Gene: RAG2

5897
RAG-2
recombination activating 2
protein-coding
11p12
Ensembl:ENSG00000175097 MIM:179616 Vega:OTTHUMG00000166393 UniprotKB:P55895
NG_007573.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.914e-2 (AD)  2.500e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ZC3HAV1L0.439
OR51F20.431
ADAMTS200.422
SLC16A60.422
SLC35G10.42
LGI20.417
OR52E40.417
AMOTL10.413
C7orf330.404
C1orf1270.403

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HHATL-0.28
SLC25A48-0.277
NPIPB6-0.276
KLF15-0.274
HPR-0.265
KIAA1755-0.263
NWD1-0.257
RFTN2-0.256
SMOX-0.252
HES6-0.25

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of RAG2 mRNA"25614096
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of RAG2 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of RAG2 mRNA16483693
D039741Antigens, Dermatophagoides"RAG2 protein affects the reaction [[Particulate Matter co-treated with Antigens, Dermatophagoides] results in increased expression of IL13 protein]"27315767
D039741Antigens, Dermatophagoides"RAG2 protein affects the reaction [[Particulate Matter co-treated with Antigens, Dermatophagoides] results in increased expression of IL5 protein]"27315767
D039741Antigens, Dermatophagoides"RAG2 protein affects the reaction [[Vehicle Emissions co-treated with Antigens, Dermatophagoides] results in increased expression of IL13 protein]"27315767
D039741Antigens, Dermatophagoides"RAG2 protein affects the reaction [[Vehicle Emissions co-treated with Antigens, Dermatophagoides] results in increased expression of IL5 protein]"27315767
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of RAG2 mRNA24449571
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in decreased expression of RAG2 mRNA28806546
C543008bis(4-hydroxyphenyl)sulfone[Pam(3)CSK(4) peptide co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of RAG2 mRNA28806546
C543008bis(4-hydroxyphenyl)sulfone[Poly I-C co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of RAG2 mRNA28806546
C006780bisphenol Abisphenol A results in decreased expression of RAG2 mRNA28806546
C006780bisphenol A[Pam(3)CSK(4) peptide co-treated with bisphenol A] results in decreased expression of RAG2 mRNA28806546
C006780bisphenol A[Poly I-C co-treated with bisphenol A] results in decreased expression of RAG2 mRNA28806546
C006780bisphenol Abisphenol A results in increased methylation of RAG2 promoter27312807
C006780bisphenol Abisphenol A affects the expression of RAG2 mRNA21786754
C000611646bisphenol Fbisphenol F results in decreased expression of RAG2 mRNA28806546
C000611646bisphenol F[Pam(3)CSK(4) peptide co-treated with bisphenol F] results in decreased expression of RAG2 mRNA28806546
C000611646bisphenol F[Poly I-C co-treated with bisphenol F] results in decreased expression of RAG2 mRNA28806546
C025191bromodichloromethane[PRF1 protein co-treated with RAG2 protein] affects the reaction [[bromodichloromethane co-treated with Dietary Fats] results in increased expression of CASP3 protein modified form]24211274
C025191bromodichloromethane[PRF1 protein co-treated with RAG2 protein] affects the reaction [[bromodichloromethane co-treated with Dietary Fats] results in increased expression of IL2 mRNA]24211274
C025191bromodichloromethane[PRF1 protein co-treated with RAG2 protein] affects the susceptibility to [bromodichloromethane co-treated with Dietary Fats]24211274
D003300CopperCopper deficiency results in increased expression of RAG2 mRNA26033743
C017160cypermethrincypermethrin results in increased expression of RAG2 mRNA21142847
D004041Dietary Fats[PRF1 protein co-treated with RAG2 protein] affects the reaction [[bromodichloromethane co-treated with Dietary Fats] results in increased expression of CASP3 protein modified form]24211274
D004041Dietary Fats[PRF1 protein co-treated with RAG2 protein] affects the reaction [[bromodichloromethane co-treated with Dietary Fats] results in increased expression of IL2 mRNA]24211274
D004041Dietary Fats[PRF1 protein co-treated with RAG2 protein] affects the susceptibility to [bromodichloromethane co-treated with Dietary Fats]24211274
D019422Dietary SucroseDietary Sucrose results in increased expression of RAG2 mRNA26033743
D000068877Imatinib MesylateCDK6 protein inhibits the reaction [Imatinib Mesylate results in increased expression of RAG2 mRNA]21536647
D000068877Imatinib MesylateImatinib Mesylate results in increased expression of RAG2 mRNA21536647
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of RAG2 mRNA22802445
C008261lead acetatelead acetate results in increased expression of RAG2 mRNA20542052
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of RAG2 mRNA12057914
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of RAG2 mRNA26011545
C017096n-butoxyethanoln-butoxyethanol results in decreased expression of RAG2 mRNA19812364
C508075Pam(3)CSK(4) peptide[Pam(3)CSK(4) peptide co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of RAG2 mRNA28806546
C508075Pam(3)CSK(4) peptide[Pam(3)CSK(4) peptide co-treated with bisphenol A] results in decreased expression of RAG2 mRNA28806546
C508075Pam(3)CSK(4) peptide[Pam(3)CSK(4) peptide co-treated with bisphenol F] results in decreased expression of RAG2 mRNA28806546
D052638Particulate Matter"RAG2 protein affects the reaction [[Particulate Matter co-treated with Antigens, Dermatophagoides] results in increased expression of IL13 protein]"27315767
D052638Particulate Matter"RAG2 protein affects the reaction [[Particulate Matter co-treated with Antigens, Dermatophagoides] results in increased expression of IL5 protein]"27315767
D016226Phosphorus, Dietary"Phosphorus, Dietary affects the expression of RAG2 mRNA"17651324
D011070Poly I-C[Poly I-C co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of RAG2 mRNA28806546
D011070Poly I-C[Poly I-C co-treated with bisphenol A] results in decreased expression of RAG2 mRNA28806546
D011070Poly I-C[Poly I-C co-treated with bisphenol F] results in decreased expression of RAG2 mRNA28806546
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of RAG2 mRNA26377647
D001335Vehicle Emissions"RAG2 protein affects the reaction [[Vehicle Emissions co-treated with Antigens, Dermatophagoides] results in increased expression of IL13 protein]"27315767
D001335Vehicle Emissions"RAG2 protein affects the reaction [[Vehicle Emissions co-treated with Antigens, Dermatophagoides] results in increased expression of IL5 protein]"27315767

