Gene: RARA

5914
NR1B1|RAR
retinoic acid receptor alpha
protein-coding
17q21.2
Ensembl:ENSG00000131759 MIM:180240 Vega:OTTHUMG00000133328 UniprotKB:P10276
NG_027701.1
PubMed
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.035e-1 (AD)  4.792e-2 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg19572487chr17:38476024RARA4.700e-8Maternal smoking in pregnancy27040690
cg19572487chr17:38476024RARA7.630e-11Maternal smoking in pregnancy27040690
cg19572487chr17:38476024RARA2.420e-13Maternal smoking in pregnancy27040690
cg10062919chr17:38503802RARA9.200e-32Smoking27651444
cg04956244chr17:38511592RARA1.500e-29Smoking27651444
cg19572487chr17:38476024RARA3.800e-20Smoking27651444
cg26878655chr17:38481877RARA4.200e-16Smoking27651444
cg27102350chr17:38501677RARA6.900e-14Smoking27651444
cg05824218chr17:38499096RARA3.800e-13Smoking27651444
cg16276850chr17:38498914RARA4.500e-10Smoking27651444
cg19572487chr17:38476024RARA5.600e-10Alcohol consumption der day27843151
cg19572487chr17:38476024RARA1.990e-22Tobacco smoking28225026
cg11094248chr17:38494580RARA2.250e-10Tobacco smoking28225026
cg19572487chr17:38476024RARA3.580e-16Smoking28686328
cg10062919chr17:38503802RARA1.400e-8Smoking28686328

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FURIN0.829
BAHD10.809
RFTN10.809
NAB20.809
SH3GL10.799
SRF0.798
MKL10.791
CABIN10.786
GMEB20.784
CHPF20.783

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.5
OR4F29-0.446
CTNNA3-0.343
PDE11A-0.336
C5orf64-0.327
LRRCC1-0.313
CDNF-0.306
SLCO1A2-0.282
ZFP57-0.277
MBNL3-0.267

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00210AdapaleneSmall Molecule106685-40-9ApprovedTarget
DB00459AcitretinSmall Molecule55079-83-9ApprovedTarget
DB00523AlitretinoinSmall Molecule5300-03-8Approved|InvestigationalTarget
DB00755TretinoinSmall Molecule302-79-4Approved|Investigational|NutraceuticalTarget
DB00799TazaroteneSmall Molecule118292-40-3Approved|InvestigationalTarget
DB00926EtretinateSmall Molecule54350-48-0WithdrawnTarget
DB00982IsotretinoinSmall Molecule4759-48-2ApprovedTarget
DB04942TamibaroteneSmall Molecule94497-51-5Approved|InvestigationalTarget
DB05785LGD-1550Small Molecule-InvestigationalTarget
ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of RARA mRNA"28903501
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of RARA mRNA"19114083
C0094072,5,2',5'-tetrachlorobiphenyl"2,5,2',5'-tetrachlorobiphenyl results in decreased expression of RARA mRNA"23829299
C0259463-methyladenine3-methyladenine inhibits the reaction [4-amino-2-trifluoromethyl-phenyl retinate results in increased degradation of [PML protein mutant form binds to RARA protein mutant form]]28130038
C4967514-(1H-imidazol-1-yl)retinoic acid4-(1H-imidazol-1-yl)retinoic acid binds to RARA protein17387344
C0388644-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid"4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid binds to and results in increased activity of RARA protein"15589975|1617801
C1216164-((4-(4-ethylphenyl)-2,2-dimethyl-(2H)-thiochromen-6-yl)ethynyl)benzoic acid"4-((4-(4-ethylphenyl)-2,2-dimethyl-(2H)-thiochromen-6-yl)ethynyl)benzoic acid binds to and results in decreased activity of RARA protein"16178010
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of RARA mRNA"18648102
C0645454-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-anthracenyl)benzoic acid"4-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-anthracenyl)benzoic acid binds to RARA protein"15589975
C5857454-amino-2-trifluoromethyl-phenyl retinate3-methyladenine inhibits the reaction [4-amino-2-trifluoromethyl-phenyl retinate results in increased degradation of [PML protein mutant form binds to RARA protein mutant form]]28130038
C5857454-amino-2-trifluoromethyl-phenyl retinate4-amino-2-trifluoromethyl-phenyl retinate results in increased degradation of [PML protein mutant form binds to RARA protein mutant form]28130038
C5857454-amino-2-trifluoromethyl-phenyl retinateATG5 protein promotes the reaction [4-amino-2-trifluoromethyl-phenyl retinate results in increased degradation of [PML protein mutant form binds to RARA protein mutant form]]28130038
C5857454-amino-2-trifluoromethyl-phenyl retinate"N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [4-amino-2-trifluoromethyl-phenyl retinate results in increased degradation of [PML protein mutant form binds to RARA protein mutant form]]"28130038
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of RARA mRNA19191707
C0194294-hydroxyretinoic acid4-hydroxyretinoic acid results in increased activity of RARA protein25492813
C0022024-oxoretinoic acid4-oxoretinoic acid results in increased activity of RARA protein25492813
C0022024-oxoretinoic acid4-oxoretinoic acid results in increased expression of RARA mRNA17034753
C0418194-oxoretinol4-oxoretinol results in increased expression of RARA mRNA17034753
D000068816AdapaleneAdapalene binds to RARA protein21864882
C106812adefovir dipivoxiladefovir dipivoxil results in decreased expression of RARA mRNA25596134
C016601afimoxifeneafimoxifene inhibits the reaction [Estrogens results in increased expression of RARA mRNA]21233418
C096920AGN 193109AGN 193109 binds to and results in decreased activity of RARA protein15589975
C096920AGN 193109AGN 193109 binds to and results in decreased activity of RARA protein16982809
C492393AGN 195183AGN 195183 binds to and results in increased activity of RARA protein16178010
C492393AGN 195183AGN 195183 binds to and results in increased activity of RARA protein17318068
D019386AlendronateAlendronate affects the expression of RARA mRNA16079270
C103303alitretinoinalitretinoin binds to and results in increased activity of RARA protein18180267
C103303alitretinoinalitretinoin promotes the reaction [RARA protein binds to PRAME protein]16179254
C103303alitretinoinalitretinoin results in decreased expression of RARA protein15375546
C103303alitretinoinalitretinoin results in increased expression of RARA mRNA11139446|1703475
C103303alitretinoinRARA protein promotes the reaction [alitretinoin results in increased expression of ABCC6 mRNA]17045963
C103303alitretinoinalitretinoin results in increased expression of RARA mRNA8892963
C103303alitretinoinalitretinoin results in increased expression of RARA protein16043492
C103303alitretinoin[Bicuculline co-treated with 4-Aminopyridine] promotes the reaction [alitretinoin results in increased activity of RARA protein]15773917
C103303alitretinoinCAMK4 protein promotes the reaction [alitretinoin results in increased activity of RARA protein]15773917
C103303alitretinoinDizocilpine Maleate inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] promotes the reaction [alitretinoin results in increased activity of RARA protein]]15773917
C103303alitretinoinKN 62 inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] promotes the reaction [alitretinoin results in increased activity of RARA protein]]15773917
C103303alitretinoinOkadaic Acid promotes the reaction [alitretinoin results in increased activity of RARA protein]15773917
