Gene: RAD17

5884
CCYC|HRAD17|R24L|RAD17SP|RAD24
RAD17 checkpoint clamp loader component
protein-coding
5q13.2
Ensembl:ENSG00000152942 MIM:603139 Vega:OTTHUMG00000099357 UniprotKB:O75943
NC_000005.10
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.030e-1 (AD)  9.178e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EXOC10.954
API50.928
SNX140.927
IMPAD10.925
ARL10.924
PWP10.923
ACTR100.922
RAB140.921
UBA50.921
TRAPPC110.92

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.596
OR4F29-0.576
MTRNR2L10-0.389
MTRNR2L6-0.382
MTRNR2L9-0.381
MTRNR2L2-0.312
MTRNR2L8-0.308
MTRNR2L3-0.304
C8orf74-0.296
TTLL10-0.293

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of RAD17 mRNA"21346803
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Particulate Matter results in decreased expression of RAD17 mRNA]28655636
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Vehicle Emissions results in decreased expression of RAD17 mRNA]28655636
D000082AcetaminophenAcetaminophen affects the expression of RAD17 mRNA25064622
D000082AcetaminophenAcetaminophen affects the expression of RAD17 mRNA17562736
D000638AmiodaroneAmiodarone affects the expression of RAD17 mRNA25064622
C006632arsenic trioxidearsenic trioxide results in increased expression of RAD17 mRNA20458559
D001280AtrazineAtrazine results in increased expression of RAD17 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of RAD17 mRNA20504355
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of RAD17 mRNA"19150397|2623829
C006780bisphenol Abisphenol A affects the expression of RAD17 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of RAD17 mRNA25181051
C557045BO-1051BO-1051 results in increased expression of RAD17 protein modified form21184746
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of RAD17 mRNA27339419
D002746ChlorpromazineChlorpromazine affects the expression of RAD17 mRNA25064622
C074702chromium hexavalent ionRAD17 protein affects the reaction [chromium hexavalent ion promotes the reaction [ATR protein results in increased phosphorylation of SMC1A protein]]16876463
C074702chromium hexavalent ionRAD17 protein affects the reaction [chromium hexavalent ion results in increased phosphorylation of SMC1A protein]16876463
C018021cobaltous chloridecobaltous chloride results in increased expression of RAD17 mRNA19376846
D016572CyclosporineCyclosporine affects the expression of RAD17 mRNA25064622
C014347decitabinedecitabine results in decreased expression of RAD17 mRNA19194470
D015255IdarubicinDexrazoxane inhibits the reaction [Idarubicin results in decreased expression of RAD17 mRNA]28973540
D015255IdarubicinIdarubicin results in decreased expression of RAD17 mRNA28973540
D003907DexamethasoneDexamethasone results in decreased expression of RAD17 mRNA12782123
D064730DexrazoxaneDexrazoxane inhibits the reaction [Idarubicin results in decreased expression of RAD17 mRNA]28973540
C000944dicrotophosdicrotophos results in decreased expression of RAD17 mRNA28302478
C024629dimethyl phthalatedimethyl phthalate affects the expression of RAD17 mRNA26924002
D000431EthanolEthanol results in decreased expression of RAD17 protein20621659
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of RAD17 mRNA25064622
D018120FinasterideFinasteride results in increased expression of RAD17 mRNA24136188
D005485FlutamideFlutamide results in increased expression of RAD17 mRNA24136188
C039281furanfuran results in increased expression of RAD17 mRNA22079235
C410337K 7174K 7174 results in increased expression of RAD17 mRNA24086573
C005223methyleugenolmethyleugenol results in decreased expression of RAD17 mRNA26011634
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of RAD17 mRNA23458150
C517284monomethyl phthalatemonomethyl phthalate affects the expression of RAD17 mRNA26924002
D009151Mustard GasMustard Gas results in increased expression of RAD17 mRNA15674844
C010615Nonidet P-40Nonidet P-40 results in increased expression of RAD17 mRNA26552463
D010269ParaquatParaquat affects the expression of RAD17 mRNA25064622
D052638Particulate Matter2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Particulate Matter results in decreased expression of RAD17 mRNA]28655636
D052638Particulate MatterParticulate Matter results in decreased expression of RAD17 mRNA28655636
C006253pirinixic acidpirinixic acid results in increased expression of RAD17 mRNA18445702
D010894PiroxicamPiroxicam results in increased expression of RAD17 mRNA21858171
D010936Plant ExtractsPlant Extracts results in increased expression of RAD17 mRNA23557933
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of RAD17 mRNA22714537
D011374ProgesteroneProgesterone results in increased expression of RAD17 mRNA23012394
D011398PromethazinePromethazine results in decreased expression of RAD17 mRNA26011634
C547185riccardin Driccardin D results in increased expression of RAD17 mRNA24069304
D012402RotenoneRotenone results in increased expression of RAD17 mRNA18191903
D012822Silicon DioxideSilicon Dioxide results in decreased expression of RAD17 mRNA25351596
C017947sodium arsenitesodium arsenite affects the expression of RAD17 mRNA29319823
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in increased expression of RAD17 mRNA"26680231
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of RAD17 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in decreased expression of RAD17 mRNA25975270
D013752TetracyclineTetracycline affects the expression of RAD17 mRNA25064622
D019284ThapsigarginThapsigargin results in decreased expression of RAD17 protein24648495
D013853ThioacetamideThioacetamide affects the expression of RAD17 mRNA25064622
D013853ThioacetamideThioacetamide results in increased expression of RAD17 mRNA23411599|2601163
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of RAD17 mRNA27404394
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of RAD17 mRNA27865774
D014118Toxins, Biological"Toxins, Biological affects the expression of RAD17 mRNA"19682533
D014212Tretinoin[Tretinoin co-treated with zoledronic acid] results in increased expression of RAD17 protein20349282
D014635Valproic AcidValproic Acid affects the expression of RAD17 mRNA25064622
D014635Valproic AcidValproic Acid results in increased expression of RAD17 mRNA29154799
D014638VanadatesVanadates results in increased expression of RAD17 mRNA22714537
D001335Vehicle Emissions2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Vehicle Emissions results in decreased expression of RAD17 mRNA]28655636
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of RAD17 mRNA28655636
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of RAD17 gene25560391
C088658zoledronic acid[Tretinoin co-treated with zoledronic acid] results in increased expression of RAD17 protein20349282

