Gene: RANGAP1

5905
Fug1|RANGAP|SD
Ran GTPase activating protein 1
protein-coding
22q13.2
Ensembl:ENSG00000100401 MIM:602362 Vega:OTTHUMG00000150940 UniprotKB:P46060
NC_000022.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.587e-1 (AD)  9.064e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
AARS0.953
PPP2R2D0.941
IGSF80.939
FXR20.938
WIPI20.938
TCOF10.936
TBC1D10B0.934
SLC22A170.932
ATP6V0C0.932
MTCH10.931

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.63
OR4F29-0.613
IL18RAP-0.474
TFPI2-0.464
KLRB1-0.46
KLRF1-0.452
CXCR2-0.446
CEACAM3-0.443
EBF1-0.438
CEACAM4-0.436

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C49562614-deoxy-11,12-didehydroandrographolide"14-deoxy-11,12-didehydroandrographolide results in decreased expression of RANGAP1 mRNA"22101062
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of RANGAP1 mRNA"25614096
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of RANGAP1 mRNA"19167446
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of RANGAP1 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of RANGAP1 mRNA"21346803
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of RANGAP1 mRNA"23196670
D000082AcetaminophenAcetaminophen results in increased expression of RANGAP1 mRNA22230336|2906747
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of RANGAP1 mRNA22100608
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of RANGAP1 mRNA19770486
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of RANGAP1 mRNA21298039
D001554BenzeneBenzene results in increased expression of RANGAP1 mRNA19162166
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of RANGAP1 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of RANGAP1 mRNA"19150397|2001819
D004958EstradiolEstradiol results in increased expression of RANGAP1 mRNA19167446
D002065BuspironeBuspirone results in decreased expression of RANGAP1 mRNA24136188
C584509C646 compoundC646 compound results in increased expression of RANGAP1 mRNA26191083
C100187chloropicrinchloropicrin results in increased expression of RANGAP1 mRNA26352163
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of RANGAP1 mRNA28472532
C018021cobaltous chloridecobaltous chloride results in decreased expression of RANGAP1 mRNA19320972|2220211
C018021cobaltous chloridezinc chloride inhibits the reaction [cobaltous chloride results in decreased expression of RANGAP1 mRNA]22202117
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of RANGAP1 mRNA"19167446
D003375CoumestrolCoumestrol results in increased expression of RANGAP1 mRNA19167446
D016572CyclosporineCyclosporine results in increased expression of RANGAP1 mRNA20106945|2556210
C014347decitabinedecitabine results in increased expression of RANGAP1 mRNA17908484
D013759DronabinolDronabinol results in decreased expression of RANGAP1 mRNA18454173
D004237DiuronDiuron results in decreased expression of RANGAP1 mRNA21551480
D004298DopamineDopamine results in increased expression of RANGAP1 mRNA21983523
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of RANGAP1 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of RANGAP1 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RANGAP1 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of RANGAP1 mRNA28196854
D018818FenoldopamFenoldopam results in increased expression of RANGAP1 mRNA21983523
D005485FlutamideFlutamide results in increased expression of RANGAP1 mRNA24136188
D019833GenisteinGenistein results in decreased expression of RANGAP1 mRNA16705744
D005839GentamicinsGentamicins results in increased expression of RANGAP1 mRNA22061828
D005897GlafenineGlafenine results in increased expression of RANGAP1 mRNA24136188
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of RANGAP1 mRNA25613284
D007545IsoproterenolIsoproterenol results in increased expression of RANGAP1 mRNA21335049
D007854LeadLead results in decreased expression of RANGAP1 mRNA19921347
D008095Lithocholic AcidLithocholic Acid results in increased phosphorylation of RANGAP1 protein21224350
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of RANGAP1 mRNA"15329391
D008777MethyltestosteroneMethyltestosterone results in decreased expression of RANGAP1 mRNA29191790
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of RANGAP1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of RANGAP1 mRNA"25554681
C031721naphthalenenaphthalene results in decreased expression of RANGAP1 protein19438287
C051752nefazodonenefazodone results in increased expression of RANGAP1 mRNA24136188
D009532NickelNickel results in increased expression of RANGAP1 mRNA25583101
C028007nickel monoxidenickel monoxide results in increased expression of RANGAP1 mRNA19167457
D015739NocodazoleNocodazole results in increased phosphorylation of [SUMO1 protein binds to RANGAP1 protein]21646468
C507134ON 01910ON 01910 affects the localization of RANGAP1 protein modified form27150054
C507134ON 01910ON 01910 results in increased phosphorylation of and results in increased sumoylation of RANGAP1 protein27150054
C507134ON 01910ON 01910 results in increased phosphorylation of RANGAP1 protein24223200
C507134ON 01910ON 01910 results in increased phosphorylation of [SUMO1 protein binds to RANGAP1 protein]21646468
C011959oridoninoridonin results in decreased expression of and affects the localization of RANGAP1 protein25746355
D010126OzoneOzone results in increased expression of RANGAP1 mRNA12763052
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of RANGAP1 mRNA18593933
D010634PhenobarbitalPhenobarbital affects the expression of RANGAP1 mRNA23091169
D010882Piperonyl ButoxidePiperonyl Butoxide results in increased expression of RANGAP1 mRNA22484513
C006253pirinixic acidpirinixic acid results in increased expression of RANGAP1 mRNA18301758
C045950propiconazolepropiconazole results in decreased expression of RANGAP1 mRNA21278054
C059514resveratrolresveratrol results in decreased expression of RANGAP1 protein25505154
C009166retinol acetateretinol acetate results in increased expression of RANGAP1 mRNA16772331
D012643Selenium[Selenium co-treated with Vitamin E] results in increased expression of RANGAP1 mRNA19244175
D012643SeleniumSelenium results in increased expression of RANGAP1 mRNA19244175
D012715Sesame OilSesame Oil results in increased expression of RANGAP1 mRNA29191790
C017947sodium arsenitesodium arsenite results in decreased expression of RANGAP1 mRNA19822182
D013629TamoxifenTamoxifen affects the expression of RANGAP1 mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of RANGAP1 mRNA21570461|2468072
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RANGAP1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of RANGAP1 mRNA17942748
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of RANGAP1 mRNA25613284
D014241TrichloroethyleneTrichloroethylene results in decreased expression of RANGAP1 mRNA14565619
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of RANGAP1 mRNA19042947
C080163trovafloxacintrovafloxacin results in decreased expression of RANGAP1 mRNA24136188
D014635Valproic AcidValproic Acid results in decreased methylation of RANGAP1 gene29154799
D014635Valproic AcidValproic Acid affects the expression of RANGAP1 mRNA17292431
D014810Vitamin E[Selenium co-treated with Vitamin E] results in increased expression of RANGAP1 mRNA19244175
D014810Vitamin EVitamin E results in increased expression of RANGAP1 mRNA19244175
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of RANGAP1 mRNA18593933
C016837zinc chloridezinc chloride inhibits the reaction [cobaltous chloride results in decreased expression of RANGAP1 mRNA]22202117

