Gene: RAD23B

5887
HHR23B|HR23B|P58
RAD23 homolog B, nucleotide excision repair protein
protein-coding
9q31.2
Ensembl:ENSG00000119318 MIM:600062 Vega:OTTHUMG00000020446 UniprotKB:P54727
NC_000009.12
PubMed
0   ANCO-SNPs
ND
7   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.057e-1 (AD)  6.349e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ARL8B0.974
UBQLN10.973
RAB1A0.972
RANBP90.972
RAB140.971
NARS0.971
CUL10.969
ATP6AP20.968
WDR820.968
MAPRE20.968

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.716
OR4F29-0.68
MTRNR2L6-0.329
CSAG1-0.329
MTRNR2L10-0.327
MTRNR2L9-0.315
KLRB1-0.3
VNN3-0.293
ASB4-0.288
FZD10-0.285

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0630022,3-dimethoxy-1,4-naphthoquinone"2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of RAD23B mRNA"19031421
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cisplatin results in increased expression of RAD23B protein]21742020
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of RAD23B mRNA"21346803
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of RAD23B mRNA"20816883
C0369902-amino-3,8-dimethylimidazo(4,5-f)quinoxaline"2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of RAD23B mRNA"20816883
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of RAD23B mRNA"18648102
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of RAD23B mRNA19038236
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of RAD23B gene27153756
D013196DihydrotestosteroneDihydrotestosterone results in decreased expression of RAD23B mRNA17023530
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of RAD23B mRNA24449571
C006632arsenic trioxide[Tretinoin co-treated with arsenic trioxide] results in increased expression of RAD23B protein15894607
D001280AtrazineAtrazine results in increased expression of RAD23B mRNA18522720
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of RAD23B mRNA28461126
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of RAD23B mRNA"19150397
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of RAD23B mRNA"20018196|2623829
C044887beta-methylcholinebeta-methylcholine affects the expression of RAD23B mRNA21179406
C006780bisphenol Abisphenol A results in decreased methylation of RAD23B gene28582417
C006780bisphenol Abisphenol A results in increased expression of RAD23B mRNA26063408
C006780bisphenol Abisphenol A affects the expression of RAD23B mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of RAD23B mRNA25181051
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in decreased expression of RAD23B mRNA25270620
C515564bromovaninbromovanin results in decreased expression of RAD23B protein21419150
C028031cadmium acetatecadmium acetate results in decreased expression of RAD23B mRNA18155341
D019256Cadmium ChlorideCadmium Chloride results in increased expression of RAD23B mRNA12160620|2647268
D019256Cadmium ChlorideCadmium Chloride results in increased expression of RAD23B mRNA11958953
D019256Cadmium ChlorideMT1 affects the reaction [Cadmium Chloride results in increased expression of RAD23B mRNA]11958953
D019256Cadmium ChlorideMT2 affects the reaction [Cadmium Chloride results in increased expression of RAD23B mRNA]11958953
D000068579CelecoxibCelecoxib results in decreased expression of RAD23B mRNA28201806
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of RAD23B mRNA23650126
C007020chlorophyllinchlorophyllin analog results in decreased expression of RAD23B protein22852132
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of RAD23B20938992
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of RAD23B gene20938992
C408982CPG-oligonucleotideCPG-oligonucleotide results in increased expression of RAD23B mRNA21878529
D016572CyclosporineCyclosporine results in increased expression of RAD23B mRNA20106945|2556210
C014347decitabine[decitabine co-treated with Depsipeptides] results in decreased expression of RAD23B mRNA17064661
D047630Depsipeptides[decitabine co-treated with Depsipeptides] results in decreased expression of RAD23B mRNA17064661
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of RAD23B mRNA]27941970
D002945Cisplatin2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cisplatin results in increased expression of RAD23B protein]21742020
D002945CisplatinCisplatin results in increased expression of RAD23B protein21742020
D002945CisplatinRAD23B mutant form inhibits the reaction [Cisplatin results in increased expression of CDKN1A protein]21742020