C103303alitretinoinSTO 609 inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] promotes the reaction [alitretinoin results in increased activity of RARA protein]]15773917
C103303alitretinointrichostatin A promotes the reaction [alitretinoin results in increased activity of RARA protein]15773917
D000487AllethrinAllethrin results in increased activity of RARA protein20143881
C068073Am 580Am 580 binds to and results in increased activity of RARA protein10779427|1617801
C068073Am 580Am 580 inhibits the reaction [Ro 41-5253 results in decreased activity of RARA protein]17290005
C068073Am 580Am 580 results in increased expression of RARA protein16636311
C068073Am 580Am 580 binds to and affects the activity of RARA protein16982809
C068073Am 580Am 580 binds to and results in increased activity of RARA protein10651997|1585563
C068073Am 580Am 580 results in increased activity of RARA protein17460283
D0157614-Aminopyridine[Bicuculline co-treated with 4-Aminopyridine] promotes the reaction [alitretinoin results in increased activity of RARA protein]15773917
D0157614-AminopyridineDizocilpine Maleate inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] promotes the reaction [alitretinoin results in increased activity of RARA protein]]15773917
D0157614-AminopyridineKN 62 inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] promotes the reaction [alitretinoin results in increased activity of RARA protein]]15773917
D0157614-AminopyridineSTO 609 inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] promotes the reaction [alitretinoin results in increased activity of RARA protein]]15773917
D000643Ammonium ChlorideAmmonium Chloride affects the expression of RARA mRNA16483693
D000966Antimony Potassium TartrateAntimony Potassium Tartrate results in increased degradation of RARA protein mutant form9834237
C037554antimony trioxideantimony trioxide results in increased degradation of RARA protein mutant form9834237
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of RARA mRNA24449571
C004984apocarotenalapocarotenal results in decreased expression of RARA mRNA17034753
C006632arsenic trioxide"4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction [arsenic trioxide results in increased degradation of RARA protein]"17018029
C006632arsenic trioxidearsenic trioxide promotes the reaction [puerarin results in decreased expression of RARA mRNA alternative form]20416161
C006632arsenic trioxidearsenic trioxide promotes the reaction [tetraarsenic tetrasulfide results in increased degradation of [PML protein mutant form binds to RARA protein mutant form]]26110921
C006632arsenic trioxidearsenic trioxide results in decreased expression of RARA mRNA mutant form27770503
C006632arsenic trioxidearsenic trioxide results in decreased expression of RARA protein23469683
C006632arsenic trioxidearsenic trioxide results in decreased expression of RARA protein mutant form27189198
C006632arsenic trioxidearsenic trioxide results in increased degradation of [PML protein mutant form binds to RARA protein mutant form]26110921
C006632arsenic trioxidearsenic trioxide results in increased degradation of RARA protein17018029
C006632arsenic trioxidearsenic trioxide results in increased degradation of RARA protein mutant form15748426|1689131
C006632arsenic trioxidecobaltous chloride promotes the reaction [arsenic trioxide results in increased degradation of RARA protein mutant form]16330433
C006632arsenic trioxideRARA gene mutant form inhibits the reaction [Tretinoin inhibits the reaction [arsenic trioxide results in increased expression of HMOX1 protein]]25003661
C006632arsenic trioxideRARA gene mutant form inhibits the reaction [Tretinoin promotes the reaction [arsenic trioxide results in increased activity of CASP3 protein]]25003661
C006632arsenic trioxideRARA gene mutant form results in decreased susceptibility to arsenic trioxide26728337
C006632arsenic trioxidetetraarsenic tetrasulfide promotes the reaction [arsenic trioxide results in increased degradation of [PML protein mutant form binds to RARA protein mutant form]]26110921
C006632arsenic trioxide[Tretinoin co-treated with arsenic trioxide] results in decreased expression of RARA mRNA alternative form19225113
C006632arsenic trioxide[vorinostat co-treated with arsenic trioxide] results in decreased expression of RARA protein mutant form27189198
C006632arsenic trioxidearsenic trioxide results in increased degradation of and results in decreased expression of RARA protein15688020
C045816arsenic trisulfidearsenic trisulfide results in increased degradation of and results in decreased expression of RARA protein12513809
C045816arsenic trisulfidearsenic trisulfide results in increased degradation of and results in decreased expression of RARA protein mutant form12513809
C015001arsenitearsenite results in increased methylation of RARA promoter23974009
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of RARA mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene affects the activity of RARA protein20624995
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of RARA mRNA21803694
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Tretinoin results in decreased expression of RARA protein]24819975
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Tretinoin results in increased degradation of RARA protein]20945414
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased ubiquitination of RARA protein20945414
D019207beta Carotenebeta Carotene results in decreased expression of RARA mRNA17034753
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of RARA mRNA19619570
D004958EstradiolEstradiol results in decreased expression of RARA mRNA19619570
D004958EstradiolEstradiol results in increased expression of RARA mRNA23019147
C095105bexarotenebexarotene binds to RARA protein9144408
D001640Bicuculline[Bicuculline co-treated with 4-Aminopyridine] promotes the reaction [alitretinoin results in increased activity of RARA protein]15773917
D001640BicucullineDizocilpine Maleate inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] promotes the reaction [alitretinoin results in increased activity of RARA protein]]15773917
D001640BicucullineKN 62 inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] promotes the reaction [alitretinoin results in increased activity of RARA protein]]15773917
D001640BicucullineSTO 609 inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] promotes the reaction [alitretinoin results in increased activity of RARA protein]]15773917
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of RARA mRNA28628672
C006780bisphenol Abisphenol A affects the methylation of RARA promoter27334623
C006780bisphenol Abisphenol A results in decreased expression of RARA mRNA14967906
C006780bisphenol Abisphenol A results in increased expression of RARA mRNA14967906|1573862
