Gene: RAB3IL1

5866
GRAB
RAB3A interacting protein like 1
protein-coding
11q12.2-q12.3
Ensembl:ENSG00000167994 Vega:OTTHUMG00000167524 UniprotKB:Q8TBN0
NC_000011.10
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.515e-1 (AD)  9.444e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs17156580chr11:61924869 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TGFB10.822
MOB3C0.801
SIPA10.798
VASP0.796
DOK10.788
PPP1R180.788
PTBP10.783
TNIP20.78
SLC39A10.78
HMOX10.777

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.423
OR4F29-0.39
PPEF1-0.386
KCNB2-0.368
XKR4-0.343
CDH8-0.342
SPHKAP-0.339
ABCC12-0.338
SLC7A4-0.338
CHRM2-0.335

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of RAB3IL1 mRNA"28903501
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of RAB3IL1 mRNA"23146750
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of RAB3IL1 mRNA"23146750
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of RAB3IL1 mRNA"23196670
D000082AcetaminophenAcetaminophen results in increased expression of RAB3IL1 mRNA29067470
D000643Ammonium ChlorideAmmonium Chloride affects the expression of RAB3IL1 mRNA16483693
D001280AtrazineAtrazine results in increased expression of RAB3IL1 mRNA22378314
C547126AZM551248AZM551248 results in increased expression of RAB3IL1 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of RAB3IL1 mRNA22228805
D004958EstradiolEstradiol results in increased expression of RAB3IL1 mRNA19484750
C006780bisphenol Abisphenol A results in increased expression of RAB3IL1 mRNA27685785
C006780bisphenol Abisphenol A results in decreased expression of RAB3IL1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of RAB3IL1 gene28505145
D002185CannabidiolCannabidiol results in decreased expression of RAB3IL1 mRNA21542829
C014347decitabinedecitabine affects the expression of RAB3IL1 mRNA23300844
D003976DiazinonDiazinon results in increased methylation of RAB3IL1 gene22964155
D002945CisplatinCisplatin affects the expression of RAB3IL1 mRNA23300844
D002945CisplatinCisplatin results in decreased expression of RAB3IL1 mRNA27392435
C069837fullerene C60fullerene C60 results in increased expression of RAB3IL1 mRNA19167457
C492448ICG 001ICG 001 results in increased expression of RAB3IL1 mRNA26191083
C544151jinfukangjinfukang results in increased expression of RAB3IL1 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of RAB3IL1 mRNA24796395|2675264
D007854LeadLead affects the expression of RAB3IL1 mRNA28903495
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of RAB3IL1 mRNA26582142
C523799MRK 003RAB3IL1 results in increased susceptibility to MRK 00319903844
C028473N-acetyl-4-benzoquinoneimineRAB3IL1 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine21177773
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of RAB3IL1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of RAB3IL1 mRNA"25554681
C028007nickel monoxidenickel monoxide results in increased expression of RAB3IL1 mRNA19167457
C016340o,p'-DDT"o,p'-DDT results in increased expression of RAB3IL1 mRNA"18204070
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of RAB3IL1 mRNA25729387
C030110oxaliplatinoxaliplatin results in decreased expression of RAB3IL1 mRNA25729387
D010936Plant ExtractsPlant Extracts results in decreased expression of RAB3IL1 mRNA23557933
D011192Potassium DichromatePotassium Dichromate results in increased expression of RAB3IL1 mRNA23608068
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of RAB3IL1 mRNA21427059
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of RAB3IL1 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in decreased expression of RAB3IL1 mRNA19073995
D012999SomanSoman results in increased expression of RAB3IL1 mRNA19281266
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of RAB3IL1 mRNA25172293
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of RAB3IL1 mRNA19933214
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of RAB3IL1 mRNA26232522
D019284ThapsigarginThapsigargin results in increased expression of RAB3IL1 mRNA22378314
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of RAB3IL1 mRNA20133372
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of RAB3IL1 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of RAB3IL1 mRNA25729387
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of RAB3IL1 mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of RAB3IL1 mRNA"26179874
D014415TunicamycinTunicamycin results in increased expression of RAB3IL1 mRNA22378314
D014635Valproic AcidValproic Acid results in increased methylation of RAB3IL1 gene29154799
D014635Valproic AcidValproic Acid affects the expression of RAB3IL1 mRNA17292431
D014635Valproic AcidValproic Acid results in increased expression of RAB3IL1 mRNA21427059
C025643vinclozolinvinclozolin results in decreased expression of RAB3IL1 mRNA23869203
C025643vinclozolinvinclozolin results in increased expression of RAB3IL1 mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI16189514  19060904  25416956  27173435  
GO:0017112Rab guanyl-nucleotide exchange factor activity-IDA20937701  
GO:0017112Rab guanyl-nucleotide exchange factor activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0015031protein transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-199991Membrane TraffickingTAS
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-8876198RAB GEFs exchange GTP for GDP on RABsTAS
R-HSA-9007101Rab regulation of traffickingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal