Gene info: ID 590

Gene: BCHE

GENE ID: 590

Synonyms: BCHED|CHE1|CHE2|E1

Description: butyrylcholinesterase

Gene type: protein-coding

Location: 3q26.1

dbXrefs: Ensembl:ENSG00000114200 MIM:177400 Vega:OTTHUMG00000158131 UniprotKB:P06276

RefSeq: NG_009031.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: CD|ND|AD

# Publications: 40

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 7.251e-1 (AD) 6.221e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
LHFPL3	0.805
PDGFRA	0.774
LUZP2	0.739
SEMA5A	0.729
PCDH15	0.716
STK32A	0.677
BLM	0.671
TGFA	0.633
KLRC3	0.629
VCAN	0.629

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ALOXE3	-0.414
HES7	-0.357
FAM83D	-0.35
SHROOM3	-0.338
SLC25A47	-0.326
CASZ1	-0.319
GRB7	-0.317
TDRG1	-0.316
BAAT	-0.312
PNLDC1	-0.311

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00122	Choline	Small Molecule	62-49-7	Approved\|Nutraceutical	Target
DB00382	Tacrine	Small Molecule	321-64-2	Investigational\|Withdrawn	Target
DB00449	Dipivefrin	Small Molecule	52365-63-6	Approved	Target
DB00545	Pyridostigmine	Small Molecule	155-97-5	Approved\|Investigational	Target
DB00674	Galantamine	Small Molecule	357-70-0	Approved	Target
DB00677	Isoflurophate	Small Molecule	55-91-4	Approved\|Investigational\|Withdrawn	Target
DB00733	Pralidoxime	Small Molecule	6735-59-7	Approved	Target
DB00772	Malathion	Small Molecule	121-75-5	Approved\|Investigational	Target
DB00863	Ranitidine	Small Molecule	66357-35-5	Approved	Target
DB00941	Hexafluronium	Small Molecule	4844-10-4	Approved	Target
DB00944	Demecarium	Small Molecule	-	Approved	Target
DB00989	Rivastigmine	Small Molecule	123441-03-2	Approved\|Investigational	Target
DB01010	Edrophonium	Small Molecule	-	Approved	Target
DB01057	Echothiophate	Small Molecule	6736-03-4	Approved	Target
DB01221	Ketamine	Small Molecule	6740-88-1	Approved	Target
DB01226	Mivacurium	Small Molecule	133814-19-4	Approved	Target
DB02811	Diethylphosphono Group	Small Molecule		Experimental	Target
DB02845	Methylphosphinic Acid	Small Molecule	4206-94-4	Experimental	Target
DB03568	Butyric Acid	Small Molecule	107-92-6	Experimental\|Investigational	Target
DB03672	9-N-Phenylmethylamino-Tacrine	Small Molecule		Experimental	Target
DB03814	2-(N-Morpholino)-Ethanesulfonic Acid	Small Molecule		Experimental	Target
DB03822	Ethyl Dihydrogen Phosphate	Small Molecule		Experimental	Target
DB04250	Butyrylthiocholine	Small Molecule		Experimental	Target
DB04892	Phenserine	Small Molecule	101246-66-6	Investigational	Target
DB07681	DODECANESULFONATE ION	Small Molecule		Experimental	Target
DB07940	9-(3-IODOBENZYLAMINO)-1,2,3,4-TETRAHYDROACRIDINE	Small Molecule		Experimental	Target
DB08200	(1R)-menthyl hexyl phosphonate group	Small Molecule		Experimental	Target
DB08201	(1S)-menthyl hexyl phosphonate group	Small Molecule		Experimental	Target
DB08658	ETHYL HYDROGEN DIETHYLAMIDOPHOSPHATE	Small Molecule		Experimental	Target
DB00082	Pegvisomant	BiotechDrug	218620-50-9	Approved	Enzyme
DB00178	Ramipril	Small Molecule	87333-19-5	Approved	Enzyme
DB00183	Pentagastrin	Small Molecule	5534-95-2	Approved	Enzyme
DB00202	Succinylcholine	Small Molecule	306-40-1	Approved	Enzyme
DB00358	Mefloquine	Small Molecule	53230-10-7	Approved\|Investigational	Enzyme
DB00391	Sulpiride	Small Molecule	15676-16-1	Approved\|Investigational	Enzyme
DB00392	Ethopropazine	Small Molecule	522-00-9	Approved	Enzyme
DB00477	Chlorpromazine	Small Molecule	50-53-3	Approved\|Investigational	Enzyme
DB00508	Triflupromazine	Small Molecule	146-54-3	Approved	Enzyme
DB00515	Cisplatin	Small Molecule	15663-27-1	Approved	Enzyme
DB00527	Cinchocaine	Small Molecule	85-79-0	Approved	Enzyme
DB00585	Nizatidine	Small Molecule	76963-41-2	Approved	Enzyme
DB00620	Triamcinolone	Small Molecule	124-94-7	Approved	Enzyme
DB00677	Isoflurophate	Small Molecule	55-91-4	Approved\|Investigational\|Withdrawn	Enzyme
DB00711	Diethylcarbamazine	Small Molecule	90-89-1	Approved\|Investigational	Enzyme
DB00721	Procaine	Small Molecule	59-46-1	Approved\|Investigational	Enzyme
DB00762	Irinotecan	Small Molecule	97682-44-5	Approved\|Investigational	Enzyme
DB00790	Perindopril	Small Molecule	82834-16-0	Approved	Enzyme
DB00856	Chlorphenesin	Small Molecule	104-29-0	Approved\|Withdrawn	Enzyme
DB00871	Terbutaline	Small Molecule	23031-25-6	Approved	Enzyme
DB00892	Oxybuprocaine	Small Molecule	99-43-4	Approved\|Investigational	Enzyme
DB00979	Cyclopentolate	Small Molecule	512-15-2	Approved	Enzyme
DB01035	Procainamide	Small Molecule	51-06-9	Approved	Enzyme
DB01116	Trimethaphan	Small Molecule	7187-66-8	Approved\|Investigational	Enzyme
DB01122	Ambenonium	Small Molecule	7648-98-8	Approved	Enzyme
DB01135	Doxacurium chloride	Small Molecule	106819-53-8	Approved	Enzyme
DB01161	Chloroprocaine	Small Molecule	133-16-4	Approved	Enzyme
DB01245	Decamethonium	Small Molecule	156-74-1	Approved	Enzyme
DB01337	Pancuronium	Small Molecule	-	Approved	Enzyme
DB01338	Pipecuronium	Small Molecule	68399-58-6	Approved	Enzyme
DB01364	Ephedrine	Small Molecule	299-42-3	Approved	Enzyme
DB01395	Drospirenone	Small Molecule	67392-87-4	Approved	Enzyme
DB01400	Neostigmine	Small Molecule	59-99-4	Approved	Enzyme
DB01408	Bambuterol	Small Molecule	81732-65-2	Approved\|Investigational	Enzyme
DB01525	Ecgonine	Small Molecule	481-37-8	Experimental\|Illicit	Enzyme
DB02811	Diethylphosphono Group	Small Molecule		Experimental	Enzyme
DB02845	Methylphosphinic Acid	Small Molecule	4206-94-4	Experimental	Enzyme
DB03568	Butyric Acid	Small Molecule	107-92-6	Experimental\|Investigational	Enzyme
DB03814	2-(N-Morpholino)-Ethanesulfonic Acid	Small Molecule		Experimental	Enzyme
DB03822	Ethyl Dihydrogen Phosphate	Small Molecule		Experimental	Enzyme
DB03976	Phosphorylisopropane	Small Molecule		Experimental	Enzyme
DB04250	Butyrylthiocholine	Small Molecule		Experimental	Enzyme
DB04920	Clevidipine	Small Molecule	167221-71-8	Approved\|Investigational	Enzyme
DB05386	recombinant human GM-CSF	BiotechDrug	-	Investigational	Enzyme
DB05875	substance P	BiotechDrug	-	Investigational	Enzyme
DB06756	Glycine betaine	Small Molecule	107-43-7	Approved\|Nutraceutical	Enzyme
DB06774	Capsaicin	Small Molecule	404-86-4	Approved	Enzyme
DB08893	Mirabegron	Small Molecule	223673-61-8	Approved	Enzyme
DB08897	Aclidinium	Small Molecule	727649-81-2	Approved	Enzyme
DB09205	Moxisylyte	Small Molecule	54-32-0	Approved\|Investigational	Enzyme
DB09288	Propacetamol	Small Molecule	66532-85-2	Approved\|Investigational	Enzyme

ID	Drug Name	Action	PubMed
C403065	10-(fluoroethoxyphosphinyl)-N-(biotinamidopentyl)decanamide	10-(fluoroethoxyphosphinyl)-N-(biotinamidopentyl)decanamide results in decreased activity of BCHE protein	15525694
C009536	1,2,3-trichloropropane	"1,2,3-trichloropropane results in decreased activity of BCHE protein"	12692652
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of BCHE mRNA"	28903501
C488676	1-(4-hydroxyiminomethylpyridinium)-4-(4-carbamoylpyridinium)butane	1-(4-hydroxyiminomethylpyridinium)-4-(4-carbamoylpyridinium)butane inhibits the reaction [Trichlorfon results in decreased activity of BCHE protein]	18825528
C000516	2-(2-cresyl)-4H-1-3-2-benzodioxaphosphorin-2-oxide	2-(2-cresyl)-4H-1-3-2-benzodioxaphosphorin-2-oxide binds to and results in decreased activity of BCHE protein	22898212
C000516	2-(2-cresyl)-4H-1-3-2-benzodioxaphosphorin-2-oxide	[2-(2-cresyl)-4H-1-3-2-benzodioxaphosphorin-2-oxide binds to and results in decreased activity of BCHE protein] which results in increased abundance of 2-cresol	22898212
C000516	2-(2-cresyl)-4H-1-3-2-benzodioxaphosphorin-2-oxide	[2-(2-cresyl)-4H-1-3-2-benzodioxaphosphorin-2-oxide binds to and results in decreased activity of BCHE protein] which results in increased abundance of salicyl alcohol	22898212
C000516	2-(2-cresyl)-4H-1-3-2-benzodioxaphosphorin-2-oxide	2-(2-cresyl)-4H-1-3-2-benzodioxaphosphorin-2-oxide binds to BCHE protein	23339663
C000516	2-(2-cresyl)-4H-1-3-2-benzodioxaphosphorin-2-oxide	2-(2-cresyl)-4H-1-3-2-benzodioxaphosphorin-2-oxide results in decreased activity of and results in decreased alkylation of BCHE protein	21438623
C000516	2-(2-cresyl)-4H-1-3-2-benzodioxaphosphorin-2-oxide	2-(2-cresyl)-4H-1-3-2-benzodioxaphosphorin-2-oxide results in decreased activity of BCHE protein	21767566\|2308534
C000516	2-(2-cresyl)-4H-1-3-2-benzodioxaphosphorin-2-oxide	2-(2-cresyl)-4H-1-3-2-benzodioxaphosphorin-2-oxide results in increased phosphorylation of BCHE protein	21438623
C000516	2-(2-cresyl)-4H-1-3-2-benzodioxaphosphorin-2-oxide	2-(2-cresyl)-4H-1-3-2-benzodioxaphosphorin-2-oxide results in decreased activity of BCHE protein	22209767
C034047	2-cresol	[2-(2-cresyl)-4H-1-3-2-benzodioxaphosphorin-2-oxide binds to and results in decreased activity of BCHE protein] which results in increased abundance of 2-cresol	22898212
C559867	2-(hydroxyimino)-N,N-dimethyl-N'-propylacetimidamide	"2-(hydroxyimino)-N,N-dimethyl-N'-propylacetimidamide inhibits the reaction [cyclohexyl methylphosphonofluoridate results in decreased activity of BCHE protein]"	21438612
C559867	2-(hydroxyimino)-N,N-dimethyl-N'-propylacetimidamide	"2-(hydroxyimino)-N,N-dimethyl-N'-propylacetimidamide inhibits the reaction [Echothiophate Iodide analog results in decreased activity of BCHE protein]"	21438612
C559867	2-(hydroxyimino)-N,N-dimethyl-N'-propylacetimidamide	"2-(hydroxyimino)-N,N-dimethyl-N'-propylacetimidamide inhibits the reaction [Sarin results in decreased activity of BCHE protein]"	21438612
C559867	2-(hydroxyimino)-N,N-dimethyl-N'-propylacetimidamide	"2-(hydroxyimino)-N,N-dimethyl-N'-propylacetimidamide inhibits the reaction [tabun results in decreased activity of BCHE protein]"	21438612
C101261	2-methyl-1-propenylbenzoate	BCHE protein results in increased hydrolysis of 2-methyl-1-propenylbenzoate	11590700
C012587	3,5,6-trichloro-2-pyridinol	"3,5,6-trichloro-2-pyridinol results in decreased activity of BCHE protein"	21224175
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of BCHE mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of BCHE mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of BCHE mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of BCHE mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BCHE mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BCHE mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BCHE mRNA"	27188386
C082366	4-nitrophenyl 2-propylmethylphosphonate	4-nitrophenyl 2-propylmethylphosphonate results in decreased activity of BCHE protein	22247004
C082366	4-nitrophenyl 2-propylmethylphosphonate	4-nitrophenyl 2-propylmethylphosphonate results in increased phosphorylation of BCHE protein	22247004
C082366	4-nitrophenyl 2-propylmethylphosphonate	4-nitrophenyl 2-propylmethylphosphonate results in decreased activity of BCHE protein	26705700
C082366	4-nitrophenyl 2-propylmethylphosphonate	pralidoxime affects the reaction [4-nitrophenyl 2-propylmethylphosphonate results in decreased activity of BCHE protein]	26705700
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of BCHE mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of BCHE mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of BCHE mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of BCHE mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BCHE mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BCHE mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BCHE mRNA"	27188386
D000082	Acetaminophen	Acetaminophen results in decreased expression of BCHE mRNA	29067470
D000109	Acetylcholine	BCHE protein results in increased hydrolysis of Acetylcholine	4631366
D000109	Acetylcholine	BCHE protein results in increased hydrolysis of Acetylcholine	4631366
D000109	Acetylcholine	Acetylcholine inhibits the reaction [Tripelennamine results in decreased activity of BCHE protein]	236606
D000109	Acetylcholine	BCHE protein results in increased degradation of Acetylcholine	16020944
D000109	Acetylcholine	BCHE protein results in increased hydrolysis of Acetylcholine	4631366
D000109	Acetylcholine	BCHE protein results in increased hydrolysis of Acetylcholine	4631366
D000109	Acetylcholine	BCHE protein results in increased hydrolysis of Acetylcholine	20122907
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Streptozocin results in increased activity of BCHE protein]	27087133
D000122	Acetylthiocholine	BCHE protein results in increased hydrolysis of Acetylthiocholine	20493178\|2327988
D000122	Acetylthiocholine	BCHE protein results in increased hydrolysis of Acetylthiocholine	26838044
C543539	acetylthiocholine iodide	acetylthiocholine iodide inhibits the reaction [BCHE protein results in increased hydrolysis of phenyl valerate]	28299395
C543539	acetylthiocholine iodide	BCHE protein results in increased hydrolysis of acetylthiocholine iodide	28299395
C543539	acetylthiocholine iodide	mipafox inhibits the reaction [BCHE protein results in increased hydrolysis of acetylthiocholine iodide]	28299395
C543539	acetylthiocholine iodide	Phenylmethylsulfonyl Fluoride inhibits the reaction [BCHE protein results in increased hydrolysis of acetylthiocholine iodide]	28299395
C543539	acetylthiocholine iodide	phenyl valerate inhibits the reaction [BCHE protein results in increased hydrolysis of acetylthiocholine iodide]	28299395
C543539	acetylthiocholine iodide	profenamine inhibits the reaction [BCHE protein results in increased hydrolysis of acetylthiocholine iodide]	28299395
C543539	acetylthiocholine iodide	Tetraisopropylpyrophosphamide inhibits the reaction [BCHE protein results in increased hydrolysis of acetylthiocholine iodide]	28299395
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of BCHE mRNA	22100608\|2715375
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of BCHE mRNA	19770486
D000448	Aldicarb	Aldicarb results in decreased activity of BCHE protein	10871426
D017962	alpha-Linolenic Acid	alpha-Linolenic Acid results in increased expression of BCHE mRNA	27106529
D017962	alpha-Linolenic Acid	alpha-Linolenic Acid results in increased secretion of BCHE protein	27106529
D024502	alpha-Tocopherol	alpha-Tocopherol inhibits the reaction [Endosulfan results in decreased activity of BCHE protein]	24299906
D000577	Amides	Amides results in decreased activity of BCHE protein	28544359
D006710	Homocysteine	Folic Acid inhibits the reaction [Homocysteine results in decreased activity of BCHE protein]	16442260
D006710	Homocysteine	Homocysteine results in decreased activity of BCHE protein	16442260
C049860	amiridine	amiridine results in decreased activity of BCHE protein	9228650
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of BCHE mRNA	16483693
C006632	arsenic trioxide	arsenic trioxide results in increased expression of BCHE mRNA	20458559
D001205	Ascorbic Acid	Lindane inhibits the reaction [[resveratrol co-treated with Ascorbic Acid co-treated with Thioctic Acid co-treated with Vitamin E] results in increased activity of BCHE protein]	20663516
D001205	Ascorbic Acid	[resveratrol co-treated with Ascorbic Acid co-treated with Thioctic Acid co-treated with Vitamin E] results in increased activity of BCHE protein	20663516
C022870	asoxime chloride	asoxime chloride binds to and results in decreased activity of BCHE protein	27693733
C022870	asoxime chloride	asoxime chloride inhibits the reaction [Paraoxon results in decreased activity of BCHE protein]	27693733
C022870	asoxime chloride	asoxime chloride inhibits the reaction [tabun results in decreased activity of BCHE protein]	27693733
C022870	asoxime chloride	asoxime chloride inhibits the reaction [Trichlorfon results in decreased activity of BCHE protein]	18825528
C022870	asoxime chloride	asoxime chloride inhibits the reaction [VX results in decreased activity of BCHE protein]	27358236\|2769373
C022870	asoxime chloride	asoxime chloride results in increased activity of BCHE protein	27358236
C022870	asoxime chloride	[BCHE protein co-treated with asoxime chloride co-treated with pro-diazepam co-treated with Atropine] results in decreased susceptibility to VX	22981459
C022870	asoxime chloride	asoxime chloride binds to and results in decreased activity of BCHE protein	16598855
D001285	Atropine	[BCHE protein co-treated with asoxime chloride co-treated with pro-diazepam co-treated with Atropine] results in decreased susceptibility to VX	22981459
D001285	Atropine	[RS194B co-treated with Atropine] affects the reaction [Sarin results in decreased activity of BCHE protein]	28693885
D001285	Atropine	[Atropine co-treated with pralidoxime] results in decreased expression of BCHE protein	17963125
D001285	Atropine	[Methyl Parathion co-treated with pralidoxime co-treated with Atropine] results in decreased expression of BCHE protein	17963125
C547126	AZM551248	AZM551248 results in decreased expression of BCHE mRNA	22323515
C500175	bacoside A	[bacoside A co-treated with Plant Preparations] inhibits the reaction [Dichlorvos results in decreased expression of BCHE protein]	27899289
C047766	bambuterol	bambuterol results in decreased activity of BCHE protein	18582854
C047766	bambuterol	bambuterol results in decreased activity of BCHE protein	18582854
C047766	bambuterol	bambuterol results in decreased activity of BCHE protein	15652380\|1858285
C047766	bambuterol	bambuterol results in decreased activity of BCHE protein	27238725
D001462	Barbital	Barbital results in decreased activity of BCHE protein	11929041
C006703	benzo(b)fluoranthene	benzo(b)fluoranthene results in increased expression of BCHE mRNA	26377693
D019817	Benzoic Acid	BCHE protein mutant form results in increased abundance of Benzoic Acid	25814464
D019817	Benzoic Acid	[BCHE protein mutant form results in increased hydrolysis of Cocaine] which results in increased abundance of Benzoic Acid	25814464
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of BCHE mRNA	22300585
D001588	Benzoylcholine	BCHE protein results in increased hydrolysis of Benzoylcholine	4998912
D001588	Benzoylcholine	BCHE protein results in increased metabolism of Benzoylcholine	25054547
D004958	Estradiol	Estradiol results in decreased expression of BCHE mRNA	19484750
C053541	bicalutamide	bicalutamide results in decreased expression of BCHE mRNA	15638997
C006780	bisphenol A	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of BCHE mRNA	28628672
C006780	bisphenol A	bisphenol A results in decreased expression of BCHE mRNA	25181051
C017100	butyrylcholine	BCHE protein results in increased hydrolysis of butyrylcholine	4631366\|4985882
C017100	butyrylcholine	Succinylcholine inhibits the reaction [BCHE protein results in increased hydrolysis of butyrylcholine]	4985882
C017100	butyrylcholine	BCHE protein results in increased hydrolysis of butyrylcholine	4631366
C017100	butyrylcholine	BCHE protein results in increased hydrolysis of butyrylcholine	4631366
C017100	butyrylcholine	BCHE protein results in increased hydrolysis of butyrylcholine	4631366
C017100	butyrylcholine	BCHE protein results in increased hydrolysis of butyrylcholine	4985882
C017100	butyrylcholine	Succinylcholine inhibits the reaction [BCHE protein results in increased hydrolysis of butyrylcholine]	4985882
C017100	butyrylcholine	BCHE protein results in increased hydrolysis of butyrylcholine	4631366\|4985882
C017100	butyrylcholine	Succinylcholine inhibits the reaction [BCHE protein results in increased hydrolysis of butyrylcholine]	4985882
C017100	butyrylcholine	BCHE protein mutant form results in decreased hydrolysis of butyrylcholine	4985882
C017100	butyrylcholine	BCHE protein results in increased hydrolysis of butyrylcholine	4631366\|4985882
C017100	butyrylcholine	Succinylcholine inhibits the reaction [BCHE protein results in increased hydrolysis of butyrylcholine]	4985882
C017100	butyrylcholine	BCHE protein results in increased hydrolysis of butyrylcholine	4985882
C017100	butyrylcholine	Succinylcholine inhibits the reaction [BCHE protein results in increased hydrolysis of butyrylcholine]	4985882
C017100	butyrylcholine	BCHE protein results in increased hydrolysis of butyrylcholine	4985882
C017100	butyrylcholine	Succinylcholine inhibits the reaction [BCHE protein results in increased hydrolysis of butyrylcholine]	4985882
C017100	butyrylcholine	BCHE protein results in increased hydrolysis of butyrylcholine	4631366
D002092	Butyrylthiocholine	BCHE protein results in increased hydrolysis of Butyrylthiocholine	23279886
D002092	Butyrylthiocholine	BCHE protein results in increased hydrolysis of Butyrylthiocholine	12558160
D002092	Butyrylthiocholine	BCHE protein results in increased metabolism of Butyrylthiocholine	12389909
D002092	Butyrylthiocholine	BCHE protein results in increased hydrolysis of Butyrylthiocholine	21802514\|2292211
D002092	Butyrylthiocholine	BCHE protein results in increased metabolism of Butyrylthiocholine	19699221\|2312324
D002092	Butyrylthiocholine	[BCHE protein results in increased metabolism of Butyrylthiocholine] which results in increased chemical synthesis of Thiocholine	19699221
D002092	Butyrylthiocholine	Cholinesterase Inhibitors inhibits the reaction [BCHE protein results in increased hydrolysis of Butyrylthiocholine]	22922115
D002092	Butyrylthiocholine	Dibucaine inhibits the reaction [BCHE protein results in increased metabolism of Butyrylthiocholine]	27109752
D002092	Butyrylthiocholine	Echothiophate Iodide inhibits the reaction [BCHE protein results in increased hydrolysis of Butyrylthiocholine]	21802514
D002092	Butyrylthiocholine	"N,N'-monomethylenebis(pyridiniumaldoxime) inhibits the reaction [Sarin analog inhibits the reaction [BCHE protein results in increased hydrolysis of Butyrylthiocholine]]"	21802514
D002092	Butyrylthiocholine	pralidoxime inhibits the reaction [Sarin analog inhibits the reaction [BCHE protein results in increased hydrolysis of Butyrylthiocholine]]	21802514
D002092	Butyrylthiocholine	Sarin analog inhibits the reaction [BCHE protein results in increased hydrolysis of Butyrylthiocholine]	21802514
D002092	Butyrylthiocholine	Sodium Fluoride inhibits the reaction [BCHE protein results in increased metabolism of Butyrylthiocholine]	27109752
D002104	Cadmium	Cadmium results in increased expression of BCHE mRNA	21120746
D019256	Cadmium Chloride	Cadmium Chloride results in increased activity of BCHE protein	25064450
D019256	Cadmium Chloride	Quercetin inhibits the reaction [Cadmium Chloride results in increased activity of BCHE protein]	25064450
D012721	Carbaryl	Carbaryl results in decreased activity of BCHE protein	16293993
D012721	Carbaryl	[Carbaryl co-treated with Propoxur co-treated with Methiocarb co-treated with Methomyl co-treated with formetanate co-treated with oxamyl co-treated with Carbofuran] affects the activity of BCHE protein	22649187
D012721	Carbaryl	Carbaryl results in decreased activity of BCHE protein	20708061
D002235	Carbofuran	Carbofuran results in decreased activity of BCHE protein	17364237
D002235	Carbofuran	Carbofuran results in decreased activity of BCHE protein	22209767
D002235	Carbofuran	[Carbaryl co-treated with Propoxur co-treated with Methiocarb co-treated with Methomyl co-treated with formetanate co-treated with oxamyl co-treated with Carbofuran] affects the activity of BCHE protein	22649187
D002235	Carbofuran	Carbofuran results in decreased activity of BCHE protein	23611293
C072795	chlorodifluoroacetaldehyde	chlorodifluoroacetaldehyde results in decreased activity of BCHE protein	8292740
D020245	p-Chloromercuribenzoic Acid	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of BCHE mRNA"	27188386
D020245	p-Chloromercuribenzoic Acid	p-Chloromercuribenzoic Acid results in decreased expression of BCHE mRNA	26272509
C004616	chloroprocaine	BCHE protein results in increased degradation of chloroprocaine	3111302
D002744	Chlorpheniramine	Chlorpheniramine results in decreased activity of BCHE protein	236606
C054028	chlorproethazine	chlorproethazine results in decreased activity of BCHE protein	18656440
D004390	Chlorpyrifos	Chlorpyrifos results in decreased activity of BCHE protein	26552522
D004390	Chlorpyrifos	[Chlorpyrifos co-treated with Diazinon] results in decreased activity of BCHE protein	23123253
D004390	Chlorpyrifos	Chlorpyrifos results in decreased activity of BCHE protein	18617161\|2039530
D004390	Chlorpyrifos	pralidoxime inhibits the reaction [Chlorpyrifos results in decreased activity of BCHE protein]	24052565
D004390	Chlorpyrifos	Chlorpyrifos results in decreased activity of BCHE protein	21767560\|9890196
D004390	Chlorpyrifos	Chlorpyrifos results in decreased expression of BCHE protein	21672545
D004390	Chlorpyrifos	Chlorpyrifos affects the expression of BCHE mRNA	18812211
D004390	Chlorpyrifos	[Chlorpyrifos co-treated with Pilocarpine] results in decreased activity of BCHE protein	22874420
D004390	Chlorpyrifos	Chlorpyrifos results in decreased activity of BCHE protein	11405414\|2069171
D004390	Chlorpyrifos	[Methyl Parathion co-treated with Chlorpyrifos] results in decreased activity of BCHE protein	11405414
D002794	Choline	Choline analog results in decreased activity of BCHE protein	17980356
D002800	Cholinesterase Inhibitors	Cholinesterase Inhibitors binds to and results in decreased activity of BCHE protein	27551891
