Gene: RAG1

5896
RAG-1|RNF74
recombination activating 1
protein-coding
11p12
Ensembl:ENSG00000166349 MIM:179615 Vega:OTTHUMG00000166392 UniprotKB:P15918
NG_007528.1
PubMed
0   ANCO-SNPs
CD|ND
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.070e-2 (AD)  2.540e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
WNT5A0.615
TMEM87B0.573
SOCS60.571
MBD20.57
PTBP30.569
CEP1200.567
SNAI20.565
EML40.562
RAB11FIP10.551
TWISTNB0.55

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NTSR2-0.325
LFNG-0.311
NXNL1-0.293
TLCD1-0.292
SLC7A10-0.278
PPP1R3C-0.274
BTBD17-0.274
MMD2-0.272
PPP1R3G-0.272
RLBP1-0.27

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of RAG1 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of RAG1 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of RAG1 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of RAG1 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of RAG1 mRNA"25510870
C5830744,4'-hexafluorisopropylidene diphenol"4,4'-hexafluorisopropylidene diphenol results in increased expression of RAG1 mRNA"27567155
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RAG1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RAG1 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of RAG1 gene27153756
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of RAG1 mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of RAG1 mRNA16483693
D001554BenzeneBenzene results in decreased expression of RAG1 mRNA15120971|1512265
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in decreased expression of RAG1 mRNA28806546
C543008bis(4-hydroxyphenyl)sulfone[Pam(3)CSK(4) peptide co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of RAG1 mRNA28806546
C543008bis(4-hydroxyphenyl)sulfone[Poly I-C co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of RAG1 mRNA28806546
C006780bisphenol Abisphenol A results in decreased expression of RAG1 mRNA28806546
C006780bisphenol A[Pam(3)CSK(4) peptide co-treated with bisphenol A] results in decreased expression of RAG1 mRNA28806546
C006780bisphenol Abisphenol A affects the methylation of RAG1 promoter27334623
C006780bisphenol Abisphenol A results in decreased expression of RAG1 mRNA25181051
C000611646bisphenol Fbisphenol F results in decreased expression of RAG1 mRNA28806546
C000611646bisphenol F[Pam(3)CSK(4) peptide co-treated with bisphenol F] results in decreased expression of RAG1 mRNA28806546
C000611646bisphenol F[Poly I-C co-treated with bisphenol F] results in decreased expression of RAG1 mRNA28806546
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of RAG1 mRNA18214934
D002994ClofibrateClofibrate results in decreased expression of RAG1 mRNA17585979
D003520CyclophosphamideCyclophosphamide results in decreased expression of RAG1 mRNA21041162
C014347decitabinedecitabine results in increased expression of RAG1 mRNA21856257
D003907DexamethasoneDexamethasone results in decreased expression of RAG1 mRNA12782123
D003907DexamethasoneDexamethasone results in decreased expression of RAG1 mRNA21041162
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of RAG1 mRNA21041162
D002117CalcitriolCalcitriol results in increased expression of RAG1 mRNA16002434
D0151279,10-Dimethyl-1,2-benzanthracene"[CYP1B1 protein affects the susceptibility to 9,10-Dimethyl-1,2-benzanthracene] which affects the expression of RAG1 mRNA"27891153
D004642EmodinEmodin results in decreased expression of RAG1 mRNA15612046
C015854estradiol valerateestradiol valerate results in decreased expression of RAG1 mRNA8010988
C008261lead acetatelead acetate results in decreased expression of RAG1 mRNA22609695
D009151Mustard GasMustard Gas results in increased expression of RAG1 mRNA15674843
D0150581-NaphthylisothiocyanateRAG1 gene mutant form inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of ALPL protein]28049044
D0150581-NaphthylisothiocyanateRAG1 gene mutant form inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of COL1A1 mRNA]28049044
D0150581-NaphthylisothiocyanateRAG1 gene mutant form inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of ITGB6 mRNA]28049044
D0150581-NaphthylisothiocyanateRAG1 gene mutant form inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of TGFB2 mRNA]28049044
D0150581-NaphthylisothiocyanateRAG1 gene mutant form results in decreased susceptibility to 1-Naphthylisothiocyanate28049044