C006780bisphenol Abisphenol A results in increased expression of RARA mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of RARA mRNA28628672
C083997buprofezinbuprofezin results in increased activity of RARA protein20143881
D002087Butyrates[Tretinoin co-treated with Butyrates] results in increased cleavage of RARA protein mutant form12130515
D002104CadmiumCadmium results in decreased expression of RARA mRNA21297354
C055494caffeic acid phenethyl estercaffeic acid phenethyl ester promotes the reaction [Tretinoin results in increased activity of RARA protein]16766008
C055494caffeic acid phenethyl estercaffeic acid phenethyl ester results in increased activity of RARA protein16766008
C055494caffeic acid phenethyl estercaffeic acid phenethyl ester results in increased expression of RARA mRNA16766008
C055494caffeic acid phenethyl estercaffeic acid phenethyl ester results in increased expression of RARA protein16766008
C055494caffeic acid phenethyl ester[Tretinoin co-treated with caffeic acid phenethyl ester] results in increased expression of RARA mRNA16766008
C055494caffeic acid phenethyl ester[Tretinoin co-treated with caffeic acid phenethyl ester] results in increased expression of RARA protein16766008
D002251Carbon Tetrachloride[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in decreased expression of RARA mRNA26778414
C099555CD 437[CD 437 results in increased activity of CASP3 protein] which results in increased degradation of RARA protein10374879
C099555CD 437CD 437 results in increased expression of RARA mRNA21548569
C004656chloroacetaldehydechloroacetaldehyde results in decreased expression of RARA mRNA25596134
D002726Chlorogenic AcidChlorogenic Acid results in increased expression of RARA mRNA20706672
D002746ChlorpromazineChlorpromazine results in decreased expression of RARA mRNA18246545
D002791Cholesterol, Dietary"[Cholesterol, Dietary co-treated with Sodium Cholate] results in increased expression of RARA protein"27394961
D002791Cholesterol, Dietary"MET gene mutant form inhibits the reaction [[Cholesterol, Dietary co-treated with Sodium Cholate] results in increased expression of RARA protein]"27394961
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of RARA gene20938992
C059262cidofovircidofovir results in increased expression of RARA mRNA25596134
D004002Clodronic AcidClodronic Acid results in decreased expression of RARA mRNA25596134
C018021cobaltous chloridecobaltous chloride promotes the reaction [arsenic trioxide results in increased degradation of RARA protein mutant form]16330433
D003372CoumaphosCoumaphos results in increased activity of RARA protein20143881
D003474CurcuminCurcumin inhibits the reaction [TGFB1 protein results in increased expression of RARA mRNA]8940178
D003520CyclophosphamideCyclophosphamide results in increased expression of RARA mRNA16141653
D016572CyclosporineCyclosporine results in decreased expression of RARA mRNA25596134
D016572CyclosporineCyclosporine results in decreased expression of RARA mRNA25596134
C014347decitabine[decitabine co-treated with Tretinoin] results in increased expression of RARA mRNA19524134
C014347decitabinedecitabine promotes the reaction [vorinostat results in increased expression of RARA mRNA]17417771
D003840Deoxycholic Acid[gluconic acid co-treated with Deoxycholic Acid] results in increased expression of RARA mRNA16556975
D003907DexamethasoneDexamethasone results in increased expression of RARA mRNA19022236
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of RARA mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of RARA mRNA28628672
D003976DiazinonDiazinon affects the expression of RARA mRNA22546817
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of RARA mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of RARA mRNA27392435
D002945CisplatinCisplatin results in decreased expression of RARA mRNA25596134|2739243
D002945CisplatinCisplatin results in increased expression of RARA mRNA18172885
C000944dicrotophosdicrotophos results in increased expression of RARA mRNA28302478
D004026DieldrinDieldrin affects the expression of RARA mRNA22546817
D004052Diethylnitrosamine[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in decreased expression of RARA mRNA26778414
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of RARA mRNA18544905
D004052Diethylnitrosamine[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of RARA mRNA18253720
D0178784,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid"4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction [arsenic trioxide results in increased degradation of RARA protein]"17018029
D016291Dizocilpine MaleateDizocilpine Maleate inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] promotes the reaction [alitretinoin results in increased activity of RARA protein]]15773917
C017435enilconazoleenilconazole results in increased activity of RARA protein20143881
D015251EpirubicinEpirubicin affects the mutagenesis of RARA gene19884644
C045651epigallocatechin gallateepigallocatechin gallate results in increased expression of RARA mRNA12628509|2070667
D004967Estrogensafimoxifene inhibits the reaction [Estrogens results in increased expression of RARA mRNA]21233418
D004967EstrogensEstrogens results in increased expression of RARA mRNA21233418
D000431EthanolEthanol results in increased expression of RARA mRNA28986285
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of RARA mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of RARA mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RARA mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of RARA mRNA16079270
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of RARA mRNA23550701
D011345FenofibrateFenofibrate results in decreased expression of RARA mRNA25596134
D011345Fenofibrate[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of RARA mRNA18253720
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of RARA gene20938992
D004397FonofosFonofos results in increased methylation of RARA promoter22847954
D005557FormaldehydeFormaldehyde results in increased expression of RARA mRNA23649840
D005620Freund's AdjuvantFreund's Adjuvant results in decreased expression of RARA mRNA20846436
C039281furanfuran results in increased methylation of RARA gene22079235
D005839GentamicinsGentamicins results in decreased expression of RARA mRNA22061828
D005839GentamicinsGentamicins results in increased expression of RARA mRNA18172885
C030691gluconic acid[gluconic acid co-treated with Deoxycholic Acid] results in increased expression of RARA mRNA16556975
D006118GriseofulvinGriseofulvin results in increased expression of RARA mRNA9548566
D0193071-(5-Isoquinolinesulfonyl)-2-Methylpiperazine1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [TGFB1 protein results in increased expression of RARA mRNA]8940178
C014026hexamethylene bisacetamide[Tretinoin co-treated with hexamethylene bisacetamide] results in increased cleavage of RARA protein mutant form12130515