D002800	Cholinesterase Inhibitors	Cholinesterase Inhibitors binds to BCHE protein	22922115
D002800	Cholinesterase Inhibitors	Cholinesterase Inhibitors inhibits the reaction [BCHE protein results in increased hydrolysis of Butyrylthiocholine]	22922115
D002800	Cholinesterase Inhibitors	pralidoxime inhibits the reaction [Cholinesterase Inhibitors binds to and results in decreased activity of BCHE protein]	27551891
D002801	Cholinesterase Reactivators	Cholinesterase Reactivators inhibits the reaction [tabun results in decreased activity of BCHE protein]	22960624
C031180	chrysene	chrysene results in increased expression of BCHE mRNA	26377693
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of BCHE protein	23857379
D003042	Cocaine	BCHE protein affects the hydrolysis of Cocaine	16275916\|1851417
D003042	Cocaine	BCHE protein affects the metabolism of Cocaine	18514640
D003042	Cocaine	BCHE protein modified form results in increased hydrolysis of Cocaine	18514178
D003042	Cocaine	BCHE protein mutant form affects the degradation of Cocaine	17989928
D003042	Cocaine	BCHE protein mutant form results in decreased metabolism of Cocaine	572161
D003042	Cocaine	BCHE protein mutant form results in decreased susceptibility to Cocaine	20971807\|2296016
D003042	Cocaine	BCHE protein mutant form results in increased hydrolysis of Cocaine	16275916\|2006081
D003042	Cocaine	BCHE protein mutant form results in increased metabolism of Cocaine	20219449\|2291763
D003042	Cocaine	BCHE protein results in increased metabolism of Cocaine	19067679\|2291763
D003042	Cocaine	BCHE protein mutant form results in increased hydrolysis of Cocaine	25814464
D003042	Cocaine	[BCHE protein mutant form results in increased hydrolysis of Cocaine] which results in increased abundance of Benzoic Acid	25814464
D003042	Cocaine	[BCHE protein mutant form results in increased hydrolysis of Cocaine] which results in increased abundance of ecgonine methyl ester	25814464
D003042	Cocaine	BCHE protein results in increased metabolism of Cocaine	19067679
D003042	Cocaine	Cocaine results in decreased activity of BCHE protein	12019200
D009249	NADP	[diphenylcresyl phosphate co-treated with NADP] results in decreased activity of BCHE protein	23085349
D009249	NADP	naringenin inhibits the reaction [[Tritolyl Phosphates co-treated with NADP] results in decreased activity of BCHE protein]	23085349
D009249	NADP	[tert-butylphenyl diphenyl phosphate co-treated with NADP] results in decreased activity of BCHE protein	23085349
D009249	NADP	[tri-o-cresyl phosphate co-treated with NADP] results in decreased activity of BCHE protein	23085349
D003300	Copper	[NSC 689534 binds to Copper] which results in increased expression of BCHE mRNA	20971185
C037886	cryptotanshinone	cryptotanshinone binds to and results in decreased activity of BCHE protein	20350537
D003471	Cuprizone	Cuprizone results in decreased expression of BCHE mRNA	27523638
C073636	cyclohexyl methylphosphonic acid	cyclohexyl methylphosphonic acid analog promotes the reaction [cyclohexyl methylphosphonic acid binds to BCHE protein]	19715348
C073636	cyclohexyl methylphosphonic acid	cyclohexyl methylphosphonic acid binds to BCHE protein	19715348
C053914	cyclohexyl methylphosphonofluoridate	cyclohexyl methylphosphonofluoridate analog results in decreased activity of BCHE protein	19715346
C053914	cyclohexyl methylphosphonofluoridate	cyclohexyl methylphosphonofluoridate results in decreased activity of BCHE protein	19428953\|2180707
C053914	cyclohexyl methylphosphonofluoridate	HLo 7 inhibits the reaction [cyclohexyl methylphosphonofluoridate results in decreased activity of BCHE protein]	25450746
C053914	cyclohexyl methylphosphonofluoridate	PON1 protein alternative form inhibits the reaction [cyclohexyl methylphosphonofluoridate results in decreased activity of BCHE protein]	21807078
C053914	cyclohexyl methylphosphonofluoridate	cyclohexyl methylphosphonofluoridate analog results in decreased activity of BCHE protein	22209767
C053914	cyclohexyl methylphosphonofluoridate	"2-(hydroxyimino)-N,N-dimethyl-N'-propylacetimidamide inhibits the reaction [cyclohexyl methylphosphonofluoridate results in decreased activity of BCHE protein]"	21438612
C053914	cyclohexyl methylphosphonofluoridate	cyclohexyl methylphosphonofluoridate results in decreased activity of BCHE protein	21438612
C053914	cyclohexyl methylphosphonofluoridate	"N'-ethyl-2-(hydroxyimino)-N,N-dimethylacetimidamide inhibits the reaction [cyclohexyl methylphosphonofluoridate results in decreased activity of BCHE protein]"	21438612
D003520	Cyclophosphamide	Cyclophosphamide results in decreased activity of BCHE protein	4959505
D003520	Cyclophosphamide	[Melphalan co-treated with Thiotepa co-treated with Cyclophosphamide] results in decreased expression of BCHE protein	4672170
D016572	Cyclosporine	Cyclosporine results in decreased expression of BCHE mRNA	20106945\|2798913
D016572	Cyclosporine	Cyclosporine results in decreased expression of BCHE mRNA	19770486
D003630	Daunorubicin	Daunorubicin results in decreased expression of BCHE protein	8906433
C010902	decabromobiphenyl ether	decabromobiphenyl ether affects the expression of BCHE mRNA	24834073
C570679	decahydro-2-naphthyl-N-n-butylcarbamate	decahydro-2-naphthyl-N-n-butylcarbamate analog results in decreased activity of BCHE protein	21630390
D003671	DEET	DEET results in decreased activity of BCHE protein	21354413
D003671	DEET	[Pyridostigmine Bromide co-treated with DEET] results in increased activity of BCHE protein	14751452
C030064	demeton-S-methyl	demeton-S-methyl results in decreased activity of BCHE protein	21238577
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of BCHE mRNA	28628672
C004717	diacetylmonoxime	diacetylmonoxime inhibits the reaction [Dichlorvos results in decreased activity of BCHE protein]	1276991
C004717	diacetylmonoxime	diacetylmonoxime inhibits the reaction [Isoflurophate results in decreased activity of BCHE protein]	1276991
C004717	diacetylmonoxime	diacetylmonoxime inhibits the reaction [Dichlorvos results in decreased activity of BCHE protein]	1276991
C004717	diacetylmonoxime	diacetylmonoxime inhibits the reaction [Isoflurophate results in decreased activity of BCHE protein]	1276991
C004717	diacetylmonoxime	diacetylmonoxime inhibits the reaction [Dichlorvos results in decreased activity of BCHE protein]	1276991
C004717	diacetylmonoxime	diacetylmonoxime inhibits the reaction [Isoflurophate results in decreased activity of BCHE protein]	1276991
D003976	Diazinon	Diazinon results in decreased activity of BCHE protein	16293993
D003976	Diazinon	Diazinon affects the activity of BCHE protein	16207942
D003976	Diazinon	[Chlorpyrifos co-treated with Diazinon] results in decreased activity of BCHE protein	23123253
D003976	Diazinon	Diazinon analog binds to and results in decreased activity of BCHE protein	20229498
D003976	Diazinon	Diazinon binds to BCHE protein	20229498
D003976	Diazinon	Diazinon results in decreased activity of BCHE protein	21983245\|7893043
D003976	Diazinon	Diazinon results in decreased activity of BCHE protein	21767560\|2220976
D003976	Diazinon	[Methyl Parathion co-treated with Diazinon] results in decreased activity of BCHE protein	11481665
D003976	Diazinon	BCHE protein affects the susceptibility to Diazinon	10871426
C000912	diazoxon	ALB protein results in decreased susceptibility to [diazoxon results in decreased activity of BCHE protein]	20211614
C000912	diazoxon	diazoxon results in decreased activity of BCHE protein	10871426
C000912	diazoxon	diazoxon results in decreased activity of BCHE protein	20211614
D003992	Dibucaine	BCHE gene mutant form inhibits the reaction [Dibucaine results in decreased activity of BCHE protein]	7205429\|7205429
D003992	Dibucaine	BCHE gene mutant form results in decreased susceptibility to Dibucaine	5365519
D003992	Dibucaine	Dibucaine inhibits the reaction [BCHE protein results in increased metabolism of Butyrylthiocholine]	27109752
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in increased expression of BCHE mRNA	27392435
D004006	Dichlorvos	Dichlorvos results in decreased activity of BCHE protein	11246494
D004006	Dichlorvos	Dichlorvos results in decreased activity of BCHE protein	11246494
D004006	Dichlorvos	Dichlorvos results in decreased activity of BCHE protein	11246494
D004006	Dichlorvos	Dichlorvos results in decreased activity of BCHE protein	11246494
D004006	Dichlorvos	Dichlorvos results in decreased activity of BCHE protein	1609493\|2301824\|
D004006	Dichlorvos	pralidoxime inhibits the reaction [Dichlorvos results in decreased activity of BCHE protein]	3421541
D004006	Dichlorvos	Dichlorvos results in decreased activity of BCHE protein	2364259
D004006	Dichlorvos	Dichlorvos results in decreased activity of BCHE protein	3627083\|4631366
D004006	Dichlorvos	Dichlorvos results in decreased activity of BCHE protein	16293993\|4631366
D004006	Dichlorvos	diacetylmonoxime inhibits the reaction [Dichlorvos results in decreased activity of BCHE protein]	1276991
D004006	Dichlorvos	Dichlorvos results in decreased activity of BCHE protein	1276991\|18368617
D004006	Dichlorvos	Dichlorvos results in decreased activity of BCHE protein	8424827
D004006	Dichlorvos	Dichlorvos analog results in decreased activity of BCHE protein	236606
D004006	Dichlorvos	Dichlorvos results in decreased activity of BCHE protein	235931\|4631366\|8
D004006	Dichlorvos	Dichlorvos results in decreased activity of BCHE protein	4631366
D004006	Dichlorvos	Dichlorvos results in decreased activity of BCHE protein	12558160
D004006	Dichlorvos	Dichlorvos results in increased phosphorylation of and results in decreased activity of BCHE protein	12389909
D004006	Dichlorvos	pralidoxime inhibits the reaction [Dichlorvos results in decreased activity of BCHE protein]	12558160
D004006	Dichlorvos	Dichlorvos binds to and results in decreased activity of BCHE protein	20229498
D004006	Dichlorvos	Dichlorvos results in decreased activity of BCHE protein	12190811\|1603676
D004006	Dichlorvos	[Dichlorvos results in decreased activity of BCHE protein] which results in increased susceptibility to Succinylcholine	12190811
D004006	Dichlorvos	pralidoxime inhibits the reaction [Dichlorvos results in decreased activity of BCHE protein]	423703
D004006	Dichlorvos	Tiapamil Hydrochloride inhibits the reaction [Dichlorvos results in decreased activity of BCHE protein]	16036766\|1619352
D004006	Dichlorvos	Dichlorvos results in decreased activity of BCHE protein	11246494
D004006	Dichlorvos	Dichlorvos results in decreased activity of BCHE protein	4631366
D004006	Dichlorvos	[bacoside A co-treated with Plant Preparations] inhibits the reaction [Dichlorvos results in decreased expression of BCHE protein]	27899289
D004006	Dichlorvos	Dichlorvos binds to and results in decreased activity of BCHE protein	16598855
D004006	Dichlorvos	Dichlorvos results in decreased activity of BCHE protein	21767560\|2220976
D004006	Dichlorvos	Dichlorvos results in decreased expression of BCHE protein	27899289
D004006	Dichlorvos	diacetylmonoxime inhibits the reaction [Dichlorvos results in decreased activity of BCHE protein]	1276991
D004006	Dichlorvos	Dichlorvos results in decreased activity of BCHE protein	1276991\|4631366\|
D004006	Dichlorvos	Dichlorvos results in decreased activity of BCHE protein	3113033
D004006	Dichlorvos	diacetylmonoxime inhibits the reaction [Dichlorvos results in decreased activity of BCHE protein]	1276991
D004006	Dichlorvos	Dichlorvos results in decreased activity of BCHE protein	1276991\|12828128
D004006	Dichlorvos	Magnesium Sulfate promotes the reaction [Dichlorvos results in decreased activity of BCHE protein]	19504058
D004006	Dichlorvos	Dichlorvos results in decreased activity of BCHE protein	11246494
D004006	Dichlorvos	Dichlorvos results in decreased activity of BCHE protein	4631366
D004041	Dietary Fats	Dietary Fats affects the expression of BCHE mRNA	19680557
D004041	Dietary Fats	Dietary Fats results in decreased expression of BCHE mRNA	18042831\|2501614
D004041	Dietary Fats	[Dietary Fats co-treated with resveratrol] results in increased expression of BCHE mRNA	21852083
D004054	Diethylstilbestrol	Diethylstilbestrol results in decreased expression of BCHE mRNA	21658437
D002117	Calcitriol	Calcitriol results in decreased expression of BCHE mRNA	21592394
D002117	Calcitriol	[Testosterone co-treated with Calcitriol] results in decreased expression of BCHE mRNA	21592394
D004111	Dimenhydrinate	Dimenhydrinate results in decreased activity of BCHE protein	236606
D004117	Dimethoate	Dimethoate results in decreased activity of BCHE protein	19793545\|2405256
D004117	Dimethoate	Dimethoate results in decreased activity of BCHE protein	26482405\|2744138
C002302	dimethoxon	dimethoxon binds to and results in decreased activity of BCHE protein	20229498
D004155	Diphenhydramine	Diphenhydramine analog results in decreased activity of BCHE protein	236606
D004155	Diphenhydramine	Diphenhydramine results in decreased activity of BCHE protein	236606
D004155	Diphenhydramine	Protons inhibits the reaction [Diphenhydramine results in decreased activity of BCHE protein]	236606
D004155	Diphenhydramine	Protons promotes the reaction [Diphenhydramine results in decreased activity of BCHE protein]	236606
D004155	Diphenhydramine	Diphenhydramine results in decreased activity of BCHE protein	236606
D004155	Diphenhydramine	Protons affects the reaction [Diphenhydramine results in decreased activity of BCHE protein]	236606
C001082	diphenylcresyl phosphate	[diphenylcresyl phosphate co-treated with NADP] results in decreased activity of BCHE protein	23085349
C076946	donepezil	donepezil results in decreased activity of BCHE protein	16036213\|1865644
C076946	donepezil	donepezil results in decreased activity of BCHE protein	18656440
C076946	donepezil	donepezil results in decreased activity of BCHE protein	19345205
D004391	Dust	Dust results in increased expression of BCHE protein	23573920
C034524	ecgonine methyl ester	BCHE protein mutant form results in increased abundance of ecgonine methyl ester	25814464
C034524	ecgonine methyl ester	[BCHE protein mutant form results in increased hydrolysis of Cocaine] which results in increased abundance of ecgonine methyl ester	25814464
C034524	ecgonine methyl ester	ecgonine methyl ester affects the activity of BCHE protein	12019200
D004456	Echothiophate Iodide	Echothiophate Iodide inhibits the reaction [BCHE protein results in increased hydrolysis of Butyrylthiocholine]	21802514
D004456	Echothiophate Iodide	Echothiophate Iodide results in decreased activity of BCHE protein	16213467\|1769851
D004456	Echothiophate Iodide	"2-(hydroxyimino)-N,N-dimethyl-N'-propylacetimidamide inhibits the reaction [Echothiophate Iodide analog results in decreased activity of BCHE protein]"	21438612
D004456	Echothiophate Iodide	Echothiophate Iodide analog results in decreased activity of BCHE protein	21438612
D004456	Echothiophate Iodide	"N'-ethyl-2-(hydroxyimino)-N,N-dimethylacetimidamide inhibits the reaction [Echothiophate Iodide analog results in decreased activity of BCHE protein]"	21438612
D004726	Endosulfan	alpha-Tocopherol inhibits the reaction [Endosulfan results in decreased activity of BCHE protein]	24299906
D004726	Endosulfan	Endosulfan results in decreased activity of BCHE protein	24299906
C118739	entinostat	entinostat results in decreased expression of BCHE mRNA	26272509
C118739	entinostat	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of BCHE mRNA"	27188386
D004785	Environmental Pollutants	Environmental Pollutants results in increased expression of BCHE protein	23573920
C005073	ethephon	ethephon binds to and results in decreased activity of BCHE protein	23410221
C005073	ethephon	ethephon results in decreased activity of BCHE protein	9890196
C042896	ethyl 4-nitrophenyl methylphosphonate	ethyl 4-nitrophenyl methylphosphonate results in decreased activity of BCHE protein	22247004
C042896	ethyl 4-nitrophenyl methylphosphonate	ethyl 4-nitrophenyl methylphosphonate results in increased phosphorylation of BCHE protein	22247004
C042896	ethyl 4-nitrophenyl methylphosphonate	ethyl 4-nitrophenyl methylphosphonate results in decreased activity of BCHE protein	26705700
C042896	ethyl 4-nitrophenyl methylphosphonate	pralidoxime affects the reaction [ethyl 4-nitrophenyl methylphosphonate results in decreased activity of BCHE protein]	26705700
D005020	Ethyl Methanesulfonate	Ethyl Methanesulfonate results in decreased expression of BCHE mRNA	23649840
C121104	ethylparaoxon	ethylparaoxon results in decreased activity of BCHE protein	19428953
C121104	ethylparaoxon	ethylparaoxon results in decreased activity of BCHE protein	28693885
C121104	ethylparaoxon	RS194B inhibits the reaction [ethylparaoxon results in decreased activity of BCHE protein]	28693885
D005284	Fenthion	Fenthion results in decreased activity of BCHE protein	24052565
C004999	ferulic acid	ferulic acid promotes the reaction [lead acetate results in increased activity of BCHE protein]	25322819
D005419	Flavonoids	Flavonoids results in decreased expression of BCHE mRNA	18035473
D005459	Fluorides	BCHE gene mutant form inhibits the reaction [Fluorides results in decreased activity of BCHE protein]	7205429\|7205429
D005459	Fluorides	BCHE gene mutant form results in decreased susceptibility to Fluorides	5365519
D005492	Folic Acid	[Folic Acid deficiency co-treated with Methotrexate] results in decreased expression of BCHE mRNA	24657277
D005492	Folic Acid	Folic Acid inhibits the reaction [Homocysteine results in decreased activity of BCHE protein]	16442260
D005557	Formaldehyde	Formaldehyde results in decreased expression of BCHE mRNA	23649840
C100163	formetanate	[Carbaryl co-treated with Propoxur co-treated with Methiocarb co-treated with Methomyl co-treated with formetanate co-treated with oxamyl co-treated with Carbofuran] affects the activity of BCHE protein	22649187
C039281	furan	furan results in increased expression of BCHE mRNA	25539665
D005702	Galantamine	Galantamine results in decreased activity of BCHE protein	19345205
D019833	Genistein	Genistein results in increased expression of BCHE mRNA	15378649
D005960	Glucosides	Glucosides inhibits the reaction [Isoflurophate results in decreased activity of BCHE protein]	20227398
D005960	Glucosides	Glucosides inhibits the reaction [Paraoxon results in decreased activity of BCHE protein]	20227398
D012739	Gonadal Steroid Hormones	Gonadal Steroid Hormones deficiency results in decreased activity of BCHE protein	20399201
D012739	Gonadal Steroid Hormones	Gonadal Steroid Hormones deficiency results in increased activity of BCHE protein	20399201
C066606	hexyl 2,5-dichlorophenylphosphoroamidate	"ALB protein results in decreased susceptibility to [hexyl 2,5-dichlorophenylphosphoroamidate results in decreased activity of BCHE protein]"	20211614
