BCAT1 mRNA18544908
C006418adrenocorticotropin zincadrenocorticotropin zinc results in decreased expression of BCAT1 mRNA19920212
D016604Aflatoxin B1Aflatoxin B1 affects the expression of BCAT1 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of BCAT1 mRNA21632981|2164198
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of BCAT1 gene27153756
C006463allyl alcoholallyl alcohol results in increased expression of BCAT1 mRNA23558518
D000499AllylamineAllylamine results in increased expression of BCAT1 mRNA23558518
D000643Ammonium ChlorideAmmonium Chloride affects the expression of BCAT1 mRNA16483693
C015001arsenitearsenite results in decreased methylation of BCAT1 promoter23974009
D001280AtrazineAtrazine results in decreased expression of BCAT1 mRNA25929836
D001280AtrazineAtrazine results in decreased expression of BCAT1 mRNA22378314
D001374AzacitidineAzacitidine results in decreased expression of BCAT1 mRNA20823114
C547126AZM551248AZM551248 results in increased expression of BCAT1 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of BCAT1 mRNA20064835|2010694
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of BCAT1 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of BCAT1 mRNA"26238291
D004958Estradiol[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of BCAT1 mRNA20823114
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of BCAT1 mRNA20660070
D004958EstradiolEstradiol results in increased expression of BCAT1 mRNA23019147
D004958EstradiolEstradiol results in increased expression of BCAT1 mRNA15289156
C002791bismuth tripotassium dicitratebismuth tripotassium dicitrate results in increased expression of BCAT1 mRNA15912405
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in increased expression of BCAT1 mRNA26496021
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in increased expression of BCAT1 mRNA25270620
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of BCAT1 mRNA22079614
D002104CadmiumCadmium affects the expression of BCAT1 mRNA21120746
D019256Cadmium ChlorideCadmium Chloride results in increased expression of BCAT1 mRNA25596134
D019256Cadmium ChlorideCadmium Chloride results in increased expression of BCAT1 protein24527689
D002220CarbamazepineCarbamazepine affects the expression of BCAT1 mRNA25979313
D002235CarbofuranCarbofuran results in increased expression of BCAT1 mRNA20211217
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of BCAT1 mRNA17484886
C004656chloroacetaldehydechloroacetaldehyde affects the expression of BCAT1 mRNA25596134
D004002Clodronic AcidClodronic Acid results in increased expression of BCAT1 mRNA25596134
D002994ClofibrateClofibrate results in decreased expression of BCAT1 mRNA22300585
C018021cobaltous chloridecobaltous chloride results in decreased expression of BCAT1 mRNA19320972
D003042CocaineCocaine affects the expression of BCAT1 mRNA20187946
D003300CopperCopper results in increased expression of BCAT1 mRNA22465980
D019327Copper SulfateCopper Sulfate results in increased expression of BCAT1 mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of BCAT1 mRNA20106945|2163298
D016572CyclosporineCyclosporine results in increased expression of BCAT1 mRNA23558518
C017180decamethrindecamethrin results in increased expression of BCAT1 mRNA19017407
D003703DemecolcineDemecolcine results in increased expression of BCAT1 mRNA23649840
D003907DexamethasoneDexamethasone results in decreased expression of BCAT1 mRNA22733784
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of BCAT1 mRNA21266533
D003994Bucladesine[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of BCAT1 mRNA20823114
D002945CisplatinCisplatin results in decreased expression of BCAT1 mRNA25596134|2739243
D002945CisplatinCisplatin results in decreased expression of BCAT1 mRNA22023808
D004026DieldrinDieldrin results in increased expression of BCAT1 mRNA23153324
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of BCAT1 mRNA15171707|1528915
D004317DoxorubicinDoxorubicin results in increased expression of BCAT1 mRNA20211217|2355851
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of BCAT1 protein23301498
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of BCAT1 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of BCAT1 mRNA16467188|1794274
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of BCAT1 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of BCAT1 mRNA17351261
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of BCAT1 mRNA15834898
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of BCAT1 mRNA23649840
D011345FenofibrateFenofibrate results in decreased expression of BCAT1 mRNA25596134
D005472FluorouracilTP53 protein affects the reaction [Fluorouracil results in decreased expression of BCAT1 mRNA]15016801
C061365flusilazoleflusilazole results in decreased expression of BCAT1 mRNA22382673
C061365flusilazoleflusilazole results in increased expression of BCAT1 mRNA22382673
D005557FormaldehydeFormaldehyde results in increased expression of BCAT1 mRNA23649840|2766457
C039281furanfuran results in increased expression of BCAT1 mRNA27387713
D019833GenisteinGenistein results in increased expression of BCAT1 mRNA15289156
D005947Glucose[INS protein co-treated with Glucose] results in increased expression of BCAT1 mRNA22634610
D006533HeptachlorHeptachlor results in increased expression of BCAT1 mRNA23153324
D017313FenretinideFenretinide results in decreased expression of BCAT1 mRNA28973697
D017313FenretinideFenretinide results in increased expression of BCAT1 mRNA28973697
D002112CalcifediolCalcifediol deficiency results in decreased expression of BCAT1 mRNA17293106
C492448ICG 001ICG 001 results in increased expression of BCAT1 mRNA26191083
D007069IfosfamideIfosfamide results in decreased expression of BCAT1 mRNA25596134