D017313FenretinideFenretinide results in decreased expression of RARA protein15375546
D017313FenretinideFenretinide results in increased expression of RARA mRNA15735044
C104181HX 600HX 600 affects the reaction [Tretinoin binds to and results in increased activity of RARA protein]9144408
C104181HX 600HX 600 promotes the reaction [[Tretinoin binds to and results in increased activity of RARA protein] which results in increased expression of TNFRSF10B mRNA]9144408
C422175HX 630HX 630 binds to RARA protein9144408
D006918HydroxyureaHydroxyurea results in increased mutagenesis of RARA gene16868089
D007052IbuprofenIbuprofen results in decreased expression of RARA mRNA25596134
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of RARA mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of RARA mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of RARA mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of RARA mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of RARA mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of RARA mRNA23086925|2429786
C063302KN 62KN 62 inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] promotes the reaction [alitretinoin results in increased activity of RARA protein]]15773917
C011890kojic acid[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of RARA mRNA18544905
C008261lead acetatelead acetate results in decreased expression of RARA mRNA22609695
C008281limonenelimonene results in decreased expression of RARA mRNA12815608
D001556LindaneLindane results in increased activity of RARA protein20143881
D008070LipopolysaccharidesLipopolysaccharides promotes the reaction [Tretinoin results in increased expression of RARA mRNA]17216566
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of RARA protein16002565
D008550Melatonin[Melatonin co-treated with Tretinoin] results in increased activity of RARA protein10965999
D008550MelatoninMelatonin promotes the reaction [Tretinoin results in increased activity of RARA protein]15813899
D008628MercuryMercury results in decreased expression of RARA mRNA22688007
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of RARA gene20938992
D008731MethoxychlorMethoxychlor affects the expression of RARA mRNA20829426
D008770MethylnitrosoureaMethylnitrosourea results in increased mutagenesis of RARA gene16868089
D008770MethylnitrosoureaCholecalciferol inhibits the reaction [Methylnitrosourea results in increased expression of RARA mRNA]21843606
D008770MethylnitrosoureaMethylnitrosourea results in increased expression of RARA mRNA21843606
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of RARA mRNA24810058
D008942MitoxantroneMitoxantrone affects the mutagenesis of RARA gene19884644
C119536nickel acetatenickel acetate affects the expression of RARA mRNA12915101
C022838nickel chloridenickel chloride affects the expression of RARA mRNA22546817
C028007nickel monoxidenickel monoxide results in increased expression of RARA mRNA19167457
C007350nitrofennitrofen results in decreased expression of RARA mRNA20638522
C007350nitrofennitrofen results in decreased expression of RARA protein24972641|2667273
C007350nitrofennitrofen results in increased expression of RARA mRNA17270546|2667273
C007350nitrofennitrofen results in increased expression of RARA protein24352370
C007350nitrofenTretinoin inhibits the reaction [nitrofen results in decreased expression of RARA protein]26672737
C007350nitrofenTretinoin inhibits the reaction [nitrofen results in increased expression of RARA protein]24352370
C007350nitrofenTretinoin promotes the reaction [nitrofen results in increased expression of RARA mRNA]26672737
C419410N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester"N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [4-amino-2-trifluoromethyl-phenyl retinate results in increased degradation of [PML protein mutant form binds to RARA protein mutant form]]"28130038
C508934N-retinoylglucosamineN-retinoylglucosamine results in increased expression of RARA mRNA16280019
C025589ochratoxin Aochratoxin A results in decreased expression of RARA mRNA23358140
D019319Okadaic AcidOkadaic Acid promotes the reaction [alitretinoin results in increased activity of RARA protein]15773917
C485800osajinosajin results in increased expression of RARA mRNA20706672
D010100OxygenOxygen deficiency results in increased expression of RARA mRNA25596134
D010278ParathionParathion results in increased methylation of RARA promoter22847954
D052638Particulate MatterParticulate Matter results in decreased methylation of RARA gene28495853
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of RARA mRNA18593933
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of RARA mRNA19162173
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of RARA mRNA19162173
D010672PhenytoinPhenytoin results in decreased expression of RARA mRNA9118846
D010672PhenytoinPhenytoin results in increased expression of RARA mRNA9988880
C003117phosalonephosalone results in increased activity of RARA protein20143881
D010795Phthalic AcidsPhthalic Acids results in increased expression of RARA mRNA22112501
D010936Plant ExtractsPlant Extracts results in decreased expression of RARA mRNA23557933
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls results in increased expression of RARA protein17287035
C474837pomiferinpomiferin results in increased expression of RARA mRNA20706672
C045362prochlorazprochloraz results in increased activity of RARA protein20143881
D011374ProgesteroneProgesterone results in decreased expression of RARA mRNA23018184
C045950propiconazolepropiconazole results in increased activity of RARA protein20143881
D011441PropylthiouracilPropylthiouracil results in decreased expression of RARA mRNA24780913
C033607puerarinarsenic trioxide promotes the reaction [puerarin results in decreased expression of RARA mRNA alternative form]20416161
C033607puerarinpuerarin results in decreased expression of RARA mRNA alternative form20416161
C033607puerarinpuerarin results in increased expression of RARA mRNA20706672
D011692Puromycin AminonucleosidePuromycin Aminonucleoside results in increased expression of RARA mRNA12660332
D011692Puromycin AminonucleosidePuromycin Aminonucleoside results in increased expression of RARA protein12660332
C513428pyrachlostrobinpyrachlostrobin results in increased activity of RARA protein20143881
C470613quinoxyfenquinoxyfen results in increased activity of RARA protein20143881
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride affects the expression of RARA mRNA16079270
C059514resveratrolresveratrol results in increased expression of RARA mRNA20706672
D015474IsotretinoinIsotretinoin results in increased expression of RARA mRNA9262057
D015474IsotretinoinIsotretinoin results in decreased expression of RARA mRNA19041696
D012176RetinoidsRARA protein promotes the reaction [Retinoids results in increased expression of FOXK2 mRNA]12075115
D012176RetinoidsRARA protein promotes the reaction [Retinoids results in increased expression of TGM2 mRNA]12075115