C066606	hexyl 2,5-dichlorophenylphosphoroamidate	"hexyl 2,5-dichlorophenylphosphoroamidate results in decreased activity of BCHE protein"	20211614
C058577	HLo 7	HLo 7 inhibits the reaction [cyclohexyl methylphosphonofluoridate results in decreased activity of BCHE protein]	25450746
D017313	Fenretinide	Fenretinide results in decreased expression of BCHE mRNA	28973697
C082359	imidacloprid	imidacloprid results in increased activity of BCHE protein	18080902
C011582	IMOL S-140	IMOL S-140 results in decreased activity of BCHE protein	21767560
D007189	Indans	Indans results in decreased activity of BCHE protein	18457821
C041508	indeno(1,2,3-cd)pyrene	"indeno(1,2,3-cd)pyrene results in decreased expression of BCHE mRNA"	26377693
C014612	indolebutyric acid	indolebutyric acid results in decreased activity of BCHE protein	19442822
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of BCHE mRNA	28628672
D007306	Insecticides	Insecticides binds to BCHE	20809544
D007306	Insecticides	Insecticides inhibits the reaction [BCHE protein results in increased metabolism of Succinylcholine]	12190811
D007306	Insecticides	Insecticides results in decreased activity of BCHE protein	19750105
D007306	Insecticides	PON1 protein polymorphism affects the reaction [Insecticides results in decreased activity of BCHE protein]	19750105
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of BCHE mRNA	28628672
D007530	Isoflurane	Isoflurane results in decreased activity of BCHE protein	11929041
D007531	Isoflurophate	Isoflurophate results in decreased activity of BCHE protein	4631366
D007531	Isoflurophate	Isoflurophate results in decreased activity of BCHE protein	4631366
D007531	Isoflurophate	diacetylmonoxime inhibits the reaction [Isoflurophate results in decreased activity of BCHE protein]	1276991
D007531	Isoflurophate	Isoflurophate results in decreased activity of BCHE protein	1276991\|4631366
D007531	Isoflurophate	Isoflurophate results in decreased activity of BCHE protein	4631366
D007531	Isoflurophate	Isoflurophate inhibits the reaction [BCHE protein results in increased hydrolysis of Succinylcholine]	4985882
D007531	Isoflurophate	Isoflurophate results in decreased activity of BCHE protein	4631366
D007531	Isoflurophate	Glucosides inhibits the reaction [Isoflurophate results in decreased activity of BCHE protein]	20227398
D007531	Isoflurophate	Isoflurophate results in decreased activity of BCHE protein	16213467\|1769851
D007531	Isoflurophate	pralidoxime inhibits the reaction [Isoflurophate results in decreased activity of BCHE protein]	20227398
D007531	Isoflurophate	Isoflurophate results in decreased activity of BCHE protein	4631366
D007531	Isoflurophate	BCHE protein results in decreased susceptibility to Isoflurophate	22982776
D007531	Isoflurophate	Isoflurophate results in decreased activity of BCHE protein	21767560\|2220976
D007531	Isoflurophate	diacetylmonoxime inhibits the reaction [Isoflurophate results in decreased activity of BCHE protein]	1276991
D007531	Isoflurophate	Isoflurophate results in decreased activity of BCHE protein	1276991\|4631366
D007531	Isoflurophate	diacetylmonoxime inhibits the reaction [Isoflurophate results in decreased activity of BCHE protein]	1276991
D007531	Isoflurophate	Isoflurophate results in decreased activity of BCHE protein	1276991\|4631366\|
D007531	Isoflurophate	Isoflurophate results in decreased activity of BCHE protein	4631366
C018326	isomalathion	isomalathion metabolite results in decreased activity of BCHE protein	17698511
C515113	isoschaftoside	isoschaftoside results in decreased activity of BCHE protein	26297990
D007547	Isosorbide	Isosorbide analog results in decreased activity of BCHE protein	18606399
D007547	Isosorbide	Isosorbide analog results in decreased activity of BCHE protein	18606399
D007547	Isosorbide	BCHE protein results in increased metabolism of Isosorbide analog	18571631
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in increased expression of BCHE mRNA	27392435
C530923	K117 compound	K117 compound inhibits the reaction [tabun results in decreased activity of BCHE protein]	20206154
C530922	K127 compound	K127 compound inhibits the reaction [tabun results in decreased activity of BCHE protein]	20206154
D048628	Ketolides	Ketolides analog results in increased expression of BCHE mRNA	24967691
C008261	lead acetate	ferulic acid promotes the reaction [lead acetate results in increased activity of BCHE protein]	25322819
C008261	lead acetate	lead acetate results in increased activity of BCHE protein	25322819
C008265	leptophos oxon	leptophos oxon results in decreased activity of BCHE protein	21673941
C532261	leucisterol	leucisterol results in decreased activity of BCHE protein	18787788
D001556	Lindane	Lindane inhibits the reaction [[resveratrol co-treated with Ascorbic Acid co-treated with Thioctic Acid co-treated with Vitamin E] results in increased activity of BCHE protein]	20663516
D001556	Lindane	Lindane results in decreased activity of BCHE protein	20455324\|2066351
C419729	macluraxanthone C	macluraxanthone C binds to and results in decreased activity of BCHE protein	19596285
D008278	Magnesium Sulfate	Magnesium Sulfate promotes the reaction [Dichlorvos results in decreased activity of BCHE protein]	19504058
C005095	malachite green	malachite green results in decreased activity of BCHE protein	16036213
C100082	malaoxon	malaoxon binds to BCHE protein	18514178
C100082	malaoxon	malaoxon binds to BCHE protein modified form	18514178
D008294	Malathion	Malathion results in decreased activity of BCHE protein	17364237\|1861716
D008294	Malathion	Obidoxime Chloride inhibits the reaction [Malathion results in decreased activity of BCHE protein]	21983245
D008294	Malathion	Malathion results in increased activity of BCHE protein	25180440
C005559	Meldola blue	Meldola blue results in decreased activity of BCHE protein	18656440
D008558	Melphalan	[Melphalan co-treated with Thiotepa co-treated with Cyclophosphamide] results in decreased expression of BCHE protein	4672170
C042720	mercuric bromide	mercuric bromide results in decreased expression of BCHE mRNA	26272509
D008627	Mercuric Chloride	Mercuric Chloride results in decreased activity of BCHE protein	17355286
C014655	methamidophos	methamidophos binds to and results in decreased activity of BCHE protein	20229498
C014655	methamidophos	methamidophos results in decreased activity of BCHE protein	21673941\|2254275
C014655	methamidophos	Thiosemicarbazones inhibits the reaction [methamidophos results in decreased activity of BCHE protein]	22542756
C014655	methamidophos	methamidophos results in decreased activity of BCHE protein	9890196
D008714	Methiocarb	[Carbaryl co-treated with Propoxur co-treated with Methiocarb co-treated with Methomyl co-treated with formetanate co-treated with oxamyl co-treated with Carbofuran] affects the activity of BCHE protein	22649187
D008724	Methomyl	[Carbaryl co-treated with Propoxur co-treated with Methiocarb co-treated with Methomyl co-treated with formetanate co-treated with oxamyl co-treated with Carbofuran] affects the activity of BCHE protein	22649187
D008727	Methotrexate	[Folic Acid deficiency co-treated with Methotrexate] results in decreased expression of BCHE mRNA	24657277
C006649	methylatropine	methylatropine inhibits the reaction [Sarin results in decreased activity of BCHE protein]	19523969
C026086	methyl demeton	methyl demeton results in decreased activity of BCHE protein	19793545
C026086	methyl demeton	Obidoxime Chloride inhibits the reaction [methyl demeton results in decreased activity of BCHE protein]	19793545
D008739	Methyl Green	Methyl Green results in decreased activity of BCHE protein	18656440
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of BCHE mRNA	23179753\|2627250
C004925	methylmercuric chloride	"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of BCHE mRNA"	27188386
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of BCHE mRNA	23649840
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of BCHE mRNA"	26251327
C008480	methylparaoxon	methylparaoxon affects the activity of BCHE protein	19428953
C008480	methylparaoxon	methylparaoxon results in decreased activity of BCHE protein	10871426
D008743	Methyl Parathion	[Methyl Parathion co-treated with Parathion] results in decreased activity of BCHE protein	1512808
D008743	Methyl Parathion	Methyl Parathion results in decreased activity of BCHE protein	1801511
D008743	Methyl Parathion	[Methyl Parathion co-treated with Chlorpyrifos] results in decreased activity of BCHE protein	11405414
D008743	Methyl Parathion	[Methyl Parathion co-treated with Diazinon] results in decreased activity of BCHE protein	11481665
D008743	Methyl Parathion	[Methyl Parathion co-treated with pralidoxime co-treated with Atropine] results in decreased expression of BCHE protein	17963125
D008743	Methyl Parathion	[Methyl Parathion co-treated with pralidoxime] results in decreased expression of BCHE protein	17963125
D008743	Methyl Parathion	Methyl Parathion results in decreased activity of BCHE protein	11405414\|1148166
D008743	Methyl Parathion	BCHE protein affects the susceptibility to Methyl Parathion	10871426
D008787	Metoclopramide	Metoclopramide inhibits the reaction [mipafox binds to and results in decreased activity of BCHE protein]	15052610
D008787	Metoclopramide	Metoclopramide inhibits the reaction [Paraoxon binds to and results in decreased activity of BCHE protein]	12518340
C005238	mipafox	mipafox results in decreased activity of BCHE protein	26838044
C005238	mipafox	Metoclopramide inhibits the reaction [mipafox binds to and results in decreased activity of BCHE protein]	15052610
C005238	mipafox	mipafox binds to and results in decreased activity of BCHE protein	15052610
C005238	mipafox	mipafox inhibits the reaction [BCHE protein results in increased hydrolysis of acetylthiocholine iodide]	28299395
C005238	mipafox	mipafox inhibits the reaction [BCHE protein results in increased hydrolysis of phenyl valerate]	28299395
C005238	mipafox	mipafox results in decreased activity of BCHE protein	28299395
C049430	mivacurium	BCHE affects the susceptibility to mivacurium	16884476\|1839984
C049430	mivacurium	BCHE gene mutant form results in increased susceptibility to mivacurium	25054547
C049430	mivacurium	BCHE gene polymorphism affects the susceptibility to mivacurium	16788378
C049430	mivacurium	BCHE protein affects the susceptibility to mivacurium	15688329
C049430	mivacurium	BCHE affects the hydrolysis of mivacurium	16884476
C049430	mivacurium	BCHE protein results in increased hydrolysis of mivacurium	15688329\|9024049
C049430	mivacurium	BCHE protein results in increased metabolism of and results in decreased activity of mivacurium	9890196
C111602	m-(N,N,N-trimethylammonio)trifluoroacetophenone	"m-(N,N,N-trimethylammonio)trifluoroacetophenone results in decreased activity of BCHE protein"	23279886
C570530	N-((5-(3-(1-benzylpiperidin-4-yl)propoxy)-1-methyl-1H-indol-2-yl)methyl)-N-methylprop-2-yn-1-amine	N-((5-(3-(1-benzylpiperidin-4-yl)propoxy)-1-methyl-1H-indol-2-yl)methyl)-N-methylprop-2-yn-1-amine results in decreased activity of BCHE protein	22023459
C570530	N-((5-(3-(1-benzylpiperidin-4-yl)propoxy)-1-methyl-1H-indol-2-yl)methyl)-N-methylprop-2-yn-1-amine	N-((5-(3-(1-benzylpiperidin-4-yl)propoxy)-1-methyl-1H-indol-2-yl)methyl)-N-methylprop-2-yn-1-amine results in decreased activity of BCHE protein	22023459
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of BCHE mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of BCHE mRNA"	25554681
C005273	naringenin	naringenin inhibits the reaction [[Tritolyl Phosphates co-treated with NADP] results in decreased activity of BCHE protein]	23085349
C057222	neferine	neferine results in decreased activity of BCHE protein	20736023
D009388	Neostigmine	BCHE affects the susceptibility to Neostigmine	18399847
D000067397	Nerve Agents	BCHE protein results in decreased susceptibility to Nerve Agents	27551784
C559866	N'-ethyl-2-(hydroxyimino)-N,N-dimethylacetimidamide	"N'-ethyl-2-(hydroxyimino)-N,N-dimethylacetimidamide inhibits the reaction [cyclohexyl methylphosphonofluoridate results in decreased activity of BCHE protein]"	21438612
C559866	N'-ethyl-2-(hydroxyimino)-N,N-dimethylacetimidamide	"N'-ethyl-2-(hydroxyimino)-N,N-dimethylacetimidamide inhibits the reaction [Echothiophate Iodide analog results in decreased activity of BCHE protein]"	21438612
C559866	N'-ethyl-2-(hydroxyimino)-N,N-dimethylacetimidamide	"N'-ethyl-2-(hydroxyimino)-N,N-dimethylacetimidamide inhibits the reaction [Sarin results in decreased activity of BCHE protein]"	21438612
C559866	N'-ethyl-2-(hydroxyimino)-N,N-dimethylacetimidamide	"N'-ethyl-2-(hydroxyimino)-N,N-dimethylacetimidamide inhibits the reaction [tabun results in decreased activity of BCHE protein]"	21438612
D009465	Neuromuscular Agents	BCHE protein polymorphism results in increased susceptibility to Neuromuscular Agents	27551784
D009532	Nickel	Nickel results in decreased expression of BCHE mRNA	25583101
C572573	N-nitroso-tris-chloroethylurea	[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of BCHE mRNA	27935865
C005514	N,N'-monomethylenebis(pyridiniumaldoxime)	"N,N'-monomethylenebis(pyridiniumaldoxime) inhibits the reaction [Sarin analog inhibits the reaction [BCHE protein results in increased hydrolysis of Butyrylthiocholine]]"	21802514
C005514	N,N'-monomethylenebis(pyridiniumaldoxime)	"N,N'-monomethylenebis(pyridiniumaldoxime) inhibits the reaction [Sarin analog results in decreased activity of BCHE protein]"	21802514
C558013	NSC 689534	[NSC 689534 binds to Copper] which results in increased expression of BCHE mRNA	20971185
D009768	Obidoxime Chloride	Obidoxime Chloride inhibits the reaction [VX results in decreased activity of BCHE protein]	20599844
D009768	Obidoxime Chloride	Obidoxime Chloride inhibits the reaction [Malathion results in decreased activity of BCHE protein]	21983245
D009768	Obidoxime Chloride	Obidoxime Chloride inhibits the reaction [methyl demeton results in decreased activity of BCHE protein]	19793545
D009768	Obidoxime Chloride	Obidoxime Chloride inhibits the reaction [Paraoxon results in decreased activity of BCHE protein]	27693733
D009768	Obidoxime Chloride	Obidoxime Chloride inhibits the reaction [tabun results in decreased activity of BCHE protein]	27693733
D009768	Obidoxime Chloride	Obidoxime Chloride inhibits the reaction [Trichlorfon results in decreased activity of BCHE protein]	18825528
D009768	Obidoxime Chloride	Obidoxime Chloride inhibits the reaction [VX results in decreased activity of BCHE protein]	27358236\|2769373
D009768	Obidoxime Chloride	Obidoxime Chloride results in increased activity of BCHE protein	27358236
D019787	Linoleic Acid	Linoleic Acid results in increased expression of BCHE mRNA	27106529
D009822	Oils, Volatile	"Oils, Volatile results in decreased activity of BCHE protein"	18810999
C009618	O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate	"O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in decreased activity of BCHE protein"	28189703
C009618	O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate	"ALB protein results in decreased susceptibility to [O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in decreased activity of BCHE protein]"	20211614
C009618	O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate	"O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in decreased activity of BCHE protein"	19699221
C009618	O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate	"O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in decreased activity of BCHE protein"	16978018\|2176756
C009618	O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate	"O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in decreased activity of BCHE protein"	18761328
C009618	O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate	"O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in decreased activity of BCHE protein"	20211614
D010755	Organophosphates	BCHE gene polymorphism affects the susceptibility to Organophosphates	26318115
D010755	Organophosphates	Organophosphates binds to and results in decreased activity of BCHE protein	27551891
D010755	Organophosphates	Organophosphates results in decreased activity of BCHE protein	19750105\|2254275
D010755	Organophosphates	PON1 protein polymorphism affects the reaction [Organophosphates results in decreased activity of BCHE protein]	19750105
D010755	Organophosphates	pralidoxime inhibits the reaction [Organophosphates binds to and results in decreased activity of BCHE protein]	27551891
D010755	Organophosphates	Organophosphates results in decreased activity of BCHE protein	3215484
D010755	Organophosphates	Organophosphates results in decreased activity of BCHE protein	20412789
D010755	Organophosphates	Organophosphates results in increased phosphorylation of BCHE protein	20412789
D009943	Organophosphorus Compounds	Organophosphorus Compounds results in decreased activity of BCHE protein	27154493
D009943	Organophosphorus Compounds	BCHE gene polymorphism results in increased susceptibility to Organophosphorus Compounds	17955620
D009943	Organophosphorus Compounds	BCHE protein affects the susceptibility to Organophosphorus Compounds	17955620
D009943	Organophosphorus Compounds	BCHE protein mutant form results in increased hydrolysis of Organophosphorus Compounds	18508040
D009943	Organophosphorus Compounds	BCHE protein results in increased metabolism of Organophosphorus Compounds	22209767
D009943	Organophosphorus Compounds	Organophosphorus Compounds inhibits the reaction [BCHE protein results in increased metabolism of Succinylcholine]	12190811\|2432808
D009943	Organophosphorus Compounds	Organophosphorus Compounds metabolite binds to BCHE protein	22989774
D009943	Organophosphorus Compounds	Organophosphorus Compounds results in decreased activity of BCHE protein	16824336\|1795562
D009943	Organophosphorus Compounds	BCHE protein results in increased metabolism of Organophosphorus Compounds	22209767
D009943	Organophosphorus Compounds	Organophosphorus Compounds results in decreased activity of BCHE protein	27154493
C011960	oxamyl	[Carbaryl co-treated with Propoxur co-treated with Methiocarb co-treated with Methomyl co-treated with formetanate co-treated with oxamyl co-treated with Carbofuran] affects the activity of BCHE protein	22649187
C011960	oxamyl	BCHE protein affects the susceptibility to oxamyl	10871426
C011960	oxamyl	oxamyl results in decreased activity of BCHE protein	10871426
D010091	Oximes	Oximes binds to and results in decreased activity of BCHE protein	18501885
