Gene: RARB

5915
HAP|MCOPS12|NR1B2|RARbeta1|RRB2
retinoic acid receptor beta
protein-coding
3p24.2
Ensembl:ENSG00000077092 MIM:180220 Vega:OTTHUMG00000130480 UniprotKB:P10826
NG_029013.3
PubMed|SNP Mapped
ND|AD
8   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.491e-1 (AD)  6.656e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1286665chr3:25534184 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GABRA40.91
CAMK40.906
GLCCI10.892
NDST30.891
SCAI0.891
AKAP50.891
ST6GALNAC50.89
HOMER10.889
NETO20.888
SSX2IP0.887

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MYL3-0.611
ROM1-0.565
RAB13-0.564
SNHG18-0.563
COPZ2-0.556
PSTPIP1-0.543
TGFB3-0.53
AGTRAP-0.518
TIMP1-0.517
HEY2-0.514

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00210AdapaleneSmall Molecule106685-40-9ApprovedTarget
DB00459AcitretinSmall Molecule55079-83-9ApprovedTarget
DB00523AlitretinoinSmall Molecule5300-03-8Approved|InvestigationalTarget
DB00755TretinoinSmall Molecule302-79-4Approved|Investigational|NutraceuticalTarget
DB00799TazaroteneSmall Molecule118292-40-3Approved|InvestigationalTarget
DB00926EtretinateSmall Molecule54350-48-0WithdrawnTarget
DB02877Arotinoid acidSmall Molecule71441-28-6ExperimentalTarget
DB04942TamibaroteneSmall Molecule94497-51-5Approved|InvestigationalTarget
DB05785LGD-1550Small Molecule-InvestigationalTarget
ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of RARB mRNA"19162173
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of RARB mRNA"21354444|2269881
C09724015-deoxy-delta(12,14)-prostaglandin J2"15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [ciglitazone promotes the reaction [SR 11237 results in increased expression of RARB protein]]"12839938
C09724015-deoxy-delta(12,14)-prostaglandin J2"15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of RARB"15254749
C0192732,2-bis(4-glycidyloxyphenyl)propane"2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [ciglitazone promotes the reaction [SR 11237 results in increased expression of RARB protein]]"12839938
C1202272-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide"2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [Tretinoin results in increased expression of RARB mRNA]"17077328
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of RARB mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of RARB mRNA"21346803
C5293723-((4,6-diphenoxy-1,3,5-triazin-2-yl)amino)benzoic acid"3-((4,6-diphenoxy-1,3,5-triazin-2-yl)amino)benzoic acid results in increased activity of RARB protein"18398471
C0647423,4-didehydroretinoic acid"3,4-didehydroretinoic acid results in increased expression of RARB mRNA"9786419
C0541893,5-di-tert-butylchalcone 4'-carboxylic acid"3,5-di-tert-butylchalcone 4'-carboxylic acid results in increased expression of RARB mRNA"7556191
C0345343,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaenoic acid"3,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaenoic acid results in increased expression of RARB mRNA"15475462
C0345343,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaenoic acid"3,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaenoic acid results in increased expression of RARB protein"15475462
C0345343,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaenoic acid"(5-fluoro-2-methyl-1-(4-pyridyl)methylene-3-(N-benzyl)-indene)-acetamide hydrochloride promotes the reaction [3,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaenoic acid results in increased expression of RARB mRNA]"15475462
C0345343,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaenoic acid"(5-fluoro-2-methyl-1-(4-pyridyl)methylene-3-(N-benzyl)-indene)-acetamide hydrochloride promotes the reaction [3,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaenoic acid results in increased expression of RARB protein]"15475462
C0345343,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaenoic acid"3,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaenoic acid results in increased expression of RARB mRNA"21071580
C4967514-(1H-imidazol-1-yl)retinoic acid4-(1H-imidazol-1-yl)retinoic acid binds to RARB protein17387344
C0388644-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid"4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid promotes the reaction [bexarotene results in increased expression of RARB mRNA]"9006080
C0388644-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid"4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in increased expression of RARB mRNA"9006080
C0388644-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid"bexarotene promotes the reaction [4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in increased expression of RARB mRNA]"9006080
C0388644-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid"4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid binds to and results in increased activity of RARB protein"15589975|1617801
C0888604-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline"4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline results in increased expression of RARB mRNA alternative form"17608728
C0888604-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline"4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline results in increased expression of RARB protein alternative form"17608728
C1216164-((4-(4-ethylphenyl)-2,2-dimethyl-(2H)-thiochromen-6-yl)ethynyl)benzoic acid"4-((4-(4-ethylphenyl)-2,2-dimethyl-(2H)-thiochromen-6-yl)ethynyl)benzoic acid binds to and results in decreased activity of RARB protein"16178010
C0645454-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-anthracenyl)benzoic acid"4-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-anthracenyl)benzoic acid binds to RARB protein"15589975
C0645454-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-anthracenyl)benzoic acid"4-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-anthracenyl)benzoic acid results in increased expression of RARB mRNA"10953040
C0645454-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-anthracenyl)benzoic acid"Chlordan inhibits the reaction [4-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-anthracenyl)benzoic acid binds to RARB protein]"15589975
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RARB mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RARB mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RARB mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RARB mRNA"27188386
