Gene info: ID 5899

Gene: RALB

GENE ID: 5899

Synonyms: -

Description: RAS like proto-oncogene B

Gene type: protein-coding

Location: 2q14.2

dbXrefs: Ensembl:ENSG00000144118 MIM:179551 Vega:OTTHUMG00000131435 UniprotKB:P11234

RefSeq: NC_000002.12

Retrived from: PubMed|SNP Mapped

SNPs: 3 ANCO-SNPs

Phenotype: ND|AD

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 6.685e-1 (AD) 5.999e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs3931840	chr2:120283771 (GRCh38.p7)	A>C	alcohol dependence	SNV(Single Nucleotide Variation)
rs1370379	chr2:120257013 (GRCh38.p7)	C>T	alcohol dependence	SNV(Single Nucleotide Variation)
rs3980213	chr2:120247403 (GRCh38.p7)	A>G	alcohol dependence	SNV(Single Nucleotide Variation)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg11305121	chr2:121011590	RALB		4.900e-11	Smoking	27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
CHP1	0.933
TMEM183A	0.916
SH3KBP1	0.915
PITPNA	0.915
DSTN	0.914
GNB1	0.91
TPGS2	0.91
DUSP3	0.91
PFN2	0.91
ACTR2	0.91

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.666
OR4F29	-0.64
S100A12	-0.341
OLAH	-0.332
HVCN1	-0.321
VNN3	-0.317
TGIF1	-0.295
S100A8	-0.293
FXYD3	-0.291
CSAG1	-0.285

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of RALB mRNA"	19114083
C049584	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine	"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of RALB mRNA"	15215175
C049584	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine	"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RALB mRNA"	15215175
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of RALB mRNA"	20959002
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RALB mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RALB mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RALB mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RALB mRNA"	27188386
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of RALB mRNA	16483693
D001241	Aspirin	Aspirin results in decreased expression of RALB mRNA	11906190
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of RALB mRNA	26238291
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of RALB mRNA	19770486
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of RALB mRNA	22228805
C006780	bisphenol A	bisphenol A results in decreased expression of RALB mRNA	12075121
C006780	bisphenol A	bisphenol A results in increased expression of RALB mRNA	25181051
D001761	Bleomycin	Bleomycin results in increased expression of RALB protein	25933445
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of RALB mRNA	27339419
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of RALB mRNA	17032414
C100187	chloropicrin	chloropicrin results in increased expression of RALB mRNA	26352163
D019327	Copper Sulfate	Copper Sulfate results in increased expression of RALB mRNA	19549813
C057862	cyanoginosin LR	cyanoginosin LR results in increased expression of RALB mRNA	17654400
D016572	Cyclosporine	Cyclosporine results in increased expression of RALB mRNA	25562108
C014347	decitabine	decitabine affects the expression of RALB mRNA	23300844
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of RALB mRNA	21266533
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of RALB mRNA	21266533
D002945	Cisplatin	Cisplatin affects the expression of RALB mRNA	23300844
D002945	Cisplatin	RALB protein results in decreased susceptibility to Cisplatin	16734730
D004041	Dietary Fats	Dietary Fats results in increased expression of RALB mRNA	18042831
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in increased expression of RALB mRNA	17032414
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of RALB mRNA	17942748
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RALB mRNA	17942748
D005839	Gentamicins	Gentamicins results in increased expression of RALB mRNA	22061828
D005897	Glafenine	Glafenine results in increased expression of RALB mRNA	24136188
D006220	Haloperidol	Haloperidol results in increased expression of RALB mRNA	15860345
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of RALB mRNA	23086925
C410337	K 7174	K 7174 results in increased expression of RALB mRNA	24086573
C029938	nickel sulfate	nickel sulfate results in decreased expression of RALB mRNA	16780908
C029938	nickel sulfate	nickel sulfate results in increased expression of RALB mRNA	16780908
C108709	oleoyl-estrone	oleoyl-estrone results in increased expression of RALB mRNA	17725831
D010100	Oxygen	Oxygen deficiency results in decreased expression of RALB mRNA	24205000
D000073878	Palm Oil	Palm Oil results in increased expression of RALB mRNA	18042831
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in decreased expression of RALB protein	26178269
D010936	Plant Extracts	Plant Extracts results in increased expression of RALB mRNA	23557933
D011794	Quercetin	Quercetin results in increased expression of RALB mRNA	21632981
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of RALB mRNA	20106945\|2163298
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of RALB mRNA	21570461
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RALB mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of RALB mRNA	22298810
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of RALB mRNA	16054898\|2095900
C012589	trichostatin A	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RALB mRNA"	27188386
C012589	trichostatin A	trichostatin A results in increased expression of RALB mRNA	15901671
D014635	Valproic Acid	Valproic Acid affects the expression of RALB mRNA	17292431
D014635	Valproic Acid	Valproic Acid results in increased expression of RALB mRNA	15901671
C029297	vinylidene chloride	vinylidene chloride results in increased expression of RALB mRNA	26682919
C111237	vorinostat	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RALB mRNA"	27188386

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003924	GTPase activity	-	IDA	19166349
GO:0005515	protein binding	-	IPI	7673236 19166349 24056301 27173435
GO:0005525	GTP binding	-	IDA	19166349
GO:0005525	GTP binding	-	IMP	24056301
GO:0019003	GDP binding	-	IDA	24056301
GO:0031625	ubiquitin protein ligase binding	-	IPI	24056301
GO:0051117	ATPase binding	-	IPI	24056301

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001928	regulation of exocyst assembly	-	ISS	-
GO:0001934	positive regulation of protein phosphorylation	-	IMP	24056301
GO:0006915	apoptotic process	-	IEA	-
GO:0007049	cell cycle	-	IEA	-
GO:0007165	signal transduction	-	TAS	2120779
GO:0007265	Ras protein signal transduction	-	IEA	-
GO:0009267	cellular response to starvation	-	IDA	24056301
GO:0032091	negative regulation of protein binding	-	IMP	24056301
GO:0032092	positive regulation of protein binding	-	IMP	24056301
GO:0051301	cell division	-	IEA	-
GO:0060178	regulation of exocyst localization	-	ISS	-
GO:0071360	cellular response to exogenous dsRNA	-	IMP	24056301
GO:0071902	positive regulation of protein serine/threonine kinase activity	-	IMP	24056301
GO:2000786	positive regulation of autophagosome assembly	-	IMP	24056301

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000145	exocyst	colocalizes_with	IDA	24056301
GO:0005776	autophagosome	colocalizes_with	IDA	24056301
GO:0005886	plasma membrane	-	IDA	17875936
GO:0030496	midbody	-	IDA	18756269
GO:0070062	extracellular exosome	-	HDA	23533145

KEGG ID	KEGG Term
hsa05200	Pathways in cancer
hsa05212	Pancreatic cancer

Reactome ID	Reactome Term	Evidence
R-HSA-162582	Signal Transduction	IEA
R-HSA-166520	Signaling by NTRKs	IEA
R-HSA-167044	Signalling to RAS	IEA
R-HSA-171007	p38MAPK events	IEA
R-HSA-187037	Signaling by NTRK1 (TRKA)	IEA
R-HSA-187687	Signalling to ERKs	IEA
R-HSA-9006934	Signaling by Receptor Tyrosine Kinases	IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
24863005	KRAS oncogene substitutions in Korean NSCLC patients: clinical implication and relationship with pAKT and RalGTPases expression. (2014 Aug)	Kim EY	Lung Cancer