D010091	Oximes	Oximes inhibits the reaction [tabun results in decreased activity of BCHE protein]	22960624
D000073878	Palm Oil	Palm Oil affects the expression of BCHE mRNA	19680557
D000073878	Palm Oil	Palm Oil results in decreased expression of BCHE mRNA	18042831
D010261	Paraoxon	Paraoxon results in decreased activity of BCHE protein	4631366
D010261	Paraoxon	Paraoxon results in decreased activity of BCHE protein	4631366
D010261	Paraoxon	Paraoxon results in decreased activity of BCHE protein	4631366
D010261	Paraoxon	Paraoxon results in decreased activity of BCHE protein	4631366
D010261	Paraoxon	Paraoxon results in decreased activity of BCHE protein	4631366
D010261	Paraoxon	Paraoxon results in decreased activity of BCHE protein	12558160
D010261	Paraoxon	Paraoxon results in increased phosphorylation of and results in decreased activity of BCHE protein	12389909
D010261	Paraoxon	pralidoxime inhibits the reaction [Paraoxon results in decreased activity of BCHE protein]	12558160
D010261	Paraoxon	Paraoxon results in decreased activity of BCHE protein	26838044
D010261	Paraoxon	ALB protein results in decreased susceptibility to [Paraoxon results in decreased activity of BCHE protein]	20211614
D010261	Paraoxon	asoxime chloride inhibits the reaction [Paraoxon results in decreased activity of BCHE protein]	27693733
D010261	Paraoxon	BCHE protein inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]	23178380
D010261	Paraoxon	BCHE protein inhibits the reaction [Paraoxon results in decreased activity of BCHE protein]	23178380
D010261	Paraoxon	Glucosides inhibits the reaction [Paraoxon results in decreased activity of BCHE protein]	20227398
D010261	Paraoxon	Metoclopramide inhibits the reaction [Paraoxon binds to and results in decreased activity of BCHE protein]	12518340
D010261	Paraoxon	Obidoxime Chloride inhibits the reaction [Paraoxon results in decreased activity of BCHE protein]	27693733
D010261	Paraoxon	Paraoxon binds to and results in decreased activity of BCHE protein	12518340\|1566902
D010261	Paraoxon	Paraoxon binds to BCHE protein	18514178
D010261	Paraoxon	Paraoxon binds to BCHE protein modified form	18514178
D010261	Paraoxon	Paraoxon results in decreased activity of BCHE protein	16213467\|1861716
D010261	Paraoxon	pralidoxime inhibits the reaction [Paraoxon results in decreased activity of BCHE protein]	20227398
D010261	Paraoxon	pyridine-4-aldoxime inhibits the reaction [Paraoxon results in decreased activity of BCHE protein]	20227398
D010261	Paraoxon	pyridoxaloxime analog inhibits the reaction [Paraoxon results in decreased activity of BCHE protein]	27693733
D010261	Paraoxon	Ranitidine inhibits the reaction [Paraoxon results in decreased activity of BCHE protein]	16193528
D010261	Paraoxon	Tiapamil Hydrochloride inhibits the reaction [Paraoxon results in decreased activity of BCHE protein]	16193528
D010261	Paraoxon	Trimedoxime inhibits the reaction [Paraoxon results in decreased activity of BCHE protein]	18617161\|2769373
D010261	Paraoxon	BCHE protein modified form inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]	24384224
D010261	Paraoxon	BCHE protein inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]	23178380
D010261	Paraoxon	BCHE protein inhibits the reaction [Paraoxon results in decreased activity of BCHE protein]	23178380
D010261	Paraoxon	BCHE protein results in decreased susceptibility to Paraoxon	23178380
D010261	Paraoxon	Paraoxon results in decreased activity of BCHE protein	23178380
D010261	Paraoxon	Paraoxon results in decreased activity of BCHE protein	4631366
D010261	Paraoxon	BCHE protein inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]	23178380
D010261	Paraoxon	BCHE protein inhibits the reaction [Paraoxon results in decreased activity of BCHE protein]	23178380
D010261	Paraoxon	BCHE protein results in decreased susceptibility to Paraoxon	23178380
D010261	Paraoxon	Paraoxon results in decreased activity of BCHE protein	22209767\|2317838
D010261	Paraoxon	Paraoxon results in decreased activity of BCHE protein	4631366
D010261	Paraoxon	Paraoxon results in decreased activity of BCHE mRNA	19272400
D010261	Paraoxon	Paraoxon results in decreased activity of BCHE protein	12629810\|4631366
D010261	Paraoxon	Paraoxon results in decreased activity of BCHE protein	4631366
D010261	Paraoxon	Paraoxon results in decreased activity of BCHE protein	20211614
D010269	Paraquat	Paraquat results in decreased activity of BCHE protein	17364237
C005409	pararosaniline	pararosaniline results in decreased activity of BCHE protein	18656440
C005409	pararosaniline	pararosaniline results in decreased activity of BCHE protein	16036213
D010278	Parathion	[Methyl Parathion co-treated with Parathion] results in decreased activity of BCHE protein	1512808
D010278	Parathion	Parathion results in decreased activity of BCHE protein	18617161\|4998912
D010278	Parathion	Parathion results in decreased activity of BCHE protein	21767560\|2220976
D010278	Parathion	Parathion results in decreased activity of BCHE protein	23933531\|7150809
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in decreased expression of BCHE mRNA	27153767
D026023	Permethrin	[Pyridostigmine Bromide co-treated with Permethrin] results in increased activity of BCHE protein	14751452
D010575	Pesticides	BCHE gene polymorphism affects the susceptibility to Pesticides	15922524\|1610544
D010575	Pesticides	BCHE protein affects the susceptibility to Pesticides	17955620
D010575	Pesticides	Pesticides results in decreased activity of BCHE protein	16824336\|1795562
D010575	Pesticides	Pesticides results in decreased activity of BCHE protein	20412789
D010575	Pesticides	Pesticides results in increased phosphorylation of BCHE protein	20412789
D010624	Phenelzine	Phenelzine results in decreased expression of BCHE protein	5801348
D010634	Phenobarbital	Phenobarbital affects the expression of BCHE mRNA	23091169
D010640	Phenothiazines	Phenothiazines results in decreased activity of BCHE protein	16036213
D010656	Phenylephrine	Phenylephrine results in decreased activity of BCHE protein	28800181
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of BCHE mRNA"	27188386
D010664	Phenylmethylsulfonyl Fluoride	Phenylmethylsulfonyl Fluoride inhibits the reaction [BCHE protein results in increased hydrolysis of acetylthiocholine iodide]	28299395
D010664	Phenylmethylsulfonyl Fluoride	Phenylmethylsulfonyl Fluoride inhibits the reaction [BCHE protein results in increased hydrolysis of phenyl valerate]	28299395
D010664	Phenylmethylsulfonyl Fluoride	Phenylmethylsulfonyl Fluoride results in decreased activity of BCHE protein	28299395
C046357	phenylsaligenin cyclic phosphate	phenylsaligenin cyclic phosphate results in decreased activity of BCHE protein	21767566
C046357	phenylsaligenin cyclic phosphate	phenylsaligenin cyclic phosphate results in decreased activity of BCHE protein	9890196
C049867	phenyl valerate	acetylthiocholine iodide inhibits the reaction [BCHE protein results in increased hydrolysis of phenyl valerate]	28299395
C049867	phenyl valerate	BCHE protein results in increased hydrolysis of phenyl valerate	28299395
C049867	phenyl valerate	mipafox inhibits the reaction [BCHE protein results in increased hydrolysis of phenyl valerate]	28299395
C049867	phenyl valerate	Phenylmethylsulfonyl Fluoride inhibits the reaction [BCHE protein results in increased hydrolysis of phenyl valerate]	28299395
C049867	phenyl valerate	phenyl valerate inhibits the reaction [BCHE protein results in increased hydrolysis of acetylthiocholine iodide]	28299395
C049867	phenyl valerate	profenamine inhibits the reaction [BCHE protein results in increased hydrolysis of phenyl valerate]	28299395
C049867	phenyl valerate	Tetraisopropylpyrophosphamide inhibits the reaction [BCHE protein results in increased hydrolysis of phenyl valerate]	28299395
D010757	Phosphorous Acids	Phosphorous Acids results in decreased activity of BCHE protein	20035729
C013196	phosphoryl chloride	phosphoryl chloride results in decreased activity of BCHE protein	12641435
C013196	phosphoryl chloride	phosphoryl chloride results in decreased activity of BCHE protein	12641435
C013196	phosphoryl chloride	phosphoryl chloride results in decreased activity of BCHE protein	12641435
D010862	Pilocarpine	[Chlorpyrifos co-treated with Pilocarpine] results in decreased activity of BCHE protein	22874420
C060836	pioglitazone	[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of BCHE mRNA	27935865
C032727	piperidine	piperidine analog results in decreased activity of BCHE protein	17681794
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of BCHE mRNA	19710929
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of BCHE mRNA	19710929
C006253	pirinixic acid	pirinixic acid results in increased expression of BCHE mRNA	17426115\|1830175
D010936	Plant Extracts	Plant Extracts binds to and results in decreased activity of BCHE protein	20350537
D010936	Plant Extracts	Plant Extracts results in decreased activity of BCHE protein	17168769
D028321	Plant Preparations	[bacoside A co-treated with Plant Preparations] inhibits the reaction [Dichlorvos results in decreased expression of BCHE protein]	27899289
D028321	Plant Preparations	Plant Preparations results in decreased activity of BCHE protein	25910439
D011078	Polychlorinated Biphenyls	Polychlorinated Biphenyls results in decreased activity of BCHE protein	17097718
C028797	pralidoxime	pralidoxime inhibits the reaction [Dichlorvos results in decreased activity of BCHE protein]	3421541
C028797	pralidoxime	pralidoxime inhibits the reaction [Dichlorvos results in decreased activity of BCHE protein]	12558160
C028797	pralidoxime	pralidoxime inhibits the reaction [Paraoxon results in decreased activity of BCHE protein]	12558160
C028797	pralidoxime	pralidoxime results in increased activity of BCHE protein modified form	12389909
C028797	pralidoxime	BCHE protein binds to pralidoxime	22922115
C028797	pralidoxime	pralidoxime inhibits the reaction [Chlorpyrifos results in decreased activity of BCHE protein]	24052565
C028797	pralidoxime	pralidoxime inhibits the reaction [Cholinesterase Inhibitors binds to and results in decreased activity of BCHE protein]	27551891
C028797	pralidoxime	pralidoxime inhibits the reaction [Dichlorvos results in decreased activity of BCHE protein]	423703
C028797	pralidoxime	pralidoxime inhibits the reaction [Isoflurophate results in decreased activity of BCHE protein]	20227398
C028797	pralidoxime	pralidoxime inhibits the reaction [Organophosphates binds to and results in decreased activity of BCHE protein]	27551891
C028797	pralidoxime	pralidoxime inhibits the reaction [Paraoxon results in decreased activity of BCHE protein]	20227398
C028797	pralidoxime	pralidoxime inhibits the reaction [quinalphos results in decreased activity of BCHE protein]	24052565
C028797	pralidoxime	pralidoxime inhibits the reaction [Sarin analog inhibits the reaction [BCHE protein results in increased hydrolysis of Butyrylthiocholine]]	21802514
C028797	pralidoxime	pralidoxime inhibits the reaction [Sarin analog results in decreased activity of BCHE protein]	21802514
C028797	pralidoxime	pralidoxime inhibits the reaction [Trichlorfon results in decreased activity of BCHE protein]	18825528
C028797	pralidoxime	pralidoxime binds to and results in decreased activity of BCHE protein	16598855
C028797	pralidoxime	[Atropine co-treated with pralidoxime] results in decreased expression of BCHE protein	17963125
C028797	pralidoxime	[Methyl Parathion co-treated with pralidoxime co-treated with Atropine] results in decreased expression of BCHE protein	17963125
C028797	pralidoxime	[Methyl Parathion co-treated with pralidoxime] results in decreased expression of BCHE protein	17963125
C028797	pralidoxime	pralidoxime affects the reaction [4-nitrophenyl 2-propylmethylphosphonate results in decreased activity of BCHE protein]	26705700
C028797	pralidoxime	pralidoxime affects the reaction [ethyl 4-nitrophenyl methylphosphonate results in decreased activity of BCHE protein]	26705700
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in decreased expression of BCHE mRNA	28903501
D011335	Proadifen	Proadifen analog results in decreased activity of BCHE protein	236606
C065249	pro-diazepam	[BCHE protein co-treated with asoxime chloride co-treated with pro-diazepam co-treated with Atropine] results in decreased susceptibility to VX	22981459
C084820	profenamine	profenamine results in decreased activity of BCHE protein	18656440
C084820	profenamine	profenamine results in decreased activity of BCHE protein	26838044
C084820	profenamine	profenamine inhibits the reaction [BCHE protein results in increased hydrolysis of acetylthiocholine iodide]	28299395
C084820	profenamine	profenamine inhibits the reaction [BCHE protein results in increased hydrolysis of phenyl valerate]	28299395
C084820	profenamine	profenamine results in decreased activity of BCHE protein	18656440\|2829939
C084820	profenamine	profenamine results in decreased activity of BCHE protein	18656440
C084820	profenamine	profenamine results in decreased activity of BCHE protein	27238725
C084820	profenamine	profenamine results in decreased expression of BCHE protein	12003252
C024273	profenofos	profenofos results in decreased activity of BCHE protein	9890196
D011374	Progesterone	Progesterone results in decreased expression of BCHE mRNA	23012394
D011395	Promazine	Promazine results in decreased activity of BCHE protein	236606
D011398	Promethazine	Promethazine results in decreased activity of BCHE protein	236606
D011398	Promethazine	Promethazine results in decreased activity of BCHE protein	236606
C009062	propionylcholine	BCHE protein results in increased hydrolysis of propionylcholine	4631366
C009063	propionylthiocholine	BCHE protein mutant form results in decreased metabolism of propionylthiocholine	10421449
C009063	propionylthiocholine	BCHE protein results in increased metabolism of propionylthiocholine	10421449
D001074	Propoxur	[Carbaryl co-treated with Propoxur co-treated with Methiocarb co-treated with Methomyl co-treated with formetanate co-treated with oxamyl co-treated with Carbofuran] affects the activity of BCHE protein	22649187
D011522	Protons	Protons inhibits the reaction [Diphenhydramine results in decreased activity of BCHE protein]	236606
D011522	Protons	Protons promotes the reaction [Diphenhydramine results in decreased activity of BCHE protein]	236606
D011522	Protons	Protons affects the reaction [Diphenhydramine results in decreased activity of BCHE protein]	236606
D011522	Protons	Protons affects the reaction [Tripelennamine results in decreased activity of BCHE protein]	236606
D011692	Puromycin Aminonucleoside	Puromycin Aminonucleoside results in increased activity of BCHE protein	1462003
C513428	pyrachlostrobin	pyrachlostrobin results in increased expression of BCHE mRNA	27029645
C050580	pyridine-4-aldoxime	pyridine-4-aldoxime inhibits the reaction [Paraoxon results in decreased activity of BCHE protein]	20227398
D011729	Pyridostigmine Bromide	[Pyridostigmine Bromide co-treated with DEET] results in increased activity of BCHE protein	14751452
D011729	Pyridostigmine Bromide	[Pyridostigmine Bromide co-treated with Permethrin] results in increased activity of BCHE protein	14751452
D011729	Pyridostigmine Bromide	Pyridostigmine Bromide results in decreased activity of BCHE protein	14751452
D011729	Pyridostigmine Bromide	Pyridostigmine Bromide results in decreased activity of BCHE protein	16914529
C028073	pyridoxaloxime	pyridoxaloxime analog binds to and results in decreased activity of BCHE protein	27693733
C028073	pyridoxaloxime	pyridoxaloxime analog inhibits the reaction [Paraoxon results in decreased activity of BCHE protein]	27693733
C028073	pyridoxaloxime	pyridoxaloxime analog inhibits the reaction [VX results in decreased activity of BCHE protein]	27693733
D011738	Pyrilamine	Pyrilamine results in decreased activity of BCHE protein	236606
D011743	Pyrimidines	Pyrimidines results in decreased activity of BCHE protein	18585370
D011794	Quercetin	Quercetin binds to and results in decreased activity of BCHE protein	19596285
D011794	Quercetin	Quercetin inhibits the reaction [Cadmium Chloride results in increased activity of BCHE protein]	25064450
C009145	quinalphos	pralidoxime inhibits the reaction [quinalphos results in decreased activity of BCHE protein]	24052565
C009145	quinalphos	quinalphos results in decreased activity of BCHE protein	24052565
D011899	Ranitidine	Ranitidine binds to and results in decreased activity of BCHE protein	15669026
D011899	Ranitidine	Ranitidine inhibits the reaction [Paraoxon results in decreased activity of BCHE protein]	16193528
C059514	resveratrol	resveratrol results in increased expression of BCHE mRNA	18586690
C059514	resveratrol	Lindane inhibits the reaction [[resveratrol co-treated with Ascorbic Acid co-treated with Thioctic Acid co-treated with Vitamin E] results in increased activity of BCHE protein]	20663516
C059514	resveratrol	[resveratrol co-treated with Ascorbic Acid co-treated with Thioctic Acid co-treated with Vitamin E] results in increased activity of BCHE protein	20663516
C059514	resveratrol	[Dietary Fats co-treated with resveratrol] results in increased expression of BCHE mRNA	21852083
D000068836	Rivastigmine	Rivastigmine results in decreased activity of BCHE protein	14535624
D000068836	Rivastigmine	Rivastigmine results in decreased activity of BCHE protein	19345205
C006266	Ro 20683	BCHE gene mutant form inhibits the reaction [Ro 20683 results in decreased activity of BCHE protein]	7205429\|7205429
C089730	rosiglitazone	rosiglitazone results in decreased expression of BCHE mRNA	25572481
C572498	RS194B	RS194B inhibits the reaction [tabun results in decreased activity of BCHE protein]	22960624
C572498	RS194B	[RS194B co-treated with Atropine] affects the reaction [Sarin results in decreased activity of BCHE protein]	28693885
C572498	RS194B	RS194B inhibits the reaction [ethylparaoxon results in decreased activity of BCHE protein]	28693885
C572498	RS194B	RS194B inhibits the reaction [Sarin analog results in decreased activity of BCHE protein]	28693885
C010631	salicyl alcohol	[2-(2-cresyl)-4H-1-3-2-benzodioxaphosphorin-2-oxide binds to and results in decreased activity of BCHE protein] which results in increased abundance of salicyl alcohol	22898212
D012524	Sarin	methylatropine inhibits the reaction [Sarin results in decreased activity of BCHE protein]	19523969
D012524	Sarin	Sarin results in decreased activity of BCHE protein	19523969
D012524	Sarin	Sarin results in decreased activity of BCHE protein	15888665\|2132974
D012524	Sarin	BCHE protein results in decreased susceptibility to Sarin	26145887
