Gene info: ID 5881

Gene: RAC3

GENE ID: 5881

Synonyms: -

Description: Rac family small GTPase 3

Gene type: protein-coding

Location: 17q25.3

dbXrefs: Ensembl:ENSG00000169750 MIM:602050 Vega:OTTHUMG00000178455 UniprotKB:P60763

RefSeq: NC_000017.11

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 3.436e-1 (AD) 2.045e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
PIN1	0.926
MFSD3	0.921
STOML1	0.918
FBLL1	0.914
PSMG3	0.911
BABAM1	0.909
SYNGR3	0.908
TUBB3	0.908
PGP	0.907
HAGH	0.906

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.541
REST	-0.535
EBF1	-0.517
OR4F29	-0.497
NEDD4	-0.492
KCNJ15	-0.489
ITGA1	-0.481
WWTR1	-0.475
IL18RAP	-0.47
CST7	-0.469

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
D000082	Acetaminophen	Acetaminophen affects the expression of RAC3 mRNA	17562736
D000447	Aldehydes	Aldehydes results in increased expression of RAC3 mRNA	25014914
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin results in increased expression of RAC3 mRNA	28522335
D000638	Amiodarone	Amiodarone results in increased expression of RAC3 mRNA	19774075
C015001	arsenite	arsenite results in decreased expression of RAC3 mRNA	18929588
C015001	arsenite	TRP53 protein affects the reaction [arsenite results in decreased expression of RAC3 mRNA]	18929588
D001285	Atropine	Atropine inhibits the reaction [Parathion results in increased expression of RAC3 protein]	17390078
D001564	Benzo(a)pyrene	Benzo(a)pyrene promotes the reaction [AHR protein binds to RAC3 promoter]	19654925
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of RAC3 mRNA	22228805
D004958	Estradiol	[Parathion co-treated with Estradiol] results in increased expression of RAC3 protein	17622325
C006780	bisphenol A	bisphenol A results in decreased methylation of RAC3 promoter	27312807
C006780	bisphenol A	bisphenol A results in decreased expression of RAC3 mRNA	25181051
C018475	butyraldehyde	butyraldehyde results in increased expression of RAC3 mRNA	26079696
C584509	C646 compound	C646 compound results in decreased expression of RAC3 mRNA	26191083
D002104	Cadmium	Cadmium results in increased oxidation of RAC3 protein	24077948
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of RAC3 mRNA	19320972
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of RAC3 mRNA	19549813
D016572	Cyclosporine	Cyclosporine results in decreased methylation of RAC3 promoter	27989131
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in increased expression of RAC3 mRNA	27392435
D004041	Dietary Fats	Dietary Fats results in increased expression of RAC3 mRNA	18042831
D004791	Enzyme Inhibitors	[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of RAC3 protein	23301498
C051890	irinotecan	irinotecan metabolite results in increased expression of RAC3 mRNA	15956246
C051890	irinotecan	irinotecan results in increased expression of RAC3 mRNA	15956246
D007529	Isoflavones	Isoflavones results in decreased expression of RAC3 mRNA	17374662
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in increased expression of RAC3 mRNA	27392435
C544151	jinfukang	jinfukang results in increased expression of RAC3 mRNA	27392435
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of RAC3 mRNA	23430699
D007854	Lead	Lead affects the expression of RAC3 mRNA	28903495
D008627	Mercuric Chloride	Mercuric Chloride affects the expression of RAC3 mRNA	20353558
C406082	monomethylarsonous acid	monomethylarsonous acid results in increased expression of RAC3 mRNA	20024957
C517284	monomethyl phthalate	monomethyl phthalate affects the expression of RAC3 mRNA	26924002
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of RAC3 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of RAC3 mRNA"	25554681
D000073878	Palm Oil	Palm Oil results in increased expression of RAC3 mRNA	18042831
D010278	Parathion	Atropine inhibits the reaction [Parathion results in increased expression of RAC3 protein]	17390078
D010278	Parathion	[Parathion co-treated with Estradiol] results in increased expression of RAC3 protein	17622325
D010278	Parathion	Parathion results in increased expression of RAC3 protein	17390078\|1762232
D052638	Particulate Matter	Particulate Matter results in decreased expression of RAC3 mRNA	28412507
C046012	pentanal	pentanal results in increased expression of RAC3 mRNA	26079696
C005556	propionaldehyde	propionaldehyde results in increased expression of RAC3 mRNA	26079696
D011441	Propylthiouracil	Propylthiouracil results in increased expression of RAC3 mRNA	24780913
C012526	quercitrin	quercitrin affects the expression of RAC3 mRNA	25193878
C059514	resveratrol	resveratrol results in decreased expression of RAC3 mRNA	17804521
D019821	Simvastatin	Simvastatin affects the localization of RAC3 protein	20045437
D053260	Soot	Soot results in decreased expression of RAC3 mRNA	22461453
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of RAC3 mRNA	24680724\|2637764
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of RAC3 mRNA	26290441
D014212	Tretinoin	Tretinoin results in decreased expression of RAC3 mRNA	23724009
D014635	Valproic Acid	Valproic Acid affects the expression of RAC3 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in increased methylation of RAC3 gene	29154799
C111237	vorinostat	vorinostat results in increased expression of RAC3 mRNA	27188386

