Gene: RAD51B

5890
R51H2|RAD51L1|REC2
RAD51 paralog B
protein-coding
14q24.1
Ensembl:ENSG00000182185 MIM:602948 Vega:OTTHUMG00000157530 UniprotKB:O15315
NG_023267.2
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.855e-2 (AD)  8.607e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MCM50.785
PARP40.773
FMO40.767
IRAK40.758
REST0.757
NPC20.749
FAM114A10.745
HFE0.744
NEDD10.739
ALDH3B10.739

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TCERG1L-0.501
HAS1-0.494
CALHM1-0.491
KCNB2-0.491
ABCC12-0.489
B3GNT4-0.487
CDH22-0.483
SSTR3-0.475
MYADML2-0.472
KCNJ6-0.472

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of RAD51B mRNA"28903501
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RAD51B mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RAD51B mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of RAD51B mRNA17562736
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of RAD51B mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of RAD51B mRNA]17585979
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of RAD51B mRNA21641981
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of RAD51B mRNA21298039
D000638AmiodaroneAmiodarone results in increased expression of RAD51B mRNA24535564
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in increased expression of RAD51B mRNA"22863853
D001151ArsenicArsenic affects the methylation of RAD51B gene25304211
C015001arsenitearsenite results in decreased expression of RAD51B mRNA18929588
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in increased expression of RAD51B mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of RAD51B mRNA20064835|2163298
C006780bisphenol Abisphenol A results in increased expression of RAD51B mRNA27685785
C006780bisphenol Abisphenol A affects the expression of RAD51B mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of RAD51B mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of RAD51B mRNA26079696
C074702chromium hexavalent ionchromium hexavalent ion results in decreased expression of RAD51B mRNA27793765
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of RAD51B mRNA17585979
D002994ClofibrateClofibrate results in increased expression of RAD51B mRNA23811191
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of RAD51B mRNA]17585979
D003300CopperCopper deficiency results in increased expression of RAD51B mRNA26033743
D019327Copper SulfateCopper Sulfate results in decreased expression of RAD51B mRNA19549813
C017160cypermethrincypermethrin results in increased expression of RAD51B mRNA21142847
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of RAD51B mRNA28962523
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of RAD51B mRNA27392435
D002945CisplatinCisplatin results in decreased expression of RAD51B mRNA27392435
D019422Dietary SucroseDietary Sucrose results in increased expression of RAD51B mRNA26033743
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of RAD51B mRNA19850644
D004051Diethylhexyl PhthalatePPARA protein promotes the reaction [Diethylhexyl Phthalate results in increased expression of RAD51B mRNA]19850644
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of RAD51B mRNA24535843
D004317DoxorubicinDoxorubicin results in decreased expression of RAD51B mRNA27181935
D004317DoxorubicinFungal Polysaccharides inhibits the reaction [Doxorubicin results in decreased expression of RAD51B mRNA]27181935
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of RAD51B mRNA22079256
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of RAD51B mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of RAD51B mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of RAD51B mRNA17942748
D011345FenofibrateFenofibrate results in increased expression of RAD51B mRNA11798191
D005557FormaldehydeFormaldehyde results in decreased expression of RAD51B mRNA23649840
D062610Fungal PolysaccharidesFungal Polysaccharides inhibits the reaction [Doxorubicin results in decreased expression of RAD51B mRNA]27181935
C039281furanfuran results in decreased expression of RAD51B mRNA24183702
C039281furanfuran results in increased expression of RAD51B mRNA20194422
C004312glycidolglycidol results in decreased expression of RAD51B mRNA24915197
D006046Gold[Gold co-treated with Polyethylene Glycols] results in decreased expression of RAD51B mRNA19695318
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of RAD51B mRNA27392435
C544151jinfukangjinfukang results in increased expression of RAD51B mRNA27392435
C008261lead acetatelead acetate results in decreased expression of RAD51B mRNA22609695
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of RAD51B mRNA27339419
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of RAD51B mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of RAD51B mRNA26011545
C005246myristicinmyristicin results in decreased expression of RAD51B mRNA24792648
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of RAD51B mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of RAD51B mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of RAD51B mRNA"25554681