D002945CisplatinRAD23B mutant form inhibits the reaction [Cisplatin results in increased expression of TP53 protein]21742020
D002945CisplatinRAD23B mutant form inhibits the reaction [Cisplatin results in increased expression of XPC protein]21742020
D002945CisplatinRAD23B results in decreased susceptibility to Cisplatin21742020
D002945CisplatinRAD23B results in increased susceptibility to Cisplatin21878529
D002945CisplatinU 0126 inhibits the reaction [Cisplatin results in increased expression of RAD23B protein]21742020
D002945Cisplatinwortmannin inhibits the reaction [Cisplatin results in increased expression of RAD23B protein]21742020
D004026DieldrinDieldrin results in increased expression of RAD23B mRNA20438755
D004128DimethylnitrosamineDimethylnitrosamine results in decreased expression of RAD23B mRNA19031421
D004317DoxorubicinDoxorubicin affects the expression of RAD23B protein29385562
D004726EndosulfanEndosulfan results in increased expression of RAD23B mRNA25569846
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of RAD23B protein23301498
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of RAD23B mRNA23649840
D018120FinasterideFinasteride results in increased expression of RAD23B mRNA24136188
D005472FluorouracilFluorouracil results in increased expression of RAD23B mRNA15109396
D005472FluorouracilRAD23B affects the susceptibility to Fluorouracil15067352
D005485FlutamideFlutamide results in increased expression of RAD23B mRNA24136188
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of RAD23B20938992
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of RAD23B gene20938992
D007213IndomethacinIndomethacin results in decreased expression of RAD23B mRNA16984733
D007213IndomethacinIndomethacin results in decreased expression of RAD23B mRNA28201806
C051890irinotecanirinotecan metabolite results in decreased expression of RAD23B mRNA15956246
C051890irinotecanirinotecan results in decreased expression of RAD23B mRNA15956246
C561695(+)-JQ1 compound(+)-JQ1 compound analog binds to RAD23B protein24972113
D007854LeadLead affects the splicing of RAD23B mRNA28903495
C045463leflunomideleflunomide results in increased expression of RAD23B mRNA24136188
D008713MethimazoleMethimazole results in decreased expression of RAD23B mRNA22504374
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of RAD23B20938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of RAD23B gene20938992
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of RAD23B mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of RAD23B mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of RAD23B mRNA"20188158
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of RAD23B mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of RAD23B mRNA"25554681
C051752nefazodonenefazodone results in increased expression of RAD23B mRNA24136188
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of RAD23B mRNA25729387
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of RAD23B protein22609092
D010634PhenobarbitalPhenobarbital affects the expression of RAD23B mRNA23091169
D010862PilocarpinePilocarpine results in increased expression of RAD23B mRNA17971868
C049032pinosylvinpinosylvin results in decreased expression of RAD23B mRNA23333577
C014153pirimiphos methylpirimiphos methyl results in decreased expression of RAD23B mRNA27845199
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of RAD23B mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of RAD23B mRNA18301758
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls affects the expression of RAD23B mRNA21334430
D011441PropylthiouracilPropylthiouracil results in decreased expression of RAD23B mRNA22504374
C059514resveratrolresveratrol affects the expression of RAD23B mRNA15748624
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in decreased expression of RAD23B mRNA21427059
C010327salinomycinsalinomycin results in decreased expression of RAD23B mRNA19682730
D012643SeleniumSelenium results in decreased expression of RAD23B mRNA19244175
C009277sodium arsenatesodium arsenate results in decreased expression of RAD23B mRNA21795629
C009277sodium arsenatesodium arsenate results in increased expression of RAD23B mRNA21795629
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of RAD23B mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of RAD23B mRNA20159946
D019284ThapsigarginThapsigargin results in decreased expression of RAD23B protein24648495
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of RAD23B mRNA25729387
