Gene: MAP4K2

5871
BL44|GCK|RAB8IP
mitogen-activated protein kinase kinase kinase kinase 2
protein-coding
11q13.1
Ensembl:ENSG00000168067 MIM:603166 Vega:OTTHUMG00000045328 UniprotKB:Q12851
NG_033040.1
PubMed
0   ANCO-SNPs
ND|AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.618e-1 (AD)  1.778e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TECPR10.904
RNF1570.901
CAMTA20.894
NECAB30.892
NEURL40.89
BRSK10.89
IQSEC10.888
ARHGEF40.888
CDK160.888
TANGO20.887

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.606
OR4F29-0.601
MTRNR2L6-0.41
MTRNR2L10-0.401
C1orf87-0.397
MARCH3-0.393
S100A12-0.391
EGFLAM-0.389
ZNF114-0.388
KCNJ15-0.386

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of MAP4K2 mRNA"21346803
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of MAP4K2 mRNA26377693
D004958EstradiolEstradiol affects the expression of MAP4K2 mRNA23557687
C006780bisphenol Abisphenol A affects the expression of MAP4K2 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of MAP4K2 mRNA25181051
C584509C646 compoundC646 compound results in increased expression of MAP4K2 mRNA26191083
D002330CarmustineCarmustine results in decreased expression of MAP4K2 mRNA15980968
C018021cobaltous chloridecobaltous chloride results in decreased expression of MAP4K2 mRNA24386269
C014347decitabinedecitabine affects the expression of MAP4K2 mRNA23300844
D002945CisplatinCisplatin affects the expression of MAP4K2 mRNA23300844
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of MAP4K2 mRNA27392435
D002945CisplatinCisplatin results in increased expression of MAP4K2 mRNA27392435
D005485FlutamideFlutamide results in decreased expression of MAP4K2 mRNA21126777
C069837fullerene C60fullerene C60 results in increased expression of MAP4K2 mRNA19167457
D005839GentamicinsGentamicins results in increased expression of MAP4K2 mRNA22061828
D017313FenretinideFenretinide results in increased expression of MAP4K2 mRNA28973697
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of MAP4K2 mRNA27392435
C544151jinfukangjinfukang results in increased expression of MAP4K2 mRNA27392435
D008694MethamphetamineMethamphetamine results in increased expression of MAP4K2 mRNA26307267
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of MAP4K2 mRNA25234470
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of MAP4K2 mRNA24810058
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of MAP4K2 mRNA"25554681
C017096n-butoxyethanoln-butoxyethanol results in decreased expression of MAP4K2 mRNA19812364
D009532NickelNickel affects the expression of MAP4K2 mRNA14575637
D009532Nickeltrichostatin A inhibits the reaction [Nickel affects the expression of MAP4K2 mRNA]14575637
C028007nickel monoxidenickel monoxide results in increased expression of MAP4K2 mRNA19167457
D009966OrphenadrineOrphenadrine affects the expression of MAP4K2 mRNA23665939
D010936Plant ExtractsPlant Extracts results in decreased expression of MAP4K2 mRNA23557933
D011084Polycyclic Aromatic HydrocarbonsPolycyclic Aromatic Hydrocarbons affects the expression of MAP4K2 mRNA23147375
D011374ProgesteroneProgesterone results in increased expression of MAP4K2 mRNA23012394
D011441PropylthiouracilPropylthiouracil results in decreased expression of MAP4K2 mRNA24780913
C017947sodium arsenitesodium arsenite affects the expression of MAP4K2 mRNA29319823
D053260SootSoot results in decreased expression of MAP4K2 mRNA26551751
C045037testosterone-3-carboxymethyloxime-bovine serum albumin conjugatetestosterone-3-carboxymethyloxime-bovine serum albumin conjugate affects the expression of MAP4K2 mRNA20189893
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MAP4K2 mRNA24680724
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of MAP4K2 mRNA20133372
D014212TretinoinTretinoin results in increased expression of MAP4K2 mRNA20530235
C012589trichostatin Atrichostatin A inhibits the reaction [Nickel affects the expression of MAP4K2 mRNA]14575637
D014415TunicamycinTunicamycin results in increased expression of MAP4K2 mRNA22378314
D014635Valproic AcidValproic Acid results in increased expression of MAP4K2 mRNA23179753
D014635Valproic AcidValproic Acid results in increased methylation of MAP4K2 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004674protein serine/threonine kinase activity-IBA21873635  
GO:0004674protein serine/threonine kinase activity-IDA11784851  
GO:0005515protein binding-IPI11784851  21044950  
GO:0005524ATP binding-IDA11784851  
GO:0008349MAP kinase kinase kinase kinase activity-IBA21873635  
GO:0031435mitogen-activated protein kinase kinase kinase binding-IPI17584736  
GO ID GO Term Qualifier Evidence PubMed
GO:0000165MAPK cascade-IBA21873635  
GO:0000185activation of MAPKKK activity-IEA-  
GO:0006468protein phosphorylation-IDA11784851  
GO:0006903vesicle targeting-IEA-  
GO:0006955immune response-TAS7515885  
GO:0007254JNK cascade-TAS7477268  
GO:0007257activation of JUN kinase activity-IDA17584736  
GO:0007346regulation of mitotic cell cycle-IBA21873635  
GO:0023014signal transduction by protein phosphorylation-IBA21873635  
GO:0032147activation of protein kinase activity-IBA21873635  
GO:0035556intracellular signal transduction-IDA11784851  
GO:0045087innate immune response-IEA-  
GO:0046330positive regulation of JNK cascade-IDA17584736  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-IEA-  
GO:0005737cytoplasm-IBA21873635  
GO:0016323basolateral plasma membrane-IEA-  
KEGG ID KEGG Term
hsa04010MAPK signaling pathway
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal