Gene: IL22RA1

58985
CRF2-9|IL22R|IL22R1
interleukin 22 receptor subunit alpha 1
protein-coding
1p36.11
Ensembl:ENSG00000142677 MIM:605457 Vega:OTTHUMG00000003041 UniprotKB:Q8N6P7
NC_000001.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.771e-1 (AD)  7.055e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
BMX0.669
TNFAIP80.649
BMP50.64
GIPC20.636
TRABD2B0.636
GPX80.633
TRIM60.627
GATA60.622
CD960.618
IRF60.617

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GREB1-0.374
FEZF2-0.345
FUT9-0.343
ZNF835-0.337
TRPM3-0.337
CHRNA4-0.333
SDK2-0.326
PLEKHA6-0.323
FOXRED2-0.32
FRMPD1-0.317

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of IL22RA1 mRNA"28903501
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in decreased expression of IL22RA1 mRNA28329830
D000082AcetaminophenAcetaminophen results in decreased expression of IL22RA1 mRNA29067470
D016604Aflatoxin B1Aflatoxin B1 affects the expression of IL22RA1 protein20106945
C006632arsenic trioxidearsenic trioxide results in increased expression of IL22RA1 mRNA22521957
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of IL22RA1 mRNA19152381
D001564Benzo(a)pyrenechlorophyllin inhibits the reaction [Benzo(a)pyrene results in increased expression of IL22RA1 mRNA]19152381
C006780bisphenol Abisphenol A results in decreased methylation of IL22RA1 promoter27312807
C006780bisphenol Abisphenol A results in decreased expression of IL22RA1 mRNA25181051
C007020chlorophyllinchlorophyllin inhibits the reaction [Benzo(a)pyrene results in increased expression of IL22RA1 mRNA]19152381
D003300CopperCopper deficiency results in increased expression of IL22RA1 mRNA26033743
D019327Copper SulfateCopper Sulfate results in decreased expression of IL22RA1 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of IL22RA1 mRNA20106945|2556210
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased expression of IL22RA1 mRNA28962523
D019422Dietary SucroseDietary Sucrose results in increased expression of IL22RA1 mRNA26033743
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in decreased expression of IL22RA1 mRNA28329830
C007738fluoranthenefluoranthene results in decreased expression of IL22RA1 mRNA28329830
D005485FlutamideFlutamide results in decreased expression of IL22RA1 mRNA24793618
D005557FormaldehydeFormaldehyde results in increased expression of IL22RA1 mRNA23649840
C069837fullerene C60fullerene C60 results in decreased expression of IL22RA1 mRNA19167457
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of IL22RA1 mRNA27432991
C011890kojic acidkojic acid results in increased expression of IL22RA1 mRNA16595896
D008627Mercuric ChlorideMercuric Chloride results in increased expression of IL22RA1 mRNA18496552
D008727MethotrexateMethotrexate results in increased expression of IL22RA1 mRNA21678067
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of IL22RA1 mRNA23649840
C028007nickel monoxidenickel monoxide results in decreased expression of IL22RA1 mRNA19167457
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of IL22RA1 mRNA28903501
D011794QuercetinQuercetin results in decreased expression of IL22RA1 mRNA21632981
C089730rosiglitazonerosiglitazone results in decreased expression of IL22RA1 mRNA25572481
D012524SarinSarin results in increased expression of IL22RA1 mRNA19522546
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of IL22RA1 mRNA23806026
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of IL22RA1 mRNA20106945
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of IL22RA1 mRNA23152189
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of IL22RA1 mRNA21570461|2892240
D014635Valproic AcidValproic Acid results in increased methylation of IL22RA1 gene29154799
D001335Vehicle EmissionsVehicle Emissions affects the methylation of IL22RA1 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004896cytokine receptor activity-IBA21873635  
GO:0004904interferon receptor activity-TAS10875937  
GO:0005515protein binding-IPI12513909  15120653  18599299  18675809  20462497  
GO:0042015interleukin-20 binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0008150biological_process-ND-  
GO:0019221cytokine-mediated signaling pathway-IBA21873635  
GO:0019221cytokine-mediated signaling pathway-TAS-  
GO:0050829defense response to Gram-negative bacterium-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-TAS-  
GO:0016021integral component of membrane-IBA21873635  
KEGG ID KEGG Term
hsa04060Cytokine-cytokine receptor interaction
hsa04630Jak-STAT signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-168256Immune SystemTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-8854691Interleukin-20 family signalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27769811Aryl Hydrocarbon Receptor Ligands in Cigarette Smoke Induce Production of Interleukin-22 to Promote Pancreatic Fibrosis in Models of Chronic Pancreatitis. (2016 Dec)Xue JGastroenterology