D014212Tretinoin[Tretinoin co-treated with arsenic trioxide] results in increased expression of RAD23B protein15894607
C012589trichostatin Atrichostatin A affects the expression of RAD23B mRNA28542535
C113580U 0126U 0126 inhibits the reaction [Cisplatin results in increased expression of RAD23B protein]21742020
C406224valdecoxibvaldecoxib results in increased expression of RAD23B mRNA24136188
D014635Valproic AcidValproic Acid results in increased expression of RAD23B mRNA23179753
D014635Valproic AcidValproic Acid results in decreased expression of RAD23B mRNA21427059
D014810Vitamin EVitamin E results in decreased expression of RAD23B mRNA19244175
D024483Vitamin K 3Vitamin K 3 affects the expression of RAD23B mRNA20044591
C009687wortmanninwortmannin inhibits the reaction [Cisplatin results in increased expression of RAD23B protein]21742020
D015032ZincZinc deficiency results in increased expression of RAD23B mRNA11739864

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003684damaged DNA binding-IEA-  
GO:0003697single-stranded DNA binding-TAS8168482  
GO:0005515protein binding-IPI10488153  10734143  15358861  16712842  16990800  17662948  
20059542  21962512  25416956  
GO:0031593polyubiquitin modification-dependent protein binding-IBA21873635  
GO:0031593polyubiquitin modification-dependent protein binding-IDA19435460  
GO:0043130ubiquitin binding-IBA21873635  
GO:0070628proteasome binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000715nucleotide-excision repair, DNA damage recognition-IDA19941824  
GO:0000715nucleotide-excision repair, DNA damage recognition-TAS-  
GO:0006289nucleotide-excision repair-IDA8168482  9734359  
GO:0006294nucleotide-excision repair, preincision complex assembly-TAS-  
GO:0006457protein folding-TAS-  
GO:0007283spermatogenesis-IEA-  
GO:0016579protein deubiquitination-TAS-  
GO:0032434regulation of proteasomal ubiquitin-dependent protein catabolic process-IDA19435460  
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process-IBA21873635  
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process-IEA-  
GO:0048568embryonic organ development-IEA-  
GO:0070911global genome nucleotide-excision repair-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000502proteasome complex-IBA21873635  
GO:0000502proteasome complex-IEA-  
GO:0005634nucleus-TAS8168482  
GO:0005654nucleoplasm-IBA21873635  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005829cytosol-IBA21873635  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0071942XPC complex-IDA11279143  
KEGG ID KEGG Term
hsa03420Nucleotide excision repair
hsa04141Protein processing in endoplasmic reticulum
Reactome ID Reactome Term Evidence
R-HSA-392499Metabolism of proteinsTAS
R-HSA-446203Asparagine N-linked glycosylationTAS
R-HSA-532668N-glycan trimming in the ER and Calnexin/Calreticulin cycleTAS
R-HSA-5688426DeubiquitinationTAS
R-HSA-5689877Josephin domain DUBsTAS
R-HSA-5696394DNA Damage Recognition in GG-NERTAS
R-HSA-5696395Formation of Incision Complex in GG-NERTAS
R-HSA-5696398Nucleotide Excision RepairTAS
R-HSA-5696399Global Genome Nucleotide Excision Repair (GG-NER)TAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-73894DNA RepairTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
16537713Genetic variation in the nucleotide excision repair pathway and bladder cancer risk. (2006 Mar)Garcia-Closas MCancer Epidemiol Biomarkers Prev
17728339High-order interactions among genetic polymorphisms in nucleotide excision repair pathway genes and smoking in modulating bladder cancer risk. (2007 Oct)Chen MCarcinogenesis
16399771Polymorphisms in nucleotide excision repair genes, smoking and breast cancer in African Americans and whites: a population-based case-control study. (2006 Jul)Mechanic LECarcinogenesis
16492920Nucleotide excision repair gene polymorphisms and risk of advanced colorectal adenoma: XPC polymorphisms modify smoking-related risk. (2006 Feb)Huang WYCancer Epidemiol Biomarkers Prev
17575242Nucleotide excision repair pathway genes and oral premalignant lesions. (2007 Jun 15)Wang YClin Cancer Res
19444904Laryngeal cancer risk associated with smoking and alcohol consumption is modified by genetic polymorphisms in ERCC5, ERCC6 and RAD23B but not by polymorphisms in five other nucleotide excision repair genes. (2009 Sep 15)Abbasi RInt J Cancer
18709642Nucleotide excision repair genes and risk of lung cancer among San Francisco Bay Area Latinos and African Americans. (2008 Nov 1)Chang JSInt J Cancer