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of RARB mRNA12419474
C0194294-hydroxyretinoic acid4-hydroxyretinoic acid results in increased activity of RARB protein25492813
C0194294-hydroxyretinoic acid4-hydroxyretinoic acid results in increased expression of RARB mRNA25492813
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased methylation of RARB promoter14656941
C0022024-oxoretinoic acid4-oxoretinoic acid results in increased expression of RARB mRNA9786419
C0022024-oxoretinoic acid4-oxoretinoic acid results in increased activity of RARB protein25492813
C0022024-oxoretinoic acid4-oxoretinoic acid results in increased expression of RARB mRNA17034753|2549281
C439285(5-fluoro-2-methyl-1-(4-pyridyl)methylene-3-(N-benzyl)-indene)-acetamide hydrochloride"(5-fluoro-2-methyl-1-(4-pyridyl)methylene-3-(N-benzyl)-indene)-acetamide hydrochloride promotes the reaction [3,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaenoic acid results in increased expression of RARB mRNA]"15475462
C439285(5-fluoro-2-methyl-1-(4-pyridyl)methylene-3-(N-benzyl)-indene)-acetamide hydrochloride"(5-fluoro-2-methyl-1-(4-pyridyl)methylene-3-(N-benzyl)-indene)-acetamide hydrochloride promotes the reaction [3,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaenoic acid results in increased expression of RARB protein]"15475462
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RARB mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RARB mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RARB mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RARB mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of RARB mRNA17562736
D000068816AdapaleneAdapalene binds to and results in increased activity of RARB protein10651997
D000068816AdapaleneAdapalene binds to RARB protein21864882|8396608
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of RARB gene27153756
C090766AGN 190299AGN 190299 binds to and results in increased activity of RARB protein16178010
C096920AGN 193109AGN 193109 binds to and results in decreased activity of RARB protein15589975
C096920AGN 193109AGN 193109 inhibits the reaction [Tretinoin results in increased expression of RARB protein]16894348
D000393Air PollutantsAir Pollutants analog results in decreased expression of RARB mRNA21757418
D000452AldrinAldrin results in increased expression of RARB mRNA15589975
C103303alitretinoinalitretinoin results in increased expression of RARB mRNA9786419
C103303alitretinoinalitretinoin binds to and results in increased activity of RARB protein18180267
C103303alitretinoin[alitretinoin binds to RARB protein] which binds to IGFBP3 promoter16760641
C103303alitretinoinalitretinoin results in increased expression of RARB mRNA11139446
C103303alitretinoinalitretinoin results in increased expression of RARB protein15375546
C103303alitretinoinalitretinoin binds to [RXRA protein binds to RARB protein]15159591
C103303alitretinoin[alitretinoin co-treated with RXRA protein] results in increased expression of RARB mRNA22310326
C103303alitretinoinalitretinoin results in increased expression of RARB mRNA16413115|8892963
C103303alitretinoinsodium arsenite inhibits the reaction [[alitretinoin co-treated with RXRA protein] results in increased expression of RARB mRNA]22310326
D000677AmsacrineAmsacrine results in increased expression of RARB mRNA alternative form17608728
D000841AnisomycinAnisomycin promotes the reaction [Tretinoin results in increased expression of RARB mRNA]16038797
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of RARB mRNA24449571
C004984apocarotenalapocarotenal results in increased expression of RARB mRNA17034753
C006632arsenic trioxidearsenic trioxide inhibits the reaction [PRAM1 protein results in decreased expression of RARB mRNA]18941112
C006632arsenic trioxidearsenic trioxide inhibits the reaction [Tretinoin results in increased expression of RARB mRNA]16184197
C006632arsenic trioxidearsenic trioxide inhibits the reaction [Tretinoin results in increased expression of RARB protein]11133770
C006632arsenic trioxidearsenic trioxide results in decreased expression of RARB mRNA10673743
C006632arsenic trioxidearsenic trioxide inhibits the reaction [Tretinoin results in increased expression of RARB mRNA]15688020
D001280AtrazineAtrazine results in decreased expression of RARB mRNA22378314
C547126AZM551248AZM551248 results in decreased expression of RARB mRNA22323515
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of RARB mRNA]22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of RARB mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of RARB mRNA22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of RARB protein17651958
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of RARB protein21467743
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide promotes the reaction [DNMT3A protein binds to RARB promoter]"20426865
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of RARB mRNA"20426865
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased methylation of RARB promoter"20426865
D019207beta Carotenebeta Carotene results in increased expression of RARB mRNA17034753
D004958EstradiolEstradiol promotes the reaction [decitabine results in increased expression of RARB mRNA]22082530
D004958EstradiolEstradiol results in decreased expression of RARB mRNA23436777
D004958Estradiol[Estradiol results in increased expression of RARB mRNA] which results in increased susceptibility to Cisplatin28323900
D004958Estradiol[Estradiol results in increased expression of RARB mRNA] which results in increased susceptibility to Doxorubicin28323900
D004958Estradiol"N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide promotes the reaction [Estradiol results in decreased expression of RARB mRNA]"23436777
C095105bexarotene"4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid promotes the reaction [bexarotene results in increased expression of RARB mRNA]"9006080
C095105bexarotene"bexarotene promotes the reaction [4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in increased expression of RARB mRNA]"9006080
C095105bexarotenebexarotene results in increased expression of RARB mRNA9006080
C095105bexarotenebexarotene results in increased expression of RARB mRNA17178900
C095105bexarotenebexarotene binds to RARB protein9144408