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-IDA26308891  
GO:0005096GTPase activator activity-IDA16428860  
GO:0005515protein binding-IPI14729961  16732283  17000644  17036045  17099698  17099700  
17353931  18093978  19549727  20414307  21988832  23395904  
26496610  
GO:0008536Ran GTPase binding-IPI16428860  
GO:0031625ubiquitin protein ligase binding-IEA-  
GO:0045296cadherin binding-HDA25468996  
GO ID GO Term Qualifier Evidence PubMed
GO:0007165signal transduction-IEA-  
GO:0046826negative regulation of protein export from nucleus-IDA16449645  
GO:0048678response to axon injury-IEA-  
GO:0090630activation of GTPase activity-IDA16428860  
GO:1904117cellular response to vasopressin-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000776kinetochorecolocalizes_withIDA17363900  
GO:0000777condensed chromosome kinetochore-IEA-  
GO:0005635nuclear envelope-IDA25468996  
GO:0005635nuclear envelope-TAS-  
GO:0005643nuclear pore-TAS8978815  
GO:0005654nucleoplasm-IEA-  
GO:0005737cytoplasm-TAS8978815  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0016235aggresome-IDA-  
GO:0030425dendrite-IEA-  
GO:0031965nuclear membrane-IDA-  
GO:0043231intracellular membrane-bounded organelle-IDA-  
GO:0044614nuclear pore cytoplasmic filaments-IEA-  
GO:0048471perinuclear region of cytoplasm-IDA26308891  
GO:0072686mitotic spindle-IEA-  
GO:1904115axon cytoplasm-IEA-  
GO:1990723cytoplasmic periphery of the nuclear pore complex-IEA-  
KEGG ID KEGG Term
hsa03013RNA transport
Reactome ID Reactome Term Evidence
R-HSA-141424Amplification of signal from the kinetochoresTAS
R-HSA-141444Amplification of signal from unattached kinetochores via a MAD2 inhibitory signalTAS
R-HSA-162582Signal TransductionTAS
R-HSA-162587HIV Life CycleTAS
R-HSA-162599Late Phase of HIV Life CycleTAS
R-HSA-162906HIV InfectionTAS
R-HSA-162909Host Interactions of HIV factorsTAS
R-HSA-1640170Cell CycleTAS
R-HSA-1643685DiseaseTAS
R-HSA-165054Rev-mediated nuclear export of HIV RNATAS
R-HSA-177243Interactions of Rev with host cellular proteinsTAS
R-HSA-194315Signaling by Rho GTPasesTAS
R-HSA-195258RHO GTPase EffectorsTAS
R-HSA-2467813Separation of Sister ChromatidsTAS
R-HSA-2500257Resolution of Sister Chromatid CohesionTAS
R-HSA-2555396Mitotic Metaphase and AnaphaseTAS
R-HSA-2990846SUMOylationTAS
R-HSA-3108232SUMO E3 ligases SUMOylate target proteinsTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-4615885SUMOylation of DNA replication proteinsTAS
R-HSA-5663205Infectious diseaseTAS
R-HSA-5663220RHO GTPases Activate ForminsTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-68877Mitotic PrometaphaseTAS
R-HSA-68882Mitotic AnaphaseTAS
R-HSA-68886M PhaseTAS
R-HSA-69278Cell Cycle, MitoticTAS
R-HSA-69618Mitotic Spindle CheckpointTAS
R-HSA-69620Cell Cycle CheckpointsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27164557Genetic Relationship between Schizophrenia and Nicotine Dependence. (2016 May 10)Chen JSci Rep