Gene: RAD52

5893
-
RAD52 homolog, DNA repair protein
protein-coding
12p13.33
Ensembl:ENSG00000002016 MIM:600392 Vega:OTTHUMG00000090361 UniprotKB:P43351
NG_017078.2
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
6   
8.998e-1 (AD)  1.632e-1 (ND)   (Frontal_Cortex)
9.524e-1 (AD)  1.549e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs6413436chr12:913513 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg14602222chr12:1025663RAD522.600e-8Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ZSWIM80.851
EYA30.842
DIDO10.837
PAN20.832
INPP5B0.831
POGZ0.83
CPT1B0.83
DFFB0.828
ZNF7850.827
CSAD0.825

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.404
OR4F29-0.364
KLRC2-0.346
TRDN-0.287
KLRB1-0.272
CACNG1-0.27
XCL2-0.258
CD3G-0.252
XPNPEP2-0.251
AGTR1-0.251

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of RAD52 mRNA"16269432
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of RAD52 mRNA"21346803
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of RAD52 mRNA"18648102
D000082AcetaminophenAcetaminophen affects the expression of RAD52 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of RAD52 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of RAD52 mRNA19770486
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of RAD52 mRNA24449571
C006632arsenic trioxidearsenic trioxide results in decreased expression of RAD52 mRNA15073043
C547126AZM551248AZM551248 results in decreased expression of RAD52 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of RAD52 mRNA20504355
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of RAD52 mRNA22228805
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of RAD52 mRNA28628672
C006780bisphenol Abisphenol A affects the expression of RAD52 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of RAD52 mRNA26063408
C006780bisphenol Abisphenol A results in increased expression of RAD52 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of RAD52 gene28505145
D019256Cadmium ChlorideCadmium Chloride results in increased expression of RAD52 mRNA23644582
D002994ClofibrateClofibrate results in decreased expression of RAD52 mRNA17585979
D016572CyclosporineCyclosporine results in increased methylation of RAD52 promoter27989131
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of RAD52 mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of RAD52 mRNA21266533
C024629dimethyl phthalatedimethyl phthalate affects the expression of RAD52 mRNA26924002
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of RAD52 mRNA23649840
D005047EtoposideBRCA1 protein mutant form inhibits the reaction [Etoposide results in increased expression of RAD52 protein]16417649
D005047EtoposideEtoposide results in increased expression of RAD52 mRNA19799994
D005047EtoposideEtoposide results in increased expression of RAD52 protein16417649
C039281furanfuran results in decreased expression of RAD52 mRNA22507866
D017313FenretinideFenretinide results in increased expression of RAD52 mRNA28973697
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of RAD52 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of RAD52 mRNA28628672
D007545IsoproterenolIsoproterenol results in increased expression of RAD52 mRNA20003209
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of RAD52 mRNA12057914
D008694MethamphetamineMethamphetamine results in decreased expression of RAD52 mRNA19564919
C005223methyleugenolmethyleugenol results in decreased expression of RAD52 mRNA21659616
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of RAD52 mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of RAD52 mRNA19799994|2364984
C517284monomethyl phthalatemonomethyl phthalate affects the expression of RAD52 mRNA26924002
C022838nickel chloridenickel chloride affects the expression of RAD52 mRNA22110744
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of RAD52 mRNA25729387
D010634PhenobarbitalPhenobarbital results in decreased expression of RAD52 mRNA19162173
C031280pyrazolepyrazole results in increased expression of RAD52 mRNA17945193
D012822Silicon DioxideSilicon Dioxide results in decreased expression of RAD52 mRNA19073995
C017947sodium arsenitesodium arsenite affects the methylation of RAD52 gene28589171
D012999SomanSoman results in decreased expression of RAD52 mRNA19281266
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of RAD52 mRNA21570461
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of RAD52 mRNA25729387
C057693troglitazonetroglitazone results in decreased expression of RAD52 mRNA28973697
D014635Valproic AcidValproic Acid results in decreased expression of RAD52 mRNA24383497
C025643vinclozolinvinclozolin results in decreased expression of RAD52 mRNA23869203

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003677DNA binding-IDA19506022  
GO:0003697single-stranded DNA binding-IMP12370410  
GO:0005515protein binding-IPI8702565  12750383  14734547  17765923  19338310  24126761  
GO:0042802identical protein binding-IMP12370410  
GO:0042802identical protein binding-IPI12750383  21804533  
GO ID GO Term Qualifier Evidence PubMed
GO:0000724double-strand break repair via homologous recombination-IBA21873635  
GO:0000730DNA recombinase assembly-IEA-  
GO:0006302double-strand break repair-TAS7774919  
GO:0006310DNA recombination-IMP8702565  12370410  
GO:0006312mitotic recombination-IBA21873635  
GO:0006974cellular response to DNA damage stimulus-IGI19506022  
GO:0010792DNA double-strand break processing involved in repair via single-strand annealing-IDA19506022  
GO:0034599cellular response to oxidative stress-IDA19506022  
GO:0045002double-strand break repair via single-strand annealing-IBA21873635  
GO:0051260protein homooligomerization-IMP12370410  
GO:2000819regulation of nucleotide-excision repair-IDA19506022  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA19506022  
GO:0005654nucleoplasm-TAS-  
GO:0032991protein-containing complex-IDA19506022  
GO:0032993protein-DNA complex-IMP12370410  
KEGG ID KEGG Term
hsa03440Homologous recombination
Reactome ID Reactome Term Evidence
R-HSA-2990846SUMOylationTAS
R-HSA-3108214SUMOylation of DNA damage response and repair proteinsTAS
R-HSA-3108232SUMO E3 ligases SUMOylate target proteinsTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-5685938HDR through Single Strand Annealing (SSA)TAS
R-HSA-5693532DNA Double-Strand Break RepairTAS
R-HSA-5693538Homology Directed RepairTAS
R-HSA-5693567HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)TAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-73894DNA RepairTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28968711Spectrum of germline mutations in smokers and non-smokers in Brazilian non-small-cell lung cancer (NSCLC) patients. (2017 Oct 26)Couto PPCarcinogenesis
26013599Functional characterization of RAD52 as a lung cancer susceptibility gene in the 12p13.33 locus. (2016 May)Lieberman RMol Carcinog
27531263[Genetic variation in DNA repair gene RAD52 is associated with the response to platinum-based chemotherapy in SCLC patients]. (2016 Jul)Li HMZhonghua Zhong Liu Za Zhi
18449888Variants in DNA double-strand break repair and DNA damage-response genes and susceptibility to lung and head and neck cancers. (2008 Jul 15)Danoy PInt J Cancer
22382497Lung cancer and DNA repair genes: multilevel association analysis from the International Lung Cancer Consortium. (2012 May)Kazma RCarcinogenesis
22585858Inherited variation at chromosome 12p13.33, including RAD52, influences the risk of squamous cell lung carcinoma. (2012 Feb)Shi JCancer Discov