D001629BezafibrateBezafibrate results in decreased expression of RARB mRNA11519881|1157999
C053541bicalutamidebicalutamide results in increased expression of RARB mRNA15790403
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in increased expression of RARB mRNA27685785
C006780bisphenol Abisphenol A results in decreased expression of RARB mRNA25181051
C402892BMS453BMS453 inhibits the reaction [Tretinoin results in increased expression of RARB mRNA]16289102
D002065BuspironeBuspirone results in decreased expression of RARB mRNA24136188
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of RARB mRNA12419474
C018475butyraldehydebutyraldehyde results in decreased expression of RARB mRNA26079696
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of RARB mRNA17484886
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of RARB mRNA27339419
D002392CatechinCatechin results in decreased metabolism of RARB promoter16037419
C099555CD 437CD 437 results in increased expression of RARB mRNA21548569
D002706ChlordanChlordan binds to RARB protein15589975
D002706Chlordan"Chlordan inhibits the reaction [4-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-anthracenyl)benzoic acid binds to RARB protein]"15589975
D002706ChlordanChlordan results in increased expression of RARB mRNA15589975
C039671ciglitazone"15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [ciglitazone promotes the reaction [SR 11237 results in increased expression of RARB protein]]"12839938
C039671ciglitazone"2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [ciglitazone promotes the reaction [SR 11237 results in increased expression of RARB protein]]"12839938
C039671ciglitazoneciglitazone promotes the reaction [SR 11237 results in increased expression of RARB protein]12839938
C039671ciglitazoneNR2F1 protein promotes the reaction [[SR 11237 co-treated with ciglitazone] results in increased expression of RARB protein]12839938
C039671ciglitazonePPARG protein promotes the reaction [ciglitazone promotes the reaction [SR 11237 results in increased expression of RARB protein]]12839938
C007076citralcitral results in decreased expression of RARB mRNA15581867
C018021cobaltous chloridecobaltous chloride results in decreased expression of RARB mRNA19320972
D003471CuprizoneCuprizone results in increased expression of RARB mRNA26577399
D003513CycloheximideCycloheximide promotes the reaction [Tretinoin results in increased expression of RARB mRNA]19450544
D003513CycloheximideCycloheximide results in increased expression of RARB mRNA19450544
D016572CyclosporineCyclosporine results in decreased expression of RARB mRNA19770486
C093628cyproconazolecyproconazole results in increased expression of RARB mRNA22045034
C014347decitabine[decitabine affects the methylation of RARB promoter] which affects the expression of RARB mRNA18852534|1885253
C014347decitabinedecitabine affects the reaction [HIST3H3 protein modified form binds to RARB gene]15959780
C014347decitabine[decitabine co-treated with Tretinoin] results in increased expression of RARB mRNA19524134
C014347decitabine[decitabine co-treated with trichostatin A] affects the reaction [HIST3H3 protein modified form binds to RARB gene]15959780
C014347decitabine[decitabine co-treated with trichostatin A co-treated with Tretinoin] affects the reaction [HIST3H3 protein modified form binds to RARB promoter]15959780
C014347decitabine[decitabine co-treated with trichostatin A] results in increased expression of RARB mRNA15959780
C014347decitabinedecitabine promotes the reaction [Tretinoin results in increased expression of RARB mRNA]17079450
C014347decitabinedecitabine promotes the reaction [Tretinoin results in increased expression of RARB protein]15959780
C014347decitabinedecitabine results in decreased metabolism of RARB gene17079450
C014347decitabinedecitabine results in decreased methylation of RARB promoter16832676
C014347decitabinedecitabine results in increased expression of RARB mRNA15959780|1796133
C014347decitabinedecitabine results in increased expression of RARB protein17961338
C014347decitabineEstradiol promotes the reaction [decitabine results in increased expression of RARB mRNA]22082530
C014347decitabine[Tretinoin co-treated with decitabine] results in increased expression of RARB mRNA15959780
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of RARB mRNA28962523
D002945Cisplatin[Estradiol results in increased expression of RARB mRNA] which results in increased susceptibility to Cisplatin28323900
D002945CisplatinCisplatin results in increased expression of RARB mRNA21865574
D002945CisplatinTretinoin promotes the reaction [Cisplatin results in increased expression of RARB mRNA]21865574
D004026DieldrinDieldrin results in increased expression of RARB mRNA15589975
D004041Dietary FatsDietary Fats results in increased expression of RARB mRNA18042831
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of RARB mRNA18544905
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with kojic acid] results in increased expression of RARB mRNA18544905
D004052Diethylnitrosamine[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of RARB mRNA18253720
C115058difenoconazoledifenoconazole results in increased expression of RARB mRNA28263823
D004317DoxorubicinDoxorubicin results in increased expression of RARB mRNA alternative form17608728
D004317Doxorubicin[Estradiol results in increased expression of RARB mRNA] which results in increased susceptibility to Doxorubicin28323900
D004642EmodinEmodin results in decreased expression of RARB mRNA22609528
D004726EndosulfanEndosulfan results in increased expression of RARB mRNA15589975
D004732EndrinEndrin results in increased expression of RARB mRNA15589975
C118739entinostatentinostat results in increased expression of RARB mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RARB mRNA"27188386
C045651epigallocatechin gallateepigallocatechin gallate results in decreased metabolism of RARB promoter16037419
C045651epigallocatechin gallateepigallocatechin gallate results in decreased methylation of RARB promoter14633667
C045651epigallocatechin gallateepigallocatechin gallate results in increased expression of RARB mRNA14633667
C045651epigallocatechin gallateepigallocatechin gallate results in increased expression of RARB protein14633667
D000431EthanolEthanol results in increased expression of RARB mRNA28986285
