Gene: RALA

5898
RAL
RAS like proto-oncogene A
protein-coding
7p14.1
Ensembl:ENSG00000006451 MIM:179550 Vega:OTTHUMG00000128775 UniprotKB:P11233
NC_000007.14
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.633e-1 (AD)  5.661e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg09325711chr7:39662764RALA6.100e-11Smoking27651444
cg20322193chr7:39664614RALA7.700e-9Smoking27651444
cg20322193chr7:39664614RALA3.830e-9Smoking28686328
cg20842915chr7:39665132RALA2.960e-8Smoking28686328

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
VPS26A0.916
RAD210.912
YWHAQ0.91
SERBP10.908
SET0.906
RAC10.901
ENOPH10.899
HTATSF10.895
CSDE10.895
CBX30.892

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.799
OR4F5-0.784
OR52H1-0.226
PRDM14-0.215
GPR87-0.213
PRAMEF17-0.211
MROH9-0.205
OR10K1-0.205
IFNK-0.204
POU5F2-0.204

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB04315Guanosine-5'-DiphosphateSmall Molecule146-91-8ExperimentalTarget
ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of RALA mRNA"19114083
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of RALA mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of RALA mRNA"21346803
C0299552-nitrotoluene2-nitrotoluene results in decreased expression of RALA mRNA16460773
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of RALA mRNA"18648102
D020106AcrylamideAcrylamide results in decreased expression of RALA mRNA28959563
D000643Ammonium ChlorideAmmonium Chloride affects the expression of RALA mRNA16483693
D000728AndrogensAndrogens affects the activity of RALA protein16964283
D000728AndrogensAndrogens affects the reaction [RALA protein affects the expression of VEGFC mRNA]16964283
D000728AndrogensAndrogens affects the reaction [Reactive Oxygen Species results in increased activity of RALA protein]16964283
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of RALA mRNA24449571
C006632arsenic trioxidearsenic trioxide results in increased expression of RALA mRNA20458559
C006632arsenic trioxideRALA protein results in decreased susceptibility to arsenic trioxide22330069
D001280AtrazineAtrazine results in decreased expression of RALA mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of RALA mRNA20064835|2623829
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of RALA mRNA"19150397|2623829
D004958EstradiolEstradiol results in increased expression of RALA mRNA21795739
C044887beta-methylcholinebeta-methylcholine affects the expression of RALA mRNA21179406
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of RALA mRNA28628672
C006780bisphenol Abisphenol A affects the expression of RALA mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of RALA mRNA25181051
D000069286BortezomibBortezomib results in increased expression of RALA mRNA20977926
C099813bromochloroacetic acidbromochloroacetic acid results in decreased expression of RALA mRNA16460773
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of RALA mRNA15336504
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of RALA protein26220685
D002713Chlorine[Ozone co-treated with Chlorine] affects the expression of RALA mRNA18636392
C100187chloropicrinchloropicrin results in increased expression of RALA mRNA26352163
D002994ClofibrateClofibrate results in increased expression of RALA mRNA17585979
C018021cobaltous chloridecobaltous chloride results in decreased expression of RALA mRNA19320972
D019327Copper SulfateCopper Sulfate results in decreased expression of RALA mRNA19549813
D003471CuprizoneCuprizone results in decreased expression of RALA mRNA26577399
D016572CyclosporineCyclosporine results in increased expression of RALA mRNA20106945
D003703DemecolcineDemecolcine results in increased expression of RALA mRNA23649840
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of RALA mRNA28628672
D003976DiazinonDiazinon results in increased methylation of RALA gene22964155
D004041Dietary FatsDietary Fats results in increased expression of RALA mRNA19030233
C024629dimethyl phthalatedimethyl phthalate affects the expression of RALA mRNA26924002
D004317Doxorubicin[[MT1 protein co-treated with MT2 protein] affects the susceptibility to Doxorubicin] which affects the expression of RALA mRNA21040762
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RALA mRNA17942748
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of RALA mRNA23649840
D018120FinasterideFinasteride results in increased expression of RALA mRNA24136188
D005485FlutamideFlutamide results in increased expression of RALA mRNA24136188
D005557FormaldehydeFormaldehyde results in increased expression of RALA mRNA23649840
D006220HaloperidolHaloperidol results in increased expression of RALA mRNA15860345
C062018HU 211RALA affects the reaction [HU 211 results in increased phosphorylation of SRC protein]16046413
D006861Hydrogen PeroxideHydrogen Peroxide results in increased activity of RALA protein15538382
D006861Hydrogen Peroxide[Hydrogen Peroxide results in increased activity of RALA protein] which results in increased phosphorylation of and results in increased activity of and affects the localization of FOXO4 protein15538382
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of RALA mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of RALA mRNA28628672
C410337K 7174K 7174 results in increased expression of RALA mRNA24086573
D007657Ketone BodiesKetone Bodies results in decreased expression of RALA mRNA15469884
D001556LindaneLindane results in increased expression of RALA mRNA17785943
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of RALA mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of RALA mRNA23649840
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of RALA protein26558463
C517284monomethyl phthalatemonomethyl phthalate affects the expression of RALA mRNA26924002
D009532NickelNickel results in increased expression of RALA mRNA25583101
D010126Ozone[Ozone co-treated with Chlorine] affects the expression of RALA mRNA18636392
D010126OzoneOzone results in decreased expression of RALA mRNA16330353
C570200P61-E7 compoundP61-E7 compound affects the localization of RALA protein22028818
C570200P61-E7 compoundP61-E7 compound affects the localization of RALA protein22028818
D010416PentachlorophenolPentachlorophenol results in increased expression of RALA mRNA23892564
C006253pirinixic acidpirinixic acid results in increased expression of RALA mRNA19162173
D011794QuercetinQuercetin results in decreased expression of RALA mRNA15309432
D017382Reactive Oxygen SpeciesAndrogens affects the reaction [Reactive Oxygen Species results in increased activity of RALA protein]16964283
D017382Reactive Oxygen SpeciesReactive Oxygen Species results in increased activity of RALA protein16964283
C541923sandostatinLARsandostatinLAR results in increased expression of RALA mRNA17210224
C017947sodium arsenitesodium arsenite affects the expression of RALA mRNA29319823
D012999SomanSoman results in decreased expression of RALA mRNA19281266
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of RALA mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RALA mRNA17942748
D014241TrichloroethyleneTrichloroethylene results in increased expression of RALA mRNA19448997
D014635Valproic AcidValproic Acid results in increased expression of RALA mRNA23179753|2800136
C088658zoledronic acidzoledronic acid results in increased expression of RALA protein28871336

