Gene: RALB

5899
-
RAS like proto-oncogene B
protein-coding
2q14.2
Ensembl:ENSG00000144118 MIM:179551 Vega:OTTHUMG00000131435 UniprotKB:P11234
NC_000002.12
PubMed|SNP Mapped
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.685e-1 (AD)  5.999e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs3931840chr2:120283771 (GRCh38.p7)A>Calcohol dependenceSNV(Single Nucleotide Variation)
rs1370379chr2:120257013 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs3980213chr2:120247403 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg11305121chr2:121011590RALB4.900e-11Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CHP10.933
TMEM183A0.916
SH3KBP10.915
PITPNA0.915
DSTN0.914
GNB10.91
TPGS20.91
DUSP30.91
PFN20.91
ACTR20.91

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.666
OR4F29-0.64
S100A12-0.341
OLAH-0.332
HVCN1-0.321
VNN3-0.317
TGIF1-0.295
S100A8-0.293
FXYD3-0.291
CSAG1-0.285

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of RALB mRNA"19114083
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of RALB mRNA"15215175
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RALB mRNA"15215175
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of RALB mRNA"20959002
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RALB mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RALB mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RALB mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RALB mRNA"27188386
D000643Ammonium ChlorideAmmonium Chloride affects the expression of RALB mRNA16483693
D001241AspirinAspirin results in decreased expression of RALB mRNA11906190
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of RALB mRNA26238291
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of RALB mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of RALB mRNA22228805
C006780bisphenol Abisphenol A results in decreased expression of RALB mRNA12075121
C006780bisphenol Abisphenol A results in increased expression of RALB mRNA25181051
D001761BleomycinBleomycin results in increased expression of RALB protein25933445
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of RALB mRNA27339419
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of RALB mRNA17032414
C100187chloropicrinchloropicrin results in increased expression of RALB mRNA26352163
D019327Copper SulfateCopper Sulfate results in increased expression of RALB mRNA19549813
C057862cyanoginosin LRcyanoginosin LR results in increased expression of RALB mRNA17654400
D016572CyclosporineCyclosporine results in increased expression of RALB mRNA25562108
C014347decitabinedecitabine affects the expression of RALB mRNA23300844
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of RALB mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of RALB mRNA21266533
D002945CisplatinCisplatin affects the expression of RALB mRNA23300844
D002945CisplatinRALB protein results in decreased susceptibility to Cisplatin16734730
D004041Dietary FatsDietary Fats results in increased expression of RALB mRNA18042831
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of RALB mRNA17032414
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of RALB mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RALB mRNA17942748
D005839GentamicinsGentamicins results in increased expression of RALB mRNA22061828
D005897GlafenineGlafenine results in increased expression of RALB mRNA24136188
D006220HaloperidolHaloperidol results in increased expression of RALB mRNA15860345
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of RALB mRNA23086925
C410337K 7174K 7174 results in increased expression of RALB mRNA24086573
C029938nickel sulfatenickel sulfate results in decreased expression of RALB mRNA16780908
C029938nickel sulfatenickel sulfate results in increased expression of RALB mRNA16780908
C108709oleoyl-estroneoleoyl-estrone results in increased expression of RALB mRNA17725831
D010100OxygenOxygen deficiency results in decreased expression of RALB mRNA24205000
D000073878Palm OilPalm Oil results in increased expression of RALB mRNA18042831
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of RALB protein26178269
D010936Plant ExtractsPlant Extracts results in increased expression of RALB mRNA23557933
D011794QuercetinQuercetin results in increased expression of RALB mRNA21632981
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of RALB mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of RALB mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RALB mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of RALB mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of RALB mRNA16054898|2095900
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RALB mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of RALB mRNA15901671
D014635Valproic AcidValproic Acid affects the expression of RALB mRNA17292431
D014635Valproic AcidValproic Acid results in increased expression of RALB mRNA15901671
C029297vinylidene chloridevinylidene chloride results in increased expression of RALB mRNA26682919
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RALB mRNA"27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003924GTPase activity-IDA19166349  
GO:0005515protein binding-IPI7673236  19166349  24056301  27173435  
GO:0005525GTP binding-IDA19166349  
GO:0005525GTP binding-IMP24056301  
GO:0019003GDP binding-IDA24056301  
GO:0031625ubiquitin protein ligase binding-IPI24056301  
GO:0051117ATPase binding-IPI24056301  
GO ID GO Term Qualifier Evidence PubMed
GO:0001928regulation of exocyst assembly-ISS-  
GO:0001934positive regulation of protein phosphorylation-IMP24056301  
GO:0006915apoptotic process-IEA-  
GO:0007049cell cycle-IEA-  
GO:0007165signal transduction-TAS2120779  
GO:0007265Ras protein signal transduction-IEA-  
GO:0009267cellular response to starvation-IDA24056301  
GO:0032091negative regulation of protein binding-IMP24056301  
GO:0032092positive regulation of protein binding-IMP24056301  
GO:0051301cell division-IEA-  
GO:0060178regulation of exocyst localization-ISS-  
GO:0071360cellular response to exogenous dsRNA-IMP24056301  
GO:0071902positive regulation of protein serine/threonine kinase activity-IMP24056301  
GO:2000786positive regulation of autophagosome assembly-IMP24056301  
GO ID GO Term Qualifier Evidence PubMed
GO:0000145exocystcolocalizes_withIDA24056301  
GO:0005776autophagosomecolocalizes_withIDA24056301  
GO:0005886plasma membrane-IDA17875936  
GO:0030496midbody-IDA18756269  
GO:0070062extracellular exosome-HDA23533145  
KEGG ID KEGG Term
hsa05200Pathways in cancer
hsa05212Pancreatic cancer
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionIEA
R-HSA-166520Signaling by NTRKsIEA
R-HSA-167044Signalling to RASIEA
R-HSA-171007p38MAPK eventsIEA
R-HSA-187037Signaling by NTRK1 (TRKA)IEA
R-HSA-187687Signalling to ERKsIEA
R-HSA-9006934Signaling by Receptor Tyrosine KinasesIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24863005KRAS oncogene substitutions in Korean NSCLC patients: clinical implication and relationship with pAKT and RalGTPases expression. (2014 Aug)Kim EYLung Cancer