D000431EthanolEthanol results in increased expression of RARB mRNA11696672
D000431EthanolEthanol results in increased expression of RARB mRNA16098508
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with Tretinoin] results in increased expression of RARB mRNA17161848
D015025ZearalenoneZearalenone results in decreased expression of RARB mRNA28965971
C033789fenarimolfenarimol results in increased expression of RARB mRNA28970091
D011345Fenofibrate[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of RARB mRNA18253720
C108339fludioxonilfludioxonil results in decreased expression of RARB mRNA23436777
C061365flusilazoleflusilazole results in increased expression of RARB mRNA28263823
D005485FlutamideFlutamide results in decreased expression of RARB mRNA24136188
D019833GenisteinGenistein results in decreased expression of RARB mRNA22228119
D006118GriseofulvinGriseofulvin results in increased expression of RARB mRNA9548566
D006220HaloperidolHaloperidol results in increased expression of RARB mRNA alternative form11564422
C409722hexaconazolehexaconazole results in increased expression of RARB mRNA22045034
D017313FenretinideFenretinide promotes the reaction [scriptaid results in increased expression of RARB mRNA]21319187
D017313FenretinideFenretinide promotes the reaction [trichostatin A results in increased expression of RARB mRNA]21319187
D017313FenretinideFenretinide results in increased expression of RARB mRNA21319187
D017313FenretinideFenretinide results in increased expression of RARB protein15375546
D017313FenretinideRARB protein promotes the reaction [Fenretinide promotes the reaction [scriptaid results in increased expression of NR4A1 protein]]21319187
D017313FenretinideRARB protein promotes the reaction [Fenretinide promotes the reaction [trichostatin A results in increased expression of NR4A1 protein]]21319187
D017313FenretinideRARB protein promotes the reaction [Fenretinide results in increased expression of NR4A1 protein]21319187
D017313Fenretinidescriptaid promotes the reaction [Fenretinide results in increased expression of RARB mRNA]21319187
D017313Fenretinidetrichostatin A promotes the reaction [Fenretinide results in increased expression of RARB mRNA]21319187
D017313FenretinideFenretinide results in increased expression of RARB mRNA28973697
C104181HX 600HX 600 affects the reaction [Tretinoin binds to and results in increased activity of RARB protein]9144408
C104181HX 600HX 600 binds to RARB protein9144408
C104181HX 600HX 600 promotes the reaction [[Tretinoin binds to and results in increased activity of RARB protein] which results in increased expression of TNFRSF10B mRNA]9144408
C422175HX 630HX 630 binds to RARB protein9144408
D006830HydralazineHydralazine results in decreased methylation of RARB promoter15862127
C027185indirubin[indirubin co-treated with tanshinone] promotes the reaction [tetraarsenic tetrasulfide results in increased expression of RARB mRNA]18344322
C027185indirubin[indirubin co-treated with tetraarsenic tetrasulfide] promotes the reaction [tanshinone results in increased expression of RARB mRNA]18344322
C027185indirubinindirubin promotes the reaction [[tetraarsenic tetrasulfide co-treated with tanshinone] inhibits the reaction [RARB protein binds to HDAC1 protein]]18344322
C027185indirubin[tanshinone co-treated with indirubin] inhibits the reaction [RARB protein binds to HDAC1 protein]18344322
C027185indirubintetraarsenic tetrasulfide promotes the reaction [[tanshinone co-treated with indirubin] inhibits the reaction [RARB protein binds to HDAC1 protein]]18344322
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of RARB mRNA24796395
D007654KetoconazoleKetoconazole results in increased expression of RARB mRNA28263823
D048628KetolidesKetolides analog results in increased expression of RARB mRNA24967691
C011890kojic acid[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of RARB mRNA18544905
C011890kojic acid[Diethylnitrosamine co-treated with kojic acid] results in increased expression of RARB mRNA18544905
C477361LAQ824[LAQ824 co-treated with Isotretinoin] results in increased acetylation of RARB promoter17237267
C477361LAQ824[LAQ824 co-treated with Isotretinoin] results in increased expression of RARB mRNA17237267
C477361LAQ824LAQ824 results in increased acetylation of RARB promoter17237267
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of RARB mRNA12057914
D008558MelphalanMelphalan results in decreased expression of RARB mRNA22363485
C042720mercuric bromidemercuric bromide results in increased expression of RARB mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RARB mRNA"27188386
D008942MitoxantroneMitoxantrone results in increased expression of RARB mRNA alternative form17608728
C028577monobutyl phthalatemonobutyl phthalate results in increased expression of RARB mRNA29162477
C523799MRK 003RARB results in decreased susceptibility to MRK 00319903844
D009151Mustard GasMustard Gas results in increased expression of RARB mRNA15674843
C451426N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide"N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide promotes the reaction [Estradiol results in decreased expression of RARB mRNA]"23436777
C451426N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide"N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in decreased expression of RARB mRNA"23436777
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of RARB mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of RARB mRNA"25554681|2562005
C051752nefazodonenefazodone results in decreased expression of RARB mRNA24136188
C017557nickel subsulfidenickel subsulfide results in decreased expression of RARB mRNA21565688
C017557nickel subsulfidenickel subsulfide results in increased methylation of RARB gene21565688
C012655nimesulidenimesulide results in decreased expression of RARB mRNA24136188
C007350nitrofennitrofen results in increased expression of RARB mRNA17270546|2667273
C007350nitrofenTretinoin promotes the reaction [nitrofen results in increased expression of RARB mRNA]26672737
C507134ON 01910ON 01910 results in increased expression of RARB mRNA22351695
C012466oxadiazonoxadiazon results in increased activity of RARB protein20143881
D017239PaclitaxelPaclitaxel results in increased expression of RARB mRNA21865574
D017239PaclitaxelTretinoin promotes the reaction [Paclitaxel results in increased expression of RARB mRNA]21865574