D012524	Sarin	"N,N'-monomethylenebis(pyridiniumaldoxime) inhibits the reaction [Sarin analog inhibits the reaction [BCHE protein results in increased hydrolysis of Butyrylthiocholine]]"	21802514
D012524	Sarin	"N,N'-monomethylenebis(pyridiniumaldoxime) inhibits the reaction [Sarin analog results in decreased activity of BCHE protein]"	21802514
D012524	Sarin	PON1 protein inhibits the reaction [Sarin results in decreased activity of BCHE protein]	21329748
D012524	Sarin	pralidoxime inhibits the reaction [Sarin analog inhibits the reaction [BCHE protein results in increased hydrolysis of Butyrylthiocholine]]	21802514
D012524	Sarin	pralidoxime inhibits the reaction [Sarin analog results in decreased activity of BCHE protein]	21802514
D012524	Sarin	Sarin analog inhibits the reaction [BCHE protein results in increased hydrolysis of Butyrylthiocholine]	21802514
D012524	Sarin	Sarin analog promotes the reaction [Sarin binds to BCHE protein]	19715348
D012524	Sarin	Sarin analog results in decreased activity of BCHE protein	19715346\|2180251
D012524	Sarin	Sarin binds to BCHE protein	19715348
D012524	Sarin	Sarin metabolite results in decreased activity of BCHE protein	17698511
D012524	Sarin	Sarin results in decreased activity of BCHE protein	17698511\|1861716
D012524	Sarin	Sarin results in decreased expression of BCHE mRNA	19522546
D012524	Sarin	Sarin results in increased phosphorylation of BCHE protein	22247004
D012524	Sarin	[RS194B co-treated with Atropine] affects the reaction [Sarin results in decreased activity of BCHE protein]	28693885
D012524	Sarin	RS194B inhibits the reaction [Sarin analog results in decreased activity of BCHE protein]	28693885
D012524	Sarin	Sarin analog results in decreased activity of BCHE protein	28693885
D012524	Sarin	Sarin results in decreased activity of BCHE protein	28693885
D012524	Sarin	Sarin results in decreased activity of BCHE protein	26778279
D012524	Sarin	"2-(hydroxyimino)-N,N-dimethyl-N'-propylacetimidamide inhibits the reaction [Sarin results in decreased activity of BCHE protein]"	21438612
D012524	Sarin	"N'-ethyl-2-(hydroxyimino)-N,N-dimethylacetimidamide inhibits the reaction [Sarin results in decreased activity of BCHE protein]"	21438612
D012524	Sarin	Sarin results in decreased activity of BCHE protein	21438612
C515112	schaftoside	schaftoside results in decreased activity of BCHE protein	26297990
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of BCHE mRNA	25895662
D012822	Silicon Dioxide	Silicon Dioxide analog results in increased expression of BCHE mRNA	23806026
D012906	Smoke	Smoke results in increased expression of BCHE mRNA	21095227
C451779	S-(N,N-diethylaminoethyl) isobutyl methylphosphothiolate	"S-(N,N-diethylaminoethyl) isobutyl methylphosphothiolate metabolite results in decreased activity of BCHE protein"	17698511
C451779	S-(N,N-diethylaminoethyl) isobutyl methylphosphothiolate	"S-(N,N-diethylaminoethyl) isobutyl methylphosphothiolate results in decreased activity of BCHE protein"	19428953
C009277	sodium arsenate	sodium arsenate results in increased expression of BCHE mRNA	21795629
D012969	Sodium Fluoride	Sodium Fluoride inhibits the reaction [BCHE protein results in increased metabolism of Butyrylthiocholine]	27109752
D012999	Soman	Soman results in decreased activity of BCHE protein	20206646
D012999	Soman	Soman results in decreased activity of BCHE protein	21329748
D012999	Soman	BCHE protein results in decreased susceptibility to Soman	23044488
D012999	Soman	PON1 protein inhibits the reaction [Soman results in decreased activity of BCHE protein]	21329748
D012999	Soman	Soman analog promotes the reaction [Soman binds to BCHE protein]	19715348
D012999	Soman	Soman analog results in decreased activity of BCHE protein	19715346
D012999	Soman	Soman binds to BCHE protein	19715348
D012999	Soman	Soman results in decreased activity of BCHE protein	17698511
D012999	Soman	Soman results in decreased susceptibility to BCHE protein	18674756
D012999	Soman	Soman analog results in decreased activity of BCHE protein	22209767
D012999	Soman	Soman results in decreased activity of BCHE protein	20816720\|2728741
D013311	Streptozocin	Acetylcysteine inhibits the reaction [Streptozocin results in increased activity of BCHE protein]	27087133
D013311	Streptozocin	Streptozocin results in increased activity of BCHE protein	27087133
D013390	Succinylcholine	BCHE protein results in increased hydrolysis of Succinylcholine	4985882
D013390	Succinylcholine	Succinylcholine inhibits the reaction [BCHE protein results in increased hydrolysis of butyrylcholine]	4985882
D013390	Succinylcholine	BCHE protein results in increased hydrolysis of Succinylcholine	4985882
D013390	Succinylcholine	Isoflurophate inhibits the reaction [BCHE protein results in increased hydrolysis of Succinylcholine]	4985882
D013390	Succinylcholine	Succinylcholine inhibits the reaction [BCHE protein results in increased hydrolysis of butyrylcholine]	4985882
D013390	Succinylcholine	Tetraisopropylpyrophosphamide inhibits the reaction [BCHE protein results in increased hydrolysis of Succinylcholine]	4985882
D013390	Succinylcholine	BCHE protein results in increased hydrolysis of Succinylcholine	4985882
D013390	Succinylcholine	Succinylcholine inhibits the reaction [BCHE protein results in increased hydrolysis of butyrylcholine]	4985882
D013390	Succinylcholine	BCHE affects the susceptibility to Succinylcholine	16884476\|1839984
D013390	Succinylcholine	BCHE gene mutant form affects the susceptibility to Succinylcholine	18075469
D013390	Succinylcholine	BCHE gene mutant form results in increased susceptibility to Succinylcholine	1147298\|1218179\|
D013390	Succinylcholine	BCHE gene polymorphism affects the susceptibility to Succinylcholine	16788378\|9110359
D013390	Succinylcholine	BCHE gene polymorphism results in increased susceptibility to Succinylcholine	6465587\|7294376
D013390	Succinylcholine	BCHE protein affects the susceptibility to Succinylcholine	15688329
D013390	Succinylcholine	BCHE protein mutant form affects the hydrolysis of Succinylcholine	18555211
D013390	Succinylcholine	BCHE protein mutant form results in decreased hydrolysis of Succinylcholine	4985882
D013390	Succinylcholine	BCHE protein mutant form results in increased susceptibility to Succinylcholine	1058931\|1218148\|
D013390	Succinylcholine	BCHE protein results in decreased abundance of Succinylcholine	5412891
D013390	Succinylcholine	BCHE protein results in increased hydrolysis of Succinylcholine	18555211\|4985882
D013390	Succinylcholine	BCHE protein results in increased metabolism of Succinylcholine	12190811\|2122836
D013390	Succinylcholine	[Dichlorvos results in decreased activity of BCHE protein] which results in increased susceptibility to Succinylcholine	12190811
D013390	Succinylcholine	Insecticides inhibits the reaction [BCHE protein results in increased metabolism of Succinylcholine]	12190811
D013390	Succinylcholine	Organophosphorus Compounds inhibits the reaction [BCHE protein results in increased metabolism of Succinylcholine]	12190811\|2432808
D013390	Succinylcholine	Succinylcholine inhibits the reaction [BCHE protein results in increased hydrolysis of butyrylcholine]	4985882
D013390	Succinylcholine	BCHE protein results in increased hydrolysis of Succinylcholine	4985882
D013390	Succinylcholine	Succinylcholine inhibits the reaction [BCHE protein results in increased hydrolysis of butyrylcholine]	4985882
D013390	Succinylcholine	BCHE protein results in increased hydrolysis of Succinylcholine	4985882
D013390	Succinylcholine	Succinylcholine inhibits the reaction [BCHE protein results in increased hydrolysis of butyrylcholine]	4985882
D013390	Succinylcholine	BCHE protein results in increased hydrolysis of Succinylcholine	15688329
D013390	Succinylcholine	BCHE protein results in increased metabolism of and results in decreased activity of Succinylcholine	9890196
C009340	succinyldithiocholine	BCHE gene mutant form inhibits the reaction [BCHE protein results in increased degradation of succinyldithiocholine]	3367107\|3367107
C035798	succinylmonocholine	BCHE protein results in increased hydrolysis of succinylmonocholine	4998912
D013578	Synephrine	Synephrine results in decreased activity of BCHE protein	28800181
C009374	tabun	asoxime chloride inhibits the reaction [tabun results in decreased activity of BCHE protein]	27693733
C009374	tabun	Cholinesterase Reactivators inhibits the reaction [tabun results in decreased activity of BCHE protein]	22960624
C009374	tabun	K117 compound inhibits the reaction [tabun results in decreased activity of BCHE protein]	20206154
C009374	tabun	K127 compound inhibits the reaction [tabun results in decreased activity of BCHE protein]	20206154
C009374	tabun	Obidoxime Chloride inhibits the reaction [tabun results in decreased activity of BCHE protein]	27693733
C009374	tabun	Oximes inhibits the reaction [tabun results in decreased activity of BCHE protein]	22960624
C009374	tabun	RS194B inhibits the reaction [tabun results in decreased activity of BCHE protein]	22960624
C009374	tabun	tabun analog affects the metabolism of and affects the activity of BCHE protein	20381476
C009374	tabun	tabun analog promotes the reaction [tabun binds to BCHE protein]	19715348
C009374	tabun	tabun analog results in decreased activity of BCHE protein	19715346
C009374	tabun	tabun binds to and results in decreased activity of BCHE protein	22960624
C009374	tabun	tabun binds to BCHE protein	19715348
C009374	tabun	tabun results in decreased activity of BCHE protein	18501885\|1861716
C009374	tabun	Trimedoxime inhibits the reaction [tabun results in decreased activity of BCHE protein]	27693733
C009374	tabun	tabun analog results in decreased activity of BCHE protein	22209767
C009374	tabun	"2-(hydroxyimino)-N,N-dimethyl-N'-propylacetimidamide inhibits the reaction [tabun results in decreased activity of BCHE protein]"	21438612
C009374	tabun	"N'-ethyl-2-(hydroxyimino)-N,N-dimethylacetimidamide inhibits the reaction [tabun results in decreased activity of BCHE protein]"	21438612
C009374	tabun	tabun binds to and results in decreased activity of BCHE protein	23345579
C009374	tabun	tabun results in decreased activity of BCHE protein	21438612
D013619	Tacrine	Tacrine results in decreased activity of BCHE protein	2606156
D013619	Tacrine	Tacrine results in decreased activity of BCHE protein	18656440\|9228650
D013619	Tacrine	Tacrine results in decreased activity of BCHE protein	18656440
D013619	Tacrine	Tacrine results in decreased activity of BCHE protein	28117934
C013698	tallow	tallow affects the expression of BCHE mRNA	19680557
C523979	tapentadol	tapentadol results in decreased activity of BCHE protein	28689766
C046393	tert-butylphenyl diphenyl phosphate	[tert-butylphenyl diphenyl phosphate co-treated with NADP] results in decreased activity of BCHE protein	23085349
D013739	Testosterone	[Testosterone co-treated with Calcitriol] results in decreased expression of BCHE mRNA	21592394
D013739	Testosterone	Testosterone results in decreased expression of BCHE mRNA	21592394
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of BCHE mRNA	28922406
D013750	Tetrachloroethylene	Tetrachloroethylene results in increased expression of BCHE mRNA	28973375
D013770	Tetraisopropylpyrophosphamide	Tetraisopropylpyrophosphamide inhibits the reaction [BCHE protein results in increased hydrolysis of Succinylcholine]	4985882
D013770	Tetraisopropylpyrophosphamide	Tetraisopropylpyrophosphamide results in decreased activity of BCHE protein	12558160
D013770	Tetraisopropylpyrophosphamide	Tetraisopropylpyrophosphamide results in decreased activity of BCHE protein	26838044
D013770	Tetraisopropylpyrophosphamide	Tetraisopropylpyrophosphamide inhibits the reaction [BCHE protein results in increased hydrolysis of acetylthiocholine iodide]	28299395
D013770	Tetraisopropylpyrophosphamide	Tetraisopropylpyrophosphamide inhibits the reaction [BCHE protein results in increased hydrolysis of phenyl valerate]	28299395
D013770	Tetraisopropylpyrophosphamide	Tetraisopropylpyrophosphamide results in decreased activity of BCHE protein	28299395
D013770	Tetraisopropylpyrophosphamide	Tetraisopropylpyrophosphamide results in decreased activity of BCHE protein	18761328
D013770	Tetraisopropylpyrophosphamide	Tetraisopropylpyrophosphamide results in decreased activity of BCHE protein	10871426
D053778	Thiazolidines	Thiazolidines results in decreased activity of BCHE protein	28544359
D013860	Thiocholine	BCHE protein results in increased chemical synthesis of Thiocholine	19699221
D013860	Thiocholine	[BCHE protein results in increased metabolism of Butyrylthiocholine] which results in increased chemical synthesis of Thiocholine	19699221
D008063	Thioctic Acid	Lindane inhibits the reaction [[resveratrol co-treated with Ascorbic Acid co-treated with Thioctic Acid co-treated with Vitamin E] results in increased activity of BCHE protein]	20663516
D008063	Thioctic Acid	[resveratrol co-treated with Ascorbic Acid co-treated with Thioctic Acid co-treated with Vitamin E] results in increased activity of BCHE protein	20663516
D013882	Thiosemicarbazones	Thiosemicarbazones inhibits the reaction [methamidophos results in decreased activity of BCHE protein]	22542756
D013852	Thiotepa	[Melphalan co-treated with Thiotepa co-treated with Cyclophosphamide] results in decreased expression of BCHE protein	4672170
D013890	Thiourea	Thiourea analog results in decreased activity of BCHE protein	28117934
D013976	Tiapamil Hydrochloride	Tiapamil Hydrochloride binds to BCHE protein	16193528
D013976	Tiapamil Hydrochloride	Tiapamil Hydrochloride inhibits the reaction [Dichlorvos results in decreased activity of BCHE protein]	16036766\|1619352
D013976	Tiapamil Hydrochloride	Tiapamil Hydrochloride inhibits the reaction [Paraoxon results in decreased activity of BCHE protein]	16193528
D014147	Tramadol	Tramadol results in decreased activity of BCHE protein	28689766
D014236	Trichlorfon	Trichlorfon results in decreased activity of BCHE protein	235931
D014236	Trichlorfon	1-(4-hydroxyiminomethylpyridinium)-4-(4-carbamoylpyridinium)butane inhibits the reaction [Trichlorfon results in decreased activity of BCHE protein]	18825528
D014236	Trichlorfon	asoxime chloride inhibits the reaction [Trichlorfon results in decreased activity of BCHE protein]	18825528
D014236	Trichlorfon	Obidoxime Chloride inhibits the reaction [Trichlorfon results in decreased activity of BCHE protein]	18825528
D014236	Trichlorfon	pralidoxime inhibits the reaction [Trichlorfon results in decreased activity of BCHE protein]	18825528
D014236	Trichlorfon	Trichlorfon results in decreased activity of BCHE protein	18825528\|235931
D014236	Trichlorfon	Trichlorfon results in decreased activity of BCHE protein	11311445\|235931
C012589	trichostatin A	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BCHE mRNA"	27188386
C012589	trichostatin A	trichostatin A results in increased expression of BCHE mRNA	24935251\|2627250
D014289	Trimedoxime	Trimedoxime binds to and results in decreased activity of BCHE protein	27693733
D014289	Trimedoxime	Trimedoxime inhibits the reaction [Paraoxon results in decreased activity of BCHE protein]	18617161\|2769373
D014289	Trimedoxime	Trimedoxime inhibits the reaction [tabun results in decreased activity of BCHE protein]	27693733
C025541	tri-o-cresyl phosphate	tri-o-cresyl phosphate results in decreased expression of BCHE protein	13019039
C025541	tri-o-cresyl phosphate	[tri-o-cresyl phosphate co-treated with NADP] results in decreased activity of BCHE protein	23085349
C025541	tri-o-cresyl phosphate	tri-o-cresyl phosphate results in decreased activity of BCHE protein	21767560
D014309	Tripelennamine	Acetylcholine inhibits the reaction [Tripelennamine results in decreased activity of BCHE protein]	236606
D014309	Tripelennamine	Protons affects the reaction [Tripelennamine results in decreased activity of BCHE protein]	236606
D014309	Tripelennamine	Tripelennamine results in decreased activity of BCHE protein	236606
C013320	tris(2-butoxyethyl) phosphate	tris(2-butoxyethyl) phosphate results in decreased activity of BCHE protein	24685621
D014317	Tritolyl Phosphates	naringenin inhibits the reaction [[Tritolyl Phosphates co-treated with NADP] results in decreased activity of BCHE protein]	23085349
D014317	Tritolyl Phosphates	Tritolyl Phosphates results in decreased activity of BCHE protein	23085349
C005460	uranyl acetate	uranyl acetate affects the expression of BCHE mRNA	19409444
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BCHE mRNA"	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of BCHE mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of BCHE mRNA	23179753\|2800136
D014635	Valproic Acid	Valproic Acid results in increased expression of BCHE mRNA	24383497\|2493525
D014635	Valproic Acid	Valproic Acid results in increased expression of BCHE mRNA	24896083
C025643	vinclozolin	vinclozolin results in increased expression of BCHE mRNA	23034163
D014810	Vitamin E	Lindane inhibits the reaction [[resveratrol co-treated with Ascorbic Acid co-treated with Thioctic Acid co-treated with Vitamin E] results in increased activity of BCHE protein]	20663516
D014810	Vitamin E	[resveratrol co-treated with Ascorbic Acid co-treated with Thioctic Acid co-treated with Vitamin E] results in increased activity of BCHE protein	20663516
C111237	vorinostat	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BCHE mRNA"	27188386
C111237	vorinostat	vorinostat results in increased expression of BCHE mRNA	26272509\|2718838
C009680	VX	[BCHE protein binds to BCHE protein] which results in decreased susceptibility to VX	20513442
C009680	VX	Obidoxime Chloride inhibits the reaction [VX results in decreased activity of BCHE protein]	20599844
C009680	VX	VX results in decreased activity of BCHE protein	20599844
C009680	VX	asoxime chloride inhibits the reaction [VX results in decreased activity of BCHE protein]	27358236\|2769373
C009680	VX	[BCHE protein co-treated with asoxime chloride co-treated with pro-diazepam co-treated with Atropine] results in decreased susceptibility to VX	22981459
C009680	VX	Obidoxime Chloride inhibits the reaction [VX results in decreased activity of BCHE protein]	27358236\|2769373
C009680	VX	pyridoxaloxime analog inhibits the reaction [VX results in decreased activity of BCHE protein]	27693733
C009680	VX	VX metabolite results in decreased activity of BCHE protein	17698511
C009680	VX	VX results in decreased activity of BCHE protein	18617161\|1942895
D015034	Zinc Oxide	Zinc Oxide results in decreased activity of BCHE protein	27441385
C088658	zoledronic acid	zoledronic acid results in decreased expression of BCHE mRNA	24714768

