Gene: RAP2B

5912
-
RAP2B, member of RAS oncogene family
protein-coding
3q25.2
Ensembl:ENSG00000181467 MIM:179541 Vega:OTTHUMG00000159655 UniprotKB:P61225
NC_000003.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.434e-1 (AD)  7.388e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
BLOC1S60.85
RNF20.847
DIAPH10.845
FKBP1A0.843
NUS10.84
LEPROTL10.838
ARL14EP0.838
UBE2W0.837
SHOC20.836
GRB20.835

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.537
OR4F29-0.49
CTNNA3-0.322
FXYD4-0.293
CSAG1-0.289
POU2AF1-0.283
C5orf64-0.282
TRPV5-0.281
ANXA13-0.271
TPPP2-0.269

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of RAP2B mRNA"21346803
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of RAP2B mRNA16788091
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RAP2B mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RAP2B mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of RAP2B mRNA25458485
D000082AcetaminophenAcetaminophen results in increased expression of RAP2B mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of RAP2B mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 affects the expression of RAP2B protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of RAP2B mRNA21641981|2210060
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of RAP2B mRNA19770486
D000643Ammonium ChlorideAmmonium Chloride affects the expression of RAP2B mRNA16483693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of RAP2B mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of RAP2B mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to RAP2B promoter]19654925
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of RAP2B mRNA19770486
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of RAP2B mRNA"26238291
C006780bisphenol Abisphenol A results in decreased expression of RAP2B mRNA20678512
C006780bisphenol Abisphenol A results in decreased expression of RAP2B mRNA25181051
C037123cadmium sulfatecadmium sulfate affects the reaction [MTF1 affects the expression of RAP2B mRNA]16221973
D002737ChloropreneChloroprene results in increased expression of RAP2B mRNA23125180
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of RAP2B mRNA20938992
D003078ColchicineColchicine results in decreased expression of RAP2B mRNA24211769
D019327Copper SulfateCopper Sulfate results in increased expression of RAP2B mRNA19549813
D003976DiazinonDiazinon results in increased methylation of RAP2B gene22964155
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of RAP2B mRNA27392435
D002945CisplatinCisplatin results in decreased expression of RAP2B mRNA24211769
D002945CisplatinCisplatin results in increased expression of RAP2B mRNA27392435
D004041Dietary FatsDietary Fats results in increased expression of RAP2B mRNA25016146
D004147DioxinsDioxins affects the expression of RAP2B mRNA20463971
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RAP2B mRNA17942748
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of RAP2B mRNA24211769
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of RAP2B mRNA23649840
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of RAP2B mRNA20938992
D005557FormaldehydeFormaldehyde results in increased expression of RAP2B mRNA23649840
D005947Glucose[INS protein co-treated with Glucose] results in increased expression of RAP2B mRNA22634610
D006918HydroxyureaHydroxyurea results in decreased expression of RAP2B mRNA24211769
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of RAP2B mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of RAP2B mRNA27392435
C410337K 7174K 7174 results in increased expression of RAP2B mRNA24086573
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of RAP2B mRNA20938992
D008727MethotrexateMethotrexate results in decreased expression of RAP2B mRNA24449571
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of RAP2B mRNA24211769
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of RAP2B mRNA23649840
C015367mevalonolactonemevalonolactone results in increased prenylation of RAP2B protein8424780
D016685MitomycinMitomycin results in decreased expression of RAP2B mRNA24211769
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of RAP2B mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of RAP2B mRNA"25554681
C025589ochratoxin Aochratoxin A results in decreased expression of RAP2B mRNA22124623
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of RAP2B mRNA23427857
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of RAP2B protein26879310
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RAP2B mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of RAP2B mRNA26272509
C009277sodium arsenatesodium arsenate results in increased expression of RAP2B mRNA23922661
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of RAP2B mRNA21632981
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of RAP2B mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with AHR gene mutant form] results in decreased expression of RAP2B mRNA19465110
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RAP2B mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of RAP2B mRNA19770486
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of RAP2B mRNA25613284
D013853ThioacetamideThioacetamide results in increased expression of RAP2B mRNA23411599
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of RAP2B mRNA20133372
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of RAP2B mRNA19969065
D014212TretinoinTretinoin results in decreased expression of RAP2B mRNA21934132
D014520UrethaneUrethane results in increased expression of RAP2B mRNA28818685
D014635Valproic AcidValproic Acid results in decreased methylation of RAP2B gene29154799
D014635Valproic AcidValproic Acid results in increased expression of RAP2B mRNA28001369
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of RAP2B gene25560391
C029297vinylidene chloridevinylidene chloride results in increased expression of RAP2B mRNA26682919
D000225AdenineAdenine results in decreased expression of RAP2B mRNA24211769

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003924GTPase activity-IEA-  
GO:0005515protein binding-IPI16189514  25416956  
GO:0005525GTP binding-IDA16213650  18582561  
GO:0019003GDP binding-IDA16213650  
GO:0019904protein domain specific binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007165signal transduction-TAS2118648  
GO:0030033microvillus assemblyNOTIMP22797597  
GO:0030168platelet activation-IDA18582561  
GO:0030336negative regulation of cell migration-IEA-  
GO:0031954positive regulation of protein autophosphorylation-IEA-  
GO:0032486Rap protein signal transduction-ISS-  
GO:0043312neutrophil degranulation-TAS-  
GO:0061097regulation of protein tyrosine kinase activity-ISS-  
GO:0070527platelet aggregation-IDA18582561  
GO:0090557establishment of endothelial intestinal barrierNOTIMP23885123  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-IDA18582561  
GO:0005886plasma membrane-IDA16213650  16540189  
GO:0005886plasma membrane-TAS-  
GO:0005923bicellular tight junction-IDA23885123  
GO:0016020membrane-IMP18582561  
GO:0035579specific granule membrane-TAS-  
GO:0044291cell-cell contact zone-IDA23885123  
GO:0045121membrane raft-IMP18582561  
GO:0055038recycling endosome membrane-ISS-  
GO:0070062extracellular exosome-HDA19056867  20458337  
GO:0070062extracellular exosome-IDA16540189  
GO:0070821tertiary granule membrane-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-6798695Neutrophil degranulationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26308105Expression and DNA methylation status of the Rap2B gene in human bronchial epithelial cells treated by cigarette smoke condensate. (2015)Zhang SInhal Toxicol