D000073878Palm OilPalm Oil results in increased expression of RARB mRNA18042831
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RARB mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of RARB mRNA26272509
C046012pentanalpentanal results in decreased expression of RARB mRNA26079696
D010575PesticidesPesticides results in decreased methylation of RARB gene28396702
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of RARB mRNA]19482888
D010634PhenobarbitalPhenobarbital affects the expression of RARB mRNA23091169
D010634PhenobarbitalPhenobarbital results in increased expression of RARB mRNA19270015|1948288
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RARB mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of RARB mRNA26272509
D010672PhenytoinPhenytoin results in increased expression of RARB mRNA9988880
C006253pirinixic acidpirinixic acid results in increased expression of RARB mRNA18301758
C045950propiconazolepropiconazole results in increased expression of RARB mRNA21278054
C045950propiconazolepropiconazole results in increased expression of RARB mRNA28970091
D011794QuercetinQuercetin results in decreased expression of RARB mRNA15309432
C406527R 115866[R 115866 co-treated with Vitamin A] results in increased expression of RARB mRNA17510468
C406527R 115866R 115866 results in increased expression of RARB mRNA17510468
C450682R116010R116010 promotes the reaction [Isotretinoin results in increased expression of RARB mRNA]17486130
C450682R116010R116010 promotes the reaction [Tretinoin results in increased expression of RARB mRNA]17486130
D015474IsotretinoinIsotretinoin results in increased expression of RARB mRNA17486130
D015474Isotretinoin[LAQ824 co-treated with Isotretinoin] results in increased acetylation of RARB promoter17237267
D015474Isotretinoin[LAQ824 co-treated with Isotretinoin] results in increased expression of RARB mRNA17237267
D015474IsotretinoinR116010 promotes the reaction [Isotretinoin results in increased expression of RARB mRNA]17486130
D015474IsotretinoinIsotretinoin results in decreased expression of RARB mRNA19041696
D015474IsotretinoinIsotretinoin results in increased expression of RARB mRNA19041696
C084904Ro 41-5253Ro 41-5253 inhibits the reaction [[RARB protein co-treated with RXRA protein] results in increased expression of SLC10A1 mRNA]25550158
C089730rosiglitazonerosiglitazone results in increased expression of RARB15254749
D012450Safflower OilSafflower Oil results in decreased expression of RARB mRNA15203375
D012450Safflower OilVitamin A inhibits the reaction [Safflower Oil results in decreased expression of RARB mRNA]15203375
C410733scriptaidFenretinide promotes the reaction [scriptaid results in increased expression of RARB mRNA]21319187
C410733scriptaidRARB protein promotes the reaction [Fenretinide promotes the reaction [scriptaid results in increased expression of NR4A1 protein]]21319187
C410733scriptaidRARB protein promotes the reaction [scriptaid results in increased expression of NR4A1 protein]21319187
C410733scriptaidscriptaid promotes the reaction [Fenretinide results in increased expression of RARB mRNA]21319187
C410733scriptaidscriptaid results in increased expression of RARB mRNA21319187
D012834SilverSilver results in increased expression of RARB mRNA27131904
D012906SmokeSmoke results in decreased expression of RARB mRNA21095227
D012906SmokeSmoke results in increased methylation of RARB promoter14656941
C017947sodium arsenitesodium arsenite inhibits the reaction [[alitretinoin co-treated with RXRA protein] results in increased expression of RARB mRNA]22310326
D053260SootSoot results in decreased expression of RARB mRNA26551751
C087130SR 11237"15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [ciglitazone promotes the reaction [SR 11237 results in increased expression of RARB protein]]"12839938
C087130SR 11237"2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [ciglitazone promotes the reaction [SR 11237 results in increased expression of RARB protein]]"12839938
C087130SR 11237ciglitazone promotes the reaction [SR 11237 results in increased expression of RARB protein]12839938
C087130SR 11237NR2F1 protein promotes the reaction [[SR 11237 co-treated with ciglitazone] results in increased expression of RARB protein]12839938
C087130SR 11237PPARG protein promotes the reaction [ciglitazone promotes the reaction [SR 11237 results in increased expression of RARB protein]]12839938
C087130SR 11237SR 11237 results in increased expression of RARB protein12839938
D014284TriiodothyronineTriiodothyronine results in increased expression of RARB mRNA15708448
C112689TAC 101TAC 101 results in increased expression of RARB mRNA19142034
C112689TAC 101TAC 101 binds to RARB protein17436592
C061133tamibaroteneCSF3 protein promotes the reaction [tamibarotene results in increased expression of RARB mRNA]27737899
C061133tamibarotenetamibarotene promotes the reaction [CSF3 protein results in increased expression of RARB mRNA]27737899
C061133tamibarotenetamibarotene results in increased expression of RARB mRNA16289102|2773789
C061133tamibarotenetamibarotene results in increased expression of RARB protein19457078
C061133tamibarotenetamibarotene binds to and results in increased activity of RARB protein16819260
C061133tamibarotenetamibarotene binds to RARB protein9144408
C021751tanshinone[indirubin co-treated with tanshinone] promotes the reaction [tetraarsenic tetrasulfide results in increased expression of RARB mRNA]18344322
C021751tanshinone[indirubin co-treated with tetraarsenic tetrasulfide] promotes the reaction [tanshinone results in increased expression of RARB mRNA]18344322
C021751tanshinoneindirubin promotes the reaction [[tetraarsenic tetrasulfide co-treated with tanshinone] inhibits the reaction [RARB protein binds to HDAC1 protein]]18344322
C021751tanshinone[tanshinone co-treated with indirubin] inhibits the reaction [RARB protein binds to HDAC1 protein]18344322
C021751tanshinonetanshinone results in increased expression of RARB mRNA18344322
C021751tanshinone[tetraarsenic tetrasulfide co-treated with tanshinone] inhibits the reaction [RARB protein binds to HDAC1 protein]18344322
C021751tanshinonetetraarsenic tetrasulfide promotes the reaction [[tanshinone co-treated with indirubin] inhibits the reaction [RARB protein binds to HDAC1 protein]]18344322