D012176RetinoidsRetinoids binds to and results in increased activity of RARA protein12075115
C014794retinol palmitateretinol palmitate promotes the reaction [RARA protein binds to MMP9 protein]17164434
C084904Ro 41-5253Am 580 inhibits the reaction [Ro 41-5253 results in decreased activity of RARA protein]17290005
C084904Ro 41-5253RARA protein results in increased susceptibility to Ro 41-525325550158
C084904Ro 41-5253Ro 41-5253 binds to and results in decreased activity of RARA protein10779427|7556191
C084904Ro 41-5253Ro 41-5253 inhibits the reaction [[RARA protein co-treated with RXRA protein] results in increased expression of SLC10A1 mRNA]25550158
C084904Ro 41-5253Ro 41-5253 inhibits the reaction [Tretinoin results in increased expression of RARA mRNA]17216566
C084904Ro 41-5253Ro 41-5253 results in decreased activity of RARA protein17290005
C084904Ro 41-5253Ro 41-5253 binds to and results in decreased activity of RARA protein8838863
C084904Ro 41-5253Ro 41-5253 binds to and results in decreased activity of RARA protein16085646|1687238
C018381salvin[Tetradecanoylphorbol Acetate co-treated with salvin] results in increased expression of RARA protein11504768
C078903seocalcitolseocalcitol results in increased expression of RARA mRNA21843606
D012834SilverSilver results in increased expression of RARA mRNA26014281
C017947sodium arsenitesodium arsenite results in decreased expression of RARA mRNA20371982
D020358Sodium Cholate"[Cholesterol, Dietary co-treated with Sodium Cholate] results in increased expression of RARA protein"27394961
D020358Sodium Cholate"MET gene mutant form inhibits the reaction [[Cholesterol, Dietary co-treated with Sodium Cholate] results in increased expression of RARA protein]"27394961
D012967Sodium Dodecyl SulfateSodium Dodecyl Sulfate results in decreased expression of RARA mRNA12815608
C458525STO 609STO 609 inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] promotes the reaction [alitretinoin results in increased activity of RARA protein]]15773917
D014284TriiodothyronineTriiodothyronine results in increased expression of RARA mRNA17403546
C112689TAC 101TAC 101 binds to RARA protein17436592
C061133tamibaroteneRARA results in decreased susceptibility to tamibarotene17611697
C061133tamibarotenetamibarotene inhibits the reaction [KLF5 protein binds to [RARA protein binds to RXRA protein]]16224062
C061133tamibarotenetamibarotene inhibits the reaction [[KLF5 protein binds to [RARA protein binds to RXRA protein]] which binds to PDGFA promoter]16224062
C061133tamibarotenetamibarotene inhibits the reaction [[RARA co-treated with RXRA] promotes the reaction [KLF5 results in increased expression of PDGFA mRNA]]16224062
C061133tamibarotenetamibarotene inhibits the reaction [RARA protein binds to PDGFA promoter]16224062
C061133tamibarotenetamibarotene results in increased expression of RARA protein19457078
C061133tamibarotenetamibarotene binds to and affects the activity of RARA protein16982755
C061133tamibarotenetamibarotene binds to and results in increased activity of RARA protein16819260
C061133tamibarotenetamibarotene binds to RARA protein9144408
C061133tamibarotenetamibarotene results in increased activity of RARA protein27737899
D013629TamoxifenTamoxifen affects the expression of RARA mRNA17555576
C012568terbufosterbufos results in increased methylation of RARA promoter22847954
D013739TestosteroneTestosterone results in decreased expression of RARA mRNA16432891
C534735tetraarsenic tetrasulfidearsenic trioxide promotes the reaction [tetraarsenic tetrasulfide results in increased degradation of [PML protein mutant form binds to RARA protein mutant form]]26110921
C534735tetraarsenic tetrasulfidetetraarsenic tetrasulfide inhibits the reaction [SET protein results in increased expression of [PML protein mutant form binds to RARA protein mutant form]]24430359
C534735tetraarsenic tetrasulfidetetraarsenic tetrasulfide promotes the reaction [arsenic trioxide results in increased degradation of [PML protein mutant form binds to RARA protein mutant form]]26110921
C534735tetraarsenic tetrasulfidetetraarsenic tetrasulfide results in increased degradation of [PML protein mutant form binds to RARA protein mutant form]26110921
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of RARA mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of RARA mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of RARA mRNA21570461|2405805
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RARA mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of RARA mRNA26290441
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of RARA mRNA15667827
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with salvin] results in increased expression of RARA protein11504768
D013876ThiophenesThiophenes analog promotes the reaction [Tretinoin results in increased expression of RARA mRNA alternative form]16140955
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased methylation of RARA gene26756918
D014212TretinoinTretinoin results in increased expression of RARA mRNA12921748
D014212Tretinoinbenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Tretinoin results in decreased expression of RARA protein]24819975
D014212Tretinoinbenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Tretinoin results in increased degradation of RARA protein]20945414
D014212Tretinoincaffeic acid phenethyl ester promotes the reaction [Tretinoin results in increased activity of RARA protein]16766008
D014212TretinoinCYP26A1 protein inhibits the reaction [Tretinoin results in increased expression of RARA mRNA]15703382
D014212Tretinoin[decitabine co-treated with Tretinoin] results in increased expression of RARA mRNA19524134
D014212TretinoinIFNG protein promotes the reaction [Tretinoin results in increased expression of RARA mRNA]16007204
D014212TretinoinLipopolysaccharides promotes the reaction [Tretinoin results in increased expression of RARA mRNA]17216566
D014212Tretinoin[Melatonin co-treated with Tretinoin] results in increased activity of RARA protein10965999
D014212TretinoinMelatonin promotes the reaction [Tretinoin results in increased activity of RARA protein]15813899
D014212Tretinoin[PCNA protein binds to RARA protein] which affects the susceptibility to Tretinoin16055921
D014212TretinoinRARA gene mutant form inhibits the reaction [Tretinoin inhibits the reaction [arsenic trioxide results in increased expression of HMOX1 protein]]25003661
D014212TretinoinRARA gene mutant form inhibits the reaction [Tretinoin promotes the reaction [arsenic trioxide results in increased activity of CASP3 protein]]25003661
D014212TretinoinRARA gene mutant form results in decreased susceptibility to Tretinoin25003661
D014212TretinoinRARA protein affects the reaction [Tretinoin results in decreased expression of CYP1A1 mRNA]22177959
D014212TretinoinRARA protein affects the reaction [Tretinoin results in decreased secretion of IFNG protein]16872382