C016030pantogabpantogab results in increased expression of RAD51B mRNA17379144
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of RAD51B mRNA]19482888
D010634PhenobarbitalPhenobarbital results in decreased expression of RAD51B mRNA23091169
D010634PhenobarbitalPhenobarbital results in increased expression of RAD51B mRNA19482888
C006253pirinixic acidpirinixic acid results in increased expression of RAD51B mRNA11798191|1530286
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in increased expression of RAD51B mRNA]17950772|2005976
D011092Polyethylene Glycols[Gold co-treated with Polyethylene Glycols] results in decreased expression of RAD51B mRNA19695318
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of RAD51B mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of RAD51B mRNA22079256
C043680ptaquilosideptaquiloside results in decreased expression of RAD51B mRNA22143989
C031280pyrazolepyrazole results in increased expression of RAD51B mRNA17945193
C410733scriptaidscriptaid affects the expression of RAD51B mRNA18813790
C017947sodium arsenitesodium arsenite results in decreased expression of RAD51B mRNA25879800
D053260SootSoot results in increased expression of RAD51B mRNA26551751
D013629TamoxifenTamoxifen affects the expression of RAD51B mRNA17555576
D013739TestosteroneTestosterone results in decreased expression of RAD51B mRNA20844152
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of RAD51B mRNA22574217
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of RAD51B mRNA23864506
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of RAD51B mRNA17942748
D013750TetrachloroethyleneTetrachloroethylene results in increased expression of RAD51B mRNA28973375
D014241TrichloroethyleneTrichloroethylene results in increased expression of RAD51B mRNA25549359|2897337
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of RAD51B mRNA19042947
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of RAD51B mRNA29024780
D014520UrethaneUrethane results in decreased expression of RAD51B mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RAD51B mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of RAD51B mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of RAD51B mRNA23179753|2493525
D014635Valproic AcidValproic Acid affects the expression of RAD51B mRNA17963808
D014635Valproic AcidValproic Acid results in increased expression of RAD51B mRNA24535564
C029297vinylidene chloridevinylidene chloride results in increased expression of RAD51B mRNA26682919
C111237vorinostatvorinostat results in increased expression of RAD51B mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000400four-way junction DNA bindingcontributes_toIDA20207730  
GO:0003677DNA binding-TAS9512535  
GO:0003690double-stranded DNA binding-IDA12441335  
GO:0003697single-stranded DNA binding-IDA12441335  
GO:0005515protein binding-IPI9469824  11751635  11842113  14595808  21965664  24141787  
25416956  
GO:0005524ATP binding-IEA-  
GO:0008094DNA-dependent ATPase activity-IDA12441335  
GO ID GO Term Qualifier Evidence PubMed
GO:0000707meiotic DNA recombinase assembly-IBA21873635  
GO:0000724double-strand break repair via homologous recombination-IMP23149936  
GO:0006281DNA repair-TAS9512535  
GO:0006310DNA recombination-TAS9512535  
GO:0007131reciprocal meiotic recombination-IBA21873635  
GO:0007131reciprocal meiotic recombination-TAS9441753  
GO:0007596blood coagulation-TAS-  
GO:0010971positive regulation of G2/M transition of mitotic cell cycle-IMP23108668  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-TAS9512535  
GO:0005654nucleoplasm-TAS-  
GO:0005657replication fork-IBA21873635  
GO:0005657replication fork-IDA20207730  
GO:0033063Rad51B-Rad51C-Rad51D-XRCC2 complex-IBA21873635  
GO:0033063Rad51B-Rad51C-Rad51D-XRCC2 complex-IDA11751635  
KEGG ID KEGG Term
hsa03440Homologous recombination
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-5685942HDR through Homologous Recombination (HRR)TAS
R-HSA-5693532DNA Double-Strand Break RepairTAS
R-HSA-5693537Resolution of D-Loop StructuresTAS
R-HSA-5693538Homology Directed RepairTAS
R-HSA-5693554Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)TAS
R-HSA-5693567HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)TAS
R-HSA-5693568Resolution of D-loop Structures through Holliday Junction IntermediatesTAS
R-HSA-5693579Homologous DNA Pairing and Strand ExchangeTAS
R-HSA-5693616Presynaptic phase of homologous DNA pairing and strand exchangeTAS
R-HSA-73894DNA RepairTAS
R-HSA-983231Factors involved in megakaryocyte development and platelet productionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29487693Uncovering genetic and non-genetic biomarkers specific for exudative age-related macular degeneration: significant association of twelve variants. (2018 Jan 30)Cascella ROncotarget
25655794Risk Prediction for Progression of Macular Degeneration: 10 Common and Rare Genetic Variants, Demographic, Environmental, and Macular Covariates. (2015 Apr)Seddon JMInvest Ophthalmol Vis Sci