C086827tazarotenetazarotene results in increased activity of RARB protein15383624
C086827tazarotenetazarotene metabolite binds to and results in increased activity of RARB protein16178010
C086827tazarotenetazarotene binds to and affects the activity of RARB protein16954431
C501413tesaglitazartesaglitazar results in decreased expression of RARB mRNA21515302
C534735tetraarsenic tetrasulfide[indirubin co-treated with tanshinone] promotes the reaction [tetraarsenic tetrasulfide results in increased expression of RARB mRNA]18344322
C534735tetraarsenic tetrasulfide[indirubin co-treated with tetraarsenic tetrasulfide] promotes the reaction [tanshinone results in increased expression of RARB mRNA]18344322
C534735tetraarsenic tetrasulfideindirubin promotes the reaction [[tetraarsenic tetrasulfide co-treated with tanshinone] inhibits the reaction [RARB protein binds to HDAC1 protein]]18344322
C534735tetraarsenic tetrasulfide[tetraarsenic tetrasulfide co-treated with tanshinone] inhibits the reaction [RARB protein binds to HDAC1 protein]18344322
C534735tetraarsenic tetrasulfidetetraarsenic tetrasulfide promotes the reaction [[tanshinone co-treated with indirubin] inhibits the reaction [RARB protein binds to HDAC1 protein]]18344322
C534735tetraarsenic tetrasulfidetetraarsenic tetrasulfide results in increased expression of RARB mRNA18344322
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of RARB mRNA12377990|1534536
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin inhibits the reaction [Tretinoin results in increased expression of RARB mRNA]7864861
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of RARB mRNA28922406
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of RARB mRNA24058054
D013750TetrachloroethyleneTetrachloroethylene results in increased expression of RARB mRNA28973375
D013853ThioacetamideThioacetamide results in decreased expression of RARB mRNA23411599
C009495titanium dioxidetitanium dioxide results in decreased expression of RARB mRNA23557971
D014212TretinoinTretinoin results in increased expression of RARB mRNA12921748|9786419
D014212Tretinoin"2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [Tretinoin results in increased expression of RARB mRNA]"17077328
D014212TretinoinAGN 193109 inhibits the reaction [Tretinoin results in increased expression of RARB protein]16894348
D014212TretinoinAKT1 protein inhibits the reaction [Tretinoin results in increased expression of RARB mRNA]16417524
D014212Tretinoinarsenic trioxide inhibits the reaction [Tretinoin results in increased expression of RARB mRNA]16184197
D014212Tretinoinarsenic trioxide inhibits the reaction [Tretinoin results in increased expression of RARB protein]11133770
D014212TretinoinBMS453 inhibits the reaction [Tretinoin results in increased expression of RARB mRNA]16289102
D014212Tretinoin[decitabine co-treated with Tretinoin] results in increased expression of RARB mRNA19524134
D014212Tretinoin[decitabine co-treated with trichostatin A co-treated with Tretinoin] affects the reaction [HIST3H3 protein modified form binds to RARB promoter]15959780
D014212Tretinoindecitabine promotes the reaction [Tretinoin results in increased expression of RARB mRNA]17079450
D014212Tretinoindecitabine promotes the reaction [Tretinoin results in increased expression of RARB protein]15959780
D014212TretinoinR116010 promotes the reaction [Tretinoin results in increased expression of RARB mRNA]17486130
D014212TretinoinRARB gene modified form results in decreased susceptibility to Tretinoin16287870
D014212TretinoinRARB protein alternative form results in decreased susceptibility to Tretinoin17001699
D014212TretinoinRARB protein alternative form results in increased susceptibility to Tretinoin16288117
D014212TretinoinRARB protein promotes the reaction [Tretinoin results in increased expression of VEGFA mRNA]17170094
D014212TretinoinRARB protein results in increased susceptibility to Tretinoin16236281
D014212TretinoinSUMO1 mutant form inhibits the reaction [Tretinoin results in increased expression of RARB mRNA]24819975
D014212TretinoinTretinoin binds to RARB protein15958702
D014212Tretinoin[Tretinoin co-treated with decitabine] results in increased expression of RARB mRNA15959780
D014212Tretinoin[Tretinoin co-treated with trichostatin A] results in increased expression of RARB mRNA15959780
D014212Tretinoin[Tretinoin co-treated with trichostatin A] results in increased expression of RARB protein15959780
D014212Tretinoin[Tretinoin co-treated with vorinostat] results in increased expression of RARB mRNA alternative form16832676
D014212TretinoinTretinoin inhibits the reaction [RARB protein binds to FOLR2 promoter]16740727
D014212TretinoinTretinoin metabolite results in increased expression of RARB mRNA25492813
D014212TretinoinTretinoin promotes the reaction [HIST4H4 protein modified form binds to RARB gene]17079450
D014212TretinoinTretinoin promotes the reaction [RARB protein alternative form binds to RBP1 promoter]17079450
D014212TretinoinTretinoin results in decreased expression of RARB mRNA10673743|1703475
D014212TretinoinTretinoin results in increased activity of RARB protein25492813
D014212TretinoinTretinoin results in increased expression of and results in increased activity of RARB protein16158052
D014212TretinoinTretinoin results in increased expression of RARB11029503
D014212TretinoinTretinoin results in increased expression of RARB mRNA10866818|1095304
D014212TretinoinTretinoin results in increased expression of RARB mRNA alternative form16832676
D014212TretinoinTretinoin results in increased expression of RARB protein11133770|1283993
D014212TretinoinTretinoin results in increased expression of RARB protein alternative form16287870
D014212Tretinoin[trichostatin A co-treated with Tretinoin] results in increased expression of RARB protein12839938
D014212Tretinointrichostatin A promotes the reaction [Tretinoin results in increased expression of RARB protein]15959780
D014212TretinoinTRIM16 protein promotes the reaction [Tretinoin results in increased expression of RARB mRNA]16636064
D014212TretinoinAKT1 protein inhibits the reaction [Tretinoin results in increased expression of RARB mRNA]16613989
D014212TretinoinALDH1A3 protein promotes the reaction [Tretinoin results in increased expression of RARB mRNA]17207476