D014212TretinoinRARA protein affects the reaction [Tretinoin results in decreased secretion of [IL12A protein binds to IL12B protein]]16872382
D014212TretinoinRARA protein affects the reaction [Tretinoin results in increased expression of CYP26A1 mRNA]16194896
D014212TretinoinRARA protein affects the reaction [Tretinoin results in increased secretion of IL10 protein]16872382
D014212TretinoinRARA protein affects the reaction [Tretinoin results in increased secretion of IL4 protein]16872382
D014212Tretinoin[RARA protein binds to RXRA protein] promotes the reaction [Tretinoin results in increased degradation of NCOA3 protein]16456540
D014212TretinoinRARA protein promotes the reaction [Tretinoin results in increased activity of STS protein]16178010
D014212TretinoinRARA protein promotes the reaction [Tretinoin results in increased expression of VEGFA mRNA]17170094
D014212TretinoinRARA protein results in increased susceptibility to Tretinoin16287870|2094541
D014212Tretinoin[RARA protein results in increased susceptibility to Tretinoin] which results in increased expression of ITGAM24819975
D014212TretinoinRo 41-5253 inhibits the reaction [Tretinoin results in increased expression of RARA mRNA]17216566
D014212TretinoinThiophenes analog promotes the reaction [Tretinoin results in increased expression of RARA mRNA alternative form]16140955
D014212TretinoinTretinoin affects the localization of RARA protein16636311
D014212Tretinoin[Tretinoin binds to and affects the activity of RARA protein] which results in increased activity of CDKN1A protein16765349
D014212TretinoinTretinoin binds to RARA protein1318502
D014212TretinoinTretinoin binds to [RXRA protein binds to RARA protein]16757381
D014212Tretinoin[Tretinoin binds to [RXRA protein binds to RARA protein]] which binds to PDK4 promoter16757381
D014212Tretinoin[Tretinoin co-treated with arsenic trioxide] results in decreased expression of RARA mRNA alternative form19225113
D014212Tretinoin[Tretinoin co-treated with Butyrates] results in increased cleavage of RARA protein mutant form12130515
D014212Tretinoin[Tretinoin co-treated with caffeic acid phenethyl ester] results in increased expression of RARA mRNA16766008
D014212Tretinoin[Tretinoin co-treated with caffeic acid phenethyl ester] results in increased expression of RARA protein16766008
D014212Tretinoin[Tretinoin co-treated with hexamethylene bisacetamide] results in increased cleavage of RARA protein mutant form12130515
D014212Tretinoin[Tretinoin co-treated with RARA protein co-treated with RXRA protein] results in increased expression of CYP26A1 mRNA17244623
D014212TretinoinTretinoin inhibits the reaction [BTG2 protein binds to RARA protein]16782888
D014212TretinoinTretinoin inhibits the reaction [CCNH protein binds to and results in increased phosphorylation of RARA protein mutant form]16935935
D014212TretinoinTretinoin inhibits the reaction [PRMT1 protein binds to RARA protein]16782888
D014212TretinoinTretinoin inhibits the reaction [RARA protein mutant form results in decreased expression of SPI1 mRNA]16352814
D014212TretinoinTretinoin inhibits the reaction [RARA protein mutant form results in decreased expression of SPI1 protein]16352814
D014212TretinoinTretinoin inhibits the reaction [SIN3A protein binds to RARA protein]16782888
D014212TretinoinTretinoin promotes the reaction [CREBBP protein binds to RARA protein]16417649
D014212TretinoinTretinoin promotes the reaction [NCOA3 protein binds to RARA protein]16456540
D014212TretinoinTretinoin promotes the reaction [PCNA protein binds to RARA protein]16055921
D014212TretinoinTretinoin promotes the reaction [RARA protein binds to CD1D promoter]17392484
D014212TretinoinTretinoin promotes the reaction [RARA protein binds to FOLR2 promoter]16740727
D014212TretinoinTretinoin promotes the reaction [RARA protein binds to NCOA1 protein]15578590
D014212TretinoinTretinoin promotes the reaction [RARA protein binds to NCOA2 protein]15578590
D014212TretinoinTretinoin promotes the reaction [RARA protein binds to NCOA3 protein]15578590
D014212TretinoinTretinoin promotes the reaction [RARA protein binds to PRAME protein]16179254
D014212TretinoinTretinoin promotes the reaction [[RARA protein binds to RXRA protein] which binds to NOS2A promoter]17306764
D014212TretinoinTretinoin results in decreased expression of RARA protein15171703|1519442
D014212TretinoinTretinoin results in increased activity of RARA protein16766008|2549281
D014212TretinoinTretinoin results in increased activity of [RARA protein binds to RXRA protein]14592536|2000867
D014212TretinoinTretinoin results in increased cleavage of RARA protein mutant form12130515
D014212TretinoinTretinoin results in increased degradation of [PML protein mutant form binds to RARA protein mutant form]28130038
D014212TretinoinTretinoin results in increased degradation of RARA protein16456540
D014212TretinoinTretinoin results in increased degradation of RARA protein mutant form15748426|1635281
D014212TretinoinTretinoin results in increased expression of and results in increased activity of RARA protein16158052
D014212TretinoinTretinoin results in increased expression of RARA mRNA14592536|1517170
D014212TretinoinTretinoin results in increased expression of RARA mRNA alternative form16140955
D014212TretinoinTretinoin results in increased expression of RARA protein15171703|1663631
D014212TretinoinTretinoin results in increased phosphorylation of RARA protein mutant form19029980
D014212TretinoinTretinoin results in increased sumoylation of and results in decreased degradation of RARA protein15171703
D014212Tretinoin[Tretinoin results in increased sumoylation of and results in decreased degradation of RARA protein] promotes the reaction [RARA protein binds to RXRA protein]15171703
D014212TretinoinTretinoin results in increased ubiquitination of and results in increased degradation of RARA protein15171703|2094541
D014212Tretinoin[Tretinoin results in increased ubiquitination of and results in increased degradation of RARA protein] inhibits the reaction [RARA protein binds to RXRA protein]15171703
D014212TretinoinZNF366 protein promotes the reaction [Tretinoin results in increased activity of [RARA protein binds to RXRA protein]]20008677
D014212TretinoinRARA protein affects the reaction [Tretinoin affects the expression of CYP26A1 mRNA]16261163
D014212TretinoinRARA protein affects the reaction [Tretinoin affects the expression of RARB mRNA]16261163
D014212TretinoinRARA protein inhibits the reaction [Tretinoin results in increased activity of [CLOCK protein binds to ARNTL protein]]17069763
D014212TretinoinTretinoin binds to and results in increased activity of RARA protein12504905|1683918
D014212Tretinoin[Tretinoin binds to RARA protein] which binds to NRL promoter16854989
D014212TretinoinTretinoin inhibits the reaction [RARA gene mutant form results in decreased expression of KRT19 mRNA]10748128