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of BCAT1 mRNA25613284
D007545IsoproterenolIsoproterenol results in increased expression of BCAT1 mRNA20211217|2355851
C544151jinfukangjinfukang results in decreased expression of BCAT1 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of BCAT1 mRNA23430699|2443544
C410337K 7174K 7174 results in increased expression of BCAT1 mRNA24086573
C008261lead acetatelead acetate results in increased expression of BCAT1 mRNA25270620
C008261lead acetatelead acetate results in increased expression of BCAT1 mRNA11578147
D017258Medroxyprogesterone Acetate[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of BCAT1 mRNA20823114
D009921MetaproterenolMetaproterenol results in increased expression of BCAT1 mRNA23558518
D008701MethapyrileneMethapyrilene results in increased expression of BCAT1 mRNA23558518
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of BCAT1 mRNA16966085
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of BCAT1 mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of BCAT1 mRNA23649840
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of BCAT1 mRNA24810058
D008917MirexMirex results in increased expression of BCAT1 mRNA23153324
D008942MitoxantroneMitoxantrone results in increased expression of BCAT1 mRNA23558518
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of BCAT1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of BCAT1 mRNA"25554681
D009532NickelNickel results in increased expression of BCAT1 mRNA25583101
C028007nickel monoxidenickel monoxide results in increased expression of BCAT1 mRNA19167457
D010100OxygenOxygen deficiency affects the expression of BCAT1 mRNA25596134
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of BCAT1 protein26178269
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of BCAT1 mRNA23427857
D010653PhenylbutazonePhenylbutazone results in increased expression of BCAT1 mRNA23558518
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of BCAT1 mRNA22714537
D011374ProgesteroneProgesterone results in increased expression of BCAT1 mRNA23018184
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of BCAT1 mRNA20660070
D011374ProgesteroneProgesterone results in increased expression of BCAT1 mRNA19690047
D011374ProgesteroneProgesterone results in decreased expression of BCAT117510236
D011441PropylthiouracilPropylthiouracil results in decreased expression of BCAT1 mRNA24780913
D011794QuercetinQuercetin results in decreased expression of BCAT1 mRNA21632981
D012601Scopolamine HydrobromideScopolamine Hydrobromide results in increased expression of BCAT1 mRNA17540011
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of BCAT1 mRNA25895662
D012999SomanSoman results in increased expression of BCAT1 mRNA19281266
D053260SootSoot results in increased expression of BCAT1 mRNA26551751
C061133tamibarotenetamibarotene affects the expression of BCAT1 mRNA15498508
D013629TamoxifenTamoxifen affects the expression of BCAT1 mRNA17555576
D013739Testosterone[bisphenol A co-treated with Testosterone] results in increased expression of BCAT1 mRNA26496021
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of BCAT1 mRNA20106945|2163298
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of BCAT1 mRNA17942748
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of BCAT1 mRNA25613284
D019284ThapsigarginThapsigargin results in increased expression of BCAT1 mRNA22378314
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of BCAT1 mRNA28065790
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased methylation of BCAT1 gene26756918
C496197trans-10,cis-12-conjugated linoleic acid"trans-10,cis-12-conjugated linoleic acid results in decreased expression of BCAT1 mRNA"17951470
D014212TretinoinTretinoin results in decreased expression of BCAT1 mRNA15498508|2193413
D014223TriamtereneTriamterene results in increased expression of BCAT1 mRNA23558518
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of BCAT1 mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of BCAT1 mRNA"26179874
D014415TunicamycinTunicamycin results in increased expression of BCAT1 mRNA22378314
D014520UrethaneUrethane results in decreased expression of BCAT1 mRNA28818685
D014635Valproic AcidValproic Acid results in decreased expression of BCAT1 mRNA23179753|2718838
D014635Valproic AcidValproic Acid results in decreased expression of BCAT1 mRNA21427059
D014750VincristineVincristine results in increased expression of BCAT1 mRNA23649840

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004084branched-chain-amino-acid transaminase activity-EXP16141215  
GO:0004084branched-chain-amino-acid transaminase activity-IBA21873635  
GO:0042802identical protein binding-IEA-  
GO:0052654L-leucine transaminase activity-IEA-  
GO:0052655L-valine transaminase activity-IEA-  
GO:0052656L-isoleucine transaminase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000082G1/S transition of mitotic cell cycle-TAS8692959  
GO:0008283cell proliferation-TAS6933702  
GO:0009082branched-chain amino acid biosynthetic process-TAS6933702  
GO:0009083branched-chain amino acid catabolic process-TAS-  
GO:0009098leucine biosynthetic process-IBA21873635  
GO:0009099valine biosynthetic process-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-IBA21873635  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa00280Valine, leucine and isoleucine degradation
hsa00290Valine, leucine and isoleucine biosynthesis
hsa00770Pantothenate and CoA biosynthesis
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-70895Branched-chain amino acid catabolismTAS
R-HSA-71291Metabolism of amino acids and derivativesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26445409Evaluation of an assay for methylated BCAT1 and IKZF1 in plasma for detection of colorectal neoplasia. (2015 Oct 6)Pedersen SKBMC Cancer