D014212TretinoinAnisomycin promotes the reaction [Tretinoin results in increased expression of RARB mRNA]16038797
D014212Tretinoinarsenic trioxide inhibits the reaction [Tretinoin results in increased expression of RARB mRNA]15688020
D014212Tretinoin[DHRS3 gene mutant form results in increased abundance of Tretinoin] which results in increased expression of RARB mRNA24005908
D014212TretinoinMED1 protein affects the reaction [Tretinoin results in increased expression of RARB mRNA alternative form]16723356
D014212TretinoinNCOA1 protein affects the reaction [Tretinoin results in increased expression of RARB mRNA alternative form]16723356
D014212TretinoinRARA protein affects the reaction [Tretinoin affects the expression of RARB mRNA]16261163
D014212TretinoinRARB protein results in increased susceptibility to Tretinoin16860305
D014212TretinoinTetrachlorodibenzodioxin inhibits the reaction [Tretinoin results in increased expression of RARB mRNA]7864861
D014212TretinoinTretinoin binds to and results in increased activity of RARB protein12504905|1683918
D014212Tretinoin[Tretinoin binds to and results in increased activity of RARB protein] which results in increased expression of and results in increased activity of SHH protein16860305
D014212TretinoinTretinoin results in increased expression of RARB8838863
D014212TretinoinTretinoin results in increased expression of RARB mRNA10600643|1283486
D014212TretinoinTretinoin results in increased expression of RARB mRNA alternative form16723356
D014212TretinoinCycloheximide promotes the reaction [Tretinoin results in increased expression of RARB mRNA]19450544
D014212Tretinoin[Ethinyl Estradiol co-treated with Tretinoin] results in increased expression of RARB mRNA17161848
D014212TretinoinIL1B protein promotes the reaction [Tretinoin results in increased expression of RARB protein]11171635
D014212TretinoinRARB mutant form inhibits the reaction [Tretinoin results in increased expression of SLC1A1 mRNA alternative form]19450544
D014212TretinoinTretinoin inhibits the reaction [Vitamin A affects the expression of RARB mRNA]16530976
D014212TretinoinTretinoin promotes the reaction [Cisplatin results in increased expression of RARB mRNA]21865574
D014212TretinoinTretinoin promotes the reaction [nitrofen results in increased expression of RARB mRNA]26672737
D014212TretinoinTretinoin promotes the reaction [Paclitaxel results in increased expression of RARB mRNA]21865574
D014212TretinoinTretinoin results in increased expression of RARB mRNA15708448|2048824
D014212TretinoinTretinoin results in increased expression of RARB mRNA alternative form19450544
D014212TretinoinTretinoin results in increased expression of RARB protein11171635|1945054
D014212TretinoinTretinoin binds to and results in increased activity of RARB protein16839186
D014212TretinoinHX 600 affects the reaction [Tretinoin binds to and results in increased activity of RARB protein]9144408
D014212TretinoinHX 600 promotes the reaction [[Tretinoin binds to and results in increased activity of RARB protein] which results in increased expression of TNFRSF10B mRNA]9144408
D014212TretinoinTretinoin binds to and results in increased activity of RARB protein16819260|9144408
D014212Tretinoin[Tretinoin binds to and results in increased activity of RARB protein] which results in increased expression of TNFRSF10B mRNA9144408
D014212TretinoinTretinoin binds to RARB protein17387344
D014212TretinoinTretinoin results in increased activity of RARB protein18398471
C032910triadimefontriadimefon results in increased expression of RARB mRNA28263823
C012589trichostatin A[decitabine co-treated with trichostatin A] affects the reaction [HIST3H3 protein modified form binds to RARB gene]15959780
C012589trichostatin A[decitabine co-treated with trichostatin A co-treated with Tretinoin] affects the reaction [HIST3H3 protein modified form binds to RARB promoter]15959780
C012589trichostatin A[decitabine co-treated with trichostatin A] results in increased expression of RARB mRNA15959780
C012589trichostatin AFenretinide promotes the reaction [trichostatin A results in increased expression of RARB mRNA]21319187
C012589trichostatin ARARB protein promotes the reaction [Fenretinide promotes the reaction [trichostatin A results in increased expression of NR4A1 protein]]21319187
C012589trichostatin ARARB protein promotes the reaction [trichostatin A results in increased expression of NR4A1 protein]21319187
C012589trichostatin A[Tretinoin co-treated with trichostatin A] results in increased expression of RARB mRNA15959780
C012589trichostatin A[Tretinoin co-treated with trichostatin A] results in increased expression of RARB protein15959780
C012589trichostatin A[trichostatin A co-treated with Tretinoin] results in increased expression of RARB protein12839938
C012589trichostatin Atrichostatin A promotes the reaction [Fenretinide results in increased expression of RARB mRNA]21319187
C012589trichostatin Atrichostatin A promotes the reaction [HIST3H3 protein modified form binds to RARB gene]15959780
C012589trichostatin Atrichostatin A promotes the reaction [Tretinoin results in increased expression of RARB protein]15959780
C012589trichostatin Atrichostatin A results in increased expression of RARB mRNA15959780|2131918
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of RARB mRNA19042947
C057693troglitazonetroglitazone results in decreased expression of RARB mRNA21515302
C080163trovafloxacintrovafloxacin results in decreased expression of RARB mRNA24136188
C525131UVI 3003UVI 3003 results in decreased expression of RARB mRNA27894914
C406224valdecoxibvaldecoxib results in decreased expression of RARB mRNA24136188
D014635Valproic AcidValproic Acid results in decreased methylation of RARB gene29154799
D014635Valproic AcidValproic Acid results in increased expression of RARB mRNA23179753|2438349
D014635Valproic AcidValproic Acid affects the expression of RARB mRNA22045034
D014638VanadatesVanadates results in increased expression of RARB mRNA22714537
C025643vinclozolinvinclozolin results in increased expression of RARB mRNA23034163
C017963vinyl carbamatevinyl carbamate results in decreased expression of RARB mRNA17849452
C029297vinylidene chloridevinylidene chloride results in decreased expression of RARB mRNA26682919
D014801Vitamin AVitamin A results in increased expression of RARB mRNA16230703