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001540	amyloid-beta binding	-	NAS	11569538
GO:0003824	catalytic activity	-	NAS	11569538
GO:0003990	acetylcholinesterase activity	-	ISS	-
GO:0004104	cholinesterase activity	-	IDA	19452557
GO:0016788	hydrolase activity, acting on ester bonds	-	TAS	-
GO:0019899	enzyme binding	-	NAS	11569538
GO:0033265	choline binding	-	IEA	-
GO:0042802	identical protein binding	-	IPI	17660298 20883446 21059932 22726956

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0007612	learning	-	IEA	-
GO:0008285	negative regulation of cell proliferation	-	IEA	-
GO:0014016	neuroblast differentiation	-	IEA	-
GO:0019695	choline metabolic process	-	IEA	-
GO:0043279	response to alkaloid	-	IEA	-
GO:0050783	cocaine metabolic process	-	TAS	8622553
GO:0050805	negative regulation of synaptic transmission	-	IEA	-
GO:0051384	response to glucocorticoid	-	IEA	-
GO:0051593	response to folic acid	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	NAS	14718574
GO:0005576	extracellular region	-	TAS	-
GO:0005641	nuclear envelope lumen	-	IEA	-
GO:0005788	endoplasmic reticulum lumen	-	IEA	-
GO:0016020	membrane	-	IEA	-
GO:0072562	blood microparticle	-	HDA	22516433