D014212TretinoinTretinoin inhibits the reaction [RARA gene mutant form results in increased expression of ITGA2 mRNA]10748128
D014212TretinoinTretinoin inhibits the reaction [RARA gene mutant form results in increased expression of ITGB4 mRNA]10748128
D014212TretinoinTretinoin inhibits the reaction [RARA gene mutant form results in increased expression of JUN mRNA]10748128
D014212TretinoinTretinoin inhibits the reaction [RARA gene mutant form results in increased expression of JUN protein]10748128
D014212TretinoinTretinoin promotes the reaction [RARA gene mutant form results in decreased expression of ITGB1 mRNA]10748128
D014212TretinoinTretinoin promotes the reaction [RARA gene mutant form results in decreased expression of KRT10 mRNA]10748128
D014212TretinoinTretinoin promotes the reaction [RARA gene mutant form results in decreased expression of KRT6 mRNA]10748128
D014212TretinoinTretinoin results in decreased expression of RARA protein15646024
D014212TretinoinTretinoin results in increased expression of RARA mRNA8892963
D014212TretinoinIL1B protein promotes the reaction [Tretinoin affects the localization of RARA protein]17078027
D014212TretinoinTretinoin affects the localization of RARA protein17078027
D014212TretinoinTretinoin inhibits the reaction [nitrofen results in decreased expression of RARA protein]26672737
D014212TretinoinTretinoin inhibits the reaction [nitrofen results in increased expression of RARA protein]24352370
D014212TretinoinTretinoin promotes the reaction [nitrofen results in increased expression of RARA mRNA]26672737
D014212TretinoinTretinoin results in increased expression of RARA mRNA26672737
D014212TretinoinTretinoin results in increased expression of RARA protein16043492|2667273
D014212TretinoinTretinoin binds to and results in increased activity of RARA protein16839186
D014212TretinoinHX 600 affects the reaction [Tretinoin binds to and results in increased activity of RARA protein]9144408
D014212TretinoinHX 600 promotes the reaction [[Tretinoin binds to and results in increased activity of RARA protein] which results in increased expression of TNFRSF10B mRNA]9144408
D014212TretinoinTretinoin binds to and results in increased activity of RARA protein16819260|9144408
D014212Tretinoin[Tretinoin binds to and results in increased activity of RARA protein] which results in increased expression of TNFRSF10B mRNA9144408
D014212TretinoinTretinoin binds to RARA protein17387344
D014212TretinoinTretinoin results in increased activity of RARA protein17290005|1839847
C012589trichostatin Atrichostatin A promotes the reaction [alitretinoin results in increased activity of RARA protein]15773917
C057693troglitazone[RARA gene mutant form co-treated with NPM1 gene mutant form] affects the susceptibility to troglitazone14508522
C525131UVI 3003UVI 3003 results in decreased expression of RARA mRNA27894914
D014635Valproic AcidValproic Acid results in decreased methylation of RARA gene28853863
D014635Valproic AcidValproic Acid results in increased expression of RARA mRNA15799026
C034028vanadyl sulfatevanadyl sulfate results in decreased expression of RARA mRNA16330358
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of RARA gene25560391|2849585
C025643vinclozolinvinclozolin results in increased expression of RARA mRNA23034163
C025643vinclozolinvinclozolin results in decreased expression of RARA mRNA22496781
D014801Vitamin AVitamin A results in increased expression of RARA mRNA12921748
D014801Vitamin A[Vitamin A co-treated with RARA protein co-treated with RXRA protein] results in increased expression of CYP26A1 mRNA17244623
D014801Vitamin AVitamin A results in increased expression of RARA mRNA17034753|1722587
D014801Vitamin A[RARA gene mutant form co-treated with Vitamin A] results in decreased expression of COL2A1 mRNA16397886
D014801Vitamin A[RARA gene mutant form co-treated with Vitamin A] results in decreased expression of SOX9 mRNA16397886
D014801Vitamin A[RARA gene mutant form co-treated with Vitamin A] results in increased expression of MEIS1 mRNA16397886
D014801Vitamin A[RARA gene mutant form co-treated with Vitamin A] results in increased expression of MEIS2 mRNA16397886
D014801Vitamin ARARG gene mutant form inhibits the reaction [[RARA gene mutant form co-treated with Vitamin A] results in decreased expression of COL2A1 mRNA]16397886
D014801Vitamin ARARG gene mutant form inhibits the reaction [[RARA gene mutant form co-treated with Vitamin A] results in decreased expression of SOX9 mRNA]16397886
D014801Vitamin ARARG gene mutant form inhibits the reaction [[RARA gene mutant form co-treated with Vitamin A] results in increased expression of MEIS1 mRNA]16397886
D014801Vitamin ARARG gene mutant form inhibits the reaction [[RARA gene mutant form co-treated with Vitamin A] results in increased expression of MEIS2 mRNA]16397886
D014801Vitamin AVitamin A deficiency results in increased expression of RARA mRNA7519440
D002762CholecalciferolRARA protein mutant form inhibits the reaction [[Cholecalciferol co-treated with TGFB1 protein] results in increased expression of CD14 mRNA]15988048
D002762CholecalciferolCholecalciferol inhibits the reaction [Methylnitrosourea results in increased expression of RARA mRNA]21843606
C111237vorinostatdecitabine promotes the reaction [vorinostat results in increased expression of RARA mRNA]17417771
C111237vorinostat[vorinostat co-treated with arsenic trioxide] results in decreased expression of RARA protein mutant form27189198
C111237vorinostatvorinostat results in decreased expression of RARA protein mutant form27189198
C111237vorinostatvorinostat results in increased expression of RARA mRNA17417771
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of RARA mRNA18593933
D015032ZincZinc deficiency results in increased expression of RARA mRNA22171008
D015032ZincZinc results in increased expression of RARA protein mutant form16330433
C088658zoledronic acidzoledronic acid results in decreased expression of RARA mRNA24714768|2559613

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000900translation repressor activity, mRNA regulatory element binding-IEA-  
GO:0000976transcription regulatory region sequence-specific DNA binding-IBA21873635  
GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding-IBA21873635  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001076transcription factor activity, RNA polymerase II transcription factor binding-IBA21873635  
GO:0001972retinoic acid binding-IDA2825025  
GO:0003700DNA-binding transcription factor activityCONTRIBUTES_TOIBA21873635  
GO:0003700DNA-binding transcription factor activity-IDA18922886  20413580  
GO:0003707steroid hormone receptor activity-IEA-  
GO:0003708retinoic acid receptor activity-IBA21873635  
GO:0003708retinoic acid receptor activity-IDA2825025  
GO:0003713transcription coactivator activity-IDA2825025  20080953  
GO:0003713transcription coactivator activity-IMP19917671  