D014801Vitamin AVitamin A results in increased expression of RARB mRNA12921748|9786419
D014801Vitamin AVitamin A results in decreased expression of RARB mRNA17034753
D014801Vitamin AVitamin A results in increased expression of RARB mRNA15754000
D014801Vitamin A[R 115866 co-treated with Vitamin A] results in increased expression of RARB mRNA17510468
D014801Vitamin ATretinoin inhibits the reaction [Vitamin A affects the expression of RARB mRNA]16530976
D014801Vitamin AVitamin A affects the expression of RARB mRNA14529804|1653097
D014801Vitamin AVitamin A deficiency results in decreased expression of RARB mRNA7519440
D014801Vitamin AVitamin A inhibits the reaction [Safflower Oil results in decreased expression of RARB mRNA]15203375
C024366vitamin A2vitamin A2 results in increased expression of RARB mRNA9786419
C111237vorinostat[Tretinoin co-treated with vorinostat] results in increased expression of RARB mRNA alternative form16832676
C111237vorinostatvorinostat results in increased expression of RARB mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000976transcription regulatory region sequence-specific DNA binding-IBA21873635  
GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding-IBA21873635  
GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding-IEA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001076transcription factor activity, RNA polymerase II transcription factor binding-IBA21873635  
GO:0003677DNA binding-TAS2153268  
GO:0003700DNA-binding transcription factor activityCONTRIBUTES_TOIBA21873635  
GO:0003707steroid hormone receptor activity-IEA-  
GO:0003708retinoic acid receptor activity-IBA21873635  
GO:0003708retinoic acid receptor activity-IEA-  
GO:0004879nuclear receptor activity-IBA21873635  
GO:0008134transcription factor binding-IBA21873635  
GO:0008144drug binding-IEA-  
GO:0008270zinc ion binding-IEA-  
GO:0030374ligand-dependent nuclear receptor transcription coactivator activity-IBA21873635  
GO:0044877protein-containing complex binding-IEA-  
GO:0046965retinoid X receptor binding-IEA-  
GO:0098531transcription factor activity, direct ligand regulated sequence-specific DNA binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IBA21873635  
GO:0000122negative regulation of transcription by RNA polymerase II-IEA-  
GO:0001657ureteric bud development-IEA-  
GO:0001889liver development-IBA21873635  
GO:0002068glandular epithelial cell development-IEA-  
GO:0003148outflow tract septum morphogenesis-IEA-  
GO:0003406retinal pigment epithelium development-IEA-  
GO:0003417growth plate cartilage development-IEA-  
GO:0006367transcription initiation from RNA polymerase II promoter-TAS-  
GO:0007165signal transduction-TAS2833708  
GO:0007275multicellular organism development-IBA21873635  
GO:0007420brain development-IBA21873635  
GO:0007507heart development-IBA21873635  
GO:0008284positive regulation of cell proliferation-IEA-  
GO:0008285negative regulation of cell proliferation-IEA-  
GO:0009755hormone-mediated signaling pathway-IBA21873635  
GO:0021756striatum development-IEA-  
GO:0030154cell differentiation-IBA21873635  
GO:0030855epithelial cell differentiation-IBA21873635  
GO:0031641regulation of myelination-IEA-  
GO:0032331negative regulation of chondrocyte differentiation-IEA-  
GO:0032526response to retinoic acid-IBA21873635  
GO:0033993response to lipid-IBA21873635  
GO:0035116embryonic hindlimb morphogenesis-IEA-  
GO:0035264multicellular organism growth-IEA-  
GO:0043065positive regulation of apoptotic process-IEA-  
GO:0043066negative regulation of apoptotic process-IEA-  
GO:0043401steroid hormone mediated signaling pathway-IEA-  
GO:0045666positive regulation of neuron differentiation-IEA-  
GO:0045944positive regulation of transcription by RNA polymerase II-IBA21873635  
GO:0045944positive regulation of transcription by RNA polymerase II-IEA-  
GO:0048048embryonic eye morphogenesis-IEA-  
GO:0048384retinoic acid receptor signaling pathway-IBA21873635  
GO:0048384retinoic acid receptor signaling pathway-IEA-  
GO:0048566embryonic digestive tract development-IMP19443732  
GO:0048568embryonic organ development-IBA21873635  
GO:0048732gland development-IBA21873635  
GO:0055012ventricular cardiac muscle cell differentiation-IEA-  
GO:0060349bone morphogenesis-IBA21873635  
GO:0060429epithelium development-IBA21873635  
GO:0071300cellular response to retinoic acid-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA18845237  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IEA-  
GO:0090575RNA polymerase II transcription factor complex-IBA21873635  
KEGG ID KEGG Term
hsa05200Pathways in cancer
hsa05222Small cell lung cancer
hsa05223Non-small cell lung cancer
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyIEA
R-HSA-162582Signal TransductionTAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-383280Nuclear Receptor transcription pathwayTAS
R-HSA-5362517Signaling by Retinoic AcidTAS
R-HSA-5617472Activation of anterior HOX genes in hindbrain development during early embryogenesisIEA
R-HSA-5619507Activation of HOX genes during differentiationIEA
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-9006931Signaling by Nuclear ReceptorsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23599765Abnormal methylation of seven genes and their associations with clinical characteristics in early stage non-small cell lung cancer. (2013 Apr)Zhao YOncol Lett
22217548Similar DNA methylation pattern in lung tumours from smokers and never-smokers with second-hand tobacco smoke exposure. (2012 Jul)Scesnaite AMutagenesis
18349282DNA methylation in tumor and matched normal tissues from non-small cell lung cancer patients. (2008 Mar)Feng QCancer Epidemiol Biomarkers Prev
20592015Molecular analysis of plasma DNA for the early detection of lung cancer by quantitative methylation-specific PCR. (2010 Jul 1)Ostrow KLClin Cancer Res
22837378Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction. (2012 Oct 1)Wilk JBAm J Respir Crit Care Med
29197760Lifetime exposure to ambient air pollution and methylation of tumor suppressor genes in breast tumors. (2018 Feb)Callahan CLEnviron Res
25754026Meta-analyses of gene methylation and smoking behavior in non-small cell lung cancer patients. (2015 Mar 10)Huang TSci Rep
28722770Asbestos-associated genome-wide DNA methylation changes in lung cancer. (2017 Nov 15)Kettunen EInt J Cancer