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003924GTPase activity-IEA-  
GO:0005515protein binding-IPI7673236  10051605  12839989  16291724  17540176  19306925  
21241894  24056301  25241761  28851898  
GO:0005525GTP binding-IDA24056301  
GO:0017022myosin binding-IPI24056301  
GO:0019003GDP binding-IDA24056301  
GO:0031625ubiquitin protein ligase binding-IPI24056301  
GO:0031755Edg-2 lysophosphatidic acid receptor binding-IDA19306925  
GO:0051117ATPase binding-IPI24056301  
GO ID GO Term Qualifier Evidence PubMed
GO:0001843neural tube closure-IEA-  
GO:0006887exocytosis-IEA-  
GO:0006935chemotaxis-TAS10848592  
GO:0007049cell cycle-IEA-  
GO:0007165signal transduction-TAS2550440  10848592  
GO:0007265Ras protein signal transduction-IEA-  
GO:0016032viral process-IEA-  
GO:0017157regulation of exocytosis-IDA20005108  
GO:0031532actin cytoskeleton reorganization-IDA10051605  
GO:0035722interleukin-12-mediated signaling pathway-TAS-  
GO:0051301cell division-IEA-  
GO:0051491positive regulation of filopodium assembly-IDA10051605  
GO:0051665membrane raft localization-IDA20005108  
GO:0061024membrane organization-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IDA17875936  
GO:0005925focal adhesion-HDA21423176  
GO:0009986cell surface-IDA19306925  
GO:0030139endocytic vesiclecolocalizes_withIDA19306925  
GO:0030659cytoplasmic vesicle membrane-TAS-  
GO:0032154cleavage furrow-IDA18756269  
GO:0043209myelin sheath-IEA-  
GO:0070062extracellular exosome-HDA19056867  19199708  20458337  23533145  
GO:0090543Flemming body-IEA-  
KEGG ID KEGG Term
hsa05200Pathways in cancer
hsa05212Pancreatic cancer
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-1445148Translocation of GLUT4 to the plasma membraneIEA
R-HSA-1445148Translocation of GLUT4 to the plasma membraneTAS
R-HSA-162582Signal TransductionIEA
R-HSA-166520Signaling by NTRKsIEA
R-HSA-167044Signalling to RASIEA
R-HSA-168256Immune SystemTAS
R-HSA-171007p38MAPK eventsIEA
R-HSA-187037Signaling by NTRK1 (TRKA)IEA
R-HSA-187687Signalling to ERKsIEA
R-HSA-199991Membrane TraffickingIEA
R-HSA-199991Membrane TraffickingTAS
R-HSA-447115Interleukin-12 family signalingTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-5653656Vesicle-mediated transportIEA
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-8950505Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulationTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesIEA
R-HSA-9020591Interleukin-12 signalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24863005KRAS oncogene substitutions in Korean NSCLC patients: clinical implication and relationship with pAKT and RalGTPases expression. (2014 Aug)Kim EYLung Cancer