C508075Pam(3)CSK(4) peptide[Pam(3)CSK(4) peptide co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of RAG1 mRNA28806546
C508075Pam(3)CSK(4) peptide[Pam(3)CSK(4) peptide co-treated with bisphenol A] results in decreased expression of RAG1 mRNA28806546
C508075Pam(3)CSK(4) peptide[Pam(3)CSK(4) peptide co-treated with bisphenol F] results in decreased expression of RAG1 mRNA28806546
D052638Particulate MatterRAG1 results in increased susceptibility to Particulate Matter20061214
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of RAG1 mRNA"25510870
D011070Poly I-C[Poly I-C co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of RAG1 mRNA28806546
D011070Poly I-C[Poly I-C co-treated with bisphenol F] results in decreased expression of RAG1 mRNA28806546
C043680ptaquiloside[ptaquiloside co-treated with Sodium Selenite] results in decreased expression of RAG1 mRNA23274088
C043680ptaquilosideptaquiloside results in decreased expression of RAG1 mRNA23274088
D015125OxyquinolineOxyquinoline results in decreased expression of RAG1 mRNA15612046
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of RAG1 mRNA25895662
D012834SilverSilver results in decreased expression of RAG1 mRNA27131904
D018038Sodium Selenite[ptaquiloside co-treated with Sodium Selenite] results in decreased expression of RAG1 mRNA23274088
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of RAG1 mRNA16102516|8122269
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of RAG1 mRNA25680692
C012589trichostatin Atrichostatin A results in increased expression of RAG1 mRNA24935251|2627250
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RAG1 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased methylation of RAG1 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of RAG1 mRNA23179753|2352703
D001335Vehicle EmissionsVehicle Emissions affects the methylation of RAG1 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003677DNA binding-TAS9630231  
GO:0004519endonuclease activity-ISS-  
GO:0004842ubiquitin-protein transferase activity-ISS-  
GO:0005515protein binding-IPI8052633  17474147  
GO:0008270zinc ion binding-ISS-  
GO:0042393histone binding-ISS-  
GO:0042803protein homodimerization activity-ISS-  
GO:0043565sequence-specific DNA binding-ISS-  
GO:0046872metal ion binding-ISS-  
GO:0061630ubiquitin protein ligase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0002250adaptive immune response-IEA-  
GO:0002331pre-B cell allelic exclusion-ISS-  
GO:0006310DNA recombination-TAS9630231  
GO:0006955immune response-TAS9630231  
GO:0008542visual learning-IEA-  
GO:0010390histone monoubiquitination-ISS-  
GO:0030183B cell differentiation-ISS-  
GO:0033077T cell differentiation in thymus-ISS-  
GO:0033151V(D)J recombination-IMP14670978  
GO:0033151V(D)J recombination-ISS-  
GO:0043029T cell homeostasis-IEA-  
GO:0043154negative regulation of cysteine-type endopeptidase activity involved in apoptotic process-IEA-  
GO:0045582positive regulation of T cell differentiation-IEA-  
GO:0048538thymus development-IEA-  
GO:0051865protein autoubiquitination-ISS-  
GO:0070244negative regulation of thymocyte apoptotic process-IEA-  
GO:0090305nucleic acid phosphodiester bond hydrolysis-IEA-  
GO:2000822regulation of behavioral fear response-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-ISS-  
GO:0005654nucleoplasm-TAS-  
KEGG ID KEGG Term
hsa05340Primary immunodeficiency
Reactome ID Reactome Term Evidence
R-HSA-1266695Interleukin-7 signalingIEA
R-HSA-1280215Cytokine Signaling in Immune systemIEA
R-HSA-162582Signal TransductionTAS
R-HSA-168256Immune SystemIEA
R-HSA-449147Signaling by InterleukinsIEA
R-HSA-5683057MAPK family signaling cascadesTAS
R-HSA-5687128MAPK6/MAPK4 signalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27526110Systemic chromosome instability in Shugoshin-1 mice resulted in compromised glutathione pathway, activation of Wnt signaling and defects in immune system in the lung. (2016 Aug 15)Yamada HYOncogenesis
20489056Hypomorphic Rag mutations can cause destructive midline granulomatous disease. (2010 Aug 26)De Ravin SSBlood
16465622Bladder cancer predisposition: a multigenic approach to DNA-repair and cell-cycle-control genes. (2006 Mar)Wu XAm J Hum Genet
23663450Genetic polymorphisms of DNA double-strand break repair pathway genes and glioma susceptibility. (2013 May 10)Zhao PBMC Cancer