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003677DNA binding-IEA-  
GO:0003682chromatin binding-ISS-  
GO:0005546phosphatidylinositol-4,5-bisphosphate binding-ISS-  
GO:0005547phosphatidylinositol-3,4,5-trisphosphate binding-ISS-  
GO:0008270zinc ion binding-ISS-  
GO:0035064methylated histone binding-ISS-  
GO:0035091phosphatidylinositol binding-ISS-  
GO:0043325phosphatidylinositol-3,4-bisphosphate binding-ISS-  
GO:0043565sequence-specific DNA binding-IBA21873635  
GO:0061630ubiquitin protein ligase activity-IEA-  
GO:0080025phosphatidylinositol-3,5-bisphosphate binding-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0002326B cell lineage commitment-IEA-  
GO:0002331pre-B cell allelic exclusion-ISS-  
GO:0002358B cell homeostatic proliferation-IEA-  
GO:0002360T cell lineage commitment-IEA-  
GO:0006325chromatin organization-IEA-  
GO:0016567protein ubiquitination-IEA-  
GO:0030183B cell differentiation-ISS-  
GO:0033077T cell differentiation in thymus-ISS-  
GO:0033151V(D)J recombination-IBA21873635  
GO:0033151V(D)J recombination-ISS-  
GO:0042742defense response to bacterium-IEA-  
GO:0046622positive regulation of organ growth-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-TAS-  
GO:0097519DNA recombinase complex-IBA21873635  
KEGG ID KEGG Term
hsa05340Primary immunodeficiency
Reactome ID Reactome Term Evidence
R-HSA-1266695Interleukin-7 signalingIEA
R-HSA-1280215Cytokine Signaling in Immune systemIEA
R-HSA-162582Signal TransductionTAS
R-HSA-168256Immune SystemIEA
R-HSA-449147Signaling by InterleukinsIEA
R-HSA-5683057MAPK family signaling cascadesTAS
R-HSA-5687128MAPK6/MAPK4 signalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
17202355Cigarette smoke impairs NK cell-dependent tumor immune surveillance. (2007 Jan 15)Lu LMJ Immunol