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003682chromatin binding-IBA21873635  
GO:0003689DNA clamp loader activityCONTRIBUTES_TOIBA21873635  
GO:0005515protein binding-IPI10593953  10884395  15538388  20424596  24534091  
GO:0005524ATP binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000076DNA replication checkpoint-TAS9660800  
GO:0000077DNA damage checkpoint-IBA21873635  
GO:0000077DNA damage checkpoint-IMP15538388  
GO:0006260DNA replication-TAS-  
GO:0006281DNA repair-IBA21873635  
GO:0006974cellular response to DNA damage stimulus-IMP15538388  
GO:0007093mitotic cell cycle checkpoint-IMP15538388  
GO:0008156negative regulation of DNA replication-IMP14657349  
GO:0033314mitotic DNA replication checkpoint-IBA21873635  
GO:0042325regulation of phosphorylation-IMP14657349  
GO ID GO Term Qualifier Evidence PubMed
GO:0000781chromosome, telomeric regioncolocalizes_withIDA15149599  
GO:0000790nuclear chromatin-IBA21873635  
GO:0005634nucleus-TAS9660800  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005730nucleolus-IDA10593953  
GO:0031389Rad17 RFC-like complex-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1640170Cell CycleTAS
R-HSA-176187Activation of ATR in response to replication stressTAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-3700989Transcriptional Regulation by TP53TAS
R-HSA-5633007Regulation of TP53 ActivityTAS
R-HSA-5685938HDR through Single Strand Annealing (SSA)TAS
R-HSA-5685942HDR through Homologous Recombination (HRR)TAS
R-HSA-5693532DNA Double-Strand Break RepairTAS
R-HSA-5693538Homology Directed RepairTAS
R-HSA-5693567HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)TAS
R-HSA-5693579Homologous DNA Pairing and Strand ExchangeTAS
R-HSA-5693607Processing of DNA double-strand break endsTAS
R-HSA-5693616Presynaptic phase of homologous DNA pairing and strand exchangeTAS
R-HSA-6804756Regulation of TP53 Activity through PhosphorylationTAS
R-HSA-69473G2/M DNA damage checkpointTAS
R-HSA-69481G2/M CheckpointsTAS
R-HSA-69620Cell Cycle CheckpointsTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-73894DNA RepairTAS
R-HSA-74160Gene expression (Transcription)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28238011Human RAD 17 Polymorphism at Codon 546 Is Associated with the Risk of Colorectal Cancer. (2017 Feb)Yasuda YActa Med Okayama
27186329Genetic polymorphism at codon 546 of the human RAD17 contributes to the risk for esophageal squamous cell carcinoma. (2016)Yasuda YInt J Mol Epidemiol Genet