Gene: RAB27A

5873
GS2|HsT18676|RAB27|RAM
RAB27A, member RAS oncogene family
protein-coding
15q21.3
Ensembl:ENSG00000069974 MIM:603868 Vega:OTTHUMG00000131959 UniprotKB:P51159
NG_009103.1
SNP Mapped
2   ANCO-SNPs
AD
0   
5.290e-1 (AD)  2.348e-1 (ND)   (Frontal_Cortex)
3.698e-1 (AD)  8.690e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs11071175chr15:55268227 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs4261468chr15:55263404 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg02712036chr15:55569533RAB27A5.220e-16Alcohol consumption per day27843151

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CASP40.859
COL4A10.849
CD930.84
ANXA20.839
IL1R10.833
MYOF0.832
S1PR30.829
DRAM10.829
ANO60.826
DSE0.822

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NEUROD6-0.438
MARCH4-0.43
LYPD8-0.429
MYADML2-0.423
KCNIP3-0.423
SLC7A4-0.419
ABCC12-0.418
EXTL1-0.416
TMEM179-0.415
BCL11A-0.414

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in increased expression of RAB27A mRNA"19162173
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RAB27A mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RAB27A mRNA"27188386
C0126064-vinyl-1-cyclohexene dioxide4-vinyl-1-cyclohexene dioxide affects the expression of RAB27A mRNA20829426
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RAB27A mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RAB27A mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of RAB27A mRNA21420995
D000082AcetaminophenAcetaminophen results in increased expression of RAB27A mRNA22230336
C103303alitretinoinalitretinoin results in decreased expression of RAB27A mRNA16449964
C103303alitretinoinRAB27A gene mutant form results in decreased susceptibility to alitretinoin16449964
D000643Ammonium ChlorideAmmonium Chloride affects the expression of RAB27A mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of RAB27A mRNA24449571
D001151ArsenicArsenic affects the methylation of RAB27A gene25304211
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in decreased expression of RAB27A mRNA"25351596
D001280AtrazineAtrazine results in increased expression of RAB27A mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of RAB27A mRNA26238291
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of RAB27A mRNA15034205
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of RAB27A mRNA22228805
D004958Estradiol[bisphenol A co-treated with Estradiol] results in decreased expression of RAB27A mRNA26496021
D004958EstradiolEstradiol results in increased expression of RAB27A mRNA22946080
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in decreased expression of RAB27A mRNA26496021
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in decreased expression of RAB27A mRNA26496021
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of RAB27A mRNA15336504
C018475butyraldehydebutyraldehyde results in decreased expression of RAB27A mRNA26079696
C018021cobaltous chloridecobaltous chloride results in decreased expression of RAB27A mRNA19320972|1937684
D019327Copper SulfateCopper Sulfate results in increased expression of RAB27A mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of RAB27A mRNA20106945|2556210
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of RAB27A mRNA17361019|2126653
D002945CisplatinCisplatin results in increased expression of RAB27A mRNA27594783
C014476diethyl maleatediethyl maleate results in decreased expression of RAB27A mRNA21161181
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of RAB27A mRNA22946080
D004237DiuronDiuron results in increased expression of RAB27A mRNA21551480
C118739entinostatentinostat results in decreased expression of RAB27A mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RAB27A mRNA"27188386
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of RAB27A mRNA23649840
D005839GentamicinsGentamicins results in increased expression of RAB27A mRNA22061828
C010974glyphosate[Surface-Active Agents co-treated with glyphosate] results in increased expression of RAB27A mRNA22467014
D017313FenretinideFenretinide results in decreased expression of RAB27A mRNA28973697
D017313FenretinideFenretinide results in increased expression of RAB27A mRNA28973697
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of RAB27A mRNA25613284
C051890irinotecanirinotecan affects the expression of RAB27A mRNA20097248
D007545IsoproterenolIsoproterenol results in increased expression of RAB27A mRNA20003209
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of RAB27A mRNA24796395|2675264
C045463leflunomideleflunomide results in decreased expression of RAB27A mRNA28988120
D008070LipopolysaccharidesRAB27A affects the susceptibility to Lipopolysaccharides21746860
D008070LipopolysaccharidesRAB27A protein affects the reaction [Lipopolysaccharides results in increased secretion of TNF protein]21746860
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of RAB27A mRNA25613284
D008731MethoxychlorMethoxychlor affects the expression of RAB27A mRNA20829426
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of RAB27A mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of RAB27A mRNA23649840
C523184mocetinostatmocetinostat results in increased expression of RAB27A mRNA27255383
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in decreased expression of RAB27A mRNA22401849
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of RAB27A mRNA"25554681
D009532NickelNickel results in increased expression of RAB27A mRNA24768652|2558310
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of RAB27A mRNA22714537
D011441PropylthiouracilPropylthiouracil results in decreased expression of RAB27A mRNA24780913
D015474IsotretinoinIsotretinoin results in decreased expression of RAB27A mRNA20436886
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of RAB27A mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in decreased expression of RAB27A mRNA25351596
C017947sodium arsenitesodium arsenite affects the expression of RAB27A mRNA29319823
C017947sodium arsenitesodium arsenite results in increased expression of RAB27A mRNA24431212|2859598
D013501Surface-Active Agents[Surface-Active Agents co-treated with glyphosate] results in increased expression of RAB27A mRNA22467014
D013605T-2 ToxinT-2 Toxin results in decreased expression of RAB27A mRNA26141394
D013739Testosterone[bisphenol A co-treated with Testosterone] results in decreased expression of RAB27A mRNA26496021
C004648testosterone enanthatetestosterone enanthate affects the expression of RAB27A mRNA17440010
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of RAB27A mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in decreased expression of RAB27A mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of RAB27A mRNA15034205
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of RAB27A mRNA25613284
C009495titanium dioxidetitanium dioxide results in increased expression of RAB27A mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased methylation of RAB27A gene26756918
D014028Tobacco Smoke PollutionNFE2L2 protein inhibits the reaction [Tobacco Smoke Pollution affects the expression of RAB27A mRNA]20133372
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of RAB27A mRNA20133372
C012589trichostatin Atrichostatin A results in decreased expression of RAB27A mRNA15901671
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of RAB27A mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of RAB27A mRNA"26179874
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RAB27A mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of RAB27A mRNA28001369
D014635Valproic AcidValproic Acid results in increased expression of RAB27A mRNA23179753|2438349
D014635Valproic AcidValproic Acid affects the expression of RAB27A mRNA17963808
D014635Valproic AcidValproic Acid results in decreased expression of RAB27A mRNA15901671
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of RAB27A gene25560391
C025643vinclozolinvinclozolin affects the expression of RAB27A mRNA19015723