GO:0003714transcription corepressor activity-IDA20080953  
GO:0004879nuclear receptor activity-IBA21873635  
GO:0005102signaling receptor binding-IDA19628791  
GO:0005515protein binding-IPI9653119  10698945  16189514  16456540  16606617  16769902  
17363140  17560333  17641689  18048326  19345331  19850744  
19917671  19934264  20080953  20133701  20543827  21478865  
21516116  21988832  22056876  22351778  23518351  24819975  
25036637  25241761  25303530  25416956  26871637  
GO:0008134transcription factor binding-IBA21873635  
GO:0008134transcription factor binding-IPI17641689  
GO:0008144drug binding-IEA-  
GO:0008270zinc ion binding-IEA-  
GO:0019899enzyme binding-IPI9628876  12039952  
GO:0019904protein domain specific binding-IPI20413580  
GO:0030374ligand-dependent nuclear receptor transcription coactivator activity-IBA21873635  
GO:0031490chromatin DNA binding-IDA19917671  
GO:0042826histone deacetylase binding-IEA-  
GO:0043422protein kinase B binding-IPI16417524  
GO:0044323retinoic acid-responsive element binding-IDA19917671  
GO:0046982protein heterodimerization activity-IDA19917671  
GO:0048027mRNA 5'-UTR binding-IEA-  
GO:0051018protein kinase A binding-IDA20215566  
GO:0051393alpha-actinin binding-IPI22351778  
GO:0098531transcription factor activity, direct ligand regulated sequence-specific DNA binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IBA21873635  
GO:0000122negative regulation of transcription by RNA polymerase II-IEA-  
GO:0001657ureteric bud development-IEA-  
GO:0001843neural tube closure-IEA-  
GO:0001889liver development-IBA21873635  
GO:0001889liver development-IEA-  
GO:0002068glandular epithelial cell development-IEA-  
GO:0003148outflow tract septum morphogenesis-IEA-  
GO:0003417growth plate cartilage development-IEA-  
GO:0006367transcription initiation from RNA polymerase II promoter-TAS-  
GO:0006468protein phosphorylation-IMP16456540  
GO:0007165signal transduction-IDA2825025  
GO:0007275multicellular organism development-IBA21873635  
GO:0007281germ cell development-IEA-  
GO:0007283spermatogenesis-IEA-  
GO:0007420brain development-IBA21873635  
GO:0007507heart development-IBA21873635  
GO:0007565female pregnancy-IEA-  
GO:0008284positive regulation of cell proliferation-IMP20080953  
GO:0008285negative regulation of cell proliferation-IEA-  
GO:0009755hormone-mediated signaling pathway-IBA21873635  
GO:0021766hippocampus development-IEA-  
GO:0030154cell differentiation-IBA21873635  
GO:0030850prostate gland development-IEA-  
GO:0030853negative regulation of granulocyte differentiation-IDA19917671  
GO:0030855epithelial cell differentiation-IBA21873635  
GO:0031076embryonic camera-type eye development-IEA-  
GO:0031641regulation of myelination-IEA-  
GO:0032355response to estradiol-IEA-  
GO:0032526response to retinoic acid-IBA21873635  
GO:0032526response to retinoic acid-IMP17538076  
GO:0032689negative regulation of interferon-gamma production-IDA18416830  
GO:0032720negative regulation of tumor necrosis factor production-IDA18416830  
GO:0032736positive regulation of interleukin-13 production-IDA18416830  
GO:0032753positive regulation of interleukin-4 production-IDA18416830  
GO:0032754positive regulation of interleukin-5 production-IDA18416830  
GO:0033189response to vitamin A-IEA-  
GO:0033993response to lipid-IBA21873635  
GO:0034097response to cytokine-IEA-  
GO:0035264multicellular organism growth-IEA-  
GO:0043066negative regulation of apoptotic process-IEA-  
GO:0043277apoptotic cell clearance-IMP19628791  
GO:0043401steroid hormone mediated signaling pathway-IEA-  
GO:0045471response to ethanol-IEA-  
GO:0045630positive regulation of T-helper 2 cell differentiation-IDA18416830  
GO:0045666positive regulation of neuron differentiation-IEA-  
GO:0045787positive regulation of cell cycle-IMP20080953  
GO:0045892negative regulation of transcription, DNA-templated-IDA20080953  
GO:0045893positive regulation of transcription, DNA-templated-IDA18845237  19850744  20080953  
GO:0045893positive regulation of transcription, DNA-templated-IMP19628791  
GO:0045944positive regulation of transcription by RNA polymerase II-IBA21873635  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA19850744  
GO:0045944positive regulation of transcription by RNA polymerase II-IMP20080953  
GO:0045947negative regulation of translational initiation-IEA-  
GO:0048167regulation of synaptic plasticity-IEA-  
GO:0048384retinoic acid receptor signaling pathway-IBA21873635  
GO:0048384retinoic acid receptor signaling pathway-IMP17538076  
GO:0048568embryonic organ development-IBA21873635  
GO:0048732gland development-IBA21873635  
GO:0051099positive regulation of binding-IMP20080953  
GO:0055012ventricular cardiac muscle cell differentiation-IEA-  
GO:0060010Sertoli cell fate commitment-IEA-  
GO:0060173limb development-IEA-  
GO:0060324face development-IEA-  
GO:0060349bone morphogenesis-IBA21873635  
GO:0060429epithelium development-IBA21873635  
GO:0060534trachea cartilage development-IEA-  
GO:0060591chondroblast differentiation-IEA-  
GO:0061037negative regulation of cartilage development-IEA-  
GO:0071222cellular response to lipopolysaccharide-IEA-  
GO:0071300cellular response to retinoic acid-IBA21873635  
GO:0071300cellular response to retinoic acid-IDA19917671  
GO:0071391cellular response to estrogen stimulus-IDA20080953  
GO ID GO Term Qualifier Evidence PubMed
GO:0000790nuclear chromatin-IDA17363140  
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA18845237  19917671  20080953  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IDA19850744  
GO:0005829cytosol-IDA-  
GO:0009986cell surface-IC2825025  
GO:0015629actin cytoskeleton-IDA-  
GO:0030425dendrite-IEA-  
GO:0043025neuronal cell body-IEA-  
GO:0048471perinuclear region of cytoplasm-IEA-  
GO:0090575RNA polymerase II transcription factor complex-IBA21873635  
KEGG ID KEGG Term
hsa05200Pathways in cancer
hsa05221Acute myeloid leukemia
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyIEA
R-HSA-162582Signal TransductionTAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-383280Nuclear Receptor transcription pathwayTAS
R-HSA-5362517Signaling by Retinoic AcidTAS
R-HSA-5617472Activation of anterior HOX genes in hindbrain development during early embryogenesisIEA
R-HSA-5619507Activation of HOX genes during differentiationIEA
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-9006931Signaling by Nuclear ReceptorsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
9415696Application of transmission disequilibrium tests to nonsyndromic oral clefts: including candidate genes and environmental exposures in the models. (1997 Dec 19)Maestri NEAm J Med Genet
28444195DNA methylome analysis reveals distinct epigenetic patterns of ascending aortic dissection and bicuspid aortic valve. (2017 May 1)Pan SCardiovasc Res
8630506Genetic mapping of a pulmonary adenoma resistance (Par1) in mouse. (1996 Apr)Manenti GNat Genet