Gene info: ID 5917

Gene: RARS

GENE ID: 5917

Synonyms: ArgRS|DALRD1|HLD9

Description: arginyl-tRNA synthetase

Gene type: protein-coding

Location: 5q34

dbXrefs: Ensembl:ENSG00000113643 MIM:107820 Vega:OTTHUMG00000130411 UniprotKB:P54136

RefSeq: NG_041809.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: OD|ND|AD

# Publications: 8

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 5.535e-2 (AD) 6.300e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
YTHDF2	0.944
PPHLN1	0.942
POLR3F	0.939
PSMA1	0.936
GNL3	0.934
MED6	0.933
PSMA5	0.93
ARL1	0.929
KDM1A	0.927
THUMPD1	0.926

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.625
OR4F29	-0.574
SH2D1A	-0.284
TRPV5	-0.281
MTRNR2L9	-0.278
ANXA13	-0.271
ASB4	-0.268
NKX6-1	-0.267
MTRNR2L6	-0.264
MYOM1	-0.263

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of RARS mRNA"	21346803
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of RARS mRNA"	21346803
D000082	Acetaminophen	Acetaminophen affects the expression of RARS mRNA	17562736
C006632	arsenic trioxide	arsenic trioxide results in increased expression of RARS protein	25419056
D001280	Atrazine	Atrazine results in increased expression of RARS mRNA	25929836
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of RARS mRNA	22228805
C006780	bisphenol A	bisphenol A results in increased expression of RARS mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased methylation of RARS gene	28505145
C013418	bromfenacoum	bromfenacoum results in increased expression of RARS protein	28903499
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of RARS protein	24527689
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of RARS mRNA	23741332
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of RARS mRNA	27339419
C054133	casticin	casticin results in decreased expression of RARS mRNA	28444820
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in decreased expression of RARS mRNA	23650126
C100187	chloropicrin	chloropicrin results in increased expression of RARS mRNA	26352163
C074702	chromium hexavalent ion	chromium hexavalent ion affects the expression of RARS mRNA	28472532
D003300	Copper	Copper results in increased expression of RARS mRNA	16629173
C000944	dicrotophos	dicrotophos results in decreased expression of RARS mRNA	28302478
D004147	Dioxins	Dioxins affects the expression of RARS mRNA	20463971
D004237	Diuron	Diuron results in increased expression of RARS mRNA	21551480
D004791	Enzyme Inhibitors	[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of RARS protein	23301498
C045651	epigallocatechin gallate	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of RARS mRNA	22079256
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of RARS mRNA	17555576
D015025	Zearalenone	Zearalenone results in decreased expression of RARS protein	25058043
D005485	Flutamide	Flutamide results in increased expression of RARS mRNA	24136188
D005839	Gentamicins	Gentamicins results in increased expression of RARS mRNA	22061828
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of RARS mRNA	20044591
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of RARS mRNA	25613284
C544151	jinfukang	jinfukang results in decreased expression of RARS mRNA	27392435
D007854	Lead	Lead affects the expression of RARS mRNA	28903495
C008261	lead acetate	lead acetate results in decreased expression of RARS mRNA	11578147
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of RARS mRNA	26011545
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of RARS mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of RARS mRNA"	25554681
C051752	nefazodone	nefazodone results in increased expression of RARS mRNA	24136188
D010936	Plant Extracts	Plant Extracts results in increased expression of RARS mRNA	23557933
C027373	potassium chromate(VI)	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of RARS mRNA	22079256
C027373	potassium chromate(VI)	potassium chromate(VI) results in decreased expression of RARS mRNA	22079256
C016104	sodium bichromate	sodium bichromate results in increased expression of RARS mRNA	25993096
D013629	Tamoxifen	Tamoxifen affects the expression of RARS mRNA	17555576
C020806	tetrabromobisphenol A	tetrabromobisphenol A affects the expression of RARS mRNA	18976794
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of RARS mRNA	21570461
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of RARS mRNA	25613284
D013853	Thioacetamide	Thioacetamide results in increased expression of RARS mRNA	23411599
D014212	Tretinoin	Tretinoin results in decreased expression of RARS mRNA	16054129
C015559	trimellitic anhydride	trimellitic anhydride results in increased expression of RARS mRNA	19042947
D014635	Valproic Acid	Valproic Acid affects the expression of RARS mRNA	17292431
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of RARS gene	25560391

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000049	tRNA binding	-	IEA	-
GO:0004814	arginine-tRNA ligase activity	-	IBA	21873635
GO:0004814	arginine-tRNA ligase activity	-	IDA	25288775
GO:0004814	arginine-tRNA ligase activity	-	TAS	-
GO:0005515	protein binding	-	IPI	16055448 24656866
GO:0005524	ATP binding	-	IEA	-
GO:0034618	arginine binding	-	IEA	-
GO:0045296	cadherin binding	-	HDA	25468996

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006418	tRNA aminoacylation for protein translation	-	TAS	-
GO:0006420	arginyl-tRNA aminoacylation	-	IBA	21873635
GO:0006420	arginyl-tRNA aminoacylation	-	IDA	25288775

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IDA	10791971
GO:0005654	nucleoplasm	-	IDA	-
GO:0005737	cytoplasm	-	IDA	10791971
GO:0005829	cytosol	-	IDA	19289464
GO:0005829	cytosol	-	TAS	-
GO:0016020	membrane	-	HDA	19946888
GO:0017101	aminoacyl-tRNA synthetase multienzyme complex	-	IDA	19131329
GO:0070062	extracellular exosome	-	HDA	19056867

KEGG ID	KEGG Term
hsa00970	Aminoacyl-tRNA biosynthesis

Reactome ID	Reactome Term	Evidence
R-HSA-1430728	Metabolism	IEA
R-HSA-2408517	SeMet incorporation into proteins	IEA
R-HSA-2408522	Selenoamino acid metabolism	IEA
R-HSA-379716	Cytosolic tRNA aminoacylation	TAS
R-HSA-379724	tRNA Aminoacylation	TAS
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-71291	Metabolism of amino acids and derivatives	IEA
R-HSA-72766	Translation	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
10433621	Nuclear retinoid acid receptor beta in bronchial epithelium of smokers before and during chemoprevention. (1999 Aug 4)	Xu XC	J Natl Cancer Inst
28000295	Drug availability adjustments in population-based studies of prescription opioid abuse. (2017 Feb)	Secora A	Pharmacoepidemiol Drug Saf
15635645	Structural variants in the retinoid receptor genes in patients with schizophrenia and other psychiatric diseases. (2005 Feb 5)	Feng J	Am J Med Genet B Neuropsychiatr Genet
22725841	Chronic ethanol consumption alters all-trans-retinoic acid concentration and expression of their receptors on the prostate: a possible link between alcoholism and prostate damage. (2013 Jan)	Fontanelli BA	Alcohol Clin Exp Res
9890171	Retinoid signaling and activator protein-1 expression in ferrets given beta-carotene supplements and exposed to tobacco smoke. (1999 Jan 6)	Wang XD	J Natl Cancer Inst
24140093	Higher fetuin-A, lower adiponectin and free leptin levels mediate effects of excess body weight on insulin resistance and risk for myelodysplastic syndrome. (2013 Dec)	Dalamaga M	Metabolism
10850430	Retinoic acid receptor and retinoid X receptor alterations in lung cancer precursor lesions. (2000 Jun 1)	Martinet N	Cancer Res
23805315	A Meta-Analysis of the Relationship between Cigarette Smoking and Incidence of Myelodysplastic Syndromes. (2013)	Tong H	PLoS One