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-112311	Neurotransmitter clearance	TAS
R-HSA-112315	Transmission across Chemical Synapses	TAS
R-HSA-112316	Neuronal System	TAS
R-HSA-1430728	Metabolism	TAS
R-HSA-1483191	Synthesis of PC	TAS
R-HSA-1483206	Glycerophospholipid biosynthesis	TAS
R-HSA-1483257	Phospholipid metabolism	TAS
R-HSA-2980736	Peptide hormone metabolism	TAS
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-422085	Synthesis, secretion, and deacylation of Ghrelin	TAS
R-HSA-556833	Metabolism of lipids	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
25524052	Safety, pharmacokinetics, and pharmacodynamics of TV-1380, a novel mutated butyrylcholinesterase treatment for cocaine addiction, after single and multiple intramuscular injections in healthy subjects. (2015 May)	Cohen-Barak O	J Clin Pharmacol
28465191	Activity of cholinesterases in a young and healthy middle-European population: Relevance for toxicology, pharmacology and clinical praxis. (2017 Aug 5)	Karasova JZ	Toxicol Lett
9449014	Enhancing cocaine metabolism with butyrylcholinesterase as a treatment strategy. (1997 Dec 15)	Gorelick DA	Drug Alcohol Depend
25814464	Reward and Toxicity of Cocaine Metabolites Generated by Cocaine Hydrolase. (2015 Aug)	Murthy V	Cell Mol Neurobiol
24643289	A highly efficient cocaine-detoxifying enzyme obtained by computational design. (2014 Mar 18)	Zheng F	Nat Commun
24892251	Physiologic and metabolic safety of butyrylcholinesterase gene therapy in mice. (2014 Jul 16)	Murthy V	Vaccine
18514640	An albumin-butyrylcholinesterase for cocaine toxicity and addiction: catalytic and pharmacokinetic properties. (2008 Sep 25)	Gao Y	Chem Biol Interact
20060817	Characterization of a high-activity mutant of human butyrylcholinesterase against (-)-cocaine. (2010 Sep 6)	Yang W	Chem Biol Interact
26082975	Assessment of Pharmacokinetic and Pharmacodynamic Interactions Between Albumin-Fused Mutated Butyrylcholinesterase and Intravenously Administered Cocaine in Recreational Cocaine Users. (2015 Aug)	Shram MJ	J Clin Psychopharmacol
24870023	Kinetic characterization of human butyrylcholinesterase mutants for the hydrolysis of cocaethylene. (2014 Jun 15)	Hou S	Biochem J
24312228	Butyrylcholinesterase genetic variants: association with cocaine dependence and related phenotypes. (2013)	Negrao AB	PLoS One
24077614	Substrate selectivity of high-activity mutants of human butyrylcholinesterase. (2013 Nov 21)	Hou S	Org Biomol Chem
16243302	Visualizing viral transduction of a cocaine-hydrolyzing, human butyrylcholinesterase in rats. (2005 Dec 15)	Gao Y	Chem Biol Interact
23000451	Plants as a source of butyrylcholinesterase variants designed for enhanced cocaine hydrolase activity. (2013 Mar 25)	Larrimore KE	Chem Biol Interact
25956553	Dysregulated cholinergic network as a novel biomarker of poor prognostic in patients with head and neck squamous cell carcinoma. (2015 May 10)	Castillo-Gonzalez AC	BMC Cancer
25321637	Butyrylcholinesterase levels and subjective effects of smoked cocaine in healthy cocaine users. (2015 Mar)	Askalsky P	Am J Drug Alcohol Abuse
22264200	Modification of pharmacokinetic and abuse-related effects of cocaine by human-derived cocaine hydrolase in monkeys. (2013 Jan)	Schindler CW	Addict Biol
19393262	Interaction between human serum esterases and environmental metal compounds. (2009 Jul)	Hernandez AF	Neurotoxicology
28874829	Plant-expressed cocaine hydrolase variants of butyrylcholinesterase exhibit altered allosteric effects of cholinesterase activity and increased inhibitor sensitivity. (2017 Sep 5)	Larrimore KE	Sci Rep
17989928	Rational design of an enzyme mutant for anti-cocaine therapeutics. (2008 Sep)	Zheng F	J Comput Aided Mol Des
23840704	Gene transfer of mutant mouse cholinesterase provides high lifetime expression and reduced cocaine responses with no evident toxicity. (2013)	Geng L	PLoS One
9725111	Attenuation of cocaine-induced locomotor activity by butyrylcholinesterase. (1998 Aug)	Carmona GN	Exp Clin Psychopharmacol
29535625	Treating Cocaine Addiction, Obesity, and Emotional Disorders by Viral Gene Transfer of Butyrylcholinesterase. (2018)	Brimijoin S	Front Pharmacol
23849058	Preparation and in vivo characterization of a cocaine hydrolase engineered from human butyrylcholinesterase for metabolizing cocaine. (2013 Aug 1)	Xue L	Biochem J
22229308	Interception of cocaine by enzyme or antibody delivered with viral gene transfer: a novel strategy for preventing relapse in recovering drug users. (2011 Dec)	Brimijoin S	CNS Neurol Disord Drug Targets
25646463	Plasma butyrylcholinesterase regulates ghrelin to control aggression. (2015 Feb 17)	Chen VP	Proc Natl Acad Sci U S A
24085526	Preclinical studies on neurobehavioral and neuromuscular effects of cocaine hydrolase gene therapy in mice. (2014 Jul)	Murthy V	J Mol Neurosci
22917637	Catalytic activities of a cocaine hydrolase engineered from human butyrylcholinesterase against (+)- and (-)-cocaine. (2013 Mar 25)	Xue L	Chem Biol Interact
24407266	Long-term reduction of cocaine self-administration in rats treated with adenoviral vector-delivered cocaine hydrolase: evidence for enzymatic activity. (2014 May)	Zlebnik NE	Neuropsychopharmacology
24582612	Amino-acid mutations to extend the biological half-life of a therapeutically valuable mutant of human butyrylcholinesterase. (2014 May 5)	Fang L	Chem Biol Interact
29234928	Alterations in acetylcholinesterase and butyrylcholinesterase activities in chronic obstructive pulmonary disease: relationships with oxidative and inflammatory markers. (2017 Dec 12)	Ben Anes A	Mol Cell Biochem
19402731	Model of human butyrylcholinesterase tetramer by homology modeling and dynamics simulation. (2009 May 7)	Pan Y	J Phys Chem B
18710224	Most efficient cocaine hydrolase designed by virtual screening of transition states. (2008 Sep 10)	Zheng F	J Am Chem Soc
28070124	An endophenotype approach to the genetics of alcohol dependence: a genome wide association study of fast beta EEG in families of African ancestry. (2017 Dec)	Meyers JL	Mol Psychiatry
24125115	Kinetic characterization of high-activity mutants of human butyrylcholinesterase for the cocaine metabolite norcocaine. (2014 Jan 1)	Zhan M	Biochem J
27154495	Effects of a cocaine hydrolase engineered from human butyrylcholinesterase on metabolic profile of cocaine in rats. (2016 Nov 25)	Chen X	Chem Biol Interact
14555401	Increased expression of glial fibrillary acidic protein in cerebellum and hippocampus: differential effects on neonatal brain regional acetylcholinesterase following maternal exposure to combined chlorpyrifos and nicotine. (2003 Nov 14)	Abdel-Rahman A	J Toxicol Environ Health A
10681384	Butyrylcholinesterase accelerates cocaine metabolism: in vitro and in vivo effects in nonhuman primates and humans. (2000 Mar)	Carmona GN	Drug Metab Dispos
27394932	Placebo-controlled evaluation of a bioengineered, cocaine-metabolizing fusion protein, TV-1380 (AlbuBChE), in the treatment of cocaine dependence. (2016 Sep 1)	Gilgun-Sherki Y	Drug Alcohol Depend
26968195	Long-Term Blockade of Cocaine Self-Administration and Locomotor Activation in Rats by an Adenoviral Vector-Delivered Cocaine Hydrolase. (2016 May)	Smethells JR	J Pharmacol Exp Ther