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003924GTPase activity-IBA21873635  
GO:0003924GTPase activity-ISS-  
GO:0005515protein binding-IPI12897212  15186776  15548590  17045265  18266782  18812475  
22899725  
GO:0005525GTP binding-IDA9066979  
GO:0005525GTP binding-ISS-  
GO:0019003GDP binding-IDA20937701  
GO:0019904protein domain specific binding-IEA-  
GO:0031489myosin V binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006605protein targeting-IEA-  
GO:0006886intracellular protein transport-IBA21873635  
GO:0006887exocytosis-IDA18812475  
GO:0007596blood coagulation-IEA-  
GO:0010628positive regulation of gene expression-IMP23092844  
GO:0019882antigen processing and presentation-IMP19717423  
GO:0030318melanocyte differentiation-IEA-  
GO:0032400melanosome localization-IMP15357836  
GO:0032402melanosome transport-IBA21873635  
GO:0032402melanosome transport-NAS11980908  
GO:0032482Rab protein signal transduction-IBA21873635  
GO:0036257multivesicular body organization-IMP23092844  
GO:0043312neutrophil degranulation-TAS-  
GO:0043316cytotoxic T cell degranulation-IEA-  
GO:0043320natural killer cell degranulation-IEA-  
GO:0045921positive regulation of exocytosis-IBA21873635  
GO:0045921positive regulation of exocytosis-IMP19966785  
GO:0048489synaptic vesicle transport-TAS21563316  
GO:0050766positive regulation of phagocytosis-IMP24404184  
GO:0071985multivesicular body sorting pathway-IMP19966785  
GO:0097278complement-dependent cytotoxicity-IMP24404184  
GO:1903307positive regulation of regulated secretory pathway-IGI22899725  
GO:1903307positive regulation of regulated secretory pathway-IMP22899725  
GO:1903428positive regulation of reactive oxygen species biosynthetic process-IMP24404184  
GO:1903435positive regulation of constitutive secretory pathway-IMP22899725  
GO:1990182exosomal secretion-IMP23092844  
GO ID GO Term Qualifier Evidence PubMed
GO:0001750photoreceptor outer segment-IEA-  
GO:0005576extracellular region-TAS-  
GO:0005764lysosome-IDA15548590  
GO:0005770late endosome-IDA17237785  
GO:0005794Golgi apparatus-IEA-  
GO:0005829cytosol-TAS-  
GO:0012505endomembrane system-IBA21873635  
GO:0016324apical plasma membrane-IEA-  
GO:0030141secretory granule-IBA21873635  
GO:0030425dendrite-IDA11266474  
GO:0030667secretory granule membrane-IEA-  
GO:0032585multivesicular body membrane-IDA19966785  
GO:0033093Weibel-Palade body-IEA-  
GO:0033162melanosome membrane-TAS-  
GO:0035580specific granule lumen-TAS-  
GO:0042470melanosome-IBA21873635  
GO:0042470melanosome-IDA11266474  11980908  
GO:0045202synapse-IEA-  
GO:0070062extracellular exosome-HDA19056867  23533145  
GO:0070382exocytic vesicle-IDA17237785  18812475  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-199991Membrane TraffickingTAS
R-HSA-264876Insulin processingIEA
R-HSA-2980736Peptide hormone metabolismIEA
R-HSA-392499Metabolism of proteinsTAS
R-HSA-392499Metabolism of proteinsIEA
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-6798695Neutrophil degranulationTAS
R-HSA-8873719RAB geranylgeranylationTAS
R-HSA-8876198RAB GEFs exchange GTP for GDP on RABsTAS
R-HSA-9007101Rab regulation of traffickingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal