Gene: QDPR

5860
DHPR|HDHPR|PKU2|SDR33C1
quinoid dihydropteridine reductase
protein-coding
4p15.32
Ensembl:ENSG00000151552 MIM:612676 Vega:OTTHUMG00000128537 UniprotKB:P09417
NG_008763.1
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.516e-1 (AD)  9.210e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DBNDD20.919
FEZ10.873
CFL20.872
SIRT20.865
PLP10.861
SEPT80.851
BIN10.846
GOLGA70.845
PIP4K2A0.844
CNP0.841

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.658
OR4F5-0.613
RNF43-0.227
PAX2-0.218
OLFM4-0.201
HS3ST3A1-0.197
NPR3-0.193
NPBWR1-0.192
TECTB-0.184
KMO-0.18

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00157NADHSmall Molecule58-68-4Approved|NutraceuticalTarget
DB038142-(N-Morpholino)-Ethanesulfonic AcidSmall MoleculeExperimentalTarget
ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of QDPR mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of QDPR mRNA"21346803
C0303702-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in increased expression of QDPR mRNA"20206263
C5724913-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol results in increased expression of QDPR protein26194647
D000082AcetaminophenAcetaminophen results in decreased expression of QDPR mRNA29067470
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of QDPR mRNA19770486
C000188alachloralachlor results in increased expression of QDPR mRNA12419858
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of QDPR protein26072098
D000643Ammonium ChlorideAmmonium Chloride affects the expression of QDPR mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of QDPR mRNA24449571
D001280AtrazineAtrazine results in decreased expression of QDPR mRNA25929836
C006780bisphenol Abisphenol A results in decreased expression of QDPR mRNA29275510
C006780bisphenol Abisphenol A affects the expression of QDPR mRNA25181051
D002104CadmiumCadmium results in increased expression of QDPR mRNA24376830
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of QDPR mRNA27339419
C010063carbonyl sulfidecarbonyl sulfide results in decreased expression of QDPR mRNA19395590
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of QDPR mRNA23650126
D002994ClofibrateClofibrate results in increased expression of QDPR protein16470657
D002995Clofibric AcidClofibric Acid affects the expression of QDPR mRNA17602206
D009249NADPNADP binds to and results in increased activity of QDPR protein25526675
D019327Copper SulfateCopper Sulfate results in decreased expression of QDPR mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of QDPR mRNA20106945|2556210
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of QDPR mRNA17361019|2126653
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of QDPR mRNA21266533
D002945CisplatinCisplatin results in increased expression of QDPR mRNA24280081
D002945CisplatinCisplatin results in decreased expression of QDPR mRNA24280081
D004041Dietary FatsDietary Fats results in decreased expression of QDPR mRNA22609946
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of QDPR mRNA11323195
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of QDPR mRNA23649840
D005419FlavonoidsFlavonoids results in decreased expression of QDPR mRNA18035473
C056933fumonisin B1fumonisin B1 results in decreased expression of QDPR mRNA16221962
C492448ICG 001ICG 001 results in increased expression of QDPR mRNA26191083
D007545IsoproterenolIsoproterenol results in decreased expression of QDPR mRNA21335049
C410337K 7174K 7174 results in decreased expression of QDPR mRNA24086573
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of QDPR mRNA"24972896
D008727MethotrexateMethotrexate results in decreased activity of QDPR protein1793349
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of QDPR mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of QDPR mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of QDPR mRNA"25620056
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in decreased expression of QDPR mRNA23602845
D010634PhenobarbitalPhenobarbital affects the expression of QDPR mRNA19159669
D010862PilocarpinePilocarpine results in increased expression of QDPR protein17366478
C006253pirinixic acidpirinixic acid results in increased expression of QDPR mRNA17426115
D010936Plant ExtractsPlant Extracts results in decreased expression of QDPR mRNA24677778
D010936Plant ExtractsPlant Extracts results in increased expression of QDPR mRNA23557933
D011794QuercetinQuercetin results in increased expression of QDPR mRNA21632981
C080703SK&F 83959SK&F 83959 results in decreased expression of QDPR protein25852303
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of QDPR mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of QDPR mRNA26232522
D014415TunicamycinTunicamycin results in decreased expression of QDPR mRNA22378314
D014635Valproic AcidValproic Acid affects the expression of QDPR mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of QDPR gene29154799
D014635Valproic AcidValproic Acid results in increased expression of QDPR mRNA23179753|2519280
D014635Valproic AcidValproic Acid affects the expression of QDPR mRNA17292431
D014635Valproic AcidValproic Acid results in increased expression of QDPR mRNA20546886
D014640VancomycinVancomycin results in increased expression of QDPR mRNA18930951
C029297vinylidene chloridevinylidene chloride results in decreased expression of QDPR mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:00041556,7-dihydropteridine reductase activity-EXP3033643  7744010  
GO:00041556,7-dihydropteridine reductase activity-IBA21873635  
GO:0009055electron transfer activity-TAS3033643  
GO:0042803protein homodimerization activity-IEA-  
GO:0070402NADPH binding-IBA21873635  
GO:0070402NADPH binding-IEA-  
GO:0070404NADH binding-IBA21873635  
GO:0070404NADH binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001889liver development-IEA-  
GO:0006520cellular amino acid metabolic process-TAS3033643  
GO:0006559L-phenylalanine catabolic process-IBA21873635  
GO:0006559L-phenylalanine catabolic process-TAS-  
GO:0006729tetrahydrobiopterin biosynthetic process-IBA21873635  
GO:0006729tetrahydrobiopterin biosynthetic process-IEA-  
GO:0010044response to aluminum ion-IEA-  
GO:0010288response to lead ion-IEA-  
GO:0022900electron transport chain-IEA-  
GO:0033762response to glucagon-IEA-  
GO:0035690cellular response to drug-IEA-  
GO:0051066dihydrobiopterin metabolic process-TAS3033643  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IDA-  
GO:0005829cytosol-TAS-  
GO:0043005neuron projection-IEA-  
GO:0070062extracellular exosome-HDA19056867  23533145  
KEGG ID KEGG Term
hsa00790Folate biosynthesis
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-6788656Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolismTAS
R-HSA-71182Phenylalanine and tyrosine catabolismTAS
R-HSA-71291Metabolism of amino acids and derivativesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
18444252Neurotransmission and bipolar disorder: a systematic family-based association study. (2008 Oct 5)Shi JAm J Med Genet B Neuropsychiatr Genet