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003924	GTPase activity	-	IBA	21873635
GO:0003924	GTPase activity	-	IDA	11956649
GO:0005515	protein binding	-	IPI	11956649 21217774
GO:0005525	GTP binding	-	IBA	21873635
GO:0005525	GTP binding	-	IEA	-
GO:0019901	protein kinase binding	-	IBA	21873635
GO:0048306	calcium-dependent protein binding	-	IPI	11756406

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000902	cell morphogenesis	-	IBA	21873635
GO:0006897	endocytosis	-	IBA	21873635
GO:0006935	chemotaxis	-	IBA	21873635
GO:0007015	actin filament organization	-	IBA	21873635
GO:0007264	small GTPase mediated signal transduction	-	IEA	-
GO:0007266	Rho protein signal transduction	-	IBA	21873635
GO:0014041	regulation of neuron maturation	-	IEA	-
GO:0016477	cell migration	-	IBA	21873635
GO:0021894	cerebral cortex GABAergic interneuron development	-	IEA	-
GO:0030031	cell projection assembly	-	IDA	11956649
GO:0030036	actin cytoskeleton organization	-	IBA	21873635
GO:0030036	actin cytoskeleton organization	-	IDA	11956649
GO:0030838	positive regulation of actin filament polymerization	-	IBA	21873635
GO:0031175	neuron projection development	-	IEA	-
GO:0031532	actin cytoskeleton reorganization	-	IBA	21873635
GO:0033630	positive regulation of cell adhesion mediated by integrin	-	IDA	11756406
GO:0035556	intracellular signal transduction	-	TAS	9252344
GO:0043652	engulfment of apoptotic cell	-	IBA	21873635
GO:0048873	homeostasis of number of cells within a tissue	-	IEA	-
GO:0050885	neuromuscular process controlling balance	-	IEA	-
GO:0051056	regulation of small GTPase mediated signal transduction	-	TAS	-
GO:0051932	synaptic transmission, GABAergic	-	IEA	-
GO:1900026	positive regulation of substrate adhesion-dependent cell spreading	-	IDA	11756406

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005737	cytoplasm	-	IBA	21873635
GO:0005829	cytosol	-	TAS	-
GO:0005856	cytoskeleton	COLOCALIZES_WITH	IBA	21873635
GO:0005886	plasma membrane	-	IBA	21873635
GO:0005886	plasma membrane	-	TAS	-
GO:0012505	endomembrane system	-	IDA	11956649
GO:0030027	lamellipodium	-	IEA	-
GO:0030426	growth cone	-	IDA	16525025
GO:0031941	filamentous actin	-	IDA	16525025
GO:0043005	neuron projection	-	IDA	16525025
GO:0043025	neuronal cell body	-	IDA	16525025
GO:0048471	perinuclear region of cytoplasm	-	IDA	11756406
GO:0070062	extracellular exosome	-	HDA	23533145
GO:0071944	cell periphery	-	IDA	11756406

KEGG ID	KEGG Term
hsa04010	MAPK signaling pathway
hsa04310	Wnt signaling pathway
hsa04360	Axon guidance
hsa04370	VEGF signaling pathway
hsa04510	Focal adhesion
hsa04520	Adherens junction
hsa04650	Natural killer cell mediated cytotoxicity
hsa04662	B cell receptor signaling pathway
hsa04664	Fc epsilon RI signaling pathway
hsa04810	Regulation of actin cytoskeleton
hsa05200	Pathways in cancer
hsa05210	Colorectal cancer
hsa05212	Pancreatic cancer
hsa05416	Viral myocarditis

Reactome ID	Reactome Term	Evidence
R-HSA-162582	Signal Transduction	TAS
R-HSA-194315	Signaling by Rho GTPases	TAS
R-HSA-194840	Rho GTPase cycle	TAS
R-HSA-195721	Signaling by WNT	TAS
R-HSA-3858494	Beta-catenin independent WNT signaling	TAS
R-HSA-4086400	PCP/CE pathway	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
14557830	Correlates of obesity in postmenopausal women with breast cancer: comparison of genetic, demographic, disease-related, life history and dietary factors. (2004 Jan)	Wasserman L	